UniProtKB - O97593 (SMC1A_BOVIN)
Structural maintenance of chromosomes protein 1A
SMC1A
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 32 – 39 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: UniProtKB
- mediator complex binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
GO - Biological processi
- cell division Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- meiotic cell cycle Source: UniProtKB
- mitotic sister chromatid cohesion Source: InterPro
- mitotic spindle assembly Source: Ensembl
- response to DNA damage checkpoint signaling Source: UniProtKB
- response to radiation Source: UniProtKB
- stem cell population maintenance Source: Ensembl
Keywordsi
Biological process | Cell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Structural maintenance of chromosomes protein 1AShort name: SMC protein 1A Short name: SMC-1A |
Gene namesi | Name:SMC1A Synonyms:SMC1, SMC1L1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:34997, SMC1A |
Subcellular locationi
Nucleus
Other locations
Note: Associates with chromatin. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function (By similarity). Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.By similarity
Cytoskeleton
- mitotic spindle pole Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear matrix Source: Ensembl
- nucleoplasm Source: Ensembl
- nucleus Source: UniProtKB
Other locations
- kinetochore Source: UniProtKB
- meiotic cohesin complex Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 957 | S → A: No effect on interaction with RPGR. 1 Publication | 1 | |
Mutagenesisi | 966 | S → A: Abolishes binding with RPGR. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118988 | 1 – 1233 | Structural maintenance of chromosomes protein 1AAdd BLAST | 1233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 358 | PhosphoserineBy similarity | 1 | |
Modified residuei | 360 | PhosphoserineBy similarity | 1 | |
Modified residuei | 648 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 713 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 957 | PhosphoserineBy similarity | 1 | |
Modified residuei | 962 | PhosphoserineBy similarity | 1 | |
Modified residuei | 966 | PhosphoserineBy similarity | 1 | |
Modified residuei | 970 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1037 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | O97593 |
PRIDEi | O97593 |
Interactioni
Subunit structurei
Forms a heterodimer with SMC3 in cohesin complexes (PubMed:10072753). Cohesin complexes are composed of the SMC1 (SMC1A or meiosis-specific SMC1B) and SMC3 heterodimer attached via their SMC hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or meiosis-specific STAG3), which interacts with RAD21. In germ cell cohesin complexes, SMC1A is mutually exclusive with SMC1B.
Found in a complex with CDCA5, SMC3 and RAD21, PDS5A/SCC-112 and PDS5B/APRIN.
Interacts with NDC80, SYCP2, STAG3, BRCA1 and BRAT1.
Found in a cohesin complex with SMC3, STAG1 and RAD21. The SMC1A-SMC3 heterodimer interacts with the NIPBL-MAU2 heterodimer (By similarity).
Interacts with RPGR (PubMed:16043481).
Found in a complex containing POLE and SMC3 (PubMed:8670910).
By similarity3 PublicationsGO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 159631, 1 interactor |
CORUMi | O97593 |
STRINGi | 9913.ENSBTAP00000023619 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 515 – 629 | SMC hingeAdd BLAST | 115 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 104 – 124 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 163 – 503 | Sequence analysisAdd BLAST | 341 | |
Coiled coili | 660 – 935 | Sequence analysisAdd BLAST | 276 | |
Coiled coili | 991 – 1068 | Sequence analysisAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1128 – 1163 | Ala/Asp-rich (DA-box)Add BLAST | 36 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0018, Eukaryota |
GeneTreei | ENSGT00940000155614 |
HOGENOMi | CLU_001042_0_2_1 |
InParanoidi | O97593 |
OMAi | YMEAIVV |
OrthoDBi | 326079at2759 |
Family and domain databases
CDDi | cd03275, ABC_SMC1_euk, 2 hits |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR003395, RecF/RecN/SMC_N IPR024704, SMC IPR028468, Smc1_ABC IPR029683, SMC1A_metazoan IPR010935, SMC_hinge IPR036277, SMC_hinge_sf |
