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Protein

Cytochrome b5

Gene

CYB5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi44Iron (heme axial ligand)1
Metal bindingi68Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aldo-keto reductase (NADP) activity Source: Reactome
  • cytochrome-c oxidase activity Source: ProtInc
  • enzyme binding Source: BHF-UCL
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000166347-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196836 Vitamin C (ascorbate) metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b5
Alternative name(s):
Microsomal cytochrome b5 type A
Short name:
MCB5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYB5A
Synonyms:CYB5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166347.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2570 CYB5A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613218 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P00167

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei109 – 131HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Methemoglobinemia and ambiguous genitalia (METAG)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by sex steroid deficiency but normal glucocorticoid and mineralocorticoid reserve, male undermasculinization, absent or disturbed pubertal development, decreased levels of erythrocyte cytochrome B5, and excessive amounts of methemoglobin in blood cells resulting in cyanosis and hypoxia.
See also OMIM:250790
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08083327 – 134Missing in METAG. 1 PublicationAdd BLAST108
Natural variantiVAR_08083444H → L in METAG. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1528

MalaCards human disease database

More...
MalaCardsi
CYB5A
MIMi250790 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166347

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90796 46,XY disorder of sex development due to isolated 17,20-lyase deficiency
621 Hereditary methemoglobinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27068

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6170

Drug and drug target database

More...
DrugBanki
DB04009 Dimethyl Propionate Ester Heme

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYB5A

Domain mapping of disease mutations (DMDM)

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DMDMi
117809

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved5 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001660102 – 134Cytochrome b5Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei19N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P00167

MaxQB - The MaxQuant DataBase

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MaxQBi
P00167

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P00167

PeptideAtlas

More...
PeptideAtlasi
P00167

PRoteomics IDEntifications database

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PRIDEi
P00167

ProteomicsDB human proteome resource

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ProteomicsDBi
12628 [P00167-2]
51226
51227 [P00167-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P00167-1 [P00167-1]
P00167-3 [P00167-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P00167

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P00167

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166347 Expressed in 233 organ(s), highest expression level in nephron tubule

CleanEx database of gene expression profiles

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CleanExi
HS_CYB5A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P00167 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P00167 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB006333
HPA047548
HPA058547

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107908, 25 interactors

Protein interaction database and analysis system

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IntActi
P00167, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000341625

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P00167

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P00167

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P00167

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 85Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome b5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0537 Eukaryota
COG5274 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156770

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000039853

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002653

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P00167

Identification of Orthologs from Complete Genome Data

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OMAi
FKSTWII

Database of Orthologous Groups

More...
OrthoDBi
EOG091G17G8

Database for complete collections of gene phylogenies

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PhylomeDBi
P00167

TreeFam database of animal gene trees

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TreeFami
TF314537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00173 Cyt-b5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00363 CYTOCHROMEB5

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01117 Cyt-b5, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55856 SSF55856, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P00167-1) [UniParc]FASTAAdd to basket
Also known as: Liver, Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEQSDEAVK YYTLEEIQKH NHSKSTWLIL HHKVYDLTKF LEEHPGGEEV
60 70 80 90 100
LREQAGGDAT ENFEDVGHST DAREMSKTFI IGELHPDDRP KLNKPPETLI
110 120 130
TTIDSSSSWW TNWVIPAISA VAVALMYRLY MAED
Length:134
Mass (Da):15,330
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6AD2AB747555048
GO
Isoform 2 (identifier: P00167-2) [UniParc]FASTAAdd to basket
Also known as: Erythrocyte, Cytoplasmic

The sequence of this isoform differs from the canonical sequence as follows:
     98-98: T → P
     99-134: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:98
Mass (Da):11,268
Checksum:i62D9B54C7BCDF9F3
GO
Isoform 3 (identifier: P00167-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-95: Missing.

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):14,169
Checksum:iAC952456B4827706
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNC7J3KNC7_HUMAN
Cytochrome b5
CYB5A
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA63169 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2 – 4Missing AA sequence (PubMed:4993957).Curated3
Sequence conflicti4Q → E AA sequence (PubMed:2752049).Curated1
Sequence conflicti15 – 18EEIQ → QEIE AA sequence (PubMed:4993957).Curated4
Sequence conflicti15 – 18EEIQ → QEIE AA sequence (PubMed:5062820).Curated4
Sequence conflicti15 – 18EEIQ → QEIE AA sequence (PubMed:4770377).Curated4
Sequence conflicti22Missing AA sequence (PubMed:4770377).Curated1
Sequence conflicti52R → W in CA771478 (Ref. 4) Curated1
Sequence conflicti62N → D AA sequence (PubMed:4993957).Curated1
Sequence conflicti62N → D AA sequence (PubMed:5062820).Curated1
Sequence conflicti62N → D AA sequence (PubMed:4770377).Curated1
Sequence conflicti89 – 91RPK → KPR AA sequence (PubMed:4030743).Curated3
Sequence conflicti89 – 91RPK → KPR AA sequence (PubMed:4993957).Curated3
Sequence conflicti89 – 91RPK → KPR AA sequence (PubMed:5062820).Curated3
Sequence conflicti89 – 91RPK → KPR AA sequence (PubMed:4770377).Curated3
Sequence conflicti122A → V AA sequence (PubMed:2752049).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08083327 – 134Missing in METAG. 1 PublicationAdd BLAST108
Natural variantiVAR_08083444H → L in METAG. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04536786 – 95Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_00124098T → P in isoform 2. 1 Publication1
Alternative sequenceiVSP_00124199 – 134Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M22865 mRNA Translation: AAA35729.1
M60174 mRNA Translation: AAA52165.1
L39945
, L39792, L39941, L39942, L39943, L39944 Genomic DNA Translation: AAA63169.1 Sequence problems.
CA771478 mRNA No translation available.
CR456990 mRNA Translation: CAG33271.1
AC090398 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66544.1
BC015182 mRNA Translation: AAH15182.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12004.1 [P00167-1]
CCDS12005.1 [P00167-2]
CCDS54188.1 [P00167-3]

