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Protein

Cytochrome b

Gene

MT-CYB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.By similarity

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Caution

The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi83Iron 1 (heme b562 axial ligand)By similarity1
Metal bindingi97Iron 2 (heme b566 axial ligand)By similarity1
Metal bindingi182Iron 1 (heme b562 axial ligand)By similarity1
Metal bindingi196Iron 2 (heme b566 axial ligand)By similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei201UbiquinoneBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding, Ubiquinone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-611105 Respiratory electron transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrion
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Mitochondrion

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198727.2

Human Gene Nomenclature Database

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HGNCi
HGNC:7427 MT-CYB

Online Mendelian Inheritance in Man (OMIM)

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MIMi
516020 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P00156

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalBy similarityAdd BLAST21
Transmembranei77 – 98HelicalBy similarityAdd BLAST22
Transmembranei113 – 133HelicalBy similarityAdd BLAST21
Transmembranei178 – 198HelicalBy similarityAdd BLAST21
Transmembranei226 – 246HelicalBy similarityAdd BLAST21
Transmembranei288 – 308HelicalBy similarityAdd BLAST21
Transmembranei320 – 340HelicalBy similarityAdd BLAST21
Transmembranei347 – 367HelicalBy similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder).2 Publications
Cardiomyopathy, infantile histiocytoid (CMIH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome.
See also OMIM:500000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013656251G → D in CMIH. 1 PublicationCorresponds to variant dbSNP:rs207460003Ensembl.1
Leber hereditary optic neuropathy (LHON)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionA maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
See also OMIM:535000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002197171D → N in LHON; secondary mutation; does not seem to directly cause the disease. 1 PublicationCorresponds to variant dbSNP:rs41518645Ensembl.1
Natural variantiVAR_002199356V → M in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs200336777Ensembl.1

Keywords - Diseasei

Cardiomyopathy, Cataract, Deafness, Disease mutation, Leber hereditary optic neuropathy, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
4519

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
MT-CYB

MalaCards human disease database

More...
MalaCardsi
MT-CYB
MIMi500000 phenotype
535000 phenotype

Open Targets

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OpenTargetsi
ENSG00000198727

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
137675 Histiocytoid cardiomyopathy
1460 Isolated complex III deficiency
104 Leber hereditary optic neuropathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31234

Chemistry databases

Drug and drug target database

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DrugBanki
DB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MT-CYB

Domain mapping of disease mutations (DMDM)

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DMDMi
408360043

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000610451 – 380Cytochrome bAdd BLAST380

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P00156

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P00156

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P00156

PeptideAtlas

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PeptideAtlasi
P00156

PRoteomics IDEntifications database

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PRIDEi
P00156

ProteomicsDB human proteome resource

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ProteomicsDBi
51225

Consortium for Top Down Proteomics

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TopDownProteomicsi
P00156

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P00156

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P00156

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198727 Expressed in 86 organ(s), highest expression level in putamen

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P00156 baseline and differential

Organism-specific databases

Human Protein Atlas

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HPAi
CAB032215
HPA068400

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110619, 12 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-560 Mitochondrial respiratory chain complex III

Protein interaction database and analysis system

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IntActi
P00156, 3 interactors

Molecular INTeraction database

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MINTi
P00156

STRING: functional protein association networks

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STRINGi
9606.ENSP00000354554

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P00156

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTEelectron microscopy3.40J/V2-379[»]
5XTHelectron microscopy3.90AJ/AV2-379[»]
5XTIelectron microscopy17.40AJ/AV2-379[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P00156

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P00156

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4663 Eukaryota
COG1290 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017948

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG017694

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P00156

KEGG Orthology (KO)

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KOi
K00412

Identification of Orthologs from Complete Genome Data

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OMAi
HETGSNN

Database of Orthologous Groups

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OrthoDBi
1335521at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P00156

TreeFam database of animal gene trees

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TreeFami
TF353088

Family and domain databases

Conserved Domains Database

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CDDi
cd00290 cytochrome_b_C, 1 hit
cd00284 Cytochrome_b_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.810.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005798 Cyt_b/b6_C
IPR036150 Cyt_b/b6_C_sf
IPR005797 Cyt_b/b6_N
IPR027387 Cytb/b6-like_sf
IPR030689 Cytochrome_b
IPR016174 Di-haem_cyt_TM

