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Protein

Alcohol dehydrogenase 1C

Gene

ADH1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi175Zinc 1; catalytic1
Binding sitei224NAD2 Publications1
Binding sitei229NAD2 Publications1
Binding sitei370NAD2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NAD2 Publications6
Nucleotide bindingi293 – 295NAD2 Publications3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1 2681
ReactomeiR-HSA-5365859 RA biosynthesis pathway
R-HSA-71384 Ethanol oxidation
SABIO-RKiP00326

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1C (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase subunit gamma
Gene namesi
Name:ADH1C
Synonyms:ADH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000248144.5
HGNCiHGNC:251 ADH1C
MIMi103730 gene
neXtProtiNX_P00326

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi126
MalaCardsiADH1C
OpenTargetsiENSG00000248144
PharmGKBiPA24572

Chemistry databases

ChEMBLiCHEMBL3285
DrugBankiDB03061 (R)-N-(1-Methyl-Hexyl)-Formamide
DB02249 2-Ethoxyethanol
DB02871 3-Butylthiolane 1-Oxide
DB02721 4-Iodopyrazole
DB03020 5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
DB02659 Cholic Acid
DB04071 Cpad
DB03559 Cyclohexylformamide
DB00898 Ethanol
DB01213 Fomepizole
DB02131 N-1-Methylheptylformamide
DB04113 N-Formylpiperidine
DB00157 NADH
DB02822 Para-Bromobenzyl Alcohol
DB02757 Pyrazole
DB03226 Trifluoroethanol

Polymorphism and mutation databases

BioMutaiADH1C
DMDMi113398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001606642 – 375Alcohol dehydrogenase 1CAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei23PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP00326
PeptideAtlasiP00326
PRIDEiP00326
ProteomicsDBi51229
TopDownProteomicsiP00326

PTM databases

iPTMnetiP00326
PhosphoSitePlusiP00326

Expressioni

Gene expression databases

BgeeiENSG00000248144 Expressed in 89 organ(s), highest expression level in liver
CleanExiHS_ADH1C
ExpressionAtlasiP00326 baseline and differential
GenevisibleiP00326 HS

Organism-specific databases

HPAiHPA047814
HPA060902

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of three types; alpha, beta and gamma.2 Publications

Protein-protein interaction databases

BioGridi106638, 2 interactors

Chemistry databases

BindingDBiP00326

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00326
SMRiP00326
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00326

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00430000030800
HOVERGENiHBG000195
InParanoidiP00326
KOiK13951
OMAiCNVCKHP
OrthoDBiEOG091G08N3

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P00326-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAAGICRSD
60 70 80 90 100
EHVVSGNLVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK
110 120 130 140 150
CRICKNPESN YCLKNDLGNP RGTLQDGTRR FTCSGKPIHH FVGVSTFSQY
160 170 180 190 200
TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVKVAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSVVM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP
260 270 280 290 300
IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ
310 320 330 340 350
NLSINPMLLL TGRTWKGAIF GGFKSKESVP KLVADFMAKK FSLDALITNI
360 370
LPFEKINEGF DLLRSGKSIR TVLTF
Length:375
Mass (Da):39,868
Last modified:January 23, 2007 - v2
Checksum:i414D73CC4C104C84
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WU81A0A087WU81_HUMAN
Alcohol dehydrogenase 1C
ADH1C
192Annotation score:
A0A087WUC4A0A087WUC4_HUMAN
Alcohol dehydrogenase 1C
ADH1C
170Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130Missing AA sequence (PubMed:6391921).Curated1
Sequence conflicti171C → R in AAH67421 (PubMed:15489334).Curated1

Polymorphismi

Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02399248R → H1 PublicationCorresponds to variant dbSNP:rs35385902Ensembl.1
Natural variantiVAR_023993166P → S1 PublicationCorresponds to variant dbSNP:rs34195308Ensembl.1
Natural variantiVAR_000428272R → Q in allele ADH3*2/gamma-2. 3 PublicationsCorresponds to variant dbSNP:rs1693482EnsemblClinVar.1
Natural variantiVAR_000429350I → V in allele ADH3*2/gamma-2. 3 PublicationsCorresponds to variant dbSNP:rs698EnsemblClinVar.1
Natural variantiVAR_023994352P → T1 PublicationCorresponds to variant dbSNP:rs35719513Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04299 mRNA Translation: CAA27842.1
X04350 mRNA Translation: CAA27876.1
M12272 mRNA Translation: AAC41757.1
D11067 Genomic DNA Translation: BAC06856.1
DQ088981 Genomic DNA Translation: AAY68222.1
AC097530 Genomic DNA No translation available.
BC062476 mRNA Translation: AAH62476.1
BC066227 mRNA Translation: AAH66227.1
BC066228 mRNA Translation: AAH66228.1
BC067419 mRNA Translation: AAH67419.1
BC067420 mRNA Translation: AAH67420.1
BC067421 mRNA Translation: AAH67421.1
BC067422 mRNA Translation: AAH67422.1
BC074771 mRNA Translation: AAH74771.1
BC074786 mRNA Translation: AAH74786.1
CCDSiCCDS54780.1
PIRiC25428 DEHUAG
RefSeqiNP_000660.1, NM_000669.4
UniGeneiHs.654537