Protein sequence database of the Protein Information Resource

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PIRi
A28936 CBHU5
JN0075 CBHU5E

NCBI Reference Sequences

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RefSeqi
NP_001177736.1, NM_001190807.2 [P00167-3]
NP_001905.1, NM_001914.3 [P00167-2]
NP_683725.1, NM_148923.3 [P00167-1]
XP_011524137.1, XM_011525835.2 [P00167-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.465413

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340533; ENSP00000341625; ENSG00000166347 [P00167-1]
ENST00000397914; ENSP00000381011; ENSG00000166347 [P00167-3]
ENST00000494131; ENSP00000436461; ENSG00000166347 [P00167-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1528

UCSC genome browser

More...
UCSCi
uc002llh.4 human [P00167-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22865 mRNA Translation: AAA35729.1
M60174 mRNA Translation: AAA52165.1
L39945
, L39792, L39941, L39942, L39943, L39944 Genomic DNA Translation: AAA63169.1 Sequence problems.
CA771478 mRNA No translation available.
CR456990 mRNA Translation: CAG33271.1
AC090398 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66544.1
BC015182 mRNA Translation: AAH15182.1
CCDSiCCDS12004.1 [P00167-1]
CCDS12005.1 [P00167-2]
CCDS54188.1 [P00167-3]
PIRiA28936 CBHU5
JN0075 CBHU5E
RefSeqiNP_001177736.1, NM_001190807.2 [P00167-3]
NP_001905.1, NM_001914.3 [P00167-2]
NP_683725.1, NM_148923.3 [P00167-1]
XP_011524137.1, XM_011525835.2 [P00167-2]
UniGeneiHs.465413

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I96NMR-A1-108[»]
ProteinModelPortaliP00167
SMRiP00167
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107908, 25 interactors
IntActiP00167, 4 interactors
STRINGi9606.ENSP00000341625

Chemistry databases

ChEMBLiCHEMBL6170
DrugBankiDB04009 Dimethyl Propionate Ester Heme

PTM databases

iPTMnetiP00167
PhosphoSitePlusiP00167

Polymorphism and mutation databases

BioMutaiCYB5A
DMDMi117809

Proteomic databases

EPDiP00167
MaxQBiP00167
PaxDbiP00167
PeptideAtlasiP00167
PRIDEiP00167
ProteomicsDBi12628 [P00167-2]
51226
51227 [P00167-2]
TopDownProteomicsiP00167-1 [P00167-1]
P00167-3 [P00167-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1528
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340533; ENSP00000341625; ENSG00000166347 [P00167-1]
ENST00000397914; ENSP00000381011; ENSG00000166347 [P00167-3]
ENST00000494131; ENSP00000436461; ENSG00000166347 [P00167-2]
GeneIDi1528
KEGGihsa:1528
UCSCiuc002llh.4 human [P00167-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1528
DisGeNETi1528
EuPathDBiHostDB:ENSG00000166347.18

GeneCards: human genes, protein and diseases

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GeneCardsi
CYB5A
HGNCiHGNC:2570 CYB5A
HPAiCAB006333
HPA047548
HPA058547
MalaCardsiCYB5A
MIMi250790 phenotype
613218 gene
neXtProtiNX_P00167
OpenTargetsiENSG00000166347
Orphaneti90796 46,XY disorder of sex development due to isolated 17,20-lyase deficiency
621 Hereditary methemoglobinemia
PharmGKBiPA27068

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0537 Eukaryota
COG5274 LUCA
GeneTreeiENSGT00940000156770
HOGENOMiHOG000039853
HOVERGENiHBG002653
InParanoidiP00167
OMAiFKSTWII
OrthoDBiEOG091G17G8
PhylomeDBiP00167
TreeFamiTF314537

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000166347-MONOMER
ReactomeiR-HSA-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CYB5A human
EvolutionaryTraceiP00167

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cytochrome_b5,_type_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1528

Protein Ontology

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PROi
PR:P00167

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166347 Expressed in 233 organ(s), highest expression level in nephron tubule
CleanExiHS_CYB5A
ExpressionAtlasiP00167 baseline and differential
GenevisibleiP00167 HS

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYB5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00167
Secondary accession number(s): A8MV91, F8WEU4, Q6IB14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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