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UniProtKB - P00183 (CPXA_PSEPU)
Protein
Camphor 5-monooxygenase
Gene
camC
Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Functioni
Involved in a camphor oxidation system.
Catalytic activityi
- (1R,4R)-camphor + 2 H+ + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]EC:1.14.15.1
Cofactori
: (R)-camphor degradation Pathwayi
This protein is involved in the pathway (R)-camphor degradation, which is part of Terpene metabolism.View all proteins of this organism that are known to be involved in the pathway (R)-camphor degradation and in Terpene metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 358 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- camphor 5-monooxygenase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
GO - Biological processi
- (+)-camphor catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.15.1, 5092 |
UniPathwayi | UPA00719 |
Names & Taxonomyi
Protein namesi | Recommended name: Camphor 5-monooxygenase (EC:1.14.15.1)Alternative name(s): Cytochrome P450-cam Short name: Cytochrome P450cam |
Gene namesi | Name:camC Synonyms:cyp101 |
Organismi | Pseudomonas putida (Arthrobacter siderocapsulatus) |
Taxonomic identifieri | 303 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL5594 |
DrugBanki | DB03836, 1,3,5-trichlorobenzene DB02617, 1-(N-Imidazolyl)-2-Hydroxy-2-(2,3-Dichlorophenyl)Octane DB02817, 5-Exo-Hydroxycamphor DB03627, Adamantane DB04032, Adamantane-1-Carboxylic Acid-5-Dimethylamino-Naphthalene-1-Sulfonylamino-Butyl-Amide DB03031, Adamantane-1-Carboxylic Acid-5-Dimethylamino-Naphthalene-1-Sulfonylamino-Octyl-Amide DB02125, Adamantanone DB04501, Camphane DB01744, Camphor DB01663, lambda-bis(2,2'-bipyridine)-(5-methyl-2-2'-bipyridine)-C9-adamantane ruthenium (II) DB01011, Metyrapone DB01703, N-(2-ferrocenylethyl)maleimide DB01826, N-Butyl Isocyanide DB03540, Norcamphor DB02851, Thiocamphor |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000052204 | 2 – 415 | Camphor 5-monooxygenaseAdd BLAST | 414 |
Interactioni
Binary interactionsi
P00183
With | #Exp. | IntAct |
---|---|---|
camB [P00259] | 3 | EBI-15706256,EBI-15706395 |
Protein-protein interaction databases
DIPi | DIP-29809N |
IntActi | P00183, 1 interactor |
Chemistry databases
BindingDBi | P00183 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P00183 |
BMRBi | P00183 |
SMRi | P00183 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00183 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR002397, Cyt_P450_B IPR017972, Cyt_P450_CS IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00359, BP450 PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P00183-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTETIQSNA NLAPLPPHVP EHLVFDFDMY NPSNLSAGVQ EAWAVLQESN