Genome annotation databases

EnsembliENST00000515683; ENSP00000426083; ENSG00000248144
GeneIDi126
KEGGihsa:126
UCSCiuc032trd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04299 mRNA Translation: CAA27842.1
X04350 mRNA Translation: CAA27876.1
M12272 mRNA Translation: AAC41757.1
D11067 Genomic DNA Translation: BAC06856.1
DQ088981 Genomic DNA Translation: AAY68222.1
AC097530 Genomic DNA No translation available.
BC062476 mRNA Translation: AAH62476.1
BC066227 mRNA Translation: AAH66227.1
BC066228 mRNA Translation: AAH66228.1
BC067419 mRNA Translation: AAH67419.1
BC067420 mRNA Translation: AAH67420.1
BC067421 mRNA Translation: AAH67421.1
BC067422 mRNA Translation: AAH67422.1
BC074771 mRNA Translation: AAH74771.1
BC074786 mRNA Translation: AAH74786.1
CCDSiCCDS54780.1
PIRiC25428 DEHUAG
RefSeqiNP_000660.1, NM_000669.4
UniGeneiHs.654537

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DDAmodel-A/B1-375[»]
1HT0X-ray2.00A/B2-375[»]
1U3WX-ray1.45A/B2-375[»]
ProteinModelPortaliP00326
SMRiP00326
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106638, 2 interactors

Chemistry databases

BindingDBiP00326
ChEMBLiCHEMBL3285
DrugBankiDB03061 (R)-N-(1-Methyl-Hexyl)-Formamide
DB02249 2-Ethoxyethanol
DB02871 3-Butylthiolane 1-Oxide
DB02721 4-Iodopyrazole
DB03020 5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
DB02659 Cholic Acid
DB04071 Cpad
DB03559 Cyclohexylformamide
DB00898 Ethanol
DB01213 Fomepizole
DB02131 N-1-Methylheptylformamide
DB04113 N-Formylpiperidine
DB00157 NADH
DB02822 Para-Bromobenzyl Alcohol
DB02757 Pyrazole
DB03226 Trifluoroethanol

PTM databases

iPTMnetiP00326
PhosphoSitePlusiP00326

Polymorphism and mutation databases

BioMutaiADH1C
DMDMi113398

Proteomic databases

MaxQBiP00326
PeptideAtlasiP00326
PRIDEiP00326
ProteomicsDBi51229
TopDownProteomicsiP00326

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000515683; ENSP00000426083; ENSG00000248144
GeneIDi126
KEGGihsa:126
UCSCiuc032trd.2 human

Organism-specific databases

CTDi126
DisGeNETi126
EuPathDBiHostDB:ENSG00000248144.5
GeneCardsiADH1C
HGNCiHGNC:251 ADH1C
HPAiHPA047814
HPA060902
MalaCardsiADH1C
MIMi103730 gene
neXtProtiNX_P00326
OpenTargetsiENSG00000248144
PharmGKBiPA24572
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00430000030800
HOVERGENiHBG000195
InParanoidiP00326
KOiK13951
OMAiCNVCKHP
OrthoDBiEOG091G08N3

Enzyme and pathway databases

BRENDAi1.1.1.1 2681
ReactomeiR-HSA-5365859 RA biosynthesis pathway
R-HSA-71384 Ethanol oxidation
SABIO-RKiP00326

Miscellaneous databases

ChiTaRSiADH1C human
EvolutionaryTraceiP00326
GeneWikiiADH1C
GenomeRNAii126
PROiPR:P00326
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000248144 Expressed in 89 organ(s), highest expression level in liver
CleanExiHS_ADH1C
ExpressionAtlasiP00326 baseline and differential
GenevisibleiP00326 HS

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1G_HUMAN
AccessioniPrimary (citable) accession number: P00326
Secondary accession number(s): Q4PJ18
, Q5WRV0, Q6LBW4, Q6NWV0, Q6NZA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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