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Entry version 133 (13 Nov 2019)
Sequence version 1 (01 May 1999)
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Protein

Adhesion G protein-coupled receptor L3

Gene

ADGRL3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi332CalciumBy similarity1
Metal bindingi380CalciumBy similarity1
Metal bindingi381Calcium; via carbonyl oxygenBy similarity1
Metal bindingi435Calcium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin, Metal-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.011

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L3By similarity
Alternative name(s):
Latrophilin-31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRL3By similarity
Synonyms:LPH31 Publication, LPHN3By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:53686 ADGRL3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 949ExtracellularSequence analysisAdd BLAST930
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei950 – 970Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini971 – 978CytoplasmicSequence analysis8
Transmembranei979 – 999Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini1000 – 1007ExtracellularSequence analysis8
Transmembranei1008 – 1028Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini1029 – 1050CytoplasmicSequence analysisAdd BLAST22
Transmembranei1051 – 1071Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1072 – 1088ExtracellularSequence analysisAdd BLAST17
Transmembranei1089 – 1109Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1110 – 1142CytoplasmicSequence analysisAdd BLAST33
Transmembranei1143 – 1163Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1164 – 1169ExtracellularSequence analysis6
Transmembranei1170 – 1190Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1191 – 1580CytoplasmicSequence analysisAdd BLAST390

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291220 – 1580Adhesion G protein-coupled receptor L3Add BLAST1561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi104 ↔ 134By similarity
Disulfide bondi113 ↔ 191By similarity
Disulfide bondi146 ↔ 178By similarity
Disulfide bondi159 ↔ 165By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi203 ↔ 385PROSITE-ProRule annotation
Glycosylationi532N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi617N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi840N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi885N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi911N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1000N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1166N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1254PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity
O-glycosylated (major) and N-glycosylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei922 – 923CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O97827

PRoteomics IDEntifications database

More...
PRIDEi
O97827

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain-specific distribution but low levels are also detected in lung and spleen.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O97827 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via olfactomedin-like domain) with FLRT3 (via extracellular domain); the interaction is direct.

Identified in a complex with FLRT3 and UNC5B; does not interact with UNC5B by itself.

Identified in a complex with FLRT3 and UNC5D; does not interact with UNC5D by itself (By similarity).

Interacts (via olfactomedin-like domain) with FLRT1 (via extracellular domain).

Interacts (via olfactomedin-like domain) with FLRT2 (via extracellular domain).

Interacts (via extracellular domain) with TENM1.

Interacts (via extracellular domain) with TENM3 (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000039471

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O97827

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 192SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini202 – 461Olfactomedin-likePROSITE-ProRule annotationAdd BLAST260
Domaini883 – 934GPSPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni317 – 347Interaction with FLRT3By similarityAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Olfactomedin-like domain is required for the synapse-promoting function and the interaction with FLRT3. The Olfactomedin-like and the SUEL-type lectin domains are required for the interaction with TENM1 (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3545 Eukaryota
KOG4193 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155527

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O97827

KEGG Orthology (KO)

More...
KOi
K04594

Database of Orthologous Groups

More...
OrthoDBi
388923at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003924 GPCR_2_latrophilin
IPR003334 GPCR_2_latrophilin_rcpt_C
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR015630 Latrophilin-3
IPR000922 Lectin_gal-bd_dom
IPR003112 Olfac-like_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12011:SF60 PTHR12011:SF60, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF02354 Latrophilin, 1 hit
PF02191 OLF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249 GPCRSECRETIN
PR01444 LATROPHILIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00284 OLF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51132 OLF, 1 hit
PS50228 SUEL_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O97827-1) [UniParc]FASTAAdd to basket
Also known as: bbbf

