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Entry version 183 (29 Sep 2021)
Sequence version 2 (09 Jan 2013)
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Protein

Cytochrome c oxidase subunit 1

Gene

mt:CoI

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

By similarity

Caution

There is no mitochondrial-type translation initiation codon present in frame in the sequence. In PubMed:19533212, the authors suggest the presence of a novel start codon coding for either Pro or Ser in Drosophila CoI transcripts. In PubMed:19540318, further evidence for the presence of the same start codon coding for Ser in D.melanogaster CoI transcript is presented.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi38CalciumBy similarity1
Metal bindingi43Calcium; via carbonyl oxygenBy similarity1
Metal bindingi59Iron 1 (low-spin heme A axial ligand); via tele nitrogenBy similarity1
Metal bindingi238Copper B; via pros nitrogenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei242OxygenBy similarity1
Metal bindingi288Copper B; via tele nitrogenBy similarity1
Metal bindingi289Copper B; via tele nitrogenBy similarity1
Metal bindingi366Magnesium; shared with subunit 2By similarity1
Metal bindingi367Magnesium; shared with subunit 2By similarity1
Metal bindingi374Iron 2 (high-spin heme A3 axial ligand); via tele nitrogenBy similarity1
Metal bindingi376Iron 1 (low-spin heme A axial ligand); via tele nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandCalcium, Copper, Heme, Iron, Magnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5628897, TP53 Regulates Metabolic Genes
R-DME-611105, Respiratory electron transport
R-DME-9707564, Cytoprotection by HMOX1

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00705

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:7.1.1.9)
Alternative name(s):
Cytochrome c oxidase polypeptide I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mt:CoI
Synonyms:CoI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrion
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Mitochondrion

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0013674, mt:CoI

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0013674

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001833251 – 511Cytochrome c oxidase subunit 1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P00399

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0013674, Expressed in arthropod fat body and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P00399, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
2595062, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0100176

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00399

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4769, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001518

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011899_7_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00399

Identification of Orthologs from Complete Genome Data

More...
OMAi
WAMMSIG

Database of Orthologous Groups

More...
OrthoDBi
728231at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P00399

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01663, Cyt_c_Oxidase_I, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.210.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023616, Cyt_c_oxase-like_su1_dom
IPR036927, Cyt_c_oxase-like_su1_sf
IPR000883, Cyt_C_Oxase_1
IPR023615, Cyt_c_Oxase_su1_BS
IPR033944, Cyt_c_oxase_su1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10422, PTHR10422, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00115, COX1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01165, CYCOXIDASEI

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81442, SSF81442, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50855, COX1, 1 hit
PS00077, COX1_CUB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P00399-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SRQWLFSTNH KDIGTLYFIF GAWAGMVGTS LSILIRAELG HPGALIGDDQ
60 70 80 90 100
IYNVIVTAHA FIMIFFMVMP IMIGGFGNWL VPLMLGAPDM AFPRMNNMSF
110 120 130 140 150
WLLPPALSLL LVSSMVENGA GTGWTVYPPL SAGIAHGGAS VDLAIFSLHL
160 170 180 190 200
AGISSILGAV NFITTVINMR STGISLDRMP LFVWSVVITA LLLLLSLPVL
210 220 230 240 250
AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG
260 270 280 290 300
MISHIISQES GKKETFGSLG MIYAMLAIGL LGFIVWAHHM FTVGMDVDTR
310 320 330 340 350
AYFTSATMII AVPTGIKIFS WLATLHGTQL SYSPAILWAL GFVFLFTVGG
360 370 380 390 400
LTGVVLANSS VDIILHDTYY VVAHFHYVLS MGAVFAIMAG FIHWYPLFTG
410 420 430 440 450
LTLNNKWLKS HFIIMFIGVN LTFFPQHFLG LAGMPRRYSD YPDAYTTWNI
460 470 480 490 500
VSTIGSTISL LGILFFFFII WESLVSQRQV IYPIQLNSSI EWYQNTPPAE
510
HSYSELPLLT N
Length:511
Mass (Da):56,372
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i332DAFF298EBBA13
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti127Y → F in strain: Zimbabwe. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J01404 Genomic DNA Translation: AAB59239.1
U37541 Genomic DNA Translation: AAC47812.2
AF200828 Genomic DNA Translation: AAF77227.1
AF200829 Genomic DNA Translation: AAF77245.1
AJ400907 Genomic DNA Translation: CAB91052.2
FJ190105 Genomic DNA Translation: ACI28543.1
FJ190106 Genomic DNA Translation: ACI28556.1
FJ190107 Genomic DNA Translation: ACI28569.1
FJ190108 Genomic DNA Translation: ACI28582.1
FJ190109 Genomic DNA Translation: ACI28595.1
FJ190110 Genomic DNA Translation: ACI28608.1
GQ229519 mRNA Translation: ACT21544.1
JX266575 Genomic DNA Translation: AFR59645.1
JX266576 Genomic DNA Translation: AFR59658.1
JX266577 Genomic DNA Translation: AFR59671.1
JX266578 Genomic DNA Translation: AFR59684.1
JX266579 Genomic DNA Translation: AFR59697.1
JX266580 Genomic DNA Translation: AFR59710.1
JQ686694 Genomic DNA Translation: AFP47060.1
JQ686695 Genomic DNA Translation: AFP47073.1
JQ686696 Genomic DNA Translation: AFP47086.1
JQ686698 Genomic DNA Translation: AFP47112.1
JQ686699 Genomic DNA Translation: AFP47125.1
KJ947872 Genomic DNA Translation: AIC64005.1
M57910 Genomic DNA Translation: AAB02282.1
M18022 Genomic DNA Translation: AAA65480.2
AY383542 Genomic DNA Translation: AAQ92343.1
U51619 Genomic DNA Translation: AAB68481.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A93307, ODFF1

