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Protein

Glutathione reductase, mitochondrial

Gene

GSR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Maintains high levels of reduced glutathione in the cytosol.

Miscellaneous

The active site is a redox-active disulfide bond.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADNote: Binds 1 FAD per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei511Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi94 – 102FAD9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • electron transfer activity Source: UniProtKB
  • flavin adenine dinucleotide binding Source: GO_Central
  • glutathione-disulfide reductase activity Source: GO_Central
  • NADP binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS02602-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.8.1.7 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-5628897 TP53 Regulates Metabolic Genes

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P00390

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione reductase, mitochondrial (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSR
Synonyms:GLUR, GRD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104687.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4623 GSR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138300 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P00390

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2936

MalaCards human disease database

More...
MalaCardsi
GSR
MIMi138300 gene+phenotype

Open Targets

More...
OpenTargetsi
ENSG00000104687

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90030 Hemolytic anemia due to glutathione reductase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29014

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2755

Drug and drug target database

More...
DrugBanki
DB02895 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol
DB02153 3-Sulfinoalanine
DB00262 Carmustine
DB03147 Flavin adenine dinucleotide
DB00143 Glutathione
DB02553 Glutathionylspermidine Disulfide
DB09110 Mesna
DB03867 Meta-Nitro-Tyrosine
DB00157 NADH
DB03310 Oxidized Glutathione Disulfide

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14916998

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 43MitochondrionSequence analysisAdd BLAST43
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003027644 – 522Glutathione reductase, mitochondrialAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei97N6-acetyllysineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi102 ↔ 107Redox-active1 Publication
Disulfide bondi134Interchain1 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P00390

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P00390

PeptideAtlas

More...
PeptideAtlasi
P00390

PRoteomics IDEntifications database

More...
PRIDEi
P00390

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51241
51242 [P00390-2]
51243 [P00390-3]
51244 [P00390-4]
51245 [P00390-5]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00759575

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P00390

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P00390

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P00390

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104687 Expressed in 218 organ(s), highest expression level in endometrium

CleanEx database of gene expression profiles

More...
CleanExi
HS_GSR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P00390 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P00390 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008632
HPA001538

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109191, 32 interactors

Protein interaction database and analysis system

More...
IntActi
P00390, 6 interactors

Molecular INTeraction database

More...
MINTi
P00390

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221130

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P00390

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P00390

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00390

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P00390

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0405 Eukaryota
COG1249 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156986

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276712

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004959

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00390

KEGG Orthology (KO)

More...
KOi
K00383

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCAIIEA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G078A

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P00390

TreeFam database of animal gene trees

More...
TreeFami
TF105353

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.390.30, 1 hit
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006322 Glutathione_Rdtase_euk/bac
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS

The PANTHER Classification System

More...
PANTHERi
PTHR42737 PTHR42737, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000350 Mercury_reductase_MerA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01421 gluta_reduc_1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Mitochondrial (identifier: P00390-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP
60 70 80 90 100
QPQGPPPAAG AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG
110 120 130 140 150
TCVNVGCVPK KVMWNTAVHS EFMHDHADYG FPSCEGKFNW RVIKEKRDAY
160 170 180 190 200
VSRLNAIYQN NLTKSHIEII RGHAAFTSDP KPTIEVSGKK YTAPHILIAT
210 220 230 240 250
GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG YIAVEMAGIL
260 270 280 290 300
SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK
310 320 330 340 350
TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ
360 370 380 390 400
TDDKGHIIVD EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY
410 420 430 440 450
KEDSKLDYNN IPTVVFSHPP IGTVGLTEDE AIHKYGIENV KTYSTSFTPM
460 470 480 490 500
YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ GLGCDEMLQG FAVAVKMGAT
510 520
KADFDNTVAI HPTSSEELVT LR
Length:522
Mass (Da):56,257
Last modified:July 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD8E2BA9D6E3757B
GO
Isoform Cytoplasmic (identifier: P00390-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: Produced by alternative initiation of isoform Mitochondrial.
Show »
Length:479
Mass (Da):51,701
Checksum:i3C0A194C96E880E7
GO
Isoform 2 (identifier: P00390-3) [UniParc]FASTAAdd to basket
Also known as: delta8

The sequence of this isoform differs from the canonical sequence as follows:
     266-294: Missing.

Show »
Length:493
Mass (Da):53,027
Checksum:iEFBA71DCDCFF1529
GO
Isoform 3 (identifier: P00390-4) [UniParc]FASTAAdd to basket
Also known as: delta9

The sequence of this isoform differs from the canonical sequence as follows:
     295-347: Missing.

