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Protein

Cytochrome b

Gene

MT-CYB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.By similarity

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Caution

The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Iron 1 (heme b562 axial ligand)By similarity1
Metal bindingi97Iron 2 (heme b566 axial ligand)By similarity1
Metal bindingi182Iron 1 (heme b562 axial ligand)By similarity1
Metal bindingi196Iron 2 (heme b566 axial ligand)By similarity1
Binding sitei201UbiquinoneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding, Ubiquinone

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene namesi
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded oniMitochondrion
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiHostDB:ENSG00000198727.2
HGNCiHGNC:7427 MT-CYB
MIMi516020 gene
neXtProtiNX_P00156

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalBy similarityAdd BLAST21
Transmembranei77 – 98HelicalBy similarityAdd BLAST22
Transmembranei113 – 133HelicalBy similarityAdd BLAST21
Transmembranei178 – 198HelicalBy similarityAdd BLAST21
Transmembranei226 – 246HelicalBy similarityAdd BLAST21
Transmembranei288 – 308HelicalBy similarityAdd BLAST21
Transmembranei320 – 340HelicalBy similarityAdd BLAST21
Transmembranei347 – 367HelicalBy similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder).2 Publications
Cardiomyopathy, infantile histiocytoid (CMIH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome.
See also OMIM:500000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013656251G → D in CMIH. 1 PublicationCorresponds to variant dbSNP:rs207460003Ensembl.1
Leber hereditary optic neuropathy (LHON)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionA maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
See also OMIM:535000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002197171D → N in LHON; secondary mutation; does not seem to directly cause the disease. 1 PublicationCorresponds to variant dbSNP:rs41518645Ensembl.1
Natural variantiVAR_002199356V → M in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs200336777Ensembl.1

Keywords - Diseasei

Cardiomyopathy, Cataract, Deafness, Disease mutation, Leber hereditary optic neuropathy, Primary mitochondrial disease

Organism-specific databases

DisGeNETi4519
GeneReviewsiMT-CYB
MalaCardsiMT-CYB
MIMi500000 phenotype
535000 phenotype
OpenTargetsiENSG00000198727
Orphaneti137675 Histiocytoid cardiomyopathy
1460 Isolated complex III deficiency
104 Leber hereditary optic neuropathy
PharmGKBiPA31234

Chemistry databases

DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

DMDMi408360043

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000610451 – 380Cytochrome bAdd BLAST380

Proteomic databases

EPDiP00156
PaxDbiP00156
PeptideAtlasiP00156
PRIDEiP00156
ProteomicsDBi51225
TopDownProteomicsiP00156

PTM databases

iPTMnetiP00156
PhosphoSitePlusiP00156

Expressioni

Gene expression databases

BgeeiENSG00000198727 Expressed in 86 organ(s), highest expression level in putamen
ExpressionAtlasiP00156 baseline and differential

Organism-specific databases

HPAiCAB032215
HPA068400

Interactioni

Subunit structurei

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.By similarity

Protein-protein interaction databases

BioGridi110619, 12 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiP00156, 3 interactors
MINTiP00156
STRINGi9606.ENSP00000354554

Chemistry databases

BindingDBiP00156

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00156
SMRiP00156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4663 Eukaryota
COG1290 LUCA
GeneTreeiENSGT00390000017948
HOVERGENiHBG017694
InParanoidiP00156
KOiK00412
OMAiHETGSNN
OrthoDBiEOG091G0DW4
PhylomeDBiP00156
TreeFamiTF353088

