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Protein

Dihydrofolate reductase

Gene

DHFR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.2 Publications

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.PROSITE-ProRule annotation7 Publications

Kineticsi

  1. KM=2.7 µM for dihydrofolate3 Publications
  2. KM=4.0 µM for NADPH3 Publications

    Pathwayi: tetrahydrofolate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.
    Proteins known to be involved in this subpathway in this organism are:
    1. Dihydrofolate reductase (DHFR), Dihydrofolate reductase 2, mitochondrial (DHFR2)
    This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei10NADP; via amide nitrogen and carbonyl oxygen3 Publications1
    Binding sitei65Substrate1 Publication1
    Binding sitei71Substrate1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi16 – 22NADP3 Publications7
    Nucleotide bindingi55 – 57NADP3 Publications3
    Nucleotide bindingi77 – 79NADP3 Publications3
    Nucleotide bindingi117 – 124NADP3 Publications8

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionOxidoreductase, RNA-binding
    Biological processMethotrexate resistance, One-carbon metabolism
    LigandNADP

    Enzyme and pathway databases

    BioCyciMetaCyc:HS09699-MONOMER
    BRENDAi1.5.1.3 2681
    ReactomeiR-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    R-HSA-196757 Metabolism of folate and pterines
    R-HSA-539107 Activation of E2F1 target genes at G1/S
    SABIO-RKiP00374
    SIGNORiP00374
    UniPathwayi
    UPA00077;UER00158

    Protein family/group databases

    MoonProtiP00374

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrofolate reductase (EC:1.5.1.3)
    Gene namesi
    Name:DHFR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 5

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000228716.6
    HGNCiHGNC:2861 DHFR
    MIMi126060 gene
    neXtProtiNX_P00374

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.
    See also OMIM:613839
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06581880L → F in DHFRD. 1 PublicationCorresponds to variant dbSNP:rs387906619EnsemblClinVar.1
    Natural variantiVAR_065819153D → V in DHFRD. 1 PublicationCorresponds to variant dbSNP:rs121913223EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi23L → F, W or Y: Decreases affinity for NADP and dihydrofolate over 10-fold. 2 Publications1
    Mutagenesisi23L → R: Strongly decreased affinity for methotrexate. Decreases catalytic rate constant 200-fold. Decreases affinity for NADP and dihydrofolate over 10-fold. 2 Publications1
    Mutagenesisi32F → R: Reduces catalytic rate 5-fold. Reduces affinity for dihydrofolate 9-fold; when associated with E-36. 1 Publication1
    Mutagenesisi36Q → E: Reduces catalytic rate 2-fold. Reduces affinity for dihydrofolate 9-fold; when associated with R-32. 3 Publications1
    Mutagenesisi36Q → K: Increases affinity for dihydrofolate about 3-fold. Reduces affinity for NADPH about 3-fold. 3 Publications1
    Mutagenesisi36Q → S: Increases affinity for dihydrofolate about 2-fold. No effect on affinity for NADPH. 3 Publications1
    Mutagenesisi65N → F: Increases affinity for dihydrofolate about 3-fold. No effect on affinity for NADPH. 2 Publications1
    Mutagenesisi65N → S: Increases affinity for dihydrofolate about 15-fold. No effect on affinity for NADPH. 2 Publications1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi1719
    MalaCardsiDHFR
    MIMi613839 phenotype
    OpenTargetsiENSG00000228716
    Orphaneti319651 Constitutional megaloblastic anemia with severe neurologic disease
    PharmGKBiPA143

    Chemistry databases

    ChEMBLiCHEMBL202
    DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB08878 Aminopterin
    DB03886 Biopterin
    DB00798 Gentamicin
    DB00563 Methotrexate
    DB00157 NADH
    DB00642 Pemetrexed
    DB06813 Pralatrexate
    DB01131 Proguanil
    DB00205 Pyrimethamine
    DB03351 Sri-9439
    DB03060 Sri-9662
    DB00440 Trimethoprim
    DB01157 Trimetrexate
    GuidetoPHARMACOLOGYi2603

    Polymorphism and mutation databases

    BioMutaiDHFR
    DMDMi118992

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001863621 – 187Dihydrofolate reductaseAdd BLAST187

    Proteomic databases

    EPDiP00374
    MaxQBiP00374
    PaxDbiP00374
    PeptideAtlasiP00374
    PRIDEiP00374
    ProteomicsDBi51237

    2D gel databases

    UCD-2DPAGEiP00374

    PTM databases

    iPTMnetiP00374
    PhosphoSitePlusiP00374
    SwissPalmiP00374

    Expressioni

    Tissue specificityi

    Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.1 Publication

    Gene expression databases

    BgeeiENSG00000228716 Expressed in 232 organ(s), highest expression level in buccal mucosa cell
    CleanExiHS_DHFR
    ExpressionAtlasiP00374 baseline and differential
    GenevisibleiP00374 HS