NCBI Reference Sequences

More...
RefSeqi
YP_009047267.1, NC_024511.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0100861; FBpp0100176; FBgn0013674

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19893533

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG34067

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01404 Genomic DNA Translation: AAB59239.1
U37541 Genomic DNA Translation: AAC47812.2
AF200828 Genomic DNA Translation: AAF77227.1
AF200829 Genomic DNA Translation: AAF77245.1
AJ400907 Genomic DNA Translation: CAB91052.2
FJ190105 Genomic DNA Translation: ACI28543.1
FJ190106 Genomic DNA Translation: ACI28556.1
FJ190107 Genomic DNA Translation: ACI28569.1
FJ190108 Genomic DNA Translation: ACI28582.1
FJ190109 Genomic DNA Translation: ACI28595.1
FJ190110 Genomic DNA Translation: ACI28608.1
GQ229519 mRNA Translation: ACT21544.1
JX266575 Genomic DNA Translation: AFR59645.1
JX266576 Genomic DNA Translation: AFR59658.1
JX266577 Genomic DNA Translation: AFR59671.1
JX266578 Genomic DNA Translation: AFR59684.1
JX266579 Genomic DNA Translation: AFR59697.1
JX266580 Genomic DNA Translation: AFR59710.1
JQ686694 Genomic DNA Translation: AFP47060.1
JQ686695 Genomic DNA Translation: AFP47073.1
JQ686696 Genomic DNA Translation: AFP47086.1
JQ686698 Genomic DNA Translation: AFP47112.1
JQ686699 Genomic DNA Translation: AFP47125.1
KJ947872 Genomic DNA Translation: AIC64005.1
M57910 Genomic DNA Translation: AAB02282.1
M18022 Genomic DNA Translation: AAA65480.2
AY383542 Genomic DNA Translation: AAQ92343.1
U51619 Genomic DNA Translation: AAB68481.2
PIRiA93307, ODFF1
RefSeqiYP_009047267.1, NC_024511.2

3D structure databases

SMRiP00399
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi2595062, 1 interactor
STRINGi7227.FBpp0100176

Proteomic databases

PaxDbiP00399

Genome annotation databases

EnsemblMetazoaiFBtr0100861; FBpp0100176; FBgn0013674
GeneIDi19893533
KEGGidme:Dmel_CG34067

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4512
FlyBaseiFBgn0013674, mt:CoI
VEuPathDBiVectorBase:FBgn0013674

Phylogenomic databases

eggNOGiKOG4769, Eukaryota
GeneTreeiENSGT00390000001518
HOGENOMiCLU_011899_7_3_1
InParanoidiP00399
OMAiWAMMSIG
OrthoDBi728231at2759
PhylomeDBiP00399

Enzyme and pathway databases

UniPathwayiUPA00705
ReactomeiR-DME-5628897, TP53 Regulates Metabolic Genes
R-DME-611105, Respiratory electron transport
R-DME-9707564, Cytoprotection by HMOX1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
19893533, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COX1, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
19893533

Protein Ontology

More...
PROi
PR:P00399

Gene expression databases

BgeeiFBgn0013674, Expressed in arthropod fat body and 19 other tissues
ExpressionAtlasiP00399, baseline and differential

Family and domain databases

CDDicd01663, Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616, Cyt_c_oxase-like_su1_dom
IPR036927, Cyt_c_oxase-like_su1_sf
IPR000883, Cyt_C_Oxase_1
IPR023615, Cyt_c_Oxase_su1_BS
IPR033944, Cyt_c_oxase_su1_dom
PANTHERiPTHR10422, PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115, COX1, 1 hit
PRINTSiPR01165, CYCOXIDASEI
SUPFAMiSSF81442, SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855, COX1, 1 hit
PS00077, COX1_CUB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00399
Secondary accession number(s): B6E0P3
, O21461, Q34349, Q6TXT7, Q7GFY7, Q7GHI7, Q9MGN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 9, 2013
Last modified: September 29, 2021
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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