Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 164 (07 Oct 2020)
Sequence version 2 (30 May 2000)
Previous versions | rss
Add a publicationFeedback
Protein

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Gene

HADH

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:9593854, PubMed:2817332). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.2 µM for (3S)-hydroxybutanoyl-CoA1 Publication
  2. KM=2.9 µM for (3S)-hydroxydecanoyl-CoA1 Publication
  3. KM=3.0 µM for (3S)-hydroxyhexadecanoyl-CoA1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid beta-oxidation

    This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.Curated
    View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei57NAD1 Publication1
    Binding sitei73Coenzyme ABy similarity1
    Binding sitei80Coenzyme ABy similarity1
    Binding sitei122NAD1 Publication1
    Binding sitei127NAD1 Publication1
    Binding sitei149Coenzyme ABy similarity1
    Binding sitei149NAD1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei170Important for catalytic activityBy similarity1
    Binding sitei173NADBy similarity1
    Binding sitei305NADBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi34 – 39NAD1 Publication6

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processFatty acid metabolism, Lipid metabolism
    LigandNAD

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-SSC-77310, Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
    R-SSC-77346, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
    R-SSC-77348, Beta oxidation of octanoyl-CoA to hexanoyl-CoA
    R-SSC-77350, Beta oxidation of hexanoyl-CoA to butanoyl-CoA
    R-SSC-77352, Beta oxidation of butanoyl-CoA to acetyl-CoA

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P00348

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00659

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (EC:1.1.1.352 Publications)
    Short name:
    HCDH
    Alternative name(s):
    L-3-hydroxyacyl CoA dehydrogenase1 Publication
    Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
    Short-chain 3-hydroxyacyl-CoA dehydrogenase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HADH
    Synonyms:HAD, HADHSC, SCHAD
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8
    • UP000008227 Componenti: Chromosome 8

    Organism-specific databases

    Vertebrate Gene Nomenclature Database

    More...
    VGNCi
    VGNC:88771, HADH

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 12MitochondrionBy similarityAdd BLAST12
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000740813 – 314Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialAdd BLAST302

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei80N6-succinyllysineBy similarity1
    Modified residuei81N6-acetyllysine; alternateBy similarity1
    Modified residuei81N6-succinyllysine; alternateBy similarity1
    Modified residuei87N6-acetyllysine; alternateBy similarity1
    Modified residuei87N6-succinyllysine; alternateBy similarity1
    Modified residuei125N6-acetyllysineBy similarity1
    Modified residuei136N6-acetyllysine; alternateBy similarity1
    Modified residuei136N6-succinyllysine; alternateBy similarity1
    Modified residuei179N6-acetyllysineBy similarity1
    Modified residuei185N6-acetyllysine; alternateBy similarity1
    Modified residuei185N6-succinyllysine; alternateBy similarity1
    Modified residuei192N6-acetyllysine; alternateBy similarity1
    Modified residuei192N6-succinyllysine; alternateBy similarity1
    Modified residuei202N6-acetyllysine; alternateBy similarity1
    Modified residuei202N6-succinyllysine; alternateBy similarity1
    Modified residuei206N6-succinyllysineBy similarity1
    Modified residuei212N6-acetyllysine; alternateBy similarity1
    Modified residuei212N6-succinyllysine; alternateBy similarity1
    Modified residuei241N6-acetyllysine; alternateBy similarity1
    Modified residuei241N6-succinyllysine; alternateBy similarity1
    Modified residuei312N6-acetyllysine; alternateBy similarity1
    Modified residuei312N6-succinyllysine; alternateBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P00348

    PeptideAtlas

    More...
    PeptideAtlasi
    P00348

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P00348

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSSSCG00000009150, Expressed in kidney and 39 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P00348, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P00348, SS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:3479790, PubMed:9593854).

    Interacts with GLUD1; this interaction inhibits the activation of glutamate dehydrogenase 1 (GLUD1) (By similarity).