    Organism-specific databases

    HPAiCAB037129
    HPA051465

    Interactioni

    Subunit structurei

    Homodimer.7 Publications

    Protein-protein interaction databases

    BioGridi108065, 16 interactors
    IntActiP00374, 5 interactors
    MINTiP00374
    STRINGi9606.ENSP00000396308

    Chemistry databases

    BindingDBiP00374

    Structurei

    Secondary structure

    1187
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliP00374
    SMRiP00374
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00374

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini4 – 185DHFRPROSITE-ProRule annotationAdd BLAST182

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni31 – 36Substrate binding1 Publication6

    Sequence similaritiesi

    Belongs to the dihydrofolate reductase family.Curated

    Phylogenomic databases

    eggNOGiKOG1324 Eukaryota
    COG0262 LUCA
    GeneTreeiENSGT00390000010283
    HOGENOMiHOG000040235
    HOVERGENiHBG000773
    InParanoidiP00374
    KOiK00287
    OMAiRDNQLPW
    OrthoDBiEOG091G0PRK
    PhylomeDBiP00374
    TreeFamiTF317636

    Family and domain databases

    CDDicd00209 DHFR, 1 hit
    Gene3Di3.40.430.10, 1 hit
    InterProiView protein in InterPro
    IPR024072 DHFR-like_dom_sf
    IPR017925 DHFR_CS
    IPR001796 DHFR_dom
    PfamiView protein in Pfam
    PF00186 DHFR_1, 1 hit
    SUPFAMiSSF53597 SSF53597, 1 hit
    PROSITEiView protein in PROSITE
    PS00075 DHFR_1, 1 hit
    PS51330 DHFR_2, 1 hit

    Sequences (2+)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: P00374-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MVGSLNCIVA VSQNMGIGKN GDLPWPPLRN EFRYFQRMTT TSSVEGKQNL
    60 70 80 90 100
    VIMGKKTWFS IPEKNRPLKG RINLVLSREL KEPPQGAHFL SRSLDDALKL
    110 120 130 140 150
    TEQPELANKV DMVWIVGGSS VYKEAMNHPG HLKLFVTRIM QDFESDTFFP
    160 170 180
    EIDLEKYKLL PEYPGVLSDV QEEKGIKYKF EVYEKND
    Length:187
    Mass (Da):21,453
    Last modified:January 23, 2007 - v2
    Checksum:iEBDF3D1EC73E1566
    GO
    Isoform 2 (identifier: P00374-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-52: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:135
    Mass (Da):15,672
    Checksum:i92704AAABEE1EF40
    GO

    Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B4DM58B4DM58_HUMAN
    Dihydrofolate reductase
    DHFR
    129Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti113V → L in AAH70280 (PubMed:15489334).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06581880L → F in DHFRD. 1 PublicationCorresponds to variant dbSNP:rs387906619EnsemblClinVar.1
    Natural variantiVAR_065819153D → V in DHFRD. 1 PublicationCorresponds to variant dbSNP:rs121913223EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0563521 – 52Missing in isoform 2. 1 PublicationAdd BLAST52

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J00140 mRNA Translation: AAA58485.1
    V00507 mRNA Translation: CAA23765.1
    J00139
    , K01612, K01613, J00138, K01614 Genomic DNA Translation: AAA58484.1
    X00855
    , X00856, X00857, X00858, X00859 Genomic DNA Translation: CAA25409.1
    AK293146 mRNA Translation: BAG56693.1
    AC008434 Genomic DNA No translation available.
    AC010270 Genomic DNA No translation available.
    BC000192 mRNA Translation: AAH00192.1
    BC003584 mRNA Translation: AAH03584.2
    BC070280 mRNA Translation: AAH70280.1
    BC071996 mRNA Translation: AAH71996.1
    CCDSiCCDS47240.1 [P00374-1]
    CCDS78028.1 [P00374-2]
    PIRiA22551 RDHUD
    RefSeqiNP_000782.1, NM_000791.3 [P00374-1]
    NP_001277283.1, NM_001290354.1 [P00374-2]
    UniGeneiHs.592364
    Hs.648635

    Genome annotation databases

    EnsembliENST00000439211; ENSP00000396308; ENSG00000228716 [P00374-1]
    ENST00000504396; ENSP00000421334; ENSG00000228716 [P00374-2]
    ENST00000505337; ENSP00000426474; ENSG00000228716 [P00374-1]
    GeneIDi1719
    KEGGihsa:1719
    UCSCiuc003kgy.2 human [P00374-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Similar proteinsi

