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UniProtKB - P00325 (ADH1B_HUMAN)

Entry version 207 (11 Dec 2019)
Sequence version 2 (23 Jan 2007)
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Protein

All-trans-retinol dehydrogenase [NAD(+)] ADH1B

Gene

ADH1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820).2 Publications

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4 µM for all-trans-4-hydroxyretinol (in allele ADH1B*1)1 Publication
  2. KM=25 µM for all-trans-4-oxoretinal (in allele ADH1B*1)1 Publication
  3. KM=11 µM for all-trans-4-hydroxyretinol (in allele ADH1B*2)1 Publication
  4. KM=27 µM for all-trans-4-oxoretinal (in allele ADH1B*2)1 Publication
  5. KM=24 µM for all-trans-3,4-didehydroretinol(in allele ADH1B*2)1 Publication
  6. KM=25 µM for all-trans-3,4-didehydroretinal(in allele ADH1B*2)1 Publication
  7. KM=0.4 µM for all-trans-retinaldehyde (in allele ADH1B*2)1 Publication
  8. KM=0.3 µM for all-trans-retinol (in allele ADH1B*2)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi47Zinc 1; catalytic1
    Metal bindingi68Zinc 1; catalytic1
    Metal bindingi98Zinc 21
    Metal bindingi101Zinc 21
    Metal bindingi104Zinc 21
    Metal bindingi112Zinc 21
    Metal bindingi175Zinc 1; catalytic1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei224NAD1
    Binding sitei229NAD1
    Binding sitei370NAD1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi200 – 205NAD6
    Nucleotide bindingi293 – 295NAD3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandMetal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:MONOMER66-321

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-71384 Ethanol oxidation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P00325

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000001880

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    All-trans-retinol dehydrogenase [NAD(+)] ADH1BCurated (EC:1.1.1.1051 Publication)
    Alternative name(s):
    Alcohol dehydrogenase 1B
    Alcohol dehydrogenase subunit beta
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ADH1BImported
    Synonyms:ADH2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000196616.12

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:250 ADH1B

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		103720 gene+phenotype

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P00325

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		125

    MalaCards human disease database

    More...    MalaCardsi    		ADH1B
    MIMi103720 gene+phenotype

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA24571

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P00325 Tclin

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3284

    Drug and drug target database

    More...    DrugBanki    		DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB02721 4-Iodopyrazole
    DB03703 Cyclohexanol
    DB00898 Ethanol
    DB01213 Fomepizole
    DB09462 Glycerin
    DB02481 N-Benzylformamide
    DB04105 N-Heptylformamide
    DB00157 NADH

    DrugCentral

    More...    DrugCentrali    		P00325

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		ADH1B

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		113394

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001606612 – 375All-trans-retinol dehydrogenase [NAD(+)] ADH1BAdd BLAST374

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
    Modified residuei23PhosphoserineCombined sources1
    Modified residuei35PhosphotyrosineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P00325

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P00325

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P00325

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P00325

    PeptideAtlas

    More...    PeptideAtlasi    		P00325

    PRoteomics IDEntifications database

    More...    PRIDEi    		P00325

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		2413
    51228 [P00325-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P00325

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P00325

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000196616 Expressed in 194 organ(s), highest expression level in adipose tissue

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P00325 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P00325 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA047814
    HPA060902

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Dimer of identical or non-identical chains of three types; alpha, beta and gamma.

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		106637, 7 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P00325, 11 interactors

    Molecular INTeraction database

    More...    MINTi    		P00325

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000306606

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P00325

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P00325 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1375
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P00325

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P00325

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the zinc-containing alcohol dehydrogenase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0022 Eukaryota
    COG1062 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000294674

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P00325

    KEGG Orthology (KO)

    More...    KOi    		K13951

    Database of Orthologous Groups

    More...    OrthoDBi    		664798at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P00325

    TreeFam database of animal gene trees

    More...    TreeFami    		TF300429

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR002328 ADH_Zn_CS
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf
    IPR020843 PKS_ER