    By similarity2 Publications

    GO - Molecular functioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9823.ENSSSCP00000009757

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1314
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P00348

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P00348

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2304, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159984

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_009834_2_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P00348

    KEGG Orthology (KO)

    More...
    KOi
    K00022

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MAHPMGP

    Database of Orthologous Groups

    More...
    OrthoDBi
    938257at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300886

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.1040.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR022694, 3-OHacyl-CoA_DH
    IPR006180, 3-OHacyl-CoA_DH_CS
    IPR006176, 3-OHacyl-CoA_DH_NAD-bd
    IPR006108, 3HC_DH_C
    IPR008927, 6-PGluconate_DH-like_C_sf
    IPR013328, 6PGD_dom2
    IPR036291, NAD(P)-bd_dom_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00725, 3HCDH, 1 hit
    PF02737, 3HCDH_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000105, HCDH, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48179, SSF48179, 1 hit
    SSF51735, SSF51735, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00067, 3HCDH, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    P00348-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAFATRQLVR SLSSSSTAAA SAKKILVKHV TVIGGGLMGA GIAQVAAATG
    60 70 80 90 100
    HTVVLVDQTE DILAKSKKGI EESLRKVAKK KFAENPKAGD EFVEKTLSSI
    110 120 130 140 150
    STSTDAASVV HSTDLVVEAI VENLKVKSEL FKRLDKFAAE HTIFASNTSS
    160 170 180 190 200
    LQITSLANAT TRQDRFAGLH FFNPVPLMKL VEVVKTPMTS QKTLESLVDF
    210 220 230 240 250
    SKTLGKHPVS CKDTPGFIVN RLLVPYLIEA VRLYERGDAS KEDIDTAMKL
    260 270 280 290 300
    GAGYPMGPFE LLDYVGLDTT KFIIDGWHEM DSQNPLFQPS PAMNKLVAEN
    310
    KFGKKTGEGF YKYK
    Length:314
    Mass (Da):34,161
    Last modified:May 30, 2000 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i596CBFD227214C3B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2C9F3C3A0A2C9F3C3_PIG
    Hydroxyacyl-coenzyme A dehydrogenas...
    HADH
    286Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A5S6HDE4A0A5S6HDE4_PIG
    Hydroxyacyl-coenzyme A dehydrogenas...
    HADH
    304Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A5G2QZU9A0A5G2QZU9_PIG
    Hydroxyacyl-coenzyme A dehydrogenas...
    HADH
    176Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108S → A AA sequence (PubMed:7409145).Curated1
    Sequence conflicti122E → EQLKVVGE AA sequence (PubMed:7409145).Curated1
    Sequence conflicti172 – 174FNP → N AA sequence (PubMed:7409145).Curated3

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF027652 mRNA Translation: AAD20939.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T46866

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_999496.1, NM_214331.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSSSCT00000049871; ENSSSCP00000053505; ENSSSCG00000009150
    ENSSSCT00015021821; ENSSSCP00015008559; ENSSSCG00015016364
    ENSSSCT00025056558; ENSSSCP00025023930; ENSSSCG00025041615
    ENSSSCT00030004417; ENSSSCP00030001758; ENSSSCG00030003353
    ENSSSCT00035031118; ENSSSCP00035012173; ENSSSCG00035023707
    ENSSSCT00040103510; ENSSSCP00040046934; ENSSSCG00040074801
    ENSSSCT00045041276; ENSSSCP00045028650; ENSSSCG00045024125
    ENSSSCT00050020134; ENSSSCP00050008385; ENSSSCG00050014864
    ENSSSCT00055013484; ENSSSCP00055010607; ENSSSCG00055006902
    ENSSSCT00060105557; ENSSSCP00060046413; ENSSSCG00060076804
    ENSSSCT00065008871; ENSSSCP00065003731; ENSSSCG00065006573
    ENSSSCT00070038976; ENSSSCP00070032640; ENSSSCG00070019666
    ENSSSCT00070039014; ENSSSCP00070032672; ENSSSCG00070019666

