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Protein

Alcohol dehydrogenase S chain

Gene
N/A
Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi174Zinc 1; catalytic1
Binding sitei223NAD1
Binding sitei228NAD1
Binding sitei369NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 204NAD6
Nucleotide bindingi292 – 294NAD3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

SABIO-RKiP00328

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase S chain (EC:1.1.1.1)
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111372

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001606572 – 374Alcohol dehydrogenase S chainAdd BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PeptideAtlasiP00328
PRIDEiP00328

PTM databases

iPTMnetiP00328

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of two types (E and S) coded by 2 separate genes at different loci.

Structurei

Secondary structure

1374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00328
SMRiP00328
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00328

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195
KOiK13951

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00328-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAGKVIKC KAAVLWEQKK PFSIEEVEVA PPKAHEVRIK MVAAGICRSD
60 70 80 90 100
DHVVSGTLVA PLPVIAGHEA AGIVESIGEG VTTVRPGDKV IPLFIPQCGK
110 120 130 140 150
CSVCKHPEGN LCLKNLSMPR GTMQDGTSRF TCRGKPIHHF LGTSTFSQYT
160 170 180 190 200
VVDEISVAKI DAASPLEKVC LVGCGFSTGY GSAVKVAKVT QGSTCAVFGL
210 220 230 240 250
GGVGLSVIMG CKAAGAARII GVDINKDKFA KAKEVGATEC VNPQDYKKPI
260 270 280 290 300
QEVLTEMSNG GVDFSFEVIG RLDTMVAALS CCQEAYGVSV IVGVPPDSQN
310 320 330 340 350
LSMNPMLLLS GRTWKGAIFG GFKSKDSVPK LVADFMAKKF ALDPLITHVL
360 370
PFEKINEGFD LLRSGKSIRT ILTF
Length:374
Mass (Da):39,623
Last modified:January 23, 2007 - v3
Checksum:i2B15710A038DA013
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44A → T AA sequence (PubMed:5466062).Curated1
Sequence conflicti60A → T AA sequence (PubMed:5466062).Curated1
Sequence conflicti116L → SL AA sequence (PubMed:5466062).Curated1
Sequence conflicti172V → I AA sequence (PubMed:5466062).Curated1
Sequence conflicti277A → T AA sequence (PubMed:5466062).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64865 mRNA Translation: AAA30932.1
PIRiB39872 DEHOAS
RefSeqiNP_001075414.1, NM_001081945.1
UniGeneiEca.13101

Genome annotation databases

GeneIDi100034175
KEGGiecb:100034175

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64865 mRNA Translation: AAA30932.1
PIRiB39872 DEHOAS
RefSeqiNP_001075414.1, NM_001081945.1
UniGeneiEca.13101

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EE2X-ray1.54A/B2-374[»]
ProteinModelPortaliP00328
SMRiP00328
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2111372

PTM databases

iPTMnetiP00328

Proteomic databases

PeptideAtlasiP00328
PRIDEiP00328

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034175
KEGGiecb:100034175

Phylogenomic databases

HOVERGENiHBG000195
KOiK13951

Enzyme and pathway databases

SABIO-RKiP00328

Miscellaneous databases

EvolutionaryTraceiP00328
PROiPR:P00328

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1S_HORSE
AccessioniPrimary (citable) accession number: P00328
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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