Note: Expressed at very high levels in peripheral blood.
Show »
Length:469
Mass (Da):50,497
Checksum:i0AD475B02A87C63E
GO
Isoform 4 (identifier: P00390-5) [UniParc]FASTAAdd to basket
Also known as: delta8+9

The sequence of this isoform differs from the canonical sequence as follows:
     266-294: Missing.
     295-347: Missing.

Show »
Length:440
Mass (Da):47,267
Checksum:i793E0A9F8706B1B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC68H0YC68_HUMAN
Glutathione reductase, mitochondria...
GSR
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF59A0A2R8YF59_HUMAN
Glutathione reductase, mitochondria...
GSR
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP88037 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019079153R → C1 PublicationCorresponds to variant dbSNP:rs8190955Ensembl.1
Natural variantiVAR_051775232G → R. Corresponds to variant dbSNP:rs8190976Ensembl.1
Natural variantiVAR_019080232G → S1 PublicationCorresponds to variant dbSNP:rs8190976Ensembl.1
Natural variantiVAR_019081261I → V1 PublicationCorresponds to variant dbSNP:rs8190997Ensembl.1
Natural variantiVAR_019082297E → D1 PublicationCorresponds to variant dbSNP:rs8191004Ensembl.1
Natural variantiVAR_014554314P → H. Corresponds to variant dbSNP:rs2020916Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189721 – 43Missing in isoform Cytoplasmic. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_042908266 – 294Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_042909295 – 347Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15722 mRNA Translation: CAA33744.1
AF228703 Genomic DNA Translation: AAF37572.1
AF228703 Genomic DNA Translation: AAF37573.1
AF228704 mRNA Translation: AAF37574.1
AY338490 Genomic DNA Translation: AAP88037.1 Different initiation.
AB519179 mRNA Translation: BAI43437.1
AB519180 mRNA Translation: BAI43438.1
AB519181 mRNA Translation: BAI43439.1
AC009314 Genomic DNA No translation available.
AC103959 Genomic DNA No translation available.
AF215848 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63443.1
CH471080 Genomic DNA Translation: EAW63445.1
BC069244 mRNA Translation: AAH69244.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34877.1 [P00390-1]
CCDS56530.1 [P00390-5]
CCDS56531.1 [P00390-3]
CCDS56532.1 [P00390-4]

Protein sequence database of the Protein Information Resource

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PIRi
S08979 RDHUU

NCBI Reference Sequences

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RefSeqi
NP_000628.2, NM_000637.3 [P00390-1]
NP_001182031.1, NM_001195102.1 [P00390-3]
NP_001182032.1, NM_001195103.1 [P00390-4]
NP_001182033.1, NM_001195104.1 [P00390-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.271510

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000221130; ENSP00000221130; ENSG00000104687 [P00390-1]
ENST00000537535; ENSP00000438845; ENSG00000104687 [P00390-5]
ENST00000541648; ENSP00000444559; ENSG00000104687 [P00390-4]
ENST00000546342; ENSP00000445516; ENSG00000104687 [P00390-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2936

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2936

UCSC genome browser

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UCSCi
uc022ato.2 human [P00390-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Glutathione reductase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15722 mRNA Translation: CAA33744.1
AF228703 Genomic DNA Translation: AAF37572.1
AF228703 Genomic DNA Translation: AAF37573.1
AF228704 mRNA Translation: AAF37574.1
AY338490 Genomic DNA Translation: AAP88037.1 Different initiation.
AB519179 mRNA Translation: BAI43437.1
AB519180 mRNA Translation: BAI43438.1
AB519181 mRNA Translation: BAI43439.1
AC009314 Genomic DNA No translation available.
AC103959 Genomic DNA No translation available.
AF215848 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63443.1
CH471080 Genomic DNA Translation: EAW63445.1
BC069244 mRNA Translation: AAH69244.1
CCDSiCCDS34877.1 [P00390-1]
CCDS56530.1 [P00390-5]
CCDS56531.1 [P00390-3]
CCDS56532.1 [P00390-4]
PIRiS08979 RDHUU
RefSeqiNP_000628.2, NM_000637.3 [P00390-1]
NP_001182031.1, NM_001195102.1 [P00390-3]
NP_001182032.1, NM_001195103.1 [P00390-4]
NP_001182033.1, NM_001195104.1 [P00390-5]
UniGeneiHs.271510