Family and domain databases

CDDicd00290 cytochrome_b_C, 1 hit
cd00284 Cytochrome_b_N, 1 hit
Gene3Di1.20.810.10, 1 hit
InterProiView protein in InterPro
IPR005798 Cyt_b/b6_C
IPR036150 Cyt_b/b6_C_sf
IPR005797 Cyt_b/b6_N
IPR027387 Cytb/b6-like_sf
IPR030689 Cytochrome_b
IPR016174 Di-haem_cyt_TM
PfamiView protein in Pfam
PF00032 Cytochrom_B_C, 1 hit
PF00033 Cytochrome_B, 1 hit
PIRSFiPIRSF038885 COB, 1 hit
SUPFAMiSSF81342 SSF81342, 1 hit
SSF81648 SSF81648, 1 hit
PROSITEiView protein in PROSITE
PS51003 CYTB_CTER, 1 hit
PS51002 CYTB_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P00156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF
60 70 80 90 100
LAMHYSPDAS TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR
110 120 130 140 150
GLYYGSFLYS ETWNIGIILL LATMATAFMG YVLPWGQMSF WGATVITNLL
160 170 180 190 200
SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT FHFILPFIIA ALATLHLLFL
210 220 230 240 250
HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM TLTLFSPDLL
260 270 280 290 300
GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI
310 320 330 340 350
LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII
360 370 380
GQVASVLYFT TILILMPTIS LIENKMLKWA
Length:380
Mass (Da):42,718
Last modified:October 3, 2012 - v2
Checksum:i600E520C262E5498
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0085857T → ICombined sources7 PublicationsCorresponds to variant dbSNP:rs193302980Ensembl.1
Natural variantiVAR_0136438N → S3 PublicationsCorresponds to variant dbSNP:rs28357679Ensembl.1
Natural variantiVAR_01364418F → L3 PublicationsCorresponds to variant dbSNP:rs28357681Ensembl.1
Natural variantiVAR_01364534G → S in mitochondrial myopathy; sporadic. 1 PublicationCorresponds to variant dbSNP:rs207459998Ensembl.1
Natural variantiVAR_03305835S → P in exercice intolerance; with cardiomyopathy and septo-optic dysplasia. 1 PublicationCorresponds to variant dbSNP:rs207460004Ensembl.1
Natural variantiVAR_01557139A → T1 PublicationCorresponds to variant dbSNP:rs2853505Ensembl.1
Natural variantiVAR_01364639A → V1 Publication1
Natural variantiVAR_01364778I → T1 PublicationCorresponds to variant dbSNP:rs200786872Ensembl.1
Natural variantiVAR_01557278I → V1 PublicationCorresponds to variant dbSNP:rs199997767Ensembl.1
Natural variantiVAR_00838880R → H in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs207459995Ensembl.1
Natural variantiVAR_00858687A → P1 Publication1
Natural variantiVAR_013648122A → T2 PublicationsCorresponds to variant dbSNP:rs28357685Ensembl.1
Natural variantiVAR_013649123T → A1 Publication1
Natural variantiVAR_013650151S → P in exercise intolerance. 1 PublicationCorresponds to variant dbSNP:rs207460001Ensembl.1
Natural variantiVAR_013651153I → T1 PublicationCorresponds to variant dbSNP:rs28357687Ensembl.1
Natural variantiVAR_013652164I → V1 PublicationCorresponds to variant dbSNP:rs201250154Ensembl.1
Natural variantiVAR_013653166G → E in hyperthrophic cardiomyopathy. 1 Publication1
Natural variantiVAR_002197171D → N in LHON; secondary mutation; does not seem to directly cause the disease. 1 PublicationCorresponds to variant dbSNP:rs41518645Ensembl.1
Natural variantiVAR_013654189 – 190IA → VT. 2
Natural variantiVAR_011339191A → T2 PublicationsCorresponds to variant dbSNP:rs2853507Ensembl.1
Natural variantiVAR_011340194T → A5 PublicationsCorresponds to variant dbSNP:rs2853508Ensembl.1
