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Entry version 176 (12 Aug 2020)
Sequence version 2 (01 Nov 1997)
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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=49 µM for NADP1 Publication
  2. KM=93 µM for 6-phospho-D-gluconate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

    This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).1 Publication
    Proteins known to be involved in the 3 steps of the subpathway in this organism are:
    1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
    2. 6-phosphogluconolactonase (pgl), 6-phosphogluconolactonase (pgl)
    3. 6-phosphogluconate dehydrogenase, decarboxylating (gndA), 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
    This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei102NADPBy similarity1
    Binding sitei102Substrate1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei183Proton acceptor1 Publication1
    Active sitei190Proton donor1 Publication1
    Binding sitei191SubstrateBy similarity1
    Binding sitei260Substrate; via amide nitrogen1
    Binding sitei287Substrate1
    Binding sitei445Substrate; shared with dimeric partner1
    Binding sitei451Substrate; shared with dimeric partner1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 15NADP6
    Nucleotide bindingi33 – 35NADP3
    Nucleotide bindingi74 – 76NADP3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processGluconate utilization, Pentose shunt
    LigandNADP

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:6PGLUCONDEHYDROG-MONOMER
    ECOL316407:JW2011-MONOMER
    MetaCyc:6PGLUCONDEHYDROG-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.1.1.44, 2026

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P00350

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00115;UER00410

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:gnd
    Ordered Locus Names:b2029, JW2011
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000900371 – 4686-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST468

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P00350

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P00350

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P00350

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    P00350
    With#Exp.IntAct
    itself4EBI-907049,EBI-907049

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4261354, 19 interactors
    850901, 1 interactor

    Database of interacting proteins

    More...
    DIPi
    DIP-9819N

    Protein interaction database and analysis system

    More...
    IntActi
    P00350, 6 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b2029

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1468
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P00350

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P00350

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni128 – 130Substrate binding3
    Regioni186 – 187Substrate bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG0362, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_024540_4_2_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P00350

    KEGG Orthology (KO)

    More...
    KOi
    K00033

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P00350

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.1040.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR008927, 6-PGluconate_DH-like_C_sf
    IPR013328, 6PGD_dom2
    IPR006114, 6PGDH_C
    IPR006113, 6PGDH_Gnd/GntZ
    IPR006115, 6PGDH_NADP-bd
    IPR006184, 6PGdom_BS
    IPR036291, NAD(P)-bd_dom_sf
    IPR006183, Pgluconate_DH

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11811, PTHR11811, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00393, 6PGD, 1 hit
    PF03446, NAD_binding_2, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000109, 6PGD, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00076, 6PGDHDRGNASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM01350, 6PGD, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48179, SSF48179, 1 hit
    SSF51735, SSF51735, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00873, gnd, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00461, 6PGD, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P00350-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSKQQIGVVG MAVMGRNLAL NIESRGYTVS IFNRSREKTE EVIAENPGKK
    60 70 80 90 100
    LVPYYTVKEF VESLETPRRI LLMVKAGAGT DAAIDSLKPY LDKGDIIIDG
    110 120 130 140 150
    GNTFFQDTIR RNRELSAEGF NFIGTGVSGG EEGALKGPSI MPGGQKEAYE
    160 170 180 190 200
    LVAPILTKIA AVAEDGEPCV TYIGADGAGH YVKMVHNGIE YGDMQLIAEA
    210 220 230 240 250
    YSLLKGGLNL TNEELAQTFT EWNNGELSSY LIDITKDIFT KKDEDGNYLV
    260 270 280 290 300
    DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKDQRVAAS
    310 320 330 340 350
    KVLSGPQAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASEEYNWD
    360 370 380 390 400
    LNYGEIAKIF RAGCIIRAQF LQKITDAYAE NPQIANLLLA PYFKQIADDY
    410 420 430 440 450
    QQALRDVVAY AVQNGIPVPT FSAAVAYYDS YRAAVLPANL IQAQRDYFGA
    460
    HTYKRIDKEG VFHTEWLD
    Length:468
    Mass (Da):51,481
    Last modified:November 1, 1997 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62A32C84DC596D86
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti306P → R in AAA23918 (PubMed:6329905).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2S → L in strain: ECOR 70. 1
    Natural varianti32F → Y in strain: ECOR 70. 1
    Natural varianti39T → Q in strain: O7:K1 / VW187. 1
    Natural varianti52V → D in strain: ECOR 10. 1
    Natural varianti55Y → F in strain: ECOR 10. 1
    Natural varianti102N → K in strain: ECOR 65. 1
    Natural varianti117A → S in strain: ECOR 70. 1
    Natural varianti123 – 125IGT → YRY in strain: O7:K1 / VW187. 3
    Natural varianti170V → F in strain: ECOR 10. 1
    Natural varianti175A → S in strain: ECOR 45. 1
    Natural varianti209N → S in strain: ECOR 68. 1
    Natural varianti211T → S in strain: ECOR 10 and ECOR 69. 1
    Natural varianti216A → T in strain: ECOR 67. 1
    Natural varianti294D → E in strain: ECOR 70. 1
    Natural varianti308A → G in strain: ECOR 68. 1
    Natural varianti313D → N in strain: ECOR 67. 1
    Natural varianti315A → G in strain: ECOR 70. 1
    Natural varianti325L → Q in strain: ECOR 69. 1
    Natural varianti330I → S in strain: ECOR 10. 1
    Natural varianti350D → A in strain: ECOR 10 and ECOR 69. 1
    Natural varianti369Q → R in strain: ECOR 10. 1
    Natural varianti422S → A in strain: ECOR 10, ECOR 65, ECOR 68, ECOR 69 and ECOR 70. 1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    K02072 Genomic DNA Translation: AAA23918.1
    M63821 Genomic DNA Translation: AAA24488.1
    M64326 Genomic DNA Translation: AAA24204.1
    M64327 Genomic DNA Translation: AAA24205.1
    M64328 Genomic DNA Translation: AAA24206.1
    M64329 Genomic DNA Translation: AAA24207.1
    M64330 Genomic DNA Translation: AAA24208.1
    M64331 Genomic DNA Translation: AAA24209.1
    U00096 Genomic DNA Translation: AAC75090.1
    AP009048 Genomic DNA Translation: BAA15869.1
    M23181 Genomic DNA Translation: AAA23924.1
    M18956 Genomic DNA Translation: AAA23919.1
    M18957 Genomic DNA Translation: AAA23920.1
    M18960 Genomic DNA Translation: AAA23922.1
    AF125322 Genomic DNA Translation: AAC27540.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    D64968, DEECGC
    I62463
    I62465