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Dihydrofolate reductase entry

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J00140 mRNA Translation: AAA58485.1
    V00507 mRNA Translation: CAA23765.1
    J00139
    , K01612, K01613, J00138, K01614 Genomic DNA Translation: AAA58484.1
    X00855
    , X00856, X00857, X00858, X00859 Genomic DNA Translation: CAA25409.1
    AK293146 mRNA Translation: BAG56693.1
    AC008434 Genomic DNA No translation available.
    AC010270 Genomic DNA No translation available.
    BC000192 mRNA Translation: AAH00192.1
    BC003584 mRNA Translation: AAH03584.2
    BC070280 mRNA Translation: AAH70280.1
    BC071996 mRNA Translation: AAH71996.1
    CCDSiCCDS47240.1 [P00374-1]
    CCDS78028.1 [P00374-2]
    PIRiA22551 RDHUD
    RefSeqiNP_000782.1, NM_000791.3 [P00374-1]
    NP_001277283.1, NM_001290354.1 [P00374-2]
    UniGeneiHs.592364
    Hs.648635

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1BOZX-ray2.10A2-187[»]
    1DHFX-ray2.30A/B2-187[»]
    1DLRX-ray2.30A2-187[»]
    1DLSX-ray2.30A2-187[»]
    1DRFX-ray2.00A2-187[»]
    1HFPX-ray2.10A2-187[»]
    1HFQX-ray2.10A2-187[»]
    1HFRX-ray2.10A2-187[»]
    1KMSX-ray1.09A2-187[»]
    1KMVX-ray1.05A2-187[»]
    1MVSX-ray1.90A1-187[»]
    1MVTX-ray1.80A1-187[»]
    1OHJX-ray2.50A2-187[»]
    1OHKX-ray2.50A2-187[»]
    1PD8X-ray2.10A2-187[»]
    1PD9X-ray2.20A2-187[»]
    1PDBX-ray2.20A2-187[»]
    1S3UX-ray2.50A2-187[»]
    1S3VX-ray1.80A2-187[»]
    1S3WX-ray1.90A2-187[»]
    1U71X-ray2.20A2-187[»]
    1U72X-ray1.90A2-187[»]
    1YHONMR-A2-187[»]
    2C2SX-ray1.40A/B2-187[»]
    2C2TX-ray1.50A/B2-187[»]
    2DHFX-ray2.30A/B2-187[»]
    2W3AX-ray1.50A/B1-187[»]
    2W3BX-ray1.27A/B1-187[»]
    2W3MX-ray1.60A/B1-187[»]
    3EIGX-ray1.70A2-187[»]
    3F8YX-ray1.45A1-187[»]
    3F8ZX-ray2.01A1-187[»]
    3F91X-ray1.90A1-187[»]
    3FS6X-ray1.23A1-187[»]
    3GHCX-ray1.30A2-187[»]
    3GHVX-ray1.30A2-187[»]
    3GHWX-ray1.24A2-187[»]
    3GI2X-ray1.53A1-187[»]
    3GYFX-ray1.70A1-187[»]
    3L3RX-ray2.00A2-187[»]
    3N0HX-ray1.92A2-187[»]
    3NTZX-ray1.35A2-187[»]
    3NU0X-ray1.35A2-187[»]
    3NXOX-ray1.35A2-187[»]
    3NXRX-ray1.35A2-187[»]
    3NXTX-ray1.70A2-187[»]
    3NXVX-ray1.90A2-187[»]
    3NXXX-ray1.35A2-187[»]
    3NXYX-ray1.90A2-187[»]
    3NZDX-ray1.80A2-187[»]
    3OAFX-ray1.70A2-187[»]
    3S3VX-ray1.53A2-187[»]
    3S7AX-ray1.80A2-187[»]
    4DDRX-ray2.05A2-187[»]
    4G95X-ray1.35A2-187[»]
    4KAKX-ray1.80A/B2-187[»]
    4KBNX-ray1.84A/B2-187[»]
    4KD7X-ray2.72A/B2-187[»]
    4KEBX-ray1.45A/B2-187[»]
    4KFJX-ray1.76A/B2-187[»]
    4M6JX-ray1.20A1-187[»]
    4M6KX-ray1.40A1-187[»]
    4M6LX-ray1.70A1-187[»]
    4QHVX-ray1.61A2-187[»]
    4QJCX-ray1.62A2-187[»]
    5HPBX-ray1.65A2-187[»]
    5HQYX-ray1.46A2-187[»]
    5HQZX-ray1.46A2-187[»]
    5HSRX-ray1.21A2-187[»]
    5HSUX-ray1.46A2-187[»]
    5HT4X-ray1.60A2-187[»]
    5HT5X-ray1.90A2-187[»]
    5HUIX-ray1.46A2-187[»]
    5HVBX-ray1.60A2-187[»]
    5HVEX-ray1.46A2-187[»]
    6DAVX-ray1.55A/B1-187[»]
    6DE4X-ray2.41A/B2-187[»]
    ProteinModelPortaliP00374
    SMRiP00374
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi108065, 16 interactors
    IntActiP00374, 5 interactors
    MINTiP00374
    STRINGi9606.ENSP00000396308