Pfam protein domain database

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Pfami
View protein in Pfam
PF00032 Cytochrom_B_C, 1 hit
PF00033 Cytochrome_B, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF038885 COB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81342 SSF81342, 1 hit
SSF81648 SSF81648, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51003 CYTB_CTER, 1 hit
PS51002 CYTB_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P00156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF
60 70 80 90 100
LAMHYSPDAS TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR
110 120 130 140 150
GLYYGSFLYS ETWNIGIILL LATMATAFMG YVLPWGQMSF WGATVITNLL
160 170 180 190 200
SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT FHFILPFIIA ALATLHLLFL
210 220 230 240 250
HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM TLTLFSPDLL
260 270 280 290 300
GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI
310 320 330 340 350
LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII
360 370 380
GQVASVLYFT TILILMPTIS LIENKMLKWA
Length:380
Mass (Da):42,718
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i600E520C262E5498
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0085857T → ICombined sources7 PublicationsCorresponds to variant dbSNP:rs193302980Ensembl.1
Natural variantiVAR_0136438N → S3 PublicationsCorresponds to variant dbSNP:rs28357679Ensembl.1
Natural variantiVAR_01364418F → L3 PublicationsCorresponds to variant dbSNP:rs28357681Ensembl.1
Natural variantiVAR_01364534G → S in mitochondrial myopathy; sporadic. 1 PublicationCorresponds to variant dbSNP:rs207459998Ensembl.1
Natural variantiVAR_03305835S → P in exercice intolerance; with cardiomyopathy and septo-optic dysplasia. 1 PublicationCorresponds to variant dbSNP:rs207460004Ensembl.1
Natural variantiVAR_01557139A → T1 PublicationCorresponds to variant dbSNP:rs2853505Ensembl.1
Natural variantiVAR_01364639A → V1 Publication1
Natural variantiVAR_01364778I → T1 PublicationCorresponds to variant dbSNP:rs200786872Ensembl.1
Natural variantiVAR_01557278I → V1 PublicationCorresponds to variant dbSNP:rs199997767Ensembl.1
Natural variantiVAR_00838880R → H in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs207459995Ensembl.1
Natural variantiVAR_00858687A → P1 Publication1
Natural variantiVAR_013648122A → T2 PublicationsCorresponds to variant dbSNP:rs28357685Ensembl.1
Natural variantiVAR_013649123T → A1 Publication1
Natural variantiVAR_013650151S → P in exercise intolerance. 1 PublicationCorresponds to variant dbSNP:rs207460001Ensembl.1
Natural variantiVAR_013651153I → T1 PublicationCorresponds to variant dbSNP:rs28357687Ensembl.1
Natural variantiVAR_013652164I → V1 PublicationCorresponds to variant dbSNP:rs201250154Ensembl.1
Natural variantiVAR_013653166G → E in hyperthrophic cardiomyopathy. 1 Publication1
Natural variantiVAR_002197171D → N in LHON; secondary mutation; does not seem to directly cause the disease. 1 PublicationCorresponds to variant dbSNP:rs41518645Ensembl.1
Natural variantiVAR_013654189 – 190IA → VT. 2
Natural variantiVAR_011339191A → T2 PublicationsCorresponds to variant dbSNP:rs2853507Ensembl.1
Natural variantiVAR_011340194T → A5 PublicationsCorresponds to variant dbSNP:rs2853508Ensembl.1
Natural variantiVAR_011341229A → T3 PublicationsCorresponds to variant dbSNP:rs193302993Ensembl.1
