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UniProtKB - P00325 (ADH1B_HUMAN)

Entry version 216 (29 Sep 2021)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

All-trans-retinol dehydrogenase [NAD(+)] ADH1B

Gene

ADH1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387).

In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387).

Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387).

Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820).

2 Publications

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4 µM for all-trans-4-hydroxyretinol (in allele ADH1B*1)1 Publication
  2. KM=25 µM for all-trans-4-oxoretinal (in allele ADH1B*1)1 Publication
  3. KM=11 µM for all-trans-4-hydroxyretinol (in allele ADH1B*2)1 Publication
  4. KM=27 µM for all-trans-4-oxoretinal (in allele ADH1B*2)1 Publication
  5. KM=24 µM for all-trans-3,4-didehydroretinol(in allele ADH1B*2)1 Publication
  6. KM=25 µM for all-trans-3,4-didehydroretinal(in allele ADH1B*2)1 Publication
  7. KM=0.4 µM for all-trans-retinaldehyde (in allele ADH1B*2)1 Publication
  8. KM=0.3 µM for all-trans-retinol (in allele ADH1B*2)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi175Zinc 1; catalytic1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei224NAD1
Binding sitei229NAD1
Binding sitei370NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi200 – 205NAD6
Nucleotide bindingi293 – 295NAD3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:MONOMER66-321

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P00325

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-71384, Ethanol oxidation

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P00325

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001880

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
All-trans-retinol dehydrogenase [NAD(+)] ADH1BCurated (EC:1.1.1.1051 Publication)
Alternative name(s):
Alcohol dehydrogenase 1B
Alcohol dehydrogenase subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADH1BImported
Synonyms:ADH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:250, ADH1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		103720, gene+phenotype

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P00325

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196616

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		125

MalaCards human disease database

More...MalaCardsi		ADH1B
MIMi103720, gene+phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24571

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P00325, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3284

Drug and drug target database

More...DrugBanki		DB02721, 4-Iodopyrazole
DB03703, Cyclohexanol
DB00898, Ethanol
DB01213, Fomepizole
DB09462, Glycerin
DB02481, N-Benzylformamide
DB04105, N-Heptylformamide
DB00157, NADH
DB03461, Nicotinamide adenine dinucleotide phosphate

DrugCentral

More...DrugCentrali		P00325

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADH1B

Domain mapping of disease mutations (DMDM)

More...DMDMi		113394

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001606612 – 375All-trans-retinol dehydrogenase [NAD(+)] ADH1BAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
Modified residuei23PhosphoserineCombined sources1
Modified residuei35PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P00325

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P00325

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P00325

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P00325

PeptideAtlas

More...PeptideAtlasi		P00325

PRoteomics IDEntifications database

More...PRIDEi		P00325

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2413
51228 [P00325-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P00325

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P00325

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196616, Expressed in adipose tissue and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P00325, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P00325, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196616, Group enriched (adipose tissue, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of identical or non-identical chains of three types; alpha, beta and gamma.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106637, 7 interactors

Protein interaction database and analysis system

More...IntActi		P00325, 11 interactors

Molecular INTeraction database

More...MINTi		P00325

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306606

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P00325

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P00325, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P00325

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P00325

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0022, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026673_14_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P00325

Database of Orthologous Groups

More...OrthoDBi		664798at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P00325

TreeFam database of animal gene trees

More...TreeFami		TF300429

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013149, ADH_C
IPR013154, ADH_N
IPR002328, ADH_Zn_CS
IPR011032, GroES-like_sf
IPR036291, NAD(P)-bd_dom_sf
IPR020843, PKS_ER

