CYC1

Functionⁱ

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Miscellaneous

Present with 7330 molecules/cell in log phase SD medium.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	20	Heme (covalent)	1
Binding siteⁱ	23	Heme (covalent)	1
Metal bindingⁱ	24	Iron (heme axial ligand)	1
Metal bindingⁱ	86	Iron (heme axial ligand)	1

GO - Molecular functionⁱ

electron transfer activity
Source: SGD
Inferred from direct assayⁱ
- 18975895
- 7851399
heme binding Source: InterPro
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Respiratory chain, Transport
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31683-MONOMER
Reactomeⁱ	R-SCE-111457 Release of apoptotic factors from the mitochondria R-SCE-111458 Formation of apoptosome R-SCE-2151201 Transcriptional activation of mitochondrial biogenesis R-SCE-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

MoonProtⁱ	P00044

MoonProtⁱ

P00044

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome c iso-1
Gene namesⁱ	Name:CYC1 Ordered Locus Names:YJR048W ORF Names:J1653
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	FungiDB:YJR048W
Saccharomyces Genome Database More...SGDⁱ	S000003809 CYC1

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	78	K → R: Loss of methylation by CTM1. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000108337	2 – 109	Cytochrome c iso-1Add BLAST		108

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	78	N6,N6,N6-trimethyllysine; by CTM11 Publication		1
Modified residueⁱ	79	N6,N6,N6-trimethyllysine2 Publications		1

Post-translational modificationⁱ

Binds 1 heme group per subunit.

Methylation may enhance its transport into mitochondria. Methylation occurs in fungi, plants, and some protozoa, but not in animals. The precise role of methylation at Lys-79 is unknown, but it seems to preclude pro-apoptotic activity, possibly by lowering affinity for APAF1.4 Publications

Keywords - PTMⁱ

Methylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P00044
PaxDbⁱ	P00044
PRIDEⁱ	P00044

Expressionⁱ

Developmental stageⁱ

Iso-1 is the predominant cytochrome c in aerobically grown cells.

Inductionⁱ

By oxygen.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CCP1	P00431	4	EBI-5393,EBI-4389

With

Entry

#Exp.

IntAct

Notes

CCP1

P00431

4

EBI-5393,EBI-4389

Protein-protein interaction databases

BioGridⁱ	33801, 128 interactors
Database of interacting proteins More...DIPⁱ	DIP-4265N
IntActⁱ	P00044, 4 interactors
Molecular INTeraction database More...MINTⁱ	P00044
STRINGⁱ	4932.YJR048W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 19	Combined sources	11
Turnⁱ	20 – 23	Combined sources	4
Beta strandⁱ	27 – 29	Combined sources	3
Beta strandⁱ	33 – 35	Combined sources	3
Helixⁱ	41 – 43	Combined sources	3
Beta strandⁱ	44 – 47	Combined sources	4
Beta strandⁱ	49 – 52	Combined sources	4
Helixⁱ	56 – 61	Combined sources	6
Beta strandⁱ	64 – 66	Combined sources	3
Helixⁱ	67 – 75	Combined sources	9
Helixⁱ	77 – 80	Combined sources	4
Beta strandⁱ	81 – 83	Combined sources	3
Helixⁱ	84 – 87	Combined sources	4
Helixⁱ	94 – 107	Combined sources	14

3D structure databases

ProteinModelPortalⁱ	P00044
SMRⁱ	P00044
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P00044

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome c family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009405
HOGENOMⁱ	HOG000009762
InParanoidⁱ	P00044
KEGG Orthology (KO) More...KOⁱ	K08738
OMAⁱ	GLFKTRC
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C56RQ

Family and domain databases

Gene3Dⁱ	1.10.760.10, 1 hit
InterProⁱ	View protein in InterPro IPR009056 Cyt_c-like_dom IPR036909 Cyt_c-like_dom_sf IPR002327 Cyt_c_1A/1B
PANTHERⁱ	PTHR11961 PTHR11961, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00034 Cytochrom_C, 1 hit
PRINTSⁱ	PR00604 CYTCHRMECIAB
SUPFAMⁱ	SSF46626 SSF46626, 1 hit
PROSITEⁱ	View protein in PROSITE PS51007 CYTC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P00044-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTEFKAGSAK KGATLFKTRC LQCHTVEKGG PHKVGPNLHG IFGRHSGQAE 
        60         70         80         90        100
GYSYTDANIK KNVLWDENNM SEYLTNPKKY IPGTKMAFGG LKKEKDRNDL 