Natural variantiVAR_011341229A → T3 PublicationsCorresponds to variant dbSNP:rs193302993Ensembl.1
Natural variantiVAR_013655236L → I3 PublicationsCorresponds to variant dbSNP:rs193302994Ensembl.1
Natural variantiVAR_013657251 – 258Missing in mitochondrial myopathy; sporadic. 1 Publication8
Natural variantiVAR_013656251G → D in CMIH. 1 PublicationCorresponds to variant dbSNP:rs207460003Ensembl.1
Natural variantiVAR_033059251G → S Associated with susceptibility to obesity. 1 PublicationCorresponds to variant dbSNP:rs199951903Ensembl.1
Natural variantiVAR_013658255N → H in cardiomyopathy; fatal; post-partum. 1 Publication1
Natural variantiVAR_015573260N → D1 Publication1
Natural variantiVAR_008389276F → L in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs207459996Ensembl.1
Natural variantiVAR_013659278Y → C in multisystem disorder. 1 PublicationCorresponds to variant dbSNP:rs207460002Ensembl.1
Natural variantiVAR_013660290G → D in exercise intolerance. 1 PublicationCorresponds to variant dbSNP:rs207459997Ensembl.1
Natural variantiVAR_013661306I → T1 PublicationCorresponds to variant dbSNP:rs369851331Ensembl.1
Natural variantiVAR_013662316M → T1 PublicationCorresponds to variant dbSNP:rs200975632Ensembl.1
Natural variantiVAR_013663329A → T1 Publication1
Natural variantiVAR_013664330A → T1 PublicationCorresponds to variant dbSNP:rs386829259Ensembl.1
Natural variantiVAR_013665334I → V1 PublicationCorresponds to variant dbSNP:rs386829260Ensembl.1
Natural variantiVAR_002198339G → E in mitochondrial myopathy. 1 Publication1
Natural variantiVAR_013666353V → M1 Publication1
Natural variantiVAR_002199356V → M in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs200336777Ensembl.1
Natural variantiVAR_013667360T → A1 PublicationCorresponds to variant dbSNP:rs28357376Ensembl.1
Natural variantiVAR_013668368T → I2 PublicationsCorresponds to variant dbSNP:rs202225494Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00662 Genomic DNA Translation: CAA24038.1
J01415 Genomic DNA Translation: AAB58955.3
U09500 Genomic DNA Translation: AAA19775.1
D38112 Genomic DNA Translation: BAA77674.1
AF346963 Genomic DNA Translation: AAK17219.1
AF346964 Genomic DNA Translation: AAK17232.2
AF346965 Genomic DNA Translation: AAK17245.2
AF346966 Genomic DNA Translation: AAK17258.1
AF346967 Genomic DNA Translation: AAK17271.2
AF346968 Genomic DNA Translation: AAK17284.2
AF346969 Genomic DNA Translation: AAK17297.2
AF346970 Genomic DNA Translation: AAK17310.2
AF346971 Genomic DNA Translation: AAK17323.2
AF346972 Genomic DNA Translation: AAK17336.2
AF346973 Genomic DNA Translation: AAK17349.2
AF346974 Genomic DNA Translation: AAK17362.2
AF346975 Genomic DNA Translation: AAK17375.2
AF346976 Genomic DNA Translation: AAK17388.1
AF346977 Genomic DNA Translation: AAK17401.1
AF346978 Genomic DNA Translation: AAK17414.1
AF346979 Genomic DNA Translation: AAK17427.1
AF346980 Genomic DNA Translation: AAK17440.2
AF346981 Genomic DNA Translation: AAK17453.2
AF346982 Genomic DNA Translation: AAK17466.1
AF346983 Genomic DNA Translation: AAK17479.1
AF346984 Genomic DNA Translation: AAK17492.2
AF346985 Genomic DNA Translation: AAK17505.2
AF346986 Genomic DNA Translation: AAK17518.2
AF346987 Genomic DNA Translation: AAK17531.2
AF346988 Genomic DNA Translation: AAK17544.1
AF346989 Genomic DNA Translation: AAK17557.2
AF346990 Genomic DNA Translation: AAK17570.1