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00829 PKS_ER, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF50129 SSF50129, 2 hits
    SSF51735 SSF51735, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00059 ADH_ZINC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P00325-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSTAGKVIKC KAAVLWEVKK PFSIEDVEVA PPKAYEVRIK MVAVGICRTD 
            60         70         80         90        100
    DHVVSGNLVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK 
           110        120        130        140        150
    CRVCKNPESN YCLKNDLGNP RGTLQDGTRR FTCRGKPIHH FLGTSTFSQY 
           160        170        180        190        200
    TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG 
           210        220        230        240        250
    LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP 
           260        270        280        290        300
    IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPASQ 
           310        320        330        340        350
    NLSINPMLLL TGRTWKGAVY GGFKSKEGIP KLVADFMAKK FSLDALITHV 
           360        370 
    LPFEKINEGF DLLHSGKSIR TVLTF
    Length:375
    Mass (Da):39,855
    Last modified:January 23, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6962B9A0F967673B
    GO
    Isoform 2 (identifier: P00325-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-40: Missing.

    Show »
    Length:335
    Mass (Da):35,412
    Checksum:iA92B71F22E3CAFA4
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    V9HW50V9HW50_HUMAN
    All-trans-retinol dehydrogenase [NA...
    ADH1B HEL-S-117
    		375Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RHZ6D6RHZ6_HUMAN
    All-trans-retinol dehydrogenase [NA...
    ADH1B
    		335Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8I → M in AAA51592 (PubMed:3397059).Curated1
    Sequence conflicti130Missing AA sequence (PubMed:6391920).Curated1
    Sequence conflicti166P → K in AAA51592 (PubMed:3397059).Curated1
    Sequence conflicti190V → VV in CAA33487 (PubMed:2547609).Curated1
    Sequence conflicti220I → V in BAG62635 (PubMed:14702039).Curated1
    Sequence conflicti230F → K in AAA51884 (PubMed:2986130).Curated1
    Sequence conflicti235E → V in AAA51592 (PubMed:3397059).Curated1
    Sequence conflicti338 – 344Missing in BAG62635 (PubMed:14702039).Curated7

    <p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    Three alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations. ADH1B variations have been associated with protection against alcohol dependence and alcohol-related aerodigestive tract cancer [MIMi:103720].5 Publications

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00042648R → H in beta-2; allele ADH1B*2; common in Asian populations; associated with a lower risk of alcoholism. Combined sources7 PublicationsCorresponds to variant dbSNP:rs1229984Ensembl.1
    Natural variantiVAR_01932257N → K2 PublicationsCorresponds to variant dbSNP:rs1041969Ensembl.1
    Natural variantiVAR_01932360T → S1 PublicationCorresponds to variant dbSNP:rs6413413Ensembl.1
    Natural variantiVAR_000427370R → C in beta-3/Indianapolis; allele ADH1B*3; decreased NAD(H) binding. 3 PublicationsCorresponds to variant dbSNP:rs2066702EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548471 – 40Missing in isoform 2. 1 PublicationAdd BLAST40

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		M24317 mRNA Translation: AAA51884.1
    X03350 mRNA Translation: CAA27056.1
    M24316 M24314 Genomic DNA Translation: AAB59496.1
    D00137 mRNA Translation: BAA00084.1
    L38290 L38289 Genomic DNA Translation: AAB48003.1
    X15447 X15455 Genomic DNA Translation: CAA33487.1
    AF153821 mRNA Translation: AAD37446.1
    DQ017646 Genomic DNA Translation: AAY22180.1
    AK301018 mRNA Translation: BAG62635.1
    AC097530 Genomic DNA No translation available.
    BC033009 mRNA Translation: AAH33009.1
    M21692 mRNA Translation: AAA51592.1
    AF040967 Genomic DNA Translation: AAB96912.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS34033.1 [P00325-1]
    CCDS68761.1 [P00325-2]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A23607 DEHUAB

    NCBI Reference Sequences

    More...    RefSeqi    		NP_000659.2, NM_000668.5
    NP_001273579.1, NM_001286650.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000305046; ENSP00000306606; ENSG00000196616
    ENST00000394887; ENSP00000378351; ENSG00000196616