ITYLKKACE

Length:109

Mass (Da):12,182

Last modified:January 23, 2007 - v2

Checksum:ⁱ1F8B6CB3B60C0BE8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M37696 Genomic DNA Translation: AAB59344.1 V01298 Genomic DNA Translation: CAA24605.1 L26347 Genomic DNA Translation: AAA62856.1 L36344 Genomic DNA Translation: AAA88751.1 Z49548 Genomic DNA Translation: CAA89576.1 X03472 Genomic DNA Translation: CAA27189.1 BK006943 Genomic DNA Translation: DAA08835.1
PIRⁱ	A00037 CCBY
NCBI Reference Sequences More...RefSeqⁱ	NP_012582.1, NM_001181706.1

Genome annotation databases

EnsemblFungiⁱ	YJR048W; YJR048W; YJR048W
GeneIDⁱ	853507
KEGGⁱ	sce:YJR048W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P00044	Cyc1p		YEASB		109
Iso-1-cytochrome c		YEAS1		109
K7_Cyc1p		YEASK		109
Cyc1p		YEASA		109
Cyc1p		YEAS8		109
+9

Protein	Similar proteins		Species	Score	Length
P00044	Cyc1p		YEASB		109
Iso-1-cytochrome c		YEAS1		109
K7_Cyc1p		YEASK		109
Cyc1p		YEASA		109
Cyc1p		YEAS8		109
+53

Protein	Similar proteins		Species	Score	Length
P00044	Cyc1p		YEASB		109
Iso-1-cytochrome c		YEAS1		109
K7_Cyc1p		YEASK		109
Cyc1p		YEASA		109
Cyc1p		YEAS8		109
+161

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M37696 Genomic DNA Translation: AAB59344.1 V01298 Genomic DNA Translation: CAA24605.1 L26347 Genomic DNA Translation: AAA62856.1 L36344 Genomic DNA Translation: AAA88751.1 Z49548 Genomic DNA Translation: CAA89576.1 X03472 Genomic DNA Translation: CAA27189.1 BK006943 Genomic DNA Translation: DAA08835.1
PIRⁱ	A00037 CCBY
NCBI Reference Sequences More...RefSeqⁱ	NP_012582.1, NM_001181706.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CHH	X-ray	1.97	A	2-107	[»]
	1CHI	X-ray	2.00	A	2-107	[»]
	1CHJ	X-ray	1.90	A	2-107	[»]
	1CIE	X-ray	1.80	A	2-107	[»]
	1CIF	X-ray	1.90	A	2-107	[»]
	1CIG	X-ray	1.80	A	2-107	[»]
	1CIH	X-ray	1.80	A	2-107	[»]
	1CRG	X-ray	2.00	A	2-107	[»]
	1CRH	X-ray	1.90	A	2-109	[»]
	1CRI	X-ray	2.00	A	2-107	[»]
	1CRJ	X-ray	2.05	A	2-107	[»]
	1CSU	X-ray	1.81	A	2-107	[»]
	1CSV	X-ray	1.90	A	2-107	[»]
	1CSW	X-ray	1.90	A	2-107	[»]
	1CSX	X-ray	1.90	A	2-107	[»]
	1CTY	X-ray	2.20	A	2-107	[»]
	1CTZ	X-ray	1.90	A	2-107	[»]
	1FHB	NMR	-	A	2-107	[»]
	1IRV	X-ray	1.90	A	2-107	[»]
	1IRW	X-ray	2.00	A	2-107	[»]
	1KYO	X-ray	2.97	W	2-109	[»]
	1LMS	NMR	-	A	2-107	[»]
	1NMI	NMR	-	A	2-107	[»]
	1RAP	X-ray	2.25	A	2-109	[»]
	1RAQ	X-ray	1.90	A	2-109	[»]
	1S6V	X-ray	1.88	B/D	2-107	[»]
	1U74	X-ray	2.40	B/D	2-107	[»]
	1YCC	X-ray	1.23	A	2-109	[»]
	1YFC	NMR	-	A	2-107	[»]
	1YIC	NMR	-	A	2-107	[»]
	2B0Z	X-ray	2.70	B	2-109	[»]
	2B10	X-ray	2.80	B/D	2-109	[»]
	2B11	X-ray	2.30	B/D	2-109	[»]
	2B12	X-ray	3.02	B	2-109	[»]
	2BCN	X-ray	1.70	B	2-107	[»]
	2GB8	NMR	-	B	2-109	[»]
	2HV4	NMR	-	A	2-107	[»]
	2JQR	NMR	-	A	2-107	[»]
	2JTI	NMR	-	B	2-109	[»]
	2LIR	NMR	-	A	2-107	[»]
	2LIT	NMR	-	A	2-107	[»]
	2MHM	NMR	-	A	2-107	[»]
	2N18	NMR	-	B	3-107	[»]
				C	2-109	[»]
	2ORL	NMR	-	A	2-107	[»]
	2PCC	X-ray	2.30	B/D	2-109	[»]
	2YCC	X-ray	1.90	A	2-107	[»]
	3CX5	X-ray	1.90	W	2-109	[»]
	3TYI	X-ray	1.40	A/B	2-107	[»]
	4MU8	X-ray	1.45	A/B	2-107	[»]
	4N0K	X-ray	1.05	A/B	2-107	[»]
	4P4Q	X-ray	2.01	B/D	7-109	[»]
	4Q5P	X-ray	1.87	A/B/C	4-107	[»]
	4QAO	X-ray	2.10	A/B/C	4-107	[»]
	4YE1	X-ray	1.39	A/B	2-109	[»]
	5CIB	X-ray	3.01	B/D	2-109	[»]
	5CIC	X-ray	2.10	B/D	2-109	[»]
	5CID	X-ray	2.76	B/D	2-109	[»]
	5CIE	X-ray	2.60	B/D	2-109	[»]
	5CIF	X-ray	2.01	B/D	7-109	[»]
	5CIG	X-ray	2.06	B/D	2-109	[»]
	5CIH	X-ray	2.60	B/D	7-109	[»]
	5KKE	X-ray	1.70	A	2-107	[»]
5KLU	X-ray	1.99	A/B	4-107	[»]
5KPF	X-ray	1.70	A/B	3-109	[»]
5LFT	X-ray	1.25	A	3-109	[»]
5LYC	X-ray	1.80	A/B	3-109	[»]
5NCV	X-ray	1.50	A/B	3-109	[»]
5T7H	X-ray	2.00	A/B/C/D	1-107	[»]
5T8W	X-ray	1.60	A/B	2-109	[»]
ProteinModelPortalⁱ	P00044
SMRⁱ	P00044
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	33801, 128 interactors
Database of interacting proteins More...DIPⁱ	DIP-4265N
IntActⁱ	P00044, 4 interactors
Molecular INTeraction database More...MINTⁱ	P00044
STRINGⁱ	4932.YJR048W