AF346991 Genomic DNA Translation: AAK17583.2
AF346992 Genomic DNA Translation: AAK17596.2
AF346993 Genomic DNA Translation: AAK17609.2
AF346994 Genomic DNA Translation: AAK17622.2
AF346995 Genomic DNA Translation: AAK17635.2
AF346996 Genomic DNA Translation: AAK17648.2
AF346997 Genomic DNA Translation: AAK17661.2
AF346998 Genomic DNA Translation: AAK17674.2
AF346999 Genomic DNA Translation: AAK17687.2
AF347000 Genomic DNA Translation: AAK17700.1
AF347001 Genomic DNA Translation: AAK17713.2
AF347002 Genomic DNA Translation: AAK17726.2
AF347003 Genomic DNA Translation: AAK17739.2
AF347004 Genomic DNA Translation: AAK17752.2
AF347005 Genomic DNA Translation: AAK17765.2
AF347006 Genomic DNA Translation: AAK17778.2
AF347007 Genomic DNA Translation: AAK17791.2
AF347008 Genomic DNA Translation: AAK17804.2
AF347009 Genomic DNA Translation: AAK17817.2
AF347010 Genomic DNA Translation: AAK17830.2
AF347011 Genomic DNA Translation: AAK17843.2
AF347012 Genomic DNA Translation: AAK17856.2
AF347013 Genomic DNA Translation: AAK17869.2
AF347014 Genomic DNA Translation: AAK17882.2
AF347015 Genomic DNA Translation: AAK17895.2
AF381981 Genomic DNA Translation: AAL54394.1
AF381982 Genomic DNA Translation: AAL54409.1
AF381983 Genomic DNA Translation: AAL54422.1
AF381984 Genomic DNA Translation: AAL54435.1
AF381985 Genomic DNA Translation: AAL54448.1
AF381986 Genomic DNA Translation: AAL54461.1
AF381987 Genomic DNA Translation: AAL54474.1
AF381988 Genomic DNA Translation: AAL54487.1
AF381989 Genomic DNA Translation: AAL54500.1
AF381990 Genomic DNA Translation: AAL54513.1
AF381991 Genomic DNA Translation: AAL54526.1
AF381992 Genomic DNA Translation: AAL54539.1
AF381993 Genomic DNA Translation: AAL54552.1
AF381994 Genomic DNA Translation: AAL54565.1
AF381995 Genomic DNA Translation: AAL54578.1
AF381996 Genomic DNA Translation: AAL54591.1
AF381997 Genomic DNA Translation: AAL54604.1
AF381998 Genomic DNA Translation: AAL54617.1
AF381999 Genomic DNA Translation: AAL54630.1
AF382000 Genomic DNA Translation: AAL54643.1
AF382001 Genomic DNA Translation: AAL54656.1
AF382002 Genomic DNA Translation: AAL54669.1
AF382003 Genomic DNA Translation: AAL54682.1
AF382004 Genomic DNA Translation: AAL54695.1
AF382005 Genomic DNA Translation: AAL54708.1
AF382006 Genomic DNA Translation: AAL54721.1
AF382007 Genomic DNA Translation: AAL54734.1
AF382008 Genomic DNA Translation: AAL54747.1
AF382009 Genomic DNA Translation: AAL54760.1
AF382010 Genomic DNA Translation: AAL54773.1
AF382011 Genomic DNA Translation: AAL54786.1
AF382012 Genomic DNA Translation: AAL54799.1
AF382013 Genomic DNA Translation: AAL54812.1
AF465942 Genomic DNA Translation: AAN14559.1
AF465945 Genomic DNA Translation: AAN14592.1
AF465946 Genomic DNA Translation: AAN14603.1
AF465947 Genomic DNA Translation: AAN14614.1
AF465948 Genomic DNA Translation: AAN14625.1
AF465949 Genomic DNA Translation: AAN14636.1
AF465953 Genomic DNA Translation: AAN14680.1
AF465956 Genomic DNA Translation: AAN14713.1
AF465968 Genomic DNA Translation: AAN14845.1
AF465971 Genomic DNA Translation: AAN14878.1
AF465972 Genomic DNA Translation: AAN14889.1
AF465973 Genomic DNA Translation: AAN14900.1
AF465974 Genomic DNA Translation: AAN14911.1
AF465975 Genomic DNA Translation: AAN14922.1
AF465977 Genomic DNA Translation: AAN14944.1
M28016 mRNA Translation: AAA31851.1
PIRiA00151 CBHU
RefSeqiYP_003024038.1, NC_012920.1