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPSQLLVFM MLLAPIIHGG KHSERHPALA SPLRHAERGP GGALPPRHLL
60 70 80 90 100
QQPAAERATA HRGPGPRGAT RGVRGPGAHG AQISAQAFSR APIPMAVVRR
110 120 130 140 150
ELSCESYPIE LRCPGTDVIM IESANYGRTD DKICDSDPAQ MENIRCYLPD
160 170 180 190 200
AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG TYKYLEVQYE CVPYKVEQKV
210 220 230 240 250
FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM PWTPYRTDTL
260 270 280 290 300
TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD
310 320 330 340 350
LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN
360 370 380 390 400
GKIVISQLNP YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN
410 420 430 440 450
EATGNKIDYI YNTDQSKDSL VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY
460 470 480 490 500
HVVKYSLDFG PLDSRSGQAH HGQVSYISPP IHLDSDLERP PVREISTTGP
510 520 530 540 550
LGTGSTTTST TLRTTTWSPG RSTTPSVSGR RNRSTSTPSP AIEVLNDITT
560 570 580 590 600
HVPSASPQIP ALEESCEAVE AREIMWFKTR QGQMAKQPCP AGTIGVSTYL
610 620 630 640 650
CLAPDGIWDP QGPDLSNCSS PWVNHITQKL KSGETAANIA RELAEQTRNH
660 670 680 690 700
LNAGDITYSV RAMDQLVGLL DVQLRNLTPG GKDSAARSLN KLQKRERSCR
710 720 730 740 750
AYVQAMVETV NNLLQPQALN AWRDLTTSDQ LRAATMLLDT VEESAFVLAD
760 770 780 790 800
NLLKTDIVRE NTDNIQLEVA RLSTEGNLED LKFPENTGHG STIQLSANTL
810 820 830 840 850
KQNGRNGEIR VAFVLYNNLG PYLSTENASM KLGTEAMSTN HSVIVNSPVI
860 870 880 890 900
TAAINKEFSN KVYLADPVVF TVKHIKQSEE NFNPNCSFWS YSKRTMTGYW
910 920 930 940 950
STQGCRLLTT NKTHTTCSCN HLTNFAVLMA HVEVKHSDAV HDLLLDVITW
960 970 980 990 1000
VGILLSLVCL LICIFTFCFF RGLQSDRNTI HKNLCISLFV AELLFLIGIN
1010 1020 1030 1040 1050
RTDQPIACAV FAALLHFFFL AAFTWMFLEG VQLYIMLVEV FESEHSRRKY
1060 1070 1080 1090 1100
FYLVGYGMPA LIVAVSAAVD YRSYGTDKVC WLRLDTYFIW SFIGPATLII
1110 1120 1130 1140 1150
MLNVIFLGIA LYKMFHHTAI LKPESGCLDN INYEDNRPFI KSWVIGAIAL
1160 1170 1180 1190 1200
LCLLGLTWAF GLMYINESTV IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK
1210 1220 1230 1240 1250
EYGKCLRTHC CSGRSTESSI GSGKTSGSRT PGRYSTGSQS RIRRMWNDTV
1260 1270 1280 1290 1300
RKQSESSFIT GDINSSASLN RGAMANHLIS NALLRPHGTN NPYNTLLGEP
1310 1320 1330 1340 1350
AVCNNPSVSM YNAQEGLLNN ARDTSVMDTL PLNGNHGNSY SIASGEYLSN
1360 1370 1380 1390 1400
CVQIIDRGYN HNETALEKKI LKELTSNYIP SYLNNHERSS EQNRNLMNKL
1410 1420 1430 1440 1450
VNNLGSGSED DAIVLDDATS FNHEESLGLE LIHEESDAPL LPPRVYSTEN
1460 1470 1480 1490 1500
HQLHHYTRRR IPQDHSESFF PLLTNEHTED LQSPHRDSLY TSMPALAGVP
1510 1520 1530 1540 1550
TAESVTTSTQ TEPPPAKCGD AEDVYYKSMP NLGSRNHVHQ LHTYYQLGRG
1560 1570 1580
SSDGFIVPPN KDGTPPEGSS KGPAHLVTSL
Length:1,580
Mass (Da):176,051
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD527CBF4B937DA8D
GO
Isoform 2 (identifier: O97827-2) [UniParc]FASTAAdd to basket
Also known as: abbf

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.

Show »
Length:1,512
Mass (Da):169,141
Checksum:i792CDD8790C4AA9B
GO
Isoform 3 (identifier: O97827-3) [UniParc]FASTAAdd to basket
Also known as: abah

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     1131-1139: Missing.

Show »
Length:1,503
Mass (Da):167,992
Checksum:iF4C8345D7F988218
GO
Isoform 4 (identifier: O97827-4) [UniParc]FASTAAdd to basket
Also known as: abah

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     1131-1139: Missing.
     1316-1351: GLLNNARDTSVMDTLPLNGNHGNSYSIASGEYLSNC → PYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1352-1580: Missing.