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    397604

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ssc:397604

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF027652 mRNA Translation: AAD20939.1
    PIRiT46866
    RefSeqiNP_999496.1, NM_214331.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3HDHX-ray2.80A/B/C13-314[»]
    SMRiP00348
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000009757

    Proteomic databases

    PaxDbiP00348
    PeptideAtlasiP00348
    PRIDEiP00348

    Genome annotation databases

    EnsembliENSSSCT00000049871; ENSSSCP00000053505; ENSSSCG00000009150
    ENSSSCT00015021821; ENSSSCP00015008559; ENSSSCG00015016364
    ENSSSCT00025056558; ENSSSCP00025023930; ENSSSCG00025041615
    ENSSSCT00030004417; ENSSSCP00030001758; ENSSSCG00030003353
    ENSSSCT00035031118; ENSSSCP00035012173; ENSSSCG00035023707
    ENSSSCT00040103510; ENSSSCP00040046934; ENSSSCG00040074801
    ENSSSCT00045041276; ENSSSCP00045028650; ENSSSCG00045024125
    ENSSSCT00050020134; ENSSSCP00050008385; ENSSSCG00050014864
    ENSSSCT00055013484; ENSSSCP00055010607; ENSSSCG00055006902
    ENSSSCT00060105557; ENSSSCP00060046413; ENSSSCG00060076804
    ENSSSCT00065008871; ENSSSCP00065003731; ENSSSCG00065006573
    ENSSSCT00070038976; ENSSSCP00070032640; ENSSSCG00070019666
    ENSSSCT00070039014; ENSSSCP00070032672; ENSSSCG00070019666
    GeneIDi397604
    KEGGissc:397604

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    3033
    VGNCiVGNC:88771, HADH

    Phylogenomic databases

    eggNOGiKOG2304, Eukaryota
    GeneTreeiENSGT00940000159984
    HOGENOMiCLU_009834_2_0_1
    InParanoidiP00348
    KOiK00022
    OMAiMAHPMGP
    OrthoDBi938257at2759
    TreeFamiTF300886

    Enzyme and pathway databases

    UniPathwayiUPA00659
    ReactomeiR-SSC-77310, Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
    R-SSC-77346, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
    R-SSC-77348, Beta oxidation of octanoyl-CoA to hexanoyl-CoA
    R-SSC-77350, Beta oxidation of hexanoyl-CoA to butanoyl-CoA
    R-SSC-77352, Beta oxidation of butanoyl-CoA to acetyl-CoA
    SABIO-RKiP00348

    Miscellaneous databases

    EvolutionaryTraceiP00348

    Gene expression databases

    BgeeiENSSSCG00000009150, Expressed in kidney and 39 other tissues
    ExpressionAtlasiP00348, baseline and differential
    GenevisibleiP00348, SS

    Family and domain databases

    Gene3Di1.10.1040.10, 1 hit
    InterProiView protein in InterPro
    IPR022694, 3-OHacyl-CoA_DH
    IPR006180, 3-OHacyl-CoA_DH_CS
    IPR006176, 3-OHacyl-CoA_DH_NAD-bd
    IPR006108, 3HC_DH_C
    IPR008927, 6-PGluconate_DH-like_C_sf
    IPR013328, 6PGD_dom2
    IPR036291, NAD(P)-bd_dom_sf
    PfamiView protein in Pfam
    PF00725, 3HCDH, 1 hit
    PF02737, 3HCDH_N, 1 hit
    PIRSFiPIRSF000105, HCDH, 1 hit
    SUPFAMiSSF48179, SSF48179, 1 hit
    SSF51735, SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00067, 3HCDH, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCDH_PIG
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00348
    Secondary accession number(s): Q9XS66
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: May 30, 2000
    Last modified: October 7, 2020
    This is version 164 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again