60 70 80 90 100
VPDLVWTRCN GGHWIATRGQ LIREAYEDYR HFSSECPFIP REAGEAYDFI
110 120 130 140 150
PTSMDPPEQR QFRALANQVV GMPVVDKLEN RIQELACSLI ESLRPQGQCN
160 170 180 190 200
FTEDYAEPFP IRIFMLLAGL PEEDIPHLKY LTDQMTRPDG SMTFAEAKEA
210 220 230 240 250
LYDYLIPIIE QRRQKPGTDA ISIVANGQVN GRPITSDEAK RMCGLLLVGG
260 270 280 290 300
LDTVVNFLSF SMEFLAKSPE HRQELIERPE RIPAACEELL RRFSLVADGR
310 320 330 340 350
ILTSDYEFHG VQLKKGDQIL LPQMLSGLDE RENACPMHVD FSRQKVSHTT
360 370 380 390 400
FGHGSHLCLG QHLARREIIV TLKEWLTRIP DFSIAPGAQI QHKSGIVSGV
410
QALPLVWDPA TTKAV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 – 57 | Missing AA sequence (PubMed:7130171).Curated | 2 | |
Sequence conflicti | 277 | E → Q AA sequence (PubMed:7130171).Curated | 1 | |
Sequence conflicti | 362 | H → S AA sequence (PubMed:7130171).Curated | 1 | |
Sequence conflicti | 408 | D → N AA sequence (PubMed:7130171).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12546 Genomic DNA Translation: AAA25760.1 D00528 Genomic DNA Translation: BAA00412.1 |
PIRi | A25660, O4PSCP |
Genome annotation databases
KEGGi | ag:AAA25760 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12546 Genomic DNA Translation: AAA25760.1 D00528 Genomic DNA Translation: BAA00412.1 |
PIRi | A25660, O4PSCP |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AKD | X-ray | 1.80 | A | 2-415 | [»] | |
1C8J | X-ray | 2.10 | A/B | 2-415 | [»] | |
1CP4 | X-ray | 1.90 | A | 2-415 | [»] | |
1DZ4 | X-ray | 1.60 | A/B | 2-415 | [»] | |
1DZ6 | X-ray | 1.90 | A/B | 2-415 | [»] | |
1DZ8 | X-ray | 1.90 | A/B | 2-415 | [»] | |
1DZ9 | X-ray | 1.90 | A/B | 2-415 | [»] | |
1GEB | X-ray | 2.03 | A | 1-415 | [»] | |
1GEK | X-ray | 1.70 | A | 1-415 | [»] | |
1GEM | X-ray | 2.00 | A | 1-415 | [»] | |
1GJM | X-ray | 2.20 | A | 2-415 | [»] | |
1IWI | X-ray | 2.00 | A | 1-415 | [»] | |
1IWJ | X-ray | 2.00 | A | 1-415 | [»] | |
1IWK | X-ray | 2.00 | A | 1-415 | [»] | |
1J51 | X-ray | 2.20 | A/B/C/D | 2-415 | [»] | |
1K2O | X-ray | 1.65 | A/B | 2-415 | [»] | |
1LWL | X-ray | 2.20 | A | 1-415 | [»] | |
1MPW | X-ray | 2.34 | A/B | 2-415 | [»] | |
1NOO | X-ray | 2.20 | A | 2-415 | [»] | |
1O76 | X-ray | 1.80 | A/B | 2-415 | [»] | |
1P2Y | X-ray | 2.30 | A | 2-415 | [»] | |
1P7R | X-ray | 2.85 | A | 2-415 | [»] | |
1PHA | X-ray | 1.63 | A | 2-415 | [»] | |
1PHB | X-ray | 1.60 | A | 2-415 | [»] | |
1PHC | X-ray | 1.60 | A | 2-415 | [»] | |
1PHD | X-ray | 1.60 | A | 2-415 | [»] | |
1PHE | X-ray | 1.60 | A | 2-415 | [»] | |
1PHF | X-ray | 1.60 | A | 2-415 | [»] | |
1PHG | X-ray | 1.60 | A | 2-415 | [»] | |
1QMQ | X-ray | 1.55 | A | 2-415 | [»] | |
1RE9 | X-ray | 1.45 | A | 2-415 | [»] | |
1RF9 | X-ray | 1.80 | A | 1-415 | [»] | |