Show »
Length:1,274
Mass (Da):142,749
Checksum:i147C1B5FC160037F
GO
Isoform 5 (identifier: O97827-5) [UniParc]FASTAAdd to basket
Also known as: abag

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     1131-1139: Missing.
     1272-1308: GAMANHLISNALLRPHGTNNPYNTLLGEPAVCNNPSV → EPYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1309-1580: Missing.

Show »
Length:1,231
Mass (Da):138,201
Checksum:i1258A8A05D64325D
GO
Isoform 6 (identifier: O97827-6) [UniParc]FASTAAdd to basket
Also known as: abbg

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     1272-1308: GAMANHLISNALLRPHGTNNPYNTLLGEPAVCNNPSV → EPYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1309-1580: Missing.

Show »
Length:1,240
Mass (Da):139,350
Checksum:i23E8B26E48F88131
GO
Isoform 7 (identifier: O97827-7) [UniParc]FASTAAdd to basket
Also known as: bbaf

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1139: Missing.

Show »
Length:1,571
Mass (Da):174,902
Checksum:i2185D5ADCB5F8607
GO
Isoform 8 (identifier: O97827-8) [UniParc]FASTAAdd to basket
Also known as: abbh

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     1316-1351: GLLNNARDTSVMDTLPLNGNHGNSYSIASGEYLSNC → PYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1352-1580: Missing.

Show »
Length:1,283
Mass (Da):143,898
Checksum:i9D87F15DD6D01EC0
GO
Isoform 9 (identifier: O97827-9) [UniParc]FASTAAdd to basket
Also known as: bbah

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1139: Missing.
     1316-1351: GLLNNARDTSVMDTLPLNGNHGNSYSIASGEYLSNC → PYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1352-1580: Missing.

Show »
Length:1,342
Mass (Da):149,658
Checksum:i51FBC79F37FF5B4B
GO
Isoform 10 (identifier: O97827-10) [UniParc]FASTAAdd to basket
Also known as: bbbh

The sequence of this isoform differs from the canonical sequence as follows:
     1316-1351: GLLNNARDTSVMDTLPLNGNHGNSYSIASGEYLSNC → PYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1352-1580: Missing.

Show »
Length:1,351
Mass (Da):150,808
Checksum:i7C085DE9224C742A
GO
Isoform 11 (identifier: O97827-11) [UniParc]FASTAAdd to basket
Also known as: bbag

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1140: Missing.
     1272-1308: GAMANHLISNALLRPHGTNNPYNTLLGEPAVCNNPSV → EPYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1309-1580: Missing.

Show »
Length:1,299
Mass (Da):145,110
Checksum:i9D83D9258D7FA821
GO
Isoform 12 (identifier: O97827-12) [UniParc]FASTAAdd to basket
Also known as: bbbg

The sequence of this isoform differs from the canonical sequence as follows:
     1272-1308: GAMANHLISNALLRPHGTNNPYNTLLGEPAVCNNPSV → EPYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1309-1580: Missing.

Show »
Length:1,308
Mass (Da):146,259
Checksum:iC3B5827E272795AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MGL8F1MGL8_BOVIN
Adhesion G protein-coupled receptor...
ADGRL3
1,575Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01011319 – 86Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_0101141131 – 1139Missing in isoform 3, isoform 4, isoform 5, isoform 7 and isoform 9. 1 Publication9
Alternative sequenceiVSP_0101151132 – 1140Missing in isoform 11. 1 Publication9
Alternative sequenceiVSP_0101161272 – 1308GAMAN…NNPSV → EPYRETSMGVKLNIAYQIGA SEQCQGYKCHGYSTTEW in isoform 5, isoform 6, isoform 11 and isoform 12. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_0101171309 – 1580Missing in isoform 5, isoform 6, isoform 11 and isoform 12. 1 PublicationAdd BLAST272
Alternative sequenceiVSP_0101191316 – 1351GLLNN…YLSNC → PYRETSMGVKLNIAYQIGAS EQCQGYKCHGYSTTEW in isoform 4, isoform 8, isoform 9 and isoform 10. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0101201352 – 1580Missing in isoform 4, isoform 8, isoform 9 and isoform 10. 1 PublicationAdd BLAST229

