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Entry version 99 (12 Aug 2020)
Sequence version 1 (01 May 1999)
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Protein

Enamelin

Gene

ENAM

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiomineralization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Enamelin
Cleaved into the following 7 chains:
89 kDa enamelin1 Publication
142 kDa enamelin1 Publication
155 kDa enamelin1 Publication
56 kDa enamelin1 Publication
32 kDa enamelin1 Publication
25 kDa enamelin1 Publication
34 kDa enamelin1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 381 PublicationAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002117639 – 1142EnamelinAdd BLAST1104
ChainiPRO_000002117739 – 66589 kDa enamelinAdd BLAST627
ChainiPRO_000002117839 – ?142 kDa enamelin
ChainiPRO_000002117939 – ?155 kDa enamelin
ChainiPRO_000002118039 – ?56 kDa enamelin
ChainiPRO_0000021181174 – 27632 kDa enamelinAdd BLAST103
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000021182277 – 5141 PublicationAdd BLAST238
ChainiPRO_0000021183515 – 66525 kDa enamelinAdd BLAST151
PropeptideiPRO_0000021184666 – 6691 Publication4
ChainiPRO_0000021185670 – ?34 kDa enamelin

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53PhosphoserineCurated1
Modified residuei191Phosphoserine1 Publication1
Modified residuei216Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi245N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi252N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi264N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei547Hydroxyproline1 Publication1
Glycosylationi929N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1040N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into several smaller polypeptides. Cleavage of N-terminal region of enamelin occurs soon after secretion.1 Publication
Phosphorylated by FAM20C in vitro.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O97939

PRoteomics IDEntifications database

More...
PRIDEi
O97939

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1, 8 N-Linked glycans

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O97939

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
O97939

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by secretory-phase ameloblasts. Intact enamelin and large-molecular-weight enamelins are limited to the most superficial layer of the developing enamel matrix, while low-molecular-weight enamelins are observed in deeper enamelin. Preferential localization among the crystallites in rod and interrod enamel.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from late differentiation to the transition stage.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000009538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O97939

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R69E, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O97939

KEGG Orthology (KO)

More...
KOi
K23444

Database of Orthologous Groups

More...
OrthoDBi
201332at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015673, Enamelin

The PANTHER Classification System

More...
PANTHERi
PTHR16784, PTHR16784, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15362, Enamelin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O97939-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLSCRHGAS SPKLDNLVPS GKMKILLVFL GLLCYSAAMP MQMPRMPGFS
60 70 80 90 100
SKSEEMMRYG HFNFMNAPHM AHLGTLYGNG MQLPQFFPQY QMPMWPQPPP
110 120 130 140 150
NKKHPQKPSA SKQQSKTDPA PESQKPNQPQ PKTPTPKQPL NEPSPTPTQP
160 170 180 190 200
EEETQTPQAF PPFGNGLFPY QQPLWHVPHR IPPGYGRPPT SNEEGGNPYF
210 220 230 240 250
GFFGYHGFGG RPPYYSEEMF EQDFEKPKEK DPPKTETPAT EPSVNTTVPE
260 270 280 290 300
TNSTQPNAPN PRGNDTSPTG TSGQGPNPRS NPTGQNGPAV NVSGQGVPRS
310 320 330 340 350
QSPWGPRQTI IHENYPNPNI RGFPARRQWR PPGPAMGHRR NGPFYRNQQI
360 370 380 390 400
QRGPRWNSFT LEGKQAVRPG YPTYRRVYGS TARSNPPNYA GNSANLRRKP
410 420 430 440 450
EGPNKNPMVT NVAPPGPKHG TVDQNENIQN PREKQVSQKE RTVVPTRDPS
460 470 480 490 500
GPWRNSQDYG INKSNYKLPQ PEDNMLVPNF NSIDQRENSY YPRGESKRAP
510 520 530 540 550
NSDGQTQTQI IPKGIVLEPR RIPYESETNQ PELKHSAYQP VYTEGIPSPA
560 570 580 590 600
KEHFPAGRNT WNQQEISPPF KEDPGRQEEH LPHLSHGSRV HVYYPDYNPY
610 620 630 640 650
DPRENSPYLR SNTWYERDDS PNTMGQPENP HYPMNTPDPK ETIPYNEEDP
660 670 680 690 700
IDPTGDEHFP GQSRWDMEEL SFKEDPTVRH YEGEQYTSNQ PKEYLPYSLD
710 720 730 740 750
NPSKPREDFL YGEFYPWNPE ENFPSYNTAP TVSSPVESRG YYANNAVGQE
760 770 780 790 800
ESTMFPSWSS WDPRIQAQGQ KEGRPYLNRN FWDQSTNLYK TPTSSPHQKE
810 820 830 840 850
NQPYSNNSPA GLQKNPTWHE GENLNYGMQI TRLNSPERDH LAFPDLIPPD
860 870 880 890 900
YPGGQKESHV FHLSQRGPCC AGGSMWPKNN PLALQDYTQS FGLAPGENPD
910 920 930 940 950
TSIGYAEDSH IKYARQTVSP TSIVPGQRNS SEKILPGESQ NPSPFKDDVS
960 970 980 990 1000
TLRRSTPCSV KSQLSQRGIM PLPEANSLQS KNTPCLTSDL GGDGNNVLEQ
1010 1020 1030 1040 1050
IFEGNQLNER TVDLTPEQLV FGTPDKEPRP EGIPNEMQGN ESERQQQRQS
1060 1070 1080 1090 1100
SILQLPCFGS KLANYHTSSI GTPSSLGRQD SFDGDPIMPT ETPNSLAGLA
1110 1120 1130 1140
TGAQFQNINV DPLNEDEHTP FDSLQIGTNP QDQVQDCLLL QA
Length:1,142
Mass (Da):128,352
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i938306BC87CC5FC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti680H → D AA sequence (PubMed:9206327).Curated1
Sequence conflicti838 – 840RDH → TTI AA sequence (PubMed:9206327).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U52196 mRNA Translation: AAD10837.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T37455

NCBI Reference Sequences

More...
RefSeqi
NP_999406.1, NM_214241.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397473

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52196 mRNA Translation: AAD10837.1
PIRiT37455
RefSeqiNP_999406.1, NM_214241.1

3D structure databases

SMRiO97939
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009538

PTM databases

GlyConnecti1, 8 N-Linked glycans
iPTMnetiO97939
UniCarbKBiO97939

Proteomic databases

PaxDbiO97939
PRIDEiO97939

Genome annotation databases

GeneIDi397473
KEGGissc:397473

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10117

Phylogenomic databases

eggNOGiENOG502R69E, Eukaryota
InParanoidiO97939
KOiK23444
OrthoDBi201332at2759

Family and domain databases

InterProiView protein in InterPro
IPR015673, Enamelin
PANTHERiPTHR16784, PTHR16784, 1 hit
PfamiView protein in Pfam
PF15362, Enamelin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENAM_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O97939
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: August 12, 2020
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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