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08240, ADH_N, 1 hit
PF00107, ADH_zinc_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00829, PKS_ER, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50129, SSF50129, 2 hits
SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00059, ADH_ZINC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P00325-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTAGKVIKC KAAVLWEVKK PFSIEDVEVA PPKAYEVRIK MVAVGICRTD 
        60         70         80         90        100
DHVVSGNLVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK 
       110        120        130        140        150
CRVCKNPESN YCLKNDLGNP RGTLQDGTRR FTCRGKPIHH FLGTSTFSQY 
       160        170        180        190        200
TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG 
       210        220        230        240        250
LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP 
       260        270        280        290        300
IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPASQ 
       310        320        330        340        350
NLSINPMLLL TGRTWKGAVY GGFKSKEGIP KLVADFMAKK FSLDALITHV 
       360        370 
LPFEKINEGF DLLHSGKSIR TVLTF
Length:375
Mass (Da):39,855
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6962B9A0F967673B
GO
Isoform 2 (identifier: P00325-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Show »
Length:335
Mass (Da):35,412
Checksum:iA92B71F22E3CAFA4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9HW50V9HW50_HUMAN
All-trans-retinol dehydrogenase [NA...
ADH1B HEL-S-117
375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHZ6D6RHZ6_HUMAN
All-trans-retinol dehydrogenase [NA...
ADH1B
335Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8I → M in AAA51592 (PubMed:3397059).Curated1
Sequence conflicti130Missing AA sequence (PubMed:6391920).Curated1
Sequence conflicti166P → K in AAA51592 (PubMed:3397059).Curated1
Sequence conflicti190V → VV in CAA33487 (PubMed:2547609).Curated1
Sequence conflicti220I → V in BAG62635 (PubMed:14702039).Curated1
Sequence conflicti230F → K in AAA51884 (PubMed:2986130).Curated1
Sequence conflicti235E → V in AAA51592 (PubMed:3397059).Curated1
Sequence conflicti338 – 344Missing in BAG62635 (PubMed:14702039).Curated7

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Three alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations. ADH1B variations have been associated with protection against alcohol dependence and alcohol-related aerodigestive tract cancer [MIMi:103720].5 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00042648R → H in beta-2; allele ADH1B*2; common in Asian populations; associated with a lower risk of alcoholism. Combined sources7 PublicationsCorresponds to variant dbSNP:rs1229984Ensembl.1
Natural variantiVAR_01932257N → K2 PublicationsCorresponds to variant dbSNP:rs1041969Ensembl.1
Natural variantiVAR_01932360T → S1 PublicationCorresponds to variant dbSNP:rs6413413Ensembl.1
Natural variantiVAR_000427370R → C in beta-3/Indianapolis; allele ADH1B*3; decreased NAD(H) binding. 3 PublicationsCorresponds to variant dbSNP:rs2066702EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548471 – 40Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M24317 mRNA Translation: AAA51884.1
X03350 mRNA Translation: CAA27056.1
M24316 M24314 Genomic DNA Translation: AAB59496.1
D00137 mRNA Translation: BAA00084.1
L38290 L38289 Genomic DNA Translation: AAB48003.1
X15447 X15455 Genomic DNA Translation: CAA33487.1
AF153821 mRNA Translation: AAD37446.1
DQ017646 Genomic DNA Translation: AAY22180.1
AK301018 mRNA Translation: BAG62635.1
AC097530 Genomic DNA No translation available.
BC033009 mRNA Translation: AAH33009.1
M21692 mRNA Translation: AAA51592.1
AF040967 Genomic DNA Translation: AAB96912.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34033.1 [P00325-1]
CCDS68761.1 [P00325-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A23607, DEHUAB

NCBI Reference Sequences

More...RefSeqi		NP_000659.2, NM_000668.5
NP_001273579.1, NM_001286650.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305046; ENSP00000306606; ENSG00000196616