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF111085 mRNA Translation: AAD05321.1
AF111086 mRNA Translation: AAD05322.1
AF111087 mRNA Translation: AAD05323.1
AF111088 mRNA Translation: AAD05324.1
AF111089 mRNA Translation: AAD05325.1
AF111090 mRNA Translation: AAD05326.1
AF111091 mRNA Translation: AAD05327.1
AF111092 mRNA Translation: AAD05328.1
AF111095 mRNA Translation: AAD05331.1
AF111093 mRNA Translation: AAD05329.1
AF111094 mRNA Translation: AAD05330.1
AF111096 mRNA Translation: AAD05332.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18389
T18390
T18391
T18392
T18393
T18394
T18395
T18398
T18405
T18407
T18408
T18409

NCBI Reference Sequences

More...
RefSeqi
NP_851376.1, NM_181033.2 [O97827-1]
XP_005208058.1, XM_005208001.3 [O97827-1]
XP_005208068.1, XM_005208011.3
XP_015327119.1, XM_015471633.1
XP_015327122.1, XM_015471636.1
XP_015327123.1, XM_015471637.1
XP_015327124.1, XM_015471638.1
XP_015327125.1, XM_015471639.1
XP_015327126.1, XM_015471640.1
XP_015327127.1, XM_015471641.1
XP_015327128.1, XM_015471642.1
XP_015327129.1, XM_015471643.1
XP_015327130.1, XM_015471644.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000018508; ENSBTAP00000018508; ENSBTAG00000013918 [O97827-7]
ENSBTAT00000051991; ENSBTAP00000049222; ENSBTAG00000013918 [O97827-1]
ENSBTAT00000066218; ENSBTAP00000055267; ENSBTAG00000013918 [O97827-10]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
282651

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:282651

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111085 mRNA Translation: AAD05321.1
AF111086 mRNA Translation: AAD05322.1
AF111087 mRNA Translation: AAD05323.1
AF111088 mRNA Translation: AAD05324.1
AF111089 mRNA Translation: AAD05325.1
AF111090 mRNA Translation: AAD05326.1
AF111091 mRNA Translation: AAD05327.1
AF111092 mRNA Translation: AAD05328.1
AF111095 mRNA Translation: AAD05331.1
AF111093 mRNA Translation: AAD05329.1
AF111094 mRNA Translation: AAD05330.1
AF111096 mRNA Translation: AAD05332.1
PIRiT18389
T18390
T18391
T18392
T18393
T18394
T18395
T18398
T18405
T18407
T18408
T18409
RefSeqiNP_851376.1, NM_181033.2 [O97827-1]
XP_005208058.1, XM_005208001.3 [O97827-1]
XP_005208068.1, XM_005208011.3
XP_015327119.1, XM_015471633.1
XP_015327122.1, XM_015471636.1
XP_015327123.1, XM_015471637.1
XP_015327124.1, XM_015471638.1
XP_015327125.1, XM_015471639.1
XP_015327126.1, XM_015471640.1
XP_015327127.1, XM_015471641.1
XP_015327128.1, XM_015471642.1
XP_015327129.1, XM_015471643.1
XP_015327130.1, XM_015471644.1

3D structure databases

SMRiO97827
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039471

Protein family/group databases

MEROPSiP02.011

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Proteomic databases

PaxDbiO97827
PRIDEiO97827

Genome annotation databases

EnsembliENSBTAT00000018508; ENSBTAP00000018508; ENSBTAG00000013918 [O97827-7]
ENSBTAT00000051991; ENSBTAP00000049222; ENSBTAG00000013918 [O97827-1]
ENSBTAT00000066218; ENSBTAP00000055267; ENSBTAG00000013918 [O97827-10]
GeneIDi282651
KEGGibta:282651

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23284
VGNCiVGNC:53686 ADGRL3

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
KOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000155527
InParanoidiO97827
KOiK04594
OrthoDBi388923at2759

Gene expression databases

ExpressionAtlasiO97827 baseline and differential

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003924 GPCR_2_latrophilin
IPR003334 GPCR_2_latrophilin_rcpt_C
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR015630 Latrophilin-3
IPR000922 Lectin_gal-bd_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR12011:SF60 PTHR12011:SF60, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF02354 Latrophilin, 1 hit
PF02191 OLF, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01444 LATROPHILIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51132 OLF, 1 hit
PS50228 SUEL_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRL3_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O97827
Secondary accession number(s): O97818
, O97819, O97820, O97821, O97822, O97823, O97824, O97825, O97826, O97828, O97829
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 1999
Last modified: November 13, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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