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Protein

Cytochrome c oxidase subunit 1

Gene

Mtco1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Iron (heme A axial ligand)Curated1
Metal bindingi240Copper BCurated1
Metal bindingi244Copper BCurated1
Metal bindingi290Copper BCurated1
Metal bindingi291Copper BCurated1
Metal bindingi376Iron (heme A3 axial ligand)Curated1
Metal bindingi378Iron (heme A axial ligand)Curated1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: MGI
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:Mtco1
Synonyms:COI, mt-Co1
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102504 mt-Co1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833631 – 514Cytochrome c oxidase subunit 1Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiP00397
PeptideAtlasiP00397
PRIDEiP00397

PTM databases

iPTMnetiP00397
PhosphoSitePlusiP00397
SwissPalmiP00397

Expressioni

Gene expression databases

BgeeiENSMUSG00000064351 Expressed in 19 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiP00397 baseline and differential

Interactioni

Subunit structurei

As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner.By similarity

Protein-protein interaction databases

DIPiDIP-61656N
STRINGi10090.ENSMUSP00000080993

Structurei

3D structure databases

ProteinModelPortaliP00397
SMRiP00397
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4769 Eukaryota
COG0843 LUCA
GeneTreeiENSGT00390000001518
HOGENOMiHOG000085274
HOVERGENiHBG003841
InParanoidiP00397
KOiK02256
OMAiMSFWLLP
OrthoDBiEOG091G035B

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

P00397-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSILIRAE LGQPGALLGD
60 70 80 90 100
DQIYNVIVTA HAFVMIFFMV MPMMIGGFGN WLVPLMIGAP DMAFPRMNNM
110 120 130 140 150
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL
160 170 180 190 200
HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP
210 220 230 240 250
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG
260 270 280 290 300
FGIISHVVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGLDVD
310 320 330 340 350
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV
360 370 380 390 400
GGLTGIVLSN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM AGFVHWFPLF
410 420 430 440 450
SGFTLDDTWA KAHFAIMFVG VNMTFFPQHF LGLSGMPRRY SDYPDAYTTW
460 470 480 490 500
NTVSSMGSFI SLTAVLIMIF MIWEAFASKR EVMSVSYAST NLEWLHGCPP
510
PYHTFEEPTY VKVK
Length:514
Mass (Da):56,910
Last modified:April 1, 2015 - v2
Checksum:i9F7FB173ED6A9763
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136L → P in AAB48646 (PubMed:7332926).Curated1
Sequence conflicti136L → P in CAA24082 (PubMed:7332926).Curated1
Sequence conflicti137A → V in AAB48646 (PubMed:7332926).Curated1
Sequence conflicti137A → V in CAA24082 (PubMed:7332926).Curated1
Sequence conflicti304Y → C in AAB48646 (PubMed:7332926).Curated1
Sequence conflicti304Y → C in CAA24082 (PubMed:7332926).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48646.1
V00711 Genomic DNA Translation: CAA24082.1
AY172335 Genomic DNA Translation: AAN85124.1
U39315 Genomic DNA Translation: AAA85227.1
PIRiA00465 ODMS1
RefSeqiNP_904330.1, NC_005089.1

Genome annotation databases

EnsembliENSMUST00000082402; ENSMUSP00000080993; ENSMUSG00000064351
GeneIDi17708
KEGGimmu:17708

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48646.1
V00711 Genomic DNA Translation: CAA24082.1
AY172335 Genomic DNA Translation: AAN85124.1
U39315 Genomic DNA Translation: AAA85227.1
PIRiA00465 ODMS1
RefSeqiNP_904330.1, NC_005089.1

3D structure databases

ProteinModelPortaliP00397
SMRiP00397
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61656N
STRINGi10090.ENSMUSP00000080993

PTM databases

iPTMnetiP00397
PhosphoSitePlusiP00397
SwissPalmiP00397

Proteomic databases

PaxDbiP00397
PeptideAtlasiP00397
PRIDEiP00397

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082402; ENSMUSP00000080993; ENSMUSG00000064351
GeneIDi17708
KEGGimmu:17708

Organism-specific databases

CTDi4512
MGIiMGI:102504 mt-Co1

Phylogenomic databases

eggNOGiKOG4769 Eukaryota
COG0843 LUCA
GeneTreeiENSGT00390000001518
HOGENOMiHOG000085274
HOVERGENiHBG003841
InParanoidiP00397
KOiK02256
OMAiMSFWLLP
OrthoDBiEOG091G035B

Enzyme and pathway databases

UniPathwayi
UPA00705

Miscellaneous databases

PROiPR:P00397
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064351 Expressed in 19 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiP00397 baseline and differential

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_MOUSE
AccessioniPrimary (citable) accession number: P00397
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 2015
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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