UniProtKB - P00127 (QCR6_YEAST)
Cytochrome b-c1 complex subunit 6, mitochondrial
QCR6
Functioni
Miscellaneous
GO - Molecular functioni
- ubiquinol-cytochrome-c reductase activity Source: InterPro
GO - Biological processi
- aerobic respiration Source: SGD
- mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-611105, Respiratory electron transport |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 6, mitochondrialAlternative name(s): Complex III subunit 6 Complex III subunit VI Cytochrome c1 non-heme 17 kDa protein Mitochondrial hinge protein Ubiquinol-cytochrome c oxidoreductase subunit 6 Ubiquinol-cytochrome c reductase 17 kDa protein |
Gene namesi | Name:QCR6 Synonyms:UCR6 Ordered Locus Names:YFR033C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YFR033C |
SGDi | S000001929, QCR6 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 3 Publications; Peripheral membrane protein 2 Publications; Intermembrane side 2 Publications
Mitochondrion
- mitochondrial intermembrane space Source: SGD
- mitochondrial respiratory chain complex III Source: SGD
- mitochondrion Source: SGD
Nucleus
- nuclear periphery Source: SGD
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193542 | 1 – 147 | Cytochrome b-c1 complex subunit 6, mitochondrialAdd BLAST | 147 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 101 ↔ 123 | 6 Publications |
Keywords - PTMi
Disulfide bondProteomic databases
MaxQBi | P00127 |
PaxDbi | P00127 |
PRIDEi | P00127 |
PTM databases
CarbonylDBi | P00127 |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). QCR6 interacts with COX5A at the CIII-CIV interface (PubMed:30598554).
7 PublicationsProtein-protein interaction databases
BioGRIDi | 31190, 107 interactors |
ComplexPortali | CPX-567, Mitochondrial electron transport complex III |
DIPi | DIP-1621N |
IntActi | P00127, 5 interactors |
MINTi | P00127 |
STRINGi | 4932.YFR033C |
Miscellaneous databases
RNActi | P00127, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P00127 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00127 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 26 – 80 | Asp/Glu-rich (acidic)Add BLAST | 55 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4763, Eukaryota |
GeneTreei | ENSGT00390000003860 |
HOGENOMi | CLU_115913_0_1_1 |
InParanoidi | P00127 |
OMAi | CKNSPQC |
Family and domain databases
DisProti | DP00853 |
Gene3Di | 1.10.287.20, 1 hit |
InterProi | View protein in InterPro IPR003422, Cyt_b-c1_6 IPR023184, Ubol_cytC_Rdtase_hinge_dom IPR036811, Ubol_cytC_Rdtase_hinge_dom_sf |
PANTHERi | PTHR15336, PTHR15336, 1 hit |
Pfami | View protein in Pfam PF02320, UCR_hinge, 1 hit |
SUPFAMi | SSF81531, SSF81531, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MGMLELVGEY WEQLKITVVP VVAAAEDDDN EQHEEKAAEG EEKEEENGDE
60 70 80 90 100
DEDEDEDEDD DDDDDEDEEE EEEVTDQLED LREHFKNTEE GKALVHHYEE
110 120 130 140
CAERVKIQQQ QPGYADLEHK EDCVEEFFHL QHYLDTATAP RLFDKLK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | G → D in CAA25220 (PubMed:6329732).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00551 Genomic DNA Translation: CAA25220.1 D50617 Genomic DNA Translation: BAA09272.1 BK006940 Genomic DNA Translation: DAA12476.1 |
PIRi | S56288, RDBYUC |
RefSeqi | NP_116691.3, NM_001179998.3 |
Genome annotation databases
EnsemblFungii | YFR033C_mRNA; YFR033C; YFR033C |
GeneIDi | 850593 |
KEGGi | sce:YFR033C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00551 Genomic DNA Translation: CAA25220.1 D50617 Genomic DNA Translation: BAA09272.1 BK006940 Genomic DNA Translation: DAA12476.1 |
PIRi | S56288, RDBYUC |
RefSeqi | NP_116691.3, NM_001179998.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EZV | X-ray | 2.30 | H | 74-147 | [»] | |
1KB9 | X-ray | 2.30 | F | 74-147 | [»] | |
1KYO | X-ray | 2.97 | F/Q | 75-147 | [»] | |
1P84 | X-ray | 2.50 | F | 74-147 | [»] | |
2IBZ | X-ray | 2.30 | H | 74-147 | [»] | |
3CX5 | X-ray | 1.90 | F/Q | 2-147 | [»] | |
3CXH | X-ray | 2.50 | F/Q | 2-147 | [»] | |
4PD4 | X-ray | 3.04 | F | 74-147 | [»] | |
6GIQ | electron microscopy | 3.23 | F/Q | 1-147 | [»] | |
6HU9 | electron microscopy | 3.35 | F/Q | 1-147 | [»] | |
6T0B | electron microscopy | 2.80 | F/Q | 1-147 | [»] | |
6T15 | electron microscopy | 3.29 | F/Q | 1-147 | [»] | |
SMRi | P00127 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 31190, 107 interactors |
ComplexPortali | CPX-567, Mitochondrial electron transport complex III |
DIPi | DIP-1621N |
IntActi | P00127, 5 interactors |
MINTi | P00127 |
STRINGi | 4932.YFR033C |
PTM databases
CarbonylDBi | P00127 |
Proteomic databases
MaxQBi | P00127 |
PaxDbi | P00127 |
PRIDEi | P00127 |
Genome annotation databases
EnsemblFungii | YFR033C_mRNA; YFR033C; YFR033C |
GeneIDi | 850593 |
KEGGi | sce:YFR033C |
Organism-specific databases
EuPathDBi | FungiDB:YFR033C |
SGDi | S000001929, QCR6 |
Phylogenomic databases
eggNOGi | KOG4763, Eukaryota |
GeneTreei | ENSGT00390000003860 |
HOGENOMi | CLU_115913_0_1_1 |
InParanoidi | P00127 |
OMAi | CKNSPQC |
Enzyme and pathway databases
Reactomei | R-SCE-611105, Respiratory electron transport |
Miscellaneous databases
EvolutionaryTracei | P00127 |
PROi | PR:P00127 |
RNActi | P00127, protein |
Family and domain databases
DisProti | DP00853 |
Gene3Di | 1.10.287.20, 1 hit |
InterProi | View protein in InterPro IPR003422, Cyt_b-c1_6 IPR023184, Ubol_cytC_Rdtase_hinge_dom IPR036811, Ubol_cytC_Rdtase_hinge_dom_sf |
PANTHERi | PTHR15336, PTHR15336, 1 hit |
Pfami | View protein in Pfam PF02320, UCR_hinge, 1 hit |
SUPFAMi | SSF81531, SSF81531, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR6_YEAST | |
Accessioni | P00127Primary (citable) accession number: P00127 Secondary accession number(s): D6VTR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome VI
Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD