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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

Gene

NDUFA12

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Alternative name(s):
Complex I-B17.2
Short name:
CI-B17.2
Short name:
CIB17.2
NADH-ubiquinone oxidoreductase subunit B17.2
Gene namesi
Name:NDUFA12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:31945 NDUFA12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188441 – 145NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO97725
PRIDEiO97725

PTM databases

iPTMnetiO97725

Expressioni

Gene expression databases

BgeeiENSBTAG00000014669

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

CORUMiO97725
DIPiDIP-38802N
IntActiO97725, 3 interactors
STRINGi9913.ENSBTAP00000019529

Structurei

3D structure databases

SMRiO97725
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA12 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3382 Eukaryota
ENOG4111XVR LUCA
GeneTreeiENSGT00390000005848
HOGENOMiHOG000140337
HOVERGENiHBG024390
InParanoidiO97725
KOiK11352
OMAiWHGWIHH
OrthoDBiEOG091G0XDC
TreeFamiTF106106

Family and domain databases

InterProiView protein in InterPro
IPR007763 NDUFA12
PANTHERiPTHR12910 PTHR12910, 1 hit
PfamiView protein in Pfam
PF05071 NDUFA12, 1 hit

Sequencei

Sequence statusi: Complete.

O97725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLQVLKRG LQQVSGHGGL RGYLRVLFRA NDVRVGTLVG EDKYGNKYYE
60 70 80 90 100
DNKQFFGRHR WVIYTTEMNG KNTFWDVDGS MVPPEWHRWL HCMTDDPPTV
110 120 130 140
KPPTARKFIW TNHKFNLSGT PQQYVPYSTT RKKIQEWVPP STPYK
Length:145
Mass (Da):17,090
Last modified:May 1, 1999 - v1
Checksum:i7471348CC3AD53C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011400 mRNA Translation: CAA09608.1
BC102502 mRNA Translation: AAI02503.1
RefSeqiNP_776731.1, NM_174306.3
UniGeneiBt.103280

Genome annotation databases

EnsembliENSBTAT00000019529; ENSBTAP00000019529; ENSBTAG00000014669
GeneIDi281742
KEGGibta:281742

Similar proteinsi

Entry informationi

Entry nameiNDUAC_BOVIN
AccessioniPrimary (citable) accession number: O97725
Secondary accession number(s): Q3T092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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