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALGNMR-A480-503[»]
1BWCX-ray2.10A45-522[»]
1DNCX-ray1.70A45-522[»]
1GRAX-ray2.00A45-522[»]
1GRBX-ray1.85A45-522[»]
1GREX-ray2.00A45-522[»]
1GRFX-ray2.00A45-522[»]
1GRGX-ray2.00A45-522[»]
1GRHX-ray3.00A45-522[»]
1GRTX-ray2.30A45-522[»]
1GSNX-ray1.70A45-522[»]
1K4QX-ray1.90A62-522[»]
1XANX-ray2.00A62-522[»]
2AAQX-ray2.60A44-522[»]
2GH5X-ray1.70A/B45-522[»]
2GRTX-ray2.70A62-522[»]
3DJGX-ray1.80X45-522[»]
3DJJX-ray1.10A45-522[»]
3DK4X-ray1.20A45-522[»]
3DK8X-ray1.10A45-522[»]
3DK9X-ray0.95A45-522[»]
3GRSX-ray1.54A45-522[»]
3GRTX-ray2.50A62-522[»]
3SQPX-ray2.21A/B45-522[»]
4GR1X-ray2.40A45-522[»]
4GRTX-ray2.80A62-522[»]
5GRTX-ray2.40A62-522[»]
ProteinModelPortaliP00390
SMRiP00390
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109191, 32 interactors
IntActiP00390, 6 interactors
MINTiP00390
STRINGi9606.ENSP00000221130

Chemistry databases

BindingDBiP00390
ChEMBLiCHEMBL2755
DrugBankiDB02895 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol
DB02153 3-Sulfinoalanine
DB00262 Carmustine
DB03147 Flavin adenine dinucleotide
DB00143 Glutathione
DB02553 Glutathionylspermidine Disulfide
DB09110 Mesna
DB03867 Meta-Nitro-Tyrosine
DB00157 NADH
DB03310 Oxidized Glutathione Disulfide

PTM databases

CarbonylDBiP00390
iPTMnetiP00390
PhosphoSitePlusiP00390

Polymorphism and mutation databases

BioMutaiGSR
DMDMi14916998

2D gel databases

REPRODUCTION-2DPAGEiIPI00759575

Proteomic databases

EPDiP00390
PaxDbiP00390
PeptideAtlasiP00390
PRIDEiP00390
ProteomicsDBi51241
51242 [P00390-2]
51243 [P00390-3]
51244 [P00390-4]
51245 [P00390-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221130; ENSP00000221130; ENSG00000104687 [P00390-1]
ENST00000537535; ENSP00000438845; ENSG00000104687 [P00390-5]
ENST00000541648; ENSP00000444559; ENSG00000104687 [P00390-4]
ENST00000546342; ENSP00000445516; ENSG00000104687 [P00390-3]
GeneIDi2936
KEGGihsa:2936
UCSCiuc022ato.2 human [P00390-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2936
DisGeNETi2936
EuPathDBiHostDB:ENSG00000104687.12

GeneCards: human genes, protein and diseases

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GeneCardsi
GSR
HGNCiHGNC:4623 GSR
HPAiCAB008632
HPA001538
MalaCardsiGSR
MIMi138300 gene+phenotype
neXtProtiNX_P00390
OpenTargetsiENSG00000104687
Orphaneti90030 Hemolytic anemia due to glutathione reductase deficiency
PharmGKBiPA29014

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0405 Eukaryota
COG1249 LUCA
GeneTreeiENSGT00940000156986
HOGENOMiHOG000276712
HOVERGENiHBG004959
InParanoidiP00390
KOiK00383
OMAiKCAIIEA
OrthoDBiEOG091G078A
PhylomeDBiP00390
TreeFamiTF105353

Enzyme and pathway databases

BioCyciMetaCyc:HS02602-MONOMER
BRENDAi1.8.1.7 2681
ReactomeiR-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-5628897 TP53 Regulates Metabolic Genes
SABIO-RKiP00390

Miscellaneous databases

EvolutionaryTraceiP00390

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Glutathione_reductase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2936

Protein Ontology

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PROi
PR:P00390

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104687 Expressed in 218 organ(s), highest expression level in endometrium
CleanExiHS_GSR
ExpressionAtlasiP00390 baseline and differential
GenevisibleiP00390 HS

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006322 Glutathione_Rdtase_euk/bac
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PANTHERiPTHR42737 PTHR42737, 1 hit
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01421 gluta_reduc_1, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSHR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00390
Secondary accession number(s): C8KIL8
, C8KIL9, C8KIM0, D3DSV3, Q7Z5C9, Q9NP63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 11, 2001
Last modified: December 5, 2018
This is version 233 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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