Natural variantiVAR_013655236L → I3 PublicationsCorresponds to variant dbSNP:rs193302994Ensembl.1
Natural variantiVAR_013657251 – 258Missing in mitochondrial myopathy; sporadic. 1 Publication8
Natural variantiVAR_013656251G → D in CMIH. 1 PublicationCorresponds to variant dbSNP:rs207460003Ensembl.1
Natural variantiVAR_033059251G → S Associated with susceptibility to obesity. 1 PublicationCorresponds to variant dbSNP:rs199951903Ensembl.1
Natural variantiVAR_013658255N → H in cardiomyopathy; fatal; post-partum. 1 Publication1
Natural variantiVAR_015573260N → D1 Publication1
Natural variantiVAR_008389276F → L in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs207459996Ensembl.1
Natural variantiVAR_013659278Y → C in multisystem disorder. 1 PublicationCorresponds to variant dbSNP:rs207460002Ensembl.1
Natural variantiVAR_013660290G → D in exercise intolerance. 1 PublicationCorresponds to variant dbSNP:rs207459997Ensembl.1
Natural variantiVAR_013661306I → T1 PublicationCorresponds to variant dbSNP:rs369851331Ensembl.1
Natural variantiVAR_013662316M → T1 PublicationCorresponds to variant dbSNP:rs200975632Ensembl.1
Natural variantiVAR_013663329A → T1 Publication1
Natural variantiVAR_013664330A → T1 PublicationCorresponds to variant dbSNP:rs386829259Ensembl.1
Natural variantiVAR_013665334I → V1 PublicationCorresponds to variant dbSNP:rs386829260Ensembl.1
Natural variantiVAR_002198339G → E in mitochondrial myopathy. 1 Publication1
Natural variantiVAR_013666353V → M1 Publication1
Natural variantiVAR_002199356V → M in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs200336777Ensembl.1
Natural variantiVAR_013667360T → A1 PublicationCorresponds to variant dbSNP:rs28357376Ensembl.1
Natural variantiVAR_013668368T → I2 PublicationsCorresponds to variant dbSNP:rs202225494Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
V00662 Genomic DNA Translation: CAA24038.1
J01415 Genomic DNA Translation: AAB58955.3
U09500 Genomic DNA Translation: AAA19775.1
D38112 Genomic DNA Translation: BAA77674.1
AF346963 Genomic DNA Translation: AAK17219.1
AF346964 Genomic DNA Translation: AAK17232.2
AF346965 Genomic DNA Translation: AAK17245.2
AF346966 Genomic DNA Translation: AAK17258.1
AF346967 Genomic DNA Translation: AAK17271.2
AF346968 Genomic DNA Translation: AAK17284.2
AF346969 Genomic DNA Translation: AAK17297.2
AF346970 Genomic DNA Translation: AAK17310.2
AF346971 Genomic DNA Translation: AAK17323.2
AF346972 Genomic DNA Translation: AAK17336.2
AF346973 Genomic DNA Translation: AAK17349.2
AF346974 Genomic DNA Translation: AAK17362.2
AF346975 Genomic DNA Translation: AAK17375.2
AF346976 Genomic DNA Translation: AAK17388.1
AF346977 Genomic DNA Translation: AAK17401.1
AF346978 Genomic DNA Translation: AAK17414.1
AF346979 Genomic DNA Translation: AAK17427.1
AF346980 Genomic DNA Translation: AAK17440.2
AF346981 Genomic DNA Translation: AAK17453.2
AF346982 Genomic DNA Translation: AAK17466.1
AF346983 Genomic DNA Translation: AAK17479.1
AF346984 Genomic DNA Translation: AAK17492.2
AF346985 Genomic DNA Translation: AAK17505.2
AF346986 Genomic DNA Translation: AAK17518.2
AF346987 Genomic DNA Translation: AAK17531.2
AF346988 Genomic DNA Translation: AAK17544.1
AF346989 Genomic DNA Translation: AAK17557.2
AF346990 Genomic DNA Translation: AAK17570.1
