UniProtKB - P00125 (CY1_BOVIN)

BLAST

>sp|P00125|CY1_BOVIN Cytochrome c1, heme protein, mitochondrial OS=Bos taurus OX=9913 GN=CYC1 PE=1 SV=2
MAAAAATLRGAMVGPRGAGLPGARARGLLCGARPGQLPLRTPQAVSLSSKSGLSRGRKVI
LSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQV
CSSCHSMDYVAYRHLVGVCYTEDEAKALAEEVEVQDGPNEDGEMFMRPGKLSDYFPKPYP
NPEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQ
AIGMAPPIYNEVLEFDDGTPATMSQVAKDVCTFLRWAAEPEHDHRKRMGLKMLLMMGLLL
PLVYAMKRHKWSVLKSRKLAYRPPK

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History
Entry version 152 (07 Nov 2018)
Sequence version 2 (27 Jun 2006)
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Protein

Cytochrome c1, heme protein, mitochondrial

Gene

CYC1

Organism

Bos taurus (Bovine)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	121	Heme (covalent)	1
Binding siteⁱ	124	Heme (covalent)	1
Metal bindingⁱ	125	Iron (heme axial ligand)	1
Metal bindingⁱ	244	Iron (heme axial ligand)PROSITE-ProRule annotation	1

GO - Molecular functionⁱ

electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
heme binding Source: InterPro
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial ATP synthesis coupled proton transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitochondrial electron transport, ubiquinol to cytochrome c
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Respiratory chain, Transport
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-BTA-611105 Respiratory electron transport

Reactomeⁱ

R-BTA-611105 Respiratory electron transport

Protein family/group databases

TCDBⁱ	3.D.3.2.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

TCDBⁱ

3.D.3.2.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome c1, heme protein, mitochondrial Alternative name(s): Complex III subunit 4 Complex III subunit IV Cytochrome b-c1 complex subunit 4 Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit Short name: Cytochrome c-1
Gene namesⁱ	Name:CYC1
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 14

Organism-specific databases

VGNCⁱ	VGNC:50266 CYC1

VGNCⁱ

VGNC:50266 CYC1

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	292 – 306	Helical; Note=Anchors to the membraneSequence analysisAdd BLAST		15

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 84	Mitochondrion1 PublicationAdd BLAST		84
ChainⁱPRO_0000108416	85 – 325	Cytochrome c1, heme protein, mitochondrialAdd BLAST		241

Post-translational modificationⁱ

Binds 1 heme group per subunit.

Proteomic databases

PaxDbⁱ	P00125
PeptideAtlas More...PeptideAtlasⁱ	P00125
PRIDEⁱ	P00125

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000012232 Expressed in 9 organ(s), highest expression level in heart

Bgeeⁱ

ENSBTAG00000012232 Expressed in 9 organ(s), highest expression level in heart

Interactionⁱ

Subunit structureⁱ

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

CORUMⁱ	P00125
Database of interacting proteins More...DIPⁱ	DIP-38976N
IntActⁱ	P00125, 10 interactors
STRINGⁱ	9913.ENSBTAP00000016224

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	100 – 102	Combined sources	3
Helixⁱ	107 – 119	Combined sources	13
Helixⁱ	121 – 123	Combined sources	3
Beta strandⁱ	127 – 131	Combined sources	5
Helixⁱ	132 – 135	Combined sources	4
Turnⁱ	136 – 138	Combined sources	3
Helixⁱ	142 – 150	Combined sources	9
Beta strandⁱ	152 – 156	Combined sources	5
Turnⁱ	160 – 162	Combined sources	3
Beta strandⁱ	165 – 168	Combined sources	4
Beta strandⁱ	171 – 174	Combined sources	4
Beta strandⁱ	178 – 181	Combined sources	4
Helixⁱ	182 – 188	Combined sources	7
Turnⁱ	189 – 191	Combined sources	3
Beta strandⁱ	197 – 199	Combined sources	3
Turnⁱ	200 – 202	Combined sources	3
Beta strandⁱ	203 – 206	Combined sources	4
Helixⁱ	207 – 215	Combined sources	9
Beta strandⁱ	229 – 233	Combined sources	5
Beta strandⁱ	235 – 237	Combined sources	3
Beta strandⁱ	240 – 244	Combined sources	5
Beta strandⁱ	248 – 250	Combined sources	3
Turnⁱ	256 – 258	Combined sources	3
Helixⁱ	263 – 278	Combined sources	16
Helixⁱ	282 – 315	Combined sources	34
Beta strandⁱ	318 – 321	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P00125
SMRⁱ	P00125
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P00125