PANTHERi | PTHR18937:SF170, PTHR18937:SF170, 1 hit |
Pfami | View protein in Pfam PF06470, SMC_hinge, 1 hit PF02463, SMC_N, 1 hit |
PIRSFi | PIRSF005719, SMC, 1 hit |
SMARTi | View protein in SMART SM00968, SMC_hinge, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF75553, SSF75553, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGFLKLIEIE NFKSYKGRQI IGPFQRFTAI IGPNGSGKSN LMDAISFVLG
60 70 80 90 100
EKTSNLRVKT LRDLIHGAPV GKPAANRAFV SMVYSEEGAE DRTFARVIVG
110 120 130 140 150
GSSEYKINNK VVQLHEYSEE LEKLGILIKA RNFLVFQGAV ESIAMKNPKE
160 170 180 190 200
RTALFEEISR SGELAQEYDK RKKEMVKAEE DTQFNYHRKK NIAAERKEAK
210 220 230 240 250
QEKEEADRYQ RLKDEVVRAQ VQLQLFKLYH NEVEIEKLNK ELASKNKEIE
260 270 280 290 300
KDKKRMDKVE DELKEKKKEL GKMMREQQQI EKEIKEKDSE LNQKRPQYIK
310 320 330 340 350
AKENTSHKIK KLEAAKKSLQ NAQKHYKKRK GDMDELEKEM LSVEKARQEF
360 370 380 390 400
EERMEEESQS QGRDLTLEEN QVKKYHRLKE EASKRAATLA QELEKFNRDQ
410 420 430 440 450
KADQDRLDLE ERKKVETEAK IKQKLREIEE NQKRIEKLEE YITTSKQSLE
460 470 480 490 500
EQKKLEGELT EEVEMAKRRI DEINKELNQV MEQLGDARID RQESSRQQRK
510 520 530 540 550
AEIMESIKRL YPGSVYGRLI DLCQPTQKKY QIAVTKVLGK NMDAIIVDSE
560 570 580 590 600
KTGRDCIQYI KEQRGEPETF LPLDYLEVKP TDEKLRELKG AKLVIDVIRY
610 620 630 640 650
EPPHIKKALQ YACGNALVCD NVEDARRIAF GGHQRHKTVA LDGTLFQKSG
660 670 680 690 700
VISGGASDLK AKARRWDEKA VDKLKEKKER LTEELKEQMK AKRKEAELRQ
710 720 730 740 750
VQSQAHGLQM RLKYSQSDLE QTKTRHLALN LQEKSKLESE LANFGPRIND
760 770 780 790 800
IKRIIQSRER EMKDLKEKMN QVEDEVFEEF CREIGVRNIR EFEEEKVKRQ
810 820 830 840 850
NEIAKKRLEF ENQKTRLGIQ LDFEKNQLKE DQDKVHMWEQ TVKKDENEIE
860 870 880 890 900
KLKKEEQRHM KIIDETMAQL QDLKNQHLAK KSEVNDKNHE MEEIRKKLGG
910 920 930 940 950
ANKEMTHLQK EVTAIETKLE QKRSDRHNLL QACKMQDIKL PLSKGTMDDI
960 970 980 990 1000
SQEEGSSQGE DSVSGSQRTS NIYAREALIE IDYGDLCEDL KDAQAEEEIK
1010 1020 1030 1040 1050
QEMNTLQQKL NEQQSVLQRI AAPNMKAMEK LESVRDKFQE TSDEFEAARK
1060 1070 1080 1090 1100
RAKKAKQAFE QIKKERFDRF NACFESVATN IDEIYKALSR NSSAQAFLGP
1110 1120 1130 1140 1150
ENPEEPYLDG INYNCVAPGK RFRPMDNLSG GEKTVAALAL LFAIHSYKPA
1160 1170 1180 1190 1200
PFFVLDEIDA ALDNTNIGKV ANYIKEQSTC NFQAIVISLK EEFYTKAESL
1210 1220 1230
IGVYPEQGDC VISKVLTFDL TKYPDANPNP NEQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1M0W1 | A0A3Q1M0W1_BOVIN | Structural maintenance of chromosom... | SMC1A | 175 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF072712 mRNA Translation: AAD13141.1 |
PIRi | S71602 |
RefSeqi | NP_777039.1, NM_174614.1 |
Genome annotation databases
Ensembli | ENSBTAT00000023619; ENSBTAP00000023619; ENSBTAG00000017761 |
GeneIDi | 282370 |
KEGGi | bta:282370 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF072712 mRNA Translation: AAD13141.1 |
PIRi | S71602 |
RefSeqi | NP_777039.1, NM_174614.1 |
3D structure databases
SMRi | O97593 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 159631, 1 interactor |
CORUMi | O97593 |
STRINGi | 9913.ENSBTAP00000023619 |
Proteomic databases
PaxDbi | O97593 |
PRIDEi | O97593 |
Genome annotation databases
Ensembli | ENSBTAT00000023619; ENSBTAP00000023619; ENSBTAG00000017761 |
GeneIDi | 282370 |
KEGGi | bta:282370 |
Organism-specific databases
CTDi | 8243 |
VGNCi | VGNC:34997, SMC1A |
Phylogenomic databases
eggNOGi | KOG0018, Eukaryota |
GeneTreei | ENSGT00940000155614 |
HOGENOMi | CLU_001042_0_2_1 |
InParanoidi | O97593 |
OMAi | YMEAIVV |
OrthoDBi | 326079at2759 |
Gene expression databases
ExpressionAtlasi | O97593, baseline and differential |
Family and domain databases
CDDi | cd03275, ABC_SMC1_euk, 2 hits |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR003395, RecF/RecN/SMC_N IPR024704, SMC IPR028468, Smc1_ABC IPR029683, SMC1A_metazoan IPR010935, SMC_hinge IPR036277, SMC_hinge_sf |
PANTHERi | PTHR18937:SF170, PTHR18937:SF170, 1 hit |
Pfami | View protein in Pfam PF06470, SMC_hinge, 1 hit PF02463, SMC_N, 1 hit |
PIRSFi | PIRSF005719, SMC, 1 hit |
SMARTi | View protein in SMART SM00968, SMC_hinge, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF75553, SSF75553, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMC1A_BOVIN | |
Accessioni | O97593Primary (citable) accession number: O97593 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 25, 2003 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families