AF346991 Genomic DNA Translation: AAK17583.2
AF346992 Genomic DNA Translation: AAK17596.2
AF346993 Genomic DNA Translation: AAK17609.2
AF346994 Genomic DNA Translation: AAK17622.2
AF346995 Genomic DNA Translation: AAK17635.2
AF346996 Genomic DNA Translation: AAK17648.2
AF346997 Genomic DNA Translation: AAK17661.2
AF346998 Genomic DNA Translation: AAK17674.2
AF346999 Genomic DNA Translation: AAK17687.2
AF347000 Genomic DNA Translation: AAK17700.1
AF347001 Genomic DNA Translation: AAK17713.2
AF347002 Genomic DNA Translation: AAK17726.2
AF347003 Genomic DNA Translation: AAK17739.2
AF347004 Genomic DNA Translation: AAK17752.2
AF347005 Genomic DNA Translation: AAK17765.2
AF347006 Genomic DNA Translation: AAK17778.2
AF347007 Genomic DNA Translation: AAK17791.2
AF347008 Genomic DNA Translation: AAK17804.2
AF347009 Genomic DNA Translation: AAK17817.2
AF347010 Genomic DNA Translation: AAK17830.2
AF347011 Genomic DNA Translation: AAK17843.2
AF347012 Genomic DNA Translation: AAK17856.2
AF347013 Genomic DNA Translation: AAK17869.2
AF347014 Genomic DNA Translation: AAK17882.2
AF347015 Genomic DNA Translation: AAK17895.2
AF381981 Genomic DNA Translation: AAL54394.1
AF381982 Genomic DNA Translation: AAL54409.1
AF381983 Genomic DNA Translation: AAL54422.1
AF381984 Genomic DNA Translation: AAL54435.1
AF381985 Genomic DNA Translation: AAL54448.1
AF381986 Genomic DNA Translation: AAL54461.1
AF381987 Genomic DNA Translation: AAL54474.1
AF381988 Genomic DNA Translation: AAL54487.1
AF381989 Genomic DNA Translation: AAL54500.1
AF381990 Genomic DNA Translation: AAL54513.1
AF381991 Genomic DNA Translation: AAL54526.1
AF381992 Genomic DNA Translation: AAL54539.1
AF381993 Genomic DNA Translation: AAL54552.1
AF381994 Genomic DNA Translation: AAL54565.1
AF381995 Genomic DNA Translation: AAL54578.1
AF381996 Genomic DNA Translation: AAL54591.1
AF381997 Genomic DNA Translation: AAL54604.1
AF381998 Genomic DNA Translation: AAL54617.1
AF381999 Genomic DNA Translation: AAL54630.1
AF382000 Genomic DNA Translation: AAL54643.1
AF382001 Genomic DNA Translation: AAL54656.1
AF382002 Genomic DNA Translation: AAL54669.1
AF382003 Genomic DNA Translation: AAL54682.1
AF382004 Genomic DNA Translation: AAL54695.1
AF382005 Genomic DNA Translation: AAL54708.1
AF382006 Genomic DNA Translation: AAL54721.1
AF382007 Genomic DNA Translation: AAL54734.1
AF382008 Genomic DNA Translation: AAL54747.1
AF382009 Genomic DNA Translation: AAL54760.1
AF382010 Genomic DNA Translation: AAL54773.1
AF382011 Genomic DNA Translation: AAL54786.1
AF382012 Genomic DNA Translation: AAL54799.1
AF382013 Genomic DNA Translation: AAL54812.1
AF465942 Genomic DNA Translation: AAN14559.1
AF465945 Genomic DNA Translation: AAN14592.1
AF465946 Genomic DNA Translation: AAN14603.1
AF465947 Genomic DNA Translation: AAN14614.1
AF465948 Genomic DNA Translation: AAN14625.1
AF465949 Genomic DNA Translation: AAN14636.1
AF465953 Genomic DNA Translation: AAN14680.1
AF465956 Genomic DNA Translation: AAN14713.1
AF465968 Genomic DNA Translation: AAN14845.1
AF465971 Genomic DNA Translation: AAN14878.1
AF465972 Genomic DNA Translation: AAN14889.1
AF465973 Genomic DNA Translation: AAN14900.1
AF465974 Genomic DNA Translation: AAN14911.1
AF465975 Genomic DNA Translation: AAN14922.1
AF465977 Genomic DNA Translation: AAN14944.1
M28016 mRNA Translation: AAA31851.1