Genome annotation databases

EnsembliENST00000361789; ENSP00000354554; ENSG00000198727
GeneIDi4519
KEGGihsa:4519

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00662 Genomic DNA Translation: CAA24038.1
J01415 Genomic DNA Translation: AAB58955.3
U09500 Genomic DNA Translation: AAA19775.1
D38112 Genomic DNA Translation: BAA77674.1
AF346963 Genomic DNA Translation: AAK17219.1
AF346964 Genomic DNA Translation: AAK17232.2
AF346965 Genomic DNA Translation: AAK17245.2
AF346966 Genomic DNA Translation: AAK17258.1
AF346967 Genomic DNA Translation: AAK17271.2
AF346968 Genomic DNA Translation: AAK17284.2
AF346969 Genomic DNA Translation: AAK17297.2
AF346970 Genomic DNA Translation: AAK17310.2
AF346971 Genomic DNA Translation: AAK17323.2
AF346972 Genomic DNA Translation: AAK17336.2
AF346973 Genomic DNA Translation: AAK17349.2
AF346974 Genomic DNA Translation: AAK17362.2
AF346975 Genomic DNA Translation: AAK17375.2
AF346976 Genomic DNA Translation: AAK17388.1
AF346977 Genomic DNA Translation: AAK17401.1
AF346978 Genomic DNA Translation: AAK17414.1
AF346979 Genomic DNA Translation: AAK17427.1
AF346980 Genomic DNA Translation: AAK17440.2
AF346981 Genomic DNA Translation: AAK17453.2
AF346982 Genomic DNA Translation: AAK17466.1
AF346983 Genomic DNA Translation: AAK17479.1
AF346984 Genomic DNA Translation: AAK17492.2
AF346985 Genomic DNA Translation: AAK17505.2
AF346986 Genomic DNA Translation: AAK17518.2
AF346987 Genomic DNA Translation: AAK17531.2
AF346988 Genomic DNA Translation: AAK17544.1
AF346989 Genomic DNA Translation: AAK17557.2
AF346990 Genomic DNA Translation: AAK17570.1
AF346991 Genomic DNA Translation: AAK17583.2
AF346992 Genomic DNA Translation: AAK17596.2
AF346993 Genomic DNA Translation: AAK17609.2
AF346994 Genomic DNA Translation: AAK17622.2
AF346995 Genomic DNA Translation: AAK17635.2
AF346996 Genomic DNA Translation: AAK17648.2
AF346997 Genomic DNA Translation: AAK17661.2
AF346998 Genomic DNA Translation: AAK17674.2
AF346999 Genomic DNA Translation: AAK17687.2
AF347000 Genomic DNA Translation: AAK17700.1
AF347001 Genomic DNA Translation: AAK17713.2
AF347002 Genomic DNA Translation: AAK17726.2
AF347003 Genomic DNA Translation: AAK17739.2
AF347004 Genomic DNA Translation: AAK17752.2
AF347005 Genomic DNA Translation: AAK17765.2
AF347006 Genomic DNA Translation: AAK17778.2
AF347007 Genomic DNA Translation: AAK17791.2
AF347008 Genomic DNA Translation: AAK17804.2
AF347009 Genomic DNA Translation: AAK17817.2
AF347010 Genomic DNA Translation: AAK17830.2
AF347011 Genomic DNA Translation: AAK17843.2
AF347012 Genomic DNA Translation: AAK17856.2
AF347013 Genomic DNA Translation: AAK17869.2
AF347014 Genomic DNA Translation: AAK17882.2
AF347015 Genomic DNA Translation: AAK17895.2
AF381981 Genomic DNA Translation: AAL54394.1
AF381982 Genomic DNA Translation: AAL54409.1
AF381983 Genomic DNA Translation: AAL54422.1
AF381984 Genomic DNA Translation: AAL54435.1
AF381985 Genomic DNA Translation: AAL54448.1
AF381986 Genomic DNA Translation: AAL54461.1
AF381987 Genomic DNA Translation: AAL54474.1
AF381988 Genomic DNA Translation: AAL54487.1
AF381989 Genomic DNA Translation: AAL54500.1
AF381990 Genomic DNA Translation: AAL54513.1
AF381991 Genomic DNA Translation: AAL54526.1
AF381992 Genomic DNA Translation: AAL54539.1
AF381993 Genomic DNA Translation: AAL54552.1
AF381994 Genomic DNA Translation: AAL54565.1
AF381995 Genomic DNA Translation: AAL54578.1
AF381996 Genomic DNA Translation: AAL54591.1
AF381997 Genomic DNA Translation: AAL54604.1
AF381998 Genomic DNA Translation: AAL54617.1
AF381999 Genomic DNA Translation: AAL54630.1
AF382000 Genomic DNA Translation: AAL54643.1
AF382001 Genomic DNA Translation: AAL54656.1
AF382002 Genomic DNA Translation: AAL54669.1
AF382003 Genomic DNA Translation: AAL54682.1
AF382004 Genomic DNA Translation: AAL54695.1
AF382005 Genomic DNA Translation: AAL54708.1
AF382006 Genomic DNA Translation: AAL54721.1
AF382007 Genomic DNA Translation: AAL54734.1
AF382008 Genomic DNA Translation: AAL54747.1
AF382009 Genomic DNA Translation: AAL54760.1
AF382010 Genomic DNA Translation: AAL54773.1
AF382011 Genomic DNA Translation: AAL54786.1
AF382012 Genomic DNA Translation: AAL54799.1
AF382013 Genomic DNA Translation: AAL54812.1
AF465942 Genomic DNA Translation: AAN14559.1
AF465945 Genomic DNA Translation: AAN14592.1
AF465946 Genomic DNA Translation: AAN14603.1
AF465947 Genomic DNA Translation: AAN14614.1
AF465948 Genomic DNA Translation: AAN14625.1
AF465949 Genomic DNA Translation: AAN14636.1
AF465953 Genomic DNA Translation: AAN14680.1
AF465956 Genomic DNA Translation: AAN14713.1
AF465968 Genomic DNA Translation: AAN14845.1
AF465971 Genomic DNA Translation: AAN14878.1
AF465972 Genomic DNA Translation: AAN14889.1
AF465973 Genomic DNA Translation: AAN14900.1
AF465974 Genomic DNA Translation: AAN14911.1
AF465975 Genomic DNA Translation: AAN14922.1
AF465977 Genomic DNA Translation: AAN14944.1
M28016 mRNA Translation: AAA31851.1
PIRiA00151 CBHU
RefSeqiYP_003024038.1, NC_012920.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTEelectron microscopy3.40J/V2-379[»]
5XTHelectron microscopy3.90AJ/AV2-379[»]
5XTIelectron microscopy17.40AJ/AV2-379[»]
ProteinModelPortaliP00156
SMRiP00156
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110619, 12 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiP00156, 3 interactors
MINTiP00156
STRINGi9606.ENSP00000354554