Database of genes from NCBI RefSeq genomes

More...GeneIDi		125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:125

UCSC genome browser

More...UCSCi		uc011cei.3, human [P00325-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24317 mRNA Translation: AAA51884.1
X03350 mRNA Translation: CAA27056.1
M24316 M24314 Genomic DNA Translation: AAB59496.1
D00137 mRNA Translation: BAA00084.1
L38290 L38289 Genomic DNA Translation: AAB48003.1
X15447 X15455 Genomic DNA Translation: CAA33487.1
AF153821 mRNA Translation: AAD37446.1
DQ017646 Genomic DNA Translation: AAY22180.1
AK301018 mRNA Translation: BAG62635.1
AC097530 Genomic DNA No translation available.
BC033009 mRNA Translation: AAH33009.1
M21692 mRNA Translation: AAA51592.1
AF040967 Genomic DNA Translation: AAB96912.1
CCDSiCCDS34033.1 [P00325-1]
CCDS68761.1 [P00325-2]
PIRiA23607, DEHUAB
RefSeqiNP_000659.2, NM_000668.5
NP_001273579.1, NM_001286650.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEHX-ray2.20A/B2-375[»]
1HDXX-ray2.50A/B2-375[»]
1HDYX-ray2.50A/B2-375[»]
1HDZX-ray2.50A/B2-375[»]
1HSZX-ray2.20A/B2-375[»]
1HTBX-ray2.40A/B2-375[»]
1U3UX-ray1.60A/B2-375[»]
1U3VX-ray1.65A/B2-375[»]
3HUDX-ray3.20A/B2-375[»]
SMRiP00325
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106637, 7 interactors
IntActiP00325, 11 interactors
MINTiP00325
STRINGi9606.ENSP00000306606

Chemistry databases

BindingDBiP00325
ChEMBLiCHEMBL3284
DrugBankiDB02721, 4-Iodopyrazole
DB03703, Cyclohexanol
DB00898, Ethanol
DB01213, Fomepizole
DB09462, Glycerin
DB02481, N-Benzylformamide
DB04105, N-Heptylformamide
DB00157, NADH
DB03461, Nicotinamide adenine dinucleotide phosphate
DrugCentraliP00325
SwissLipidsiSLP:000001880

PTM databases

iPTMnetiP00325
PhosphoSitePlusiP00325

Genetic variation databases

BioMutaiADH1B
DMDMi113394

Proteomic databases

EPDiP00325
jPOSTiP00325
MassIVEiP00325
PaxDbiP00325
PeptideAtlasiP00325
PRIDEiP00325
ProteomicsDBi2413
51228 [P00325-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14861, 283 antibodies

The DNASU plasmid repository

More...DNASUi		125

Genome annotation databases

EnsembliENST00000305046; ENSP00000306606; ENSG00000196616
GeneIDi125
KEGGihsa:125
UCSCiuc011cei.3, human [P00325-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		125
DisGeNETi125

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADH1B
HGNCiHGNC:250, ADH1B
HPAiENSG00000196616, Group enriched (adipose tissue, liver)
MalaCardsiADH1B
MIMi103720, gene+phenotype
neXtProtiNX_P00325
PharmGKBiPA24571
VEuPathDBiHostDB:ENSG00000196616

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0022, Eukaryota
HOGENOMiCLU_026673_14_0_1
InParanoidiP00325
OrthoDBi664798at2759
PhylomeDBiP00325
TreeFamiTF300429

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-321
PathwayCommonsiP00325
ReactomeiR-HSA-71384, Ethanol oxidation
SABIO-RKiP00325

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		125, 1 hit in 972 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADH1B, human
EvolutionaryTraceiP00325

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ADH1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		125
PharosiP00325, Tclin

Protein Ontology

More...PROi		PR:P00325
RNActiP00325, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196616, Expressed in adipose tissue and 203 other tissues
ExpressionAtlasiP00325, baseline and differential
GenevisibleiP00325, HS

Family and domain databases

InterProiView protein in InterPro
IPR013149, ADH_C
IPR013154, ADH_N
IPR002328, ADH_Zn_CS
IPR011032, GroES-like_sf
IPR036291, NAD(P)-bd_dom_sf
IPR020843, PKS_ER
PfamiView protein in Pfam
PF08240, ADH_N, 1 hit
PF00107, ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829, PKS_ER, 1 hit
SUPFAMiSSF50129, SSF50129, 2 hits
SSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059, ADH_ZINC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADH1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00325
Secondary accession number(s): A8MYN5
, B4DRS9, B4DVC3, Q13711, Q4ZGI9, Q96KI7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 216 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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