Protein sequence database of the Protein Information Resource

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PIRi
A00151 CBHU

NCBI Reference Sequences

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RefSeqi
YP_003024038.1, NC_012920.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000361789; ENSP00000354554; ENSG00000198727

Database of genes from NCBI RefSeq genomes

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GeneIDi
4519

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4519

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00662 Genomic DNA Translation: CAA24038.1
J01415 Genomic DNA Translation: AAB58955.3
U09500 Genomic DNA Translation: AAA19775.1
D38112 Genomic DNA Translation: BAA77674.1
AF346963 Genomic DNA Translation: AAK17219.1
AF346964 Genomic DNA Translation: AAK17232.2
AF346965 Genomic DNA Translation: AAK17245.2
AF346966 Genomic DNA Translation: AAK17258.1
AF346967 Genomic DNA Translation: AAK17271.2
AF346968 Genomic DNA Translation: AAK17284.2
AF346969 Genomic DNA Translation: AAK17297.2
AF346970 Genomic DNA Translation: AAK17310.2
AF346971 Genomic DNA Translation: AAK17323.2
AF346972 Genomic DNA Translation: AAK17336.2
AF346973 Genomic DNA Translation: AAK17349.2
AF346974 Genomic DNA Translation: AAK17362.2
AF346975 Genomic DNA Translation: AAK17375.2
AF346976 Genomic DNA Translation: AAK17388.1
AF346977 Genomic DNA Translation: AAK17401.1
AF346978 Genomic DNA Translation: AAK17414.1
AF346979 Genomic DNA Translation: AAK17427.1
AF346980 Genomic DNA Translation: AAK17440.2
AF346981 Genomic DNA Translation: AAK17453.2
AF346982 Genomic DNA Translation: AAK17466.1
AF346983 Genomic DNA Translation: AAK17479.1
AF346984 Genomic DNA Translation: AAK17492.2
AF346985 Genomic DNA Translation: AAK17505.2
AF346986 Genomic DNA Translation: AAK17518.2
AF346987 Genomic DNA Translation: AAK17531.2
AF346988 Genomic DNA Translation: AAK17544.1
AF346989 Genomic DNA Translation: AAK17557.2
AF346990 Genomic DNA Translation: AAK17570.1
AF346991 Genomic DNA Translation: AAK17583.2
AF346992 Genomic DNA Translation: AAK17596.2
AF346993 Genomic DNA Translation: AAK17609.2
AF346994 Genomic DNA Translation: AAK17622.2
AF346995 Genomic DNA Translation: AAK17635.2
AF346996 Genomic DNA Translation: AAK17648.2
AF346997 Genomic DNA Translation: AAK17661.2
AF346998 Genomic DNA Translation: AAK17674.2
AF346999 Genomic DNA Translation: AAK17687.2
AF347000 Genomic DNA Translation: AAK17700.1
AF347001 Genomic DNA Translation: AAK17713.2
AF347002 Genomic DNA Translation: AAK17726.2
AF347003 Genomic DNA Translation: AAK17739.2
AF347004 Genomic DNA Translation: AAK17752.2
AF347005 Genomic DNA Translation: AAK17765.2
AF347006 Genomic DNA Translation: AAK17778.2
AF347007 Genomic DNA Translation: AAK17791.2
AF347008 Genomic DNA Translation: AAK17804.2
AF347009 Genomic DNA Translation: AAK17817.2
AF347010 Genomic DNA Translation: AAK17830.2
AF347011 Genomic DNA Translation: AAK17843.2
AF347012 Genomic DNA Translation: AAK17856.2
AF347013 Genomic DNA Translation: AAK17869.2
AF347014 Genomic DNA Translation: AAK17882.2
AF347015 Genomic DNA Translation: AAK17895.2
AF381981 Genomic DNA Translation: AAL54394.1
AF381982 Genomic DNA Translation: AAL54409.1
AF381983 Genomic DNA Translation: AAL54422.1
AF381984 Genomic DNA Translation: AAL54435.1
AF381985 Genomic DNA Translation: AAL54448.1
AF381986 Genomic DNA Translation: AAL54461.1
AF381987 Genomic DNA Translation: AAL54474.1
AF381988 Genomic DNA Translation: AAL54487.1
AF381989 Genomic DNA Translation: AAL54500.1
AF381990 Genomic DNA Translation: AAL54513.1
AF381991 Genomic DNA Translation: AAL54526.1
AF381992 Genomic DNA Translation: AAL54539.1
AF381993 Genomic DNA Translation: AAL54552.1
AF381994 Genomic DNA Translation: AAL54565.1
AF381995 Genomic DNA Translation: AAL54578.1
AF381996 Genomic DNA Translation: AAL54591.1
AF381997 Genomic DNA Translation: AAL54604.1
AF381998 Genomic DNA Translation: AAL54617.1
AF381999 Genomic DNA Translation: AAL54630.1
AF382000 Genomic DNA Translation: AAL54643.1
AF382001 Genomic DNA Translation: AAL54656.1
AF382002 Genomic DNA Translation: AAL54669.1
AF382003 Genomic DNA Translation: AAL54682.1
AF382004 Genomic DNA Translation: AAL54695.1
AF382005 Genomic DNA Translation: AAL54708.1
AF382006 Genomic DNA Translation: AAL54721.1
AF382007 Genomic DNA Translation: AAL54734.1
AF382008 Genomic DNA Translation: AAL54747.1
AF382009 Genomic DNA Translation: AAL54760.1
AF382010 Genomic DNA Translation: AAL54773.1
AF382011 Genomic DNA Translation: AAL54786.1
AF382012 Genomic DNA Translation: AAL54799.1
AF382013 Genomic DNA Translation: AAL54812.1
AF465942 Genomic DNA Translation: AAN14559.1
AF465945 Genomic DNA Translation: AAN14592.1
AF465946 Genomic DNA Translation: AAN14603.1
AF465947 Genomic DNA Translation: AAN14614.1
AF465948 Genomic DNA Translation: AAN14625.1
AF465949 Genomic DNA Translation: AAN14636.1
AF465953 Genomic DNA Translation: AAN14680.1
AF465956 Genomic DNA Translation: AAN14713.1
AF465968 Genomic DNA Translation: AAN14845.1
AF465971 Genomic DNA Translation: AAN14878.1
AF465972 Genomic DNA Translation: AAN14889.1
AF465973 Genomic DNA Translation: AAN14900.1
AF465974 Genomic DNA Translation: AAN14911.1
AF465975 Genomic DNA Translation: AAN14922.1
AF465977 Genomic DNA Translation: AAN14944.1
M28016 mRNA Translation: AAA31851.1
PIRiA00151 CBHU
RefSeqiYP_003024038.1, NC_012920.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTEelectron microscopy3.40J/V2-379[»]
5XTHelectron microscopy3.90AJ/AV2-379[»]
5XTIelectron microscopy17.40AJ/AV2-379[»]
ProteinModelPortaliP00156
SMRiP00156
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110619, 12 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiP00156, 3 interactors
MINTiP00156
STRINGi9606.ENSP00000354554

