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Protein

Cytochrome c

Gene

cyc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19Heme (covalent)1
Binding sitei22Heme (covalent)1
Metal bindingi23Iron (heme axial ligand)1
Metal bindingi85Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-111457 Release of apoptotic factors from the mitochondria
R-SPO-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:cyc1
ORF Names:SPCC191.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC191.07
PomBaseiSPCC191.07 cyc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001083332 – 109Cytochrome cAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77N6,N6,N6-trimethyllysine1 Publication1

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP00046
PaxDbiP00046
PRIDEiP00046

Interactioni

Protein-protein interaction databases

BioGridi275718, 1 interactor
STRINGi4896.SPCC191.07.1

Structurei

3D structure databases

ProteinModelPortaliP00046
SMRiP00046
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

HOGENOMiHOG000009762
InParanoidiP00046
KOiK08738
OMAiGLFKTRC
OrthoDBiEOG092C56RQ
PhylomeDBiP00046

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B
PANTHERiPTHR11961 PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034 Cytochrom_C, 1 hit
PRINTSiPR00604 CYTCHRMECIAB
SUPFAMiSSF46626 SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00046-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYAPGDEKK GASLFKTRCA QCHTVEKGGA NKVGPNLHGV FGRKTGQAEG
60 70 80 90 100
FSYTEANRDK GITWDEETLF AYLENPKKYI PGTKMAFAGF KKPADRNNVI

TYLKKATSE
Length:109
Mass (Da):12,022
Last modified:January 23, 2007 - v3
Checksum:i28F4BAA1E9B906F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58R → K AA sequence (PubMed:207525).Curated1
Sequence conflicti60K → R AA sequence (PubMed:207525).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01318 Genomic DNA Translation: AAA35300.1
CU329672 Genomic DNA Translation: CAB41053.1
PIRiT41220 CCZP
RefSeqiNP_588296.1, NM_001023286.2

Genome annotation databases

EnsemblFungiiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07
GeneIDi2539146
KEGGispo:SPCC191.07

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01318 Genomic DNA Translation: AAA35300.1
CU329672 Genomic DNA Translation: CAB41053.1
PIRiT41220 CCZP
RefSeqiNP_588296.1, NM_001023286.2

3D structure databases

ProteinModelPortaliP00046
SMRiP00046
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275718, 1 interactor
STRINGi4896.SPCC191.07.1

Proteomic databases

MaxQBiP00046
PaxDbiP00046
PRIDEiP00046

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07
GeneIDi2539146
KEGGispo:SPCC191.07

Organism-specific databases

EuPathDBiFungiDB:SPCC191.07
PomBaseiSPCC191.07 cyc1

Phylogenomic databases

HOGENOMiHOG000009762
InParanoidiP00046
KOiK08738
OMAiGLFKTRC
OrthoDBiEOG092C56RQ
PhylomeDBiP00046

Enzyme and pathway databases

ReactomeiR-SPO-111457 Release of apoptotic factors from the mitochondria
R-SPO-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

PROiPR:P00046

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B
PANTHERiPTHR11961 PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034 Cytochrom_C, 1 hit
PRINTSiPR00604 CYTCHRMECIAB
SUPFAMiSSF46626 SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYC_SCHPO
AccessioniPrimary (citable) accession number: P00046
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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