1T85 | X-ray | 1.80 | A | 2-415 | [»] | |
1T86 | X-ray | 1.90 | A/B | 2-415 | [»] | |
1T87 | X-ray | 1.80 | A/B | 2-415 | [»] | |
1T88 | X-ray | 1.90 | A/B | 2-415 | [»] | |
1UYU | X-ray | 2.00 | A/B | 2-415 | [»] | |
1YRC | X-ray | 1.40 | A | 2-415 | [»] | |
1YRD | X-ray | 1.70 | A | 2-415 | [»] | |
2A1M | X-ray | 2.10 | A/B | 1-415 | [»] | |
2A1N | X-ray | 1.90 | A/B | 1-415 | [»] | |
2A1O | X-ray | 1.55 | A/B | 1-415 | [»] | |
2CP4 | X-ray | 2.10 | A | 2-415 | [»] | |
2CPP | X-ray | 1.63 | A | 2-415 | [»] | |
2FE6 | X-ray | 1.50 | A | 1-415 | [»] | |
2FER | X-ray | 1.70 | A | 11-415 | [»] | |
2FEU | X-ray | 1.70 | A/B | 11-415 | [»] | |
2FRZ | X-ray | 2.10 | A/B | 2-415 | [»] | |
2GQX | X-ray | 2.10 | A/B | 11-415 | [»] | |
2GR6 | X-ray | 2.30 | A/B | 11-415 | [»] | |
2H7Q | X-ray | 1.50 | A | 2-415 | [»] | |
2H7R | X-ray | 2.10 | A | 2-415 | [»] | |
2H7S | X-ray | 2.15 | A/C | 2-415 | [»] | |
2L8M | NMR | - | A | 1-415 | [»] | |
2LQD | NMR | - | A | 3-415 | [»] | |
2M56 | NMR | - | A | 12-415 | [»] | |
2QBL | X-ray | 1.80 | A | 1-415 | [»] | |
2QBM | X-ray | 1.80 | A | 1-415 | [»] | |
2QBN | X-ray | 1.75 | A | 1-415 | [»] | |
2QBO | X-ray | 1.90 | A | 1-415 | [»] | |
2Z97 | X-ray | 1.80 | A | 1-415 | [»] | |
2ZAW | X-ray | 1.55 | A | 1-415 | [»] | |
2ZAX | X-ray | 1.60 | A | 1-415 | [»] | |
2ZUH | X-ray | 1.55 | A | 1-415 | [»] | |
2ZUI | X-ray | 1.50 | A | 1-415 | [»] | |
2ZUJ | X-ray | 1.60 | A | 1-415 | [»] | |
2ZWT | X-ray | 1.35 | A | 1-415 | [»] | |
2ZWU | X-ray | 1.30 | A | 1-415 | [»] | |
3CP4 | X-ray | 2.30 | A | 2-415 | [»] | |
3CPP | X-ray | 1.90 | A | 2-415 | [»] | |
3FWF | X-ray | 1.83 | A/B | 11-415 | [»] | |
3FWG | X-ray | 1.55 | A/B | 11-415 | [»] | |
3FWI | X-ray | 2.40 | A | 11-415 | [»] | |
3FWJ | X-ray | 1.90 | A | 11-415 | [»] | |
3L61 | X-ray | 1.50 | A | 2-415 | [»] | |
3L62 | X-ray | 1.70 | A | 2-415 | [»] | |
3L63 | X-ray | 1.50 | A | 2-415 | [»] | |
3OIA | X-ray | 1.65 | A | 2-415 | [»] | |
3OL5 | X-ray | 1.75 | A | 2-415 | [»] | |
3P6M | X-ray | 2.00 | A | 2-415 | [»] | |
3P6N | X-ray | 1.70 | A | 2-415 | [»] | |
3P6O | X-ray | 2.00 | A | 2-415 | [»] | |
3P6P | X-ray | 1.90 | A | 2-415 | [»] | |
3P6Q | X-ray | 1.95 | A | 2-415 | [»] | |
3P6R | X-ray | 2.10 | A | 2-415 | [»] | |
3P6S | X-ray | 2.00 | A | 2-415 | [»] | |
3P6T | X-ray | 1.90 | A | 2-415 | [»] | |
3P6U | X-ray | 1.70 | A | 2-415 | [»] | |
3P6V | X-ray | 2.00 | A | 2-415 | [»] | |
3P6W | X-ray | 2.10 | A | 2-415 | [»] | |
3P6X | X-ray | 1.65 | A | 2-415 | [»] | |
3W9C | X-ray | 2.50 | A | 2-415 | [»] | |
3WRH | X-ray | 1.62 | A/E | 1-415 | [»] | |
3WRI | X-ray | 2.90 | A/B | 1-415 | [»] | |
3WRJ | X-ray | 1.85 | A/E | 1-415 | [»] | |
3WRK | X-ray | 2.61 | A/D | 1-415 | [»] | |