EvolutionaryTraceⁱ

P00125

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	108 – 209	Cytochrome cPROSITE-ProRule annotationAdd BLAST		102

Sequence similaritiesⁱ

Belongs to the cytochrome c family.Curated

Keywords - Domainⁱ

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3052 Eukaryota COG2857 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012445
HOGENOMⁱ	HOG000003867
HOVERGENⁱ	HBG001239
InParanoidⁱ	P00125
KEGG Orthology (KO) More...KOⁱ	K00413
OMAⁱ	SRKIAYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FT2
TreeFamⁱ	TF314799

Family and domain databases

Gene3Dⁱ	1.10.760.10, 1 hit
InterProⁱ	View protein in InterPro IPR009056 Cyt_c-like_dom IPR036909 Cyt_c-like_dom_sf IPR002326 Cyt_c1 IPR021157 Cyt_c1_TM_anchor_C
PANTHERⁱ	PTHR10266 PTHR10266, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02167 Cytochrom_C1, 1 hit
PRINTSⁱ	PR00603 CYTOCHROMEC1
SUPFAMⁱ	SSF46626 SSF46626, 1 hit SSF81496 SSF81496, 1 hit
PROSITEⁱ	View protein in PROSITE PS51007 CYTC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P00125-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAAAATLRG AMVGPRGAGL PGARARGLLC GARPGQLPLR TPQAVSLSSK 
        60         70         80         90        100
SGLSRGRKVI LSALGMLAAG GAGLAVALHS AVSASDLELH PPSYPWSHRG 
       110        120        130        140        150
LLSSLDHTSI RRGFQVYKQV CSSCHSMDYV AYRHLVGVCY TEDEAKALAE 
       160        170        180        190        200
EVEVQDGPNE DGEMFMRPGK LSDYFPKPYP NPEAARAANN GALPPDLSYI 
       210        220        230        240        250
VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ AIGMAPPIYN 
       260        270        280        290        300
EVLEFDDGTP ATMSQVAKDV CTFLRWAAEP EHDHRKRMGL KMLLMMGLLL 
       310        320 
PLVYAMKRHK WSVLKSRKLA YRPPK

Length:325

Mass (Da):35,297

Last modified:June 27, 2006 - v2

Checksum:ⁱ588ED1DEFEAABD6D

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC109917 mRNA Translation: AAI09918.1 U97172 Genomic DNA Translation: AAB57834.1
PIRⁱ	A00118 CCBO1
NCBI Reference Sequences More...RefSeqⁱ	NP_001033179.1, NM_001038090.2
UniGeneⁱ	Bt.1808

Genome annotation databases

Ensemblⁱ	ENSBTAT00000016224; ENSBTAP00000016224; ENSBTAG00000012232
GeneIDⁱ	512500
KEGGⁱ	bta:512500

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P00125	Cytochrome c1, heme protein, mitochondrial (Fragment)		wild yak		283	UniRef100_P00125
Cytochrome c-1 (Fragment)		BOVIN		182
UPI000B423613		BOVIN		240
UPI0000110887		BOVIN		241
UPI0000112A43		BOVIN		75
+1

Protein	Similar proteins		Species	Score	Length	Source
P00125	Cytochrome c1, heme protein, mitochondrial		MOUSE		325	UniRef90_P00125
Cytochrome c1, heme protein, mitochondrial (Fragment)		wild yak		283
Cytochrome c-1 (Fragment)		BOVIN		182
Cytochrome c1, heme protein, mitochondrial		HETGA		366
cytochrome c1, heme protein, mitochondrial		Enhydra lutris kenyoni		327
+57

Protein	Similar proteins		Species	Score	Length	Source
P00125	Cytochrome c1, heme protein, mitochondrial	)	HUMAN		325	UniRef50_P08574
Cytochrome c1, heme protein, mitochondrial		MOUSE		325
cytochrome c1, heme protein, mitochondrial-like		LIPVE		326
Uncharacterized protein		MAIZE		326
Cytochrome c-1		RAT		326
+260

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC109917 mRNA Translation: AAI09918.1 U97172 Genomic DNA Translation: AAB57834.1
PIRⁱ	A00118 CCBO1
RefSeqⁱ	NP_001033179.1, NM_001038090.2
UniGeneⁱ	Bt.1808

