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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:UQCRH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13Mitochondrion1 PublicationAdd BLAST13
ChainiPRO_000019354014 – 91Cytochrome b-c1 complex subunit 6, mitochondrialAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 811 Publication
Modified residuei42N6-acetyllysineBy similarity1
Disulfide bondi53 ↔ 671 Publication
Modified residuei85N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP00126
PeptideAtlasiP00126
PRIDEiP00126

Expressioni

Gene expression databases

BgeeiENSBTAG00000009603

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

CORUMiP00126
DIPiDIP-38973N
IntActiP00126, 2 interactors
STRINGi9913.ENSBTAP00000012635

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 24Combined sources8
Helixi29 – 37Combined sources9
Beta strandi38 – 40Combined sources3
Helixi41 – 58Combined sources18
Beta strandi61 – 63Combined sources3
Helixi68 – 85Combined sources18
Helixi86 – 89Combined sources4

3D structure databases

ProteinModelPortaliP00126
SMRiP00126
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00126

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 25Poly-Glu8

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4763 Eukaryota
ENOG411247S LUCA
GeneTreeiENSGT00390000003860
HOGENOMiHOG000243673
HOVERGENiHBG001487
InParanoidiP00126
KOiK00416
OMAiSQTEEDC
OrthoDBiEOG091G13DH
TreeFamiTF105036

Family and domain databases

Gene3Di1.10.287.20, 1 hit
InterProiView protein in InterPro
IPR003422 Cyt_b-c1_6
IPR023184 Ubol_cytC_Rdtase_hinge_dom
IPR036811 Ubol_cytC_Rdtase_hinge_dom_sf
PANTHERiPTHR15336 PTHR15336, 1 hit
PfamiView protein in Pfam
PF02320 UCR_hinge, 1 hit
PIRSFiPIRSF000019 Bc1_11K, 1 hit
SUPFAMiSSF81531 SSF81531, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEDEQRML TGSGDPKEEE EEEEELVDPL TTVREQCEQL EKCVKARERL
60 70 80 90
ELCDERVSSR SQTEEDCTEE LLDFLHARDH CVAHKLFNSL K
Length:91
Mass (Da):10,624
Last modified:June 27, 2006 - v2
Checksum:iF444A2E7B6A147D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102729 mRNA Translation: AAI02730.1
PIRiA00119 CCBO11
RefSeqiNP_001029917.1, NM_001034745.2
UniGeneiBt.27327

Genome annotation databases

EnsembliENSBTAT00000012635; ENSBTAP00000012635; ENSBTAG00000009603
GeneIDi613899
KEGGibta:613899

Similar proteinsi

Entry informationi

Entry nameiQCR6_BOVIN
AccessioniPrimary (citable) accession number: P00126
Secondary accession number(s): Q3SZS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: April 25, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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