Chemistry databases

BindingDBiP00156
DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

PTM databases

iPTMnetiP00156
PhosphoSitePlusiP00156

Polymorphism and mutation databases

DMDMi408360043

Proteomic databases

EPDiP00156
PaxDbiP00156
PeptideAtlasiP00156
PRIDEiP00156
ProteomicsDBi51225
TopDownProteomicsiP00156

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361789; ENSP00000354554; ENSG00000198727
GeneIDi4519
KEGGihsa:4519

Organism-specific databases

CTDi4519
DisGeNETi4519
EuPathDBiHostDB:ENSG00000198727.2
GeneCardsiMT-CYB
GeneReviewsiMT-CYB
HGNCiHGNC:7427 MT-CYB
HPAiCAB032215
HPA068400
MalaCardsiMT-CYB
MIMi500000 phenotype
516020 gene
535000 phenotype
neXtProtiNX_P00156
OpenTargetsiENSG00000198727
Orphaneti137675 Histiocytoid cardiomyopathy
1460 Isolated complex III deficiency
104 Leber hereditary optic neuropathy
PharmGKBiPA31234
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4663 Eukaryota
COG1290 LUCA
GeneTreeiENSGT00390000017948
HOVERGENiHBG017694
InParanoidiP00156
KOiK00412
OMAiHETGSNN
OrthoDBiEOG091G0DW4
PhylomeDBiP00156
TreeFamiTF353088

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSiCYTB human
GeneWikiiMT-CYB
GenomeRNAii4519
PROiPR:P00156
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198727 Expressed in 86 organ(s), highest expression level in putamen
ExpressionAtlasiP00156 baseline and differential

Family and domain databases

CDDicd00290 cytochrome_b_C, 1 hit
cd00284 Cytochrome_b_N, 1 hit
Gene3Di1.20.810.10, 1 hit
InterProiView protein in InterPro
IPR005798 Cyt_b/b6_C
IPR036150 Cyt_b/b6_C_sf
IPR005797 Cyt_b/b6_N
IPR027387 Cytb/b6-like_sf
IPR030689 Cytochrome_b
IPR016174 Di-haem_cyt_TM
PfamiView protein in Pfam
PF00032 Cytochrom_B_C, 1 hit
PF00033 Cytochrome_B, 1 hit
PIRSFiPIRSF038885 COB, 1 hit
SUPFAMiSSF81342 SSF81342, 1 hit
SSF81648 SSF81648, 1 hit
PROSITEiView protein in PROSITE
PS51003 CYTB_CTER, 1 hit
PS51002 CYTB_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYB_HUMAN
AccessioniPrimary (citable) accession number: P00156
Secondary accession number(s): Q34786
, Q8HBR6, Q8HNQ0, Q8HNQ1, Q8HNQ9, Q8HNR4, Q8HNR7, Q8W7V8, Q8WCV9, Q8WCY2, Q8WCY7, Q8WCY8, Q9B1A6, Q9B1B6, Q9B1B8, Q9B1D4, Q9B1X6, Q9B2V0, Q9B2V8, Q9B2W0, Q9B2W3, Q9B2W8, Q9B2X1, Q9B2X7, Q9B2X9, Q9B2Y3, Q9B2Z0, Q9B2Z4, Q9T6H6, Q9T9Y0, Q9TEH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 203 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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