3WRL | X-ray | 1.65 | A/E | 1-415 | [»] | |
3WRM | X-ray | 1.95 | A/F | 1-415 | [»] | |
4CP4 | X-ray | 2.10 | A | 2-415 | [»] | |
4CPP | X-ray | 2.11 | A | 2-415 | [»] | |
4EK1 | X-ray | 1.97 | A/B | 2-415 | [»] | |
4G3R | X-ray | 2.20 | A/B | 2-415 | [»] | |
4JWS | X-ray | 2.15 | A/B | 1-415 | [»] | |
4JWU | X-ray | 2.20 | A/B | 1-415 | [»] | |
4JX1 | X-ray | 2.09 | A/B/E/F | 1-415 | [»] | |
4KKY | X-ray | 2.00 | X | 2-414 | [»] | |
4L49 | X-ray | 2.13 | A | 1-415 | [»] | |
4L4A | X-ray | 2.10 | A | 1-415 | [»] | |
4L4B | X-ray | 2.10 | A | 1-415 | [»] | |
4L4C | X-ray | 2.20 | A/B | 1-415 | [»] | |
4L4D | X-ray | 2.10 | A | 1-415 | [»] | |
4L4E | X-ray | 1.26 | A | 1-415 | [»] | |
4L4F | X-ray | 1.29 | A | 1-415 | [»] | |
4L4G | X-ray | 1.55 | A | 1-415 | [»] | |
5CP4 | X-ray | 1.75 | A | 2-415 | [»] | |
5CPP | X-ray | 2.08 | A | 2-415 | [»] | |
5GXG | X-ray | 1.70 | A | 2-415 | [»] | |
5IK1 | X-ray | 1.53 | A | 10-415 | [»] | |
5WK7 | X-ray | 1.98 | A | 1-415 | [»] | |
5WK9 | X-ray | 1.98 | A | 1-415 | [»] | |
6CP4 | X-ray | 1.90 | A | 2-415 | [»] | |
6CPP | X-ray | 1.90 | A | 2-415 | [»] | |
6NBL | X-ray | 2.15 | A/B | 1-415 | [»] | |
6WE6 | X-ray | 2.16 | A/B | 1-415 | [»] | |
6WFL | X-ray | 1.60 | A | 1-415 | [»] | |
7CPP | X-ray | 2.00 | A | 2-415 | [»] | |
8CPP | X-ray | 2.10 | A | 2-415 | [»] | |
AlphaFoldDBi | P00183 | |||||
BMRBi | P00183 | |||||
SMRi | P00183 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-29809N |
IntActi | P00183, 1 interactor |
Chemistry databases
BindingDBi | P00183 |
ChEMBLi | CHEMBL5594 |
DrugBanki | DB03836, 1,3,5-trichlorobenzene DB02617, 1-(N-Imidazolyl)-2-Hydroxy-2-(2,3-Dichlorophenyl)Octane DB02817, 5-Exo-Hydroxycamphor DB03627, Adamantane DB04032, Adamantane-1-Carboxylic Acid-5-Dimethylamino-Naphthalene-1-Sulfonylamino-Butyl-Amide DB03031, Adamantane-1-Carboxylic Acid-5-Dimethylamino-Naphthalene-1-Sulfonylamino-Octyl-Amide DB02125, Adamantanone DB04501, Camphane DB01744, Camphor DB01663, lambda-bis(2,2'-bipyridine)-(5-methyl-2-2'-bipyridine)-C9-adamantane ruthenium (II) DB01011, Metyrapone DB01703, N-(2-ferrocenylethyl)maleimide DB01826, N-Butyl Isocyanide DB03540, Norcamphor DB02851, Thiocamphor |
Genome annotation databases
KEGGi | ag:AAA25760 |
Enzyme and pathway databases
UniPathwayi | UPA00719 |
BRENDAi | 1.14.15.1, 5092 |
Miscellaneous databases
EvolutionaryTracei | P00183 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR002397, Cyt_P450_B IPR017972, Cyt_P450_CS IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00359, BP450 PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CPXA_PSEPU | |
Accessioni | P00183Primary (citable) accession number: P00183 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families