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Protein

Alcohol dehydrogenase E chain

Gene
N/A
Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+1 PublicationNote: Binds 2 Zn2+ ions per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticCombined sources2 Publications1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateCombined sources1
Metal bindingi68Zinc 1; catalyticCombined sources2 Publications1
Binding sitei68SubstrateCombined sources1
Metal bindingi98Zinc 2Combined sources2 Publications1
Metal bindingi101Zinc 2Combined sources2 Publications1
Metal bindingi104Zinc 2Combined sources2 Publications1
Metal bindingi112Zinc 2Combined sources2 Publications1
Metal bindingi175Zinc 1; catalyticCombined sources1 Publication1
Binding sitei224NADCombined sources1 Publication1
Binding sitei229NADCombined sources1 Publication1
Binding sitei293NAD; via carbonyl oxygenBy similarity1
Binding sitei320NAD; via amide nitrogenBy similarity1
Binding sitei370NADCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADCombined sources1 Publication6
Nucleotide bindingi293 – 295NADCombined sources1 Publication3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1 2120
SABIO-RKiP00327

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase E chain (EC:1.1.1.1)
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111372

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001606562 – 375Alcohol dehydrogenase E chainAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00327
PeptideAtlasiP00327
PRIDEiP00327

PTM databases

iPTMnetiP00327

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of two types (E and S) coded by 2 separate genes at different loci.

Protein-protein interaction databases

STRINGi9796.ENSECAP00000017080

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00327
SMRiP00327
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00327

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
HOVERGENiHBG000195
KOiK13951

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00327-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAGKVIKC KAAVLWEEKK PFSIEEVEVA PPKAHEVRIK MVATGICRSD
60 70 80 90 100
DHVVSGTLVT PLPVIAGHEA AGIVESIGEG VTTVRPGDKV IPLFTPQCGK
110 120 130 140 150
CRVCKHPEGN FCLKNDLSMP RGTMQDGTSR FTCRGKPIHH FLGTSTFSQY
160 170 180 190 200
TVVDEISVAK IDAASPLEKV CLIGCGFSTG YGSAVKVAKV TQGSTCAVFG
210 220 230 240 250
LGGVGLSVIM GCKAAGAARI IGVDINKDKF AKAKEVGATE CVNPQDYKKP
260 270 280 290 300
IQEVLTEMSN GGVDFSFEVI GRLDTMVTAL SCCQEAYGVS VIVGVPPDSQ
310 320 330 340 350
NLSMNPMLLL SGRTWKGAIF GGFKSKDSVP KLVADFMAKK FALDPLITHV
360 370
LPFEKINEGF DLLRSGESIR TILTF
Length:375
Mass (Da):39,936
Last modified:January 23, 2007 - v2
Checksum:iDA701D2F6AB69C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64864 mRNA Translation: AAA30931.1
PIRiA39872 DEHOAL
RefSeqiNP_001075997.1, NM_001082528.1
UniGeneiEca.13101

Genome annotation databases

GeneIDi100034242
KEGGiecb:100034242

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64864 mRNA Translation: AAA30931.1
PIRiA39872 DEHOAL
RefSeqiNP_001075997.1, NM_001082528.1
UniGeneiEca.13101

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A71X-ray2.00A/B2-375[»]
1A72X-ray2.60A2-375[»]
1ADBX-ray2.40A/B2-375[»]
1ADCX-ray2.70A/B2-375[»]
1ADFX-ray2.90A2-375[»]
1ADGX-ray2.70A2-375[»]
1AXEX-ray2.00A/B2-375[»]
1AXGX-ray2.50A/B/C/D2-375[»]
1BTOX-ray2.00A/B/C/D2-375[»]
1HETX-ray1.15A/B2-375[»]
1HEUX-ray1.15A/B2-375[»]
1HF3X-ray1.95A/B2-375[»]
1HLDX-ray2.10A/B2-375[»]
1JU9X-ray2.00A/B2-375[»]
1LDEX-ray2.50A/B/C/D2-375[»]
1LDYX-ray2.50A/B/C/D2-375[»]
1MG0X-ray1.80A/B/C/D2-375[»]
1MGOX-ray1.20A/B2-375[»]
1N8KX-ray1.13A/B2-375[»]
1N92X-ray1.47A/B2-375[»]
1P1RX-ray1.57A/B/C/D2-375[»]
1QLHX-ray2.07A2-375[»]
1QLJX-ray2.80A2-375[»]
1QV6X-ray1.80A/B2-375[»]
1QV7X-ray1.80A/B2-375[»]
1YE3X-ray1.59A2-375[»]
2JHFX-ray1.00A/B2-375[»]
2JHGX-ray1.20A/B2-375[»]
2OHXX-ray1.80A/B2-375[»]
2OXIX-ray2.10A/B2-375[»]
3BTOX-ray1.66A/B/C/D2-375[»]
3OQ6X-ray1.20A/B2-375[»]
4DWVX-ray1.14A/B2-375[»]
4DXHX-ray1.12A/B2-375[»]
4NFHX-ray1.20A/B2-375[»]
4NFSX-ray1.10A/B2-375[»]
4NG5X-ray1.10A/B2-375[»]
4XD2X-ray1.10A/B2-375[»]
5ADHX-ray2.90A2-375[»]
5CDGX-ray1.40A/B2-375[»]
5CDSX-ray1.40A/B2-375[»]
5CDTX-ray1.70A/B2-375[»]
5CDUX-ray1.60A/B2-375[»]
5KCPX-ray1.10A/B2-375[»]
5KCZX-ray1.14A/B2-375[»]
5KJ1X-ray1.20A/B2-375[»]
5KJ6X-ray1.14A/B2-375[»]
5KJCX-ray1.20A/B2-375[»]
5KJEX-ray1.26A/B2-375[»]
5KJFX-ray1.20A/B2-375[»]
5VJ5X-ray1.90A/B2-375[»]
5VJGX-ray1.90A2-375[»]
5VKRX-ray1.80A2-375[»]
5VL0X-ray1.20A/B/C/D2-375[»]
5VN1X-ray1.25A/B/C/D2-375[»]
6ADHX-ray2.90A/B2-375[»]
6CXXX-ray1.26A/B2-375[»]
6CY3X-ray2.30A2-375[»]
7ADHX-ray3.20A2-375[»]
8ADHX-ray2.40A2-375[»]
ProteinModelPortaliP00327
SMRiP00327
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000017080

Chemistry databases

ChEMBLiCHEMBL2111372

PTM databases

iPTMnetiP00327

Proteomic databases

PaxDbiP00327
PeptideAtlasiP00327
PRIDEiP00327

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034242
KEGGiecb:100034242

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
HOVERGENiHBG000195
KOiK13951

Enzyme and pathway databases

BRENDAi1.1.1.1 2120
SABIO-RKiP00327

Miscellaneous databases

EvolutionaryTraceiP00327
PROiPR:P00327

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1E_HORSE
AccessioniPrimary (citable) accession number: P00327
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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