Chemistry databases

BindingDBiP00156
DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

PTM databases

iPTMnetiP00156
PhosphoSitePlusiP00156

Polymorphism and mutation databases

BioMutaiMT-CYB
DMDMi408360043

Proteomic databases

EPDiP00156
jPOSTiP00156
PaxDbiP00156
PeptideAtlasiP00156
PRIDEiP00156
ProteomicsDBi51225
TopDownProteomicsiP00156

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361789; ENSP00000354554; ENSG00000198727
GeneIDi4519
KEGGihsa:4519

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4519
DisGeNETi4519
EuPathDBiHostDB:ENSG00000198727.2

GeneCards: human genes, protein and diseases

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GeneCardsi
MT-CYB
GeneReviewsiMT-CYB
HGNCiHGNC:7427 MT-CYB
HPAiCAB032215
HPA068400
MalaCardsiMT-CYB
MIMi500000 phenotype
516020 gene
535000 phenotype
neXtProtiNX_P00156
OpenTargetsiENSG00000198727
Orphaneti137675 Histiocytoid cardiomyopathy
1460 Isolated complex III deficiency
104 Leber hereditary optic neuropathy
PharmGKBiPA31234

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4663 Eukaryota
COG1290 LUCA
GeneTreeiENSGT00390000017948
HOVERGENiHBG017694
InParanoidiP00156
KOiK00412
OMAiHETGSNN
OrthoDBi1335521at2759
PhylomeDBiP00156
TreeFamiTF353088

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CYTB human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MT-CYB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4519

Protein Ontology

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PROi
PR:P00156

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198727 Expressed in 86 organ(s), highest expression level in putamen
ExpressionAtlasiP00156 baseline and differential

Family and domain databases

CDDicd00290 cytochrome_b_C, 1 hit
cd00284 Cytochrome_b_N, 1 hit
Gene3Di1.20.810.10, 1 hit
InterProiView protein in InterPro
IPR005798 Cyt_b/b6_C
IPR036150 Cyt_b/b6_C_sf
IPR005797 Cyt_b/b6_N
IPR027387 Cytb/b6-like_sf
IPR030689 Cytochrome_b
IPR016174 Di-haem_cyt_TM
PfamiView protein in Pfam
PF00032 Cytochrom_B_C, 1 hit
PF00033 Cytochrome_B, 1 hit
PIRSFiPIRSF038885 COB, 1 hit
SUPFAMiSSF81342 SSF81342, 1 hit
SSF81648 SSF81648, 1 hit
PROSITEiView protein in PROSITE
PS51003 CYTB_CTER, 1 hit
PS51002 CYTB_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00156
Secondary accession number(s): Q34786
, Q8HBR6, Q8HNQ0, Q8HNQ1, Q8HNQ9, Q8HNR4, Q8HNR7, Q8W7V8, Q8WCV9, Q8WCY2, Q8WCY7, Q8WCY8, Q9B1A6, Q9B1B6, Q9B1B8, Q9B1D4, Q9B1X6, Q9B2V0, Q9B2V8, Q9B2W0, Q9B2W3, Q9B2W8, Q9B2X1, Q9B2X7, Q9B2X9, Q9B2Y3, Q9B2Z0, Q9B2Z4, Q9T6H6, Q9T9Y0, Q9TEH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 3, 2012
Last modified: January 16, 2019
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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