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		125

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:125

    UCSC genome browser

    More...    UCSCi    		uc011cei.3 human [P00325-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		M24317 mRNA Translation: AAA51884.1
    X03350 mRNA Translation: CAA27056.1
    M24316 M24314 Genomic DNA Translation: AAB59496.1
    D00137 mRNA Translation: BAA00084.1
    L38290 L38289 Genomic DNA Translation: AAB48003.1
    X15447 X15455 Genomic DNA Translation: CAA33487.1
    AF153821 mRNA Translation: AAD37446.1
    DQ017646 Genomic DNA Translation: AAY22180.1
    AK301018 mRNA Translation: BAG62635.1
    AC097530 Genomic DNA No translation available.
    BC033009 mRNA Translation: AAH33009.1
    M21692 mRNA Translation: AAA51592.1
    AF040967 Genomic DNA Translation: AAB96912.1
    CCDSiCCDS34033.1 [P00325-1]
    CCDS68761.1 [P00325-2]
    PIRiA23607 DEHUAB
    RefSeqiNP_000659.2, NM_000668.5
    NP_001273579.1, NM_001286650.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1DEHX-ray2.20A/B2-375[»]
    1HDXX-ray2.50A/B2-375[»]
    1HDYX-ray2.50A/B2-375[»]
    1HDZX-ray2.50A/B2-375[»]
    1HSZX-ray2.20A/B2-375[»]
    1HTBX-ray2.40A/B2-375[»]
    1U3UX-ray1.60A/B2-375[»]
    1U3VX-ray1.65A/B2-375[»]
    3HUDX-ray3.20A/B2-375[»]
    SMRiP00325
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi106637, 7 interactors
    IntActiP00325, 11 interactors
    MINTiP00325
    STRINGi9606.ENSP00000306606

    Chemistry databases

    BindingDBiP00325
    ChEMBLiCHEMBL3284
    DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB02721 4-Iodopyrazole
    DB03703 Cyclohexanol
    DB00898 Ethanol
    DB01213 Fomepizole
    DB09462 Glycerin
    DB02481 N-Benzylformamide
    DB04105 N-Heptylformamide
    DB00157 NADH
    DrugCentraliP00325
    SwissLipidsiSLP:000001880

    PTM databases

    iPTMnetiP00325
    PhosphoSitePlusiP00325

    Polymorphism and mutation databases

    BioMutaiADH1B
    DMDMi113394

    Proteomic databases

    EPDiP00325
    jPOSTiP00325
    MassIVEiP00325
    PaxDbiP00325
    PeptideAtlasiP00325
    PRIDEiP00325
    ProteomicsDBi2413
    51228 [P00325-1]

    Genome annotation databases

    EnsembliENST00000305046; ENSP00000306606; ENSG00000196616
    ENST00000394887; ENSP00000378351; ENSG00000196616
    GeneIDi125
    KEGGihsa:125
    UCSCiuc011cei.3 human [P00325-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		125
    DisGeNETi125
    EuPathDBiHostDB:ENSG00000196616.12

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		ADH1B
    HGNCiHGNC:250 ADH1B
    HPAiHPA047814
    HPA060902
    MalaCardsiADH1B
    MIMi103720 gene+phenotype
    neXtProtiNX_P00325
    PharmGKBiPA24571

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0022 Eukaryota
    COG1062 LUCA
    HOGENOMiHOG000294674
    InParanoidiP00325
    KOiK13951
    OrthoDBi664798at2759
    PhylomeDBiP00325
    TreeFamiTF300429

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER66-321
    ReactomeiR-HSA-71384 Ethanol oxidation
    SABIO-RKiP00325

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		ADH1B human
    EvolutionaryTraceiP00325

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		ADH1B

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		125
    PharosiP00325 Tclin

    Protein Ontology

    More...    PROi    		PR:P00325
    RNActiP00325 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000196616 Expressed in 194 organ(s), highest expression level in adipose tissue
    ExpressionAtlasiP00325 baseline and differential
    GenevisibleiP00325 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR002328 ADH_Zn_CS
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf
    IPR020843 PKS_ER
    PfamiView protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit
    SMARTiView protein in SMART
    SM00829 PKS_ER, 1 hit
    SUPFAMiSSF50129 SSF50129, 2 hits
    SSF51735 SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00059 ADH_ZINC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADH1B_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00325
    Secondary accession number(s): A8MYN5
    , B4DRS9, B4DVC3, Q13711, Q4ZGI9, Q96KI7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: December 11, 2019
    This is version 207 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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