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Protein

Cytochrome c1, heme protein, mitochondrial

Gene

CYC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121Heme (covalent)1
Binding sitei124Heme (covalent)1
Metal bindingi125Iron (heme axial ligand)1
Metal bindingi244Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport

Protein family/group databases

TCDBi3.D.3.2.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Short name:
Cytochrome c-1
Gene namesi
Name:CYC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:50266 CYC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 306Helical; Note=Anchors to the membraneSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 84Mitochondrion1 PublicationAdd BLAST84
ChainiPRO_000010841685 – 325Cytochrome c1, heme protein, mitochondrialAdd BLAST241

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

PaxDbiP00125
PeptideAtlasiP00125
PRIDEiP00125

Expressioni

Gene expression databases

BgeeiENSBTAG00000012232 Expressed in 9 organ(s), highest expression level in heart

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

CORUMiP00125
DIPiDIP-38976N
IntActiP00125, 10 interactors
STRINGi9913.ENSBTAP00000016224

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00125
SMRiP00125
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00125

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 209Cytochrome cPROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3052 Eukaryota
COG2857 LUCA
GeneTreeiENSGT00390000012445
HOGENOMiHOG000003867
HOVERGENiHBG001239
InParanoidiP00125
KOiK00413
OMAiSRKIAYR
OrthoDBiEOG091G0FT2
TreeFamiTF314799

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002326 Cyt_c1
IPR021157 Cyt_c1_TM_anchor_C
PANTHERiPTHR10266 PTHR10266, 1 hit
PfamiView protein in Pfam
PF02167 Cytochrom_C1, 1 hit
PRINTSiPR00603 CYTOCHROMEC1
SUPFAMiSSF46626 SSF46626, 1 hit
SSF81496 SSF81496, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00125-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAATLRG AMVGPRGAGL PGARARGLLC GARPGQLPLR TPQAVSLSSK
60 70 80 90 100
SGLSRGRKVI LSALGMLAAG GAGLAVALHS AVSASDLELH PPSYPWSHRG
110 120 130 140 150
LLSSLDHTSI RRGFQVYKQV CSSCHSMDYV AYRHLVGVCY TEDEAKALAE
160 170 180 190 200
EVEVQDGPNE DGEMFMRPGK LSDYFPKPYP NPEAARAANN GALPPDLSYI
210 220 230 240 250
VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ AIGMAPPIYN
260 270 280 290 300
EVLEFDDGTP ATMSQVAKDV CTFLRWAAEP EHDHRKRMGL KMLLMMGLLL
310 320
PLVYAMKRHK WSVLKSRKLA YRPPK
Length:325
Mass (Da):35,297
Last modified:June 27, 2006 - v2
Checksum:i588ED1DEFEAABD6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109917 mRNA Translation: AAI09918.1
U97172 Genomic DNA Translation: AAB57834.1
PIRiA00118 CCBO1
RefSeqiNP_001033179.1, NM_001038090.2
UniGeneiBt.1808

Genome annotation databases

EnsembliENSBTAT00000016224; ENSBTAP00000016224; ENSBTAG00000012232
GeneIDi512500
KEGGibta:512500

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109917 mRNA Translation: AAI09918.1
U97172 Genomic DNA Translation: AAB57834.1
PIRiA00118 CCBO1
RefSeqiNP_001033179.1, NM_001038090.2
UniGeneiBt.1808

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16D85-325[»]
1BE3X-ray3.00D85-325[»]
1BGYX-ray3.00D/P85-325[»]
1L0LX-ray2.35D85-325[»]
1L0NX-ray2.60D85-325[»]
1NTKX-ray2.60D85-325[»]
1NTMX-ray2.40D85-325[»]
1NTZX-ray2.60D85-325[»]
1NU1X-ray3.20D85-325[»]
1PP9X-ray2.10D/Q85-325[»]
1PPJX-ray2.10D/Q85-325[»]
1QCRX-ray2.70D251-325[»]
1SQBX-ray2.69D85-325[»]
1SQPX-ray2.70D85-325[»]
1SQQX-ray3.00D85-325[»]
1SQVX-ray2.85D85-325[»]
1SQXX-ray2.60D85-325[»]
2A06X-ray2.10D/Q85-325[»]
2BCCX-ray3.50D85-325[»]
2FYUX-ray2.26D85-325[»]
2YBBelectron microscopy19.00D/d85-325[»]
3BCCX-ray3.70D85-325[»]
4D6TX-ray3.57D/Q61-325[»]
4D6UX-ray4.09D/Q1-325[»]
5GPNelectron microscopy5.40D/P85-325[»]
5KLVX-ray2.65D85-325[»]
5LUFelectron microscopy9.10d/p85-325[»]
5NMIX-ray3.50D/Q86-325[»]
5OKDX-ray3.10D1-325[»]
6FO0electron microscopy4.10D/Q1-325[»]
6FO2electron microscopy4.40D/Q1-325[»]
6FO6electron microscopy4.10D/Q1-325[»]
ProteinModelPortaliP00125
SMRiP00125
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP00125
DIPiDIP-38976N
IntActiP00125, 10 interactors
STRINGi9913.ENSBTAP00000016224

Protein family/group databases

TCDBi3.D.3.2.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

Proteomic databases

PaxDbiP00125
PeptideAtlasiP00125
PRIDEiP00125

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016224; ENSBTAP00000016224; ENSBTAG00000012232
GeneIDi512500
KEGGibta:512500

Organism-specific databases

CTDi1537
VGNCiVGNC:50266 CYC1

Phylogenomic databases

eggNOGiKOG3052 Eukaryota
COG2857 LUCA
GeneTreeiENSGT00390000012445
HOGENOMiHOG000003867
HOVERGENiHBG001239
InParanoidiP00125
KOiK00413
OMAiSRKIAYR
OrthoDBiEOG091G0FT2
TreeFamiTF314799

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport

Miscellaneous databases

EvolutionaryTraceiP00125

Gene expression databases

BgeeiENSBTAG00000012232 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002326 Cyt_c1
IPR021157 Cyt_c1_TM_anchor_C
PANTHERiPTHR10266 PTHR10266, 1 hit
PfamiView protein in Pfam
PF02167 Cytochrom_C1, 1 hit
PRINTSiPR00603 CYTOCHROMEC1
SUPFAMiSSF46626 SSF46626, 1 hit
SSF81496 SSF81496, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCY1_BOVIN
AccessioniPrimary (citable) accession number: P00125
Secondary accession number(s): Q2TBM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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