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Protein

C-C chemokine receptor type 8

Gene

CCR8

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for the chemokines CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 8
Short name:
C-C CKR-8
Short name:
CC-CKR-8
Short name:
CCR-8
Alternative name(s):
CD_antigen: CDw198
Gene namesi
Name:CCR8
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 63Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini64 – 73CytoplasmicSequence analysis10
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini94 – 107ExtracellularSequence analysisAdd BLAST14
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 172Helical; Name=4Sequence analysisAdd BLAST26
Topological domaini173 – 203ExtracellularSequence analysisAdd BLAST31
Transmembranei204 – 223Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini224 – 239CytoplasmicSequence analysisAdd BLAST16
Transmembranei240 – 264Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini265 – 281ExtracellularSequence analysisAdd BLAST17
Transmembranei282 – 305Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini306 – 356CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692891 – 356C-C chemokine receptor type 8Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000030243

Structurei

3D structure databases

ProteinModelPortaliO97665
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ9D Eukaryota
ENOG410YUBT LUCA
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO97665

Family and domain databases

InterProiView protein in InterPro
IPR004068 Chemokine_CCR8
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01530 CHEMOKINER8
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O97665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYTLDPSMT TMTDYYYPDS LSSPCDGELI QRNDKLLLAV FYCLLFVFSL
60 70 80 90 100
LGNSLVILVL VVCKKLRNIT DIYLLNLALS DLLFVFSFPF QTYYQLDQWV
110 120 130 140 150
FGTVMCKVVS GFYYIGFYSS MFFITLMSVD RYLAVVHAVY AIKVRTIRMG
160 170 180 190 200
TTTLSLLVWL TAIMATIPLL VFYQVASEDG VLQCYSFYNQ QTLKWKIFTN
210 220 230 240 250
FEMNILGLLI PFTIFMFCYI KILHQLKRCQ NHNKTKAIRL VLIVVIASLL
260 270 280 290 300
FWVPFNVVLF LTSLHSMHIL DGCSISQQLN YATHVTEIIS FTHCCVNPVI
310 320 330 340 350
YAFVGEKFKK HLSEIFQKSC SHIFIYLGRQ MPRESCEKSS SCQQHSFRSS

SIDYIL
Length:356
Mass (Da):41,211
Last modified:May 1, 1999 - v1
Checksum:i1979628DEE44845B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100205 Genomic DNA Translation: AAC72403.1
UniGeneiMmu.24189

Similar proteinsi

Entry informationi

Entry nameiCCR8_MACMU
AccessioniPrimary (citable) accession number: O97665
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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