Protein family/group databases

MoonProtⁱ	P00044

MoonProtⁱ

P00044

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P00044
PaxDbⁱ	P00044
PRIDEⁱ	P00044

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YJR048W; YJR048W; YJR048W
GeneIDⁱ	853507
KEGGⁱ	sce:YJR048W

Organism-specific databases

EuPathDBⁱ	FungiDB:YJR048W
Saccharomyces Genome Database More...SGDⁱ	S000003809 CYC1

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009405
HOGENOMⁱ	HOG000009762
InParanoidⁱ	P00044
KEGG Orthology (KO) More...KOⁱ	K08738
OMAⁱ	GLFKTRC
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C56RQ

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31683-MONOMER
Reactomeⁱ	R-SCE-111457 Release of apoptotic factors from the mitochondria R-SCE-111458 Formation of apoptosome R-SCE-2151201 Transcriptional activation of mitochondrial biogenesis R-SCE-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

EvolutionaryTraceⁱ	P00044
Protein Ontology More...PROⁱ	PR:P00044

Family and domain databases

Gene3Dⁱ	1.10.760.10, 1 hit
InterProⁱ	View protein in InterPro IPR009056 Cyt_c-like_dom IPR036909 Cyt_c-like_dom_sf IPR002327 Cyt_c_1A/1B
PANTHERⁱ	PTHR11961 PTHR11961, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00034 Cytochrom_C, 1 hit
PRINTSⁱ	PR00604 CYTCHRMECIAB
SUPFAMⁱ	SSF46626 SSF46626, 1 hit
PROSITEⁱ	View protein in PROSITE PS51007 CYTC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CYC1_YEAST
Accessionⁱ	P00044Primary (citable) accession number: P00044 Secondary accession number(s): D6VWL9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 23, 2007
	Last modified:	May 23, 2018
	This is version 204 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P00044 (CYC1_YEAST)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cytochrome c iso-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