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BCC	X-ray	3.16	D	85-325	[»]
	1BE3	X-ray	3.00	D	85-325	[»]
	1BGY	X-ray	3.00	D/P	85-325	[»]
	1L0L	X-ray	2.35	D	85-325	[»]
	1L0N	X-ray	2.60	D	85-325	[»]
	1NTK	X-ray	2.60	D	85-325	[»]
	1NTM	X-ray	2.40	D	85-325	[»]
	1NTZ	X-ray	2.60	D	85-325	[»]
	1NU1	X-ray	3.20	D	85-325	[»]
	1PP9	X-ray	2.10	D/Q	85-325	[»]
	1PPJ	X-ray	2.10	D/Q	85-325	[»]
	1QCR	X-ray	2.70	D	251-325	[»]
	1SQB	X-ray	2.69	D	85-325	[»]
	1SQP	X-ray	2.70	D	85-325	[»]
	1SQQ	X-ray	3.00	D	85-325	[»]
	1SQV	X-ray	2.85	D	85-325	[»]
	1SQX	X-ray	2.60	D	85-325	[»]
	2A06	X-ray	2.10	D/Q	85-325	[»]
	2BCC	X-ray	3.50	D	85-325	[»]
	2FYU	X-ray	2.26	D	85-325	[»]
	2YBB	electron microscopy	19.00	D/d	85-325	[»]
	3BCC	X-ray	3.70	D	85-325	[»]
	4D6T	X-ray	3.57	D/Q	61-325	[»]
	4D6U	X-ray	4.09	D/Q	1-325	[»]
	5GPN	electron microscopy	5.40	D/P	85-325	[»]
	5KLV	X-ray	2.65	D	85-325	[»]
	5LUF	electron microscopy	9.10	d/p	85-325	[»]
	5NMI	X-ray	3.50	D/Q	86-325	[»]
	5OKD	X-ray	3.10	D	1-325	[»]
	6FO0	electron microscopy	4.10	D/Q	1-325	[»]
	6FO2	electron microscopy	4.40	D/Q	1-325	[»]
	6FO6	electron microscopy	4.10	D/Q	1-325	[»]
ProteinModelPortalⁱ	P00125
SMRⁱ	P00125
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	P00125
DIPⁱ	DIP-38976N
IntActⁱ	P00125, 10 interactors
STRINGⁱ	9913.ENSBTAP00000016224

Protein family/group databases

TCDBⁱ	3.D.3.2.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

TCDBⁱ

3.D.3.2.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

Proteomic databases

PaxDbⁱ	P00125
PeptideAtlasⁱ	P00125
PRIDEⁱ	P00125

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000016224; ENSBTAP00000016224; ENSBTAG00000012232
GeneIDⁱ	512500
KEGGⁱ	bta:512500

Organism-specific databases

CTDⁱ	1537
VGNCⁱ	VGNC:50266 CYC1

Phylogenomic databases

eggNOGⁱ	KOG3052 Eukaryota COG2857 LUCA
GeneTreeⁱ	ENSGT00390000012445
HOGENOMⁱ	HOG000003867
HOVERGENⁱ	HBG001239
InParanoidⁱ	P00125
KOⁱ	K00413
OMAⁱ	SRKIAYR
OrthoDBⁱ	EOG091G0FT2
TreeFamⁱ	TF314799

Enzyme and pathway databases

Reactomeⁱ	R-BTA-611105 Respiratory electron transport

Reactomeⁱ

R-BTA-611105 Respiratory electron transport

Miscellaneous databases

EvolutionaryTraceⁱ	P00125

EvolutionaryTraceⁱ

P00125

Gene expression databases

Bgeeⁱ	ENSBTAG00000012232 Expressed in 9 organ(s), highest expression level in heart

Bgeeⁱ

ENSBTAG00000012232 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

Gene3Dⁱ	1.10.760.10, 1 hit
InterProⁱ	View protein in InterPro IPR009056 Cyt_c-like_dom IPR036909 Cyt_c-like_dom_sf IPR002326 Cyt_c1 IPR021157 Cyt_c1_TM_anchor_C
PANTHERⁱ	PTHR10266 PTHR10266, 1 hit
Pfamⁱ	View protein in Pfam PF02167 Cytochrom_C1, 1 hit
PRINTSⁱ	PR00603 CYTOCHROMEC1
SUPFAMⁱ	SSF46626 SSF46626, 1 hit SSF81496 SSF81496, 1 hit
PROSITEⁱ	View protein in PROSITE PS51007 CYTC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CY1_BOVIN
Accessionⁱ	P00125Primary (citable) accession number: P00125 Secondary accession number(s): Q2TBM2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	June 27, 2006
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - P00125 (CY1_BOVIN)

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Cytochrome c1, heme protein, mitochondrial

CYC1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