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_416533.1, NC_000913.3
    WP_000043484.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC75090; AAC75090; b2029
    BAA15869; BAA15869; BAA15869

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    946554

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW2011
    eco:b2029

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.223

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    K02072 Genomic DNA Translation: AAA23918.1
    M63821 Genomic DNA Translation: AAA24488.1
    M64326 Genomic DNA Translation: AAA24204.1
    M64327 Genomic DNA Translation: AAA24205.1
    M64328 Genomic DNA Translation: AAA24206.1
    M64329 Genomic DNA Translation: AAA24207.1
    M64330 Genomic DNA Translation: AAA24208.1
    M64331 Genomic DNA Translation: AAA24209.1
    U00096 Genomic DNA Translation: AAC75090.1
    AP009048 Genomic DNA Translation: BAA15869.1
    M23181 Genomic DNA Translation: AAA23924.1
    M18956 Genomic DNA Translation: AAA23919.1
    M18957 Genomic DNA Translation: AAA23920.1
    M18960 Genomic DNA Translation: AAA23922.1
    AF125322 Genomic DNA Translation: AAC27540.1
    PIRiD64968, DEECGC
    I62463
    I62465
    RefSeqiNP_416533.1, NC_000913.3
    WP_000043484.1, NZ_LN832404.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2ZYAX-ray1.60A/B1-468[»]
    2ZYDX-ray1.50A/B1-468[»]
    3FWNX-ray1.50A/B1-468[»]
    SMRiP00350
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi4261354, 19 interactors
    850901, 1 interactor
    DIPiDIP-9819N
    IntActiP00350, 6 interactors
    STRINGi511145.b2029

    Proteomic databases

    jPOSTiP00350
    PaxDbiP00350
    PRIDEiP00350

    Genome annotation databases

    EnsemblBacteriaiAAC75090; AAC75090; b2029
    BAA15869; BAA15869; BAA15869
    GeneIDi946554
    KEGGiecj:JW2011
    eco:b2029
    PATRICifig|1411691.4.peg.223

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0406

    Phylogenomic databases

    eggNOGiCOG0362, Bacteria
    HOGENOMiCLU_024540_4_2_6
    InParanoidiP00350
    KOiK00033
    PhylomeDBiP00350

    Enzyme and pathway databases

    UniPathwayiUPA00115;UER00410
    BioCyciEcoCyc:6PGLUCONDEHYDROG-MONOMER
    ECOL316407:JW2011-MONOMER
    MetaCyc:6PGLUCONDEHYDROG-MONOMER
    BRENDAi1.1.1.44, 2026
    SABIO-RKiP00350

    Miscellaneous databases

    EvolutionaryTraceiP00350

    Protein Ontology

    More...
    PROi
    PR:P00350

    Family and domain databases

    Gene3Di1.10.1040.10, 1 hit
    InterProiView protein in InterPro
    IPR008927, 6-PGluconate_DH-like_C_sf
    IPR013328, 6PGD_dom2
    IPR006114, 6PGDH_C
    IPR006113, 6PGDH_Gnd/GntZ
    IPR006115, 6PGDH_NADP-bd
    IPR006184, 6PGdom_BS
    IPR036291, NAD(P)-bd_dom_sf
    IPR006183, Pgluconate_DH
    PANTHERiPTHR11811, PTHR11811, 1 hit
    PfamiView protein in Pfam
    PF00393, 6PGD, 1 hit
    PF03446, NAD_binding_2, 1 hit
    PIRSFiPIRSF000109, 6PGD, 1 hit
    PRINTSiPR00076, 6PGDHDRGNASE
    SMARTiView protein in SMART
    SM01350, 6PGD, 1 hit
    SUPFAMiSSF48179, SSF48179, 1 hit
    SSF51735, SSF51735, 1 hit
    TIGRFAMsiTIGR00873, gnd, 1 hit
    PROSITEiView protein in PROSITE
    PS00461, 6PGD, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei6PGD_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00350
    Secondary accession number(s): P78080
    , Q47571, Q59366, Q59402, Q59411, Q59412, Q59413, Q59414, Q59416, Q79DT3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1997
    Last modified: August 12, 2020
    This is version 176 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
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