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Entry version 124 (07 Apr 2021)
Sequence version 1 (21 Jul 1986)
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Protein

Cytochrome c

Gene
N/A
Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Miscellaneous

The tentative assignment of Gln-24 and Glu-69 is based on indirect evidence (electrophoretic mobilities and comparisons with other cytochromes c).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei22Heme; covalentPROSITE-ProRule annotation1 Publication1
Binding sitei25Heme; covalentPROSITE-ProRule annotation1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi26Iron (heme axial ligand)1
Metal bindingi88Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTriticum aestivum (Wheat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4565 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000019116 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001083131 – 112Cytochrome cAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylalanine1 Publication1
Modified residuei80N6,N6,N6-trimethyllysine1 Publication1
Modified residuei94N6,N6,N6-trimethyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Acetylation, Methylation

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P00068

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P00068, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4565.Traes_1AL_45A9AD1EA.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00068

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3453, Eukaryota

Identification of Orthologs from Complete Genome Data

More...
OMAi
GTKMICV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.760.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009056, Cyt_c-like_dom
IPR036909, Cyt_c-like_dom_sf
IPR002327, Cyt_c_1A/1B

The PANTHER Classification System

More...
PANTHERi
PTHR11961, PTHR11961, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00034, Cytochrom_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00604, CYTCHRMECIAB

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46626, SSF46626, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51007, CYTC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P00068-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ASFSEAPPGN PDAGAKIFKT KCAQCHTVDA GAGHKQGPNL HGLFGRQSGT
60 70 80 90 100
TAGYSYSAAN KNKAVEWEEN TLYDYLLNPK KYIPGTKMVF PGLKKPQDRA
110
DLIAYLKKAT SS
Length:112
Mass (Da):12,048
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA66BC561B6E5F863
GO

Sequence databases

Protein sequence database of the Protein Information Resource

More...
PIRi
A00060, CCWT

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
TraesCAD_scaffold_038108_01G000200.1; TraesCAD_scaffold_038108_01G000200.1; TraesCAD_scaffold_038108_01G000200
TraesCLE_scaffold_060241_01G000100.1; TraesCLE_scaffold_060241_01G000100.1; TraesCLE_scaffold_060241_01G000100
TraesPAR_scaffold_050924_01G000200.1; TraesPAR_scaffold_050924_01G000200.1; TraesPAR_scaffold_050924_01G000200
TraesROB_scaffold_057684_01G000400.1; TraesROB_scaffold_057684_01G000400.1; TraesROB_scaffold_057684_01G000400
TraesWEE_scaffold_035863_01G000400.1; TraesWEE_scaffold_035863_01G000400.1; TraesWEE_scaffold_035863_01G000400

Gramene; a comparative resource for plants

More...
Gramenei
TraesCAD_scaffold_038108_01G000200.1; TraesCAD_scaffold_038108_01G000200.1; TraesCAD_scaffold_038108_01G000200
TraesCLE_scaffold_060241_01G000100.1; TraesCLE_scaffold_060241_01G000100.1; TraesCLE_scaffold_060241_01G000100
TraesPAR_scaffold_050924_01G000200.1; TraesPAR_scaffold_050924_01G000200.1; TraesPAR_scaffold_050924_01G000200
TraesROB_scaffold_057684_01G000400.1; TraesROB_scaffold_057684_01G000400.1; TraesROB_scaffold_057684_01G000400
TraesWEE_scaffold_035863_01G000400.1; TraesWEE_scaffold_035863_01G000400.1; TraesWEE_scaffold_035863_01G000400

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

PIRiA00060, CCWT

3D structure databases

SMRiP00068
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4565.Traes_1AL_45A9AD1EA.1

PTM databases

iPTMnetiP00068

Genome annotation databases

EnsemblPlantsiTraesCAD_scaffold_038108_01G000200.1; TraesCAD_scaffold_038108_01G000200.1; TraesCAD_scaffold_038108_01G000200
TraesCLE_scaffold_060241_01G000100.1; TraesCLE_scaffold_060241_01G000100.1; TraesCLE_scaffold_060241_01G000100
TraesPAR_scaffold_050924_01G000200.1; TraesPAR_scaffold_050924_01G000200.1; TraesPAR_scaffold_050924_01G000200
TraesROB_scaffold_057684_01G000400.1; TraesROB_scaffold_057684_01G000400.1; TraesROB_scaffold_057684_01G000400
TraesWEE_scaffold_035863_01G000400.1; TraesWEE_scaffold_035863_01G000400.1; TraesWEE_scaffold_035863_01G000400
GrameneiTraesCAD_scaffold_038108_01G000200.1; TraesCAD_scaffold_038108_01G000200.1; TraesCAD_scaffold_038108_01G000200
TraesCLE_scaffold_060241_01G000100.1; TraesCLE_scaffold_060241_01G000100.1; TraesCLE_scaffold_060241_01G000100
TraesPAR_scaffold_050924_01G000200.1; TraesPAR_scaffold_050924_01G000200.1; TraesPAR_scaffold_050924_01G000200
TraesROB_scaffold_057684_01G000400.1; TraesROB_scaffold_057684_01G000400.1; TraesROB_scaffold_057684_01G000400
TraesWEE_scaffold_035863_01G000400.1; TraesWEE_scaffold_035863_01G000400.1; TraesWEE_scaffold_035863_01G000400

Phylogenomic databases

eggNOGiKOG3453, Eukaryota
OMAiGTKMICV

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P00068

Gene expression databases

ExpressionAtlasiP00068, baseline and differential

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056, Cyt_c-like_dom
IPR036909, Cyt_c-like_dom_sf
IPR002327, Cyt_c_1A/1B
PANTHERiPTHR11961, PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034, Cytochrom_C, 1 hit
PRINTSiPR00604, CYTCHRMECIAB
SUPFAMiSSF46626, SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007, CYTC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYC_WHEAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00068
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 7, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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