    Chemistry databases

    BindingDBiP00374
    ChEMBLiCHEMBL202
    DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB08878 Aminopterin
    DB03886 Biopterin
    DB00798 Gentamicin
    DB00563 Methotrexate
    DB00157 NADH
    DB00642 Pemetrexed
    DB06813 Pralatrexate
    DB01131 Proguanil
    DB00205 Pyrimethamine
    DB03351 Sri-9439
    DB03060 Sri-9662
    DB00440 Trimethoprim
    DB01157 Trimetrexate
    GuidetoPHARMACOLOGYi2603

    Protein family/group databases

    MoonProtiP00374

    PTM databases

    iPTMnetiP00374
    PhosphoSitePlusiP00374
    SwissPalmiP00374

    Polymorphism and mutation databases

    BioMutaiDHFR
    DMDMi118992

    2D gel databases

    UCD-2DPAGEiP00374

    Proteomic databases

    EPDiP00374
    MaxQBiP00374
    PaxDbiP00374
    PeptideAtlasiP00374
    PRIDEiP00374
    ProteomicsDBi51237

    Protocols and materials databases

    DNASUi1719
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000439211; ENSP00000396308; ENSG00000228716 [P00374-1]
    ENST00000504396; ENSP00000421334; ENSG00000228716 [P00374-2]
    ENST00000505337; ENSP00000426474; ENSG00000228716 [P00374-1]
    GeneIDi1719
    KEGGihsa:1719
    UCSCiuc003kgy.2 human [P00374-1]

    Organism-specific databases

    CTDi1719
    DisGeNETi1719
    EuPathDBiHostDB:ENSG00000228716.6
    GeneCardsiDHFR
    HGNCiHGNC:2861 DHFR
    HPAiCAB037129
    HPA051465
    MalaCardsiDHFR
    MIMi126060 gene
    613839 phenotype
    neXtProtiNX_P00374
    OpenTargetsiENSG00000228716
    Orphaneti319651 Constitutional megaloblastic anemia with severe neurologic disease
    PharmGKBiPA143
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1324 Eukaryota
    COG0262 LUCA
    GeneTreeiENSGT00390000010283
    HOGENOMiHOG000040235
    HOVERGENiHBG000773
    InParanoidiP00374
    KOiK00287
    OMAiRDNQLPW
    OrthoDBiEOG091G0PRK
    PhylomeDBiP00374
    TreeFamiTF317636

    Enzyme and pathway databases

    UniPathwayi
    UPA00077;UER00158

    BioCyciMetaCyc:HS09699-MONOMER
    BRENDAi1.5.1.3 2681
    ReactomeiR-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    R-HSA-196757 Metabolism of folate and pterines
    R-HSA-539107 Activation of E2F1 target genes at G1/S
    SABIO-RKiP00374
    SIGNORiP00374

    Miscellaneous databases

    ChiTaRSiDHFR human
    EvolutionaryTraceiP00374
    GeneWikiiDihydrofolate_reductase
    GenomeRNAii1719
    PROiPR:P00374
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000228716 Expressed in 232 organ(s), highest expression level in buccal mucosa cell
    CleanExiHS_DHFR
    ExpressionAtlasiP00374 baseline and differential
    GenevisibleiP00374 HS

    Family and domain databases

    CDDicd00209 DHFR, 1 hit
    Gene3Di3.40.430.10, 1 hit
    InterProiView protein in InterPro
    IPR024072 DHFR-like_dom_sf
    IPR017925 DHFR_CS
    IPR001796 DHFR_dom
    PfamiView protein in Pfam
    PF00186 DHFR_1, 1 hit
    SUPFAMiSSF53597 SSF53597, 1 hit
    PROSITEiView protein in PROSITE
    PS00075 DHFR_1, 1 hit
    PS51330 DHFR_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiDYR_HUMAN
    AccessioniPrimary (citable) accession number: P00374
    Secondary accession number(s): B4DDD2, Q14130, Q6IRW8
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: September 12, 2018
    This is version 203 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    UniProt is an ELIXIR core data resource
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