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Protein

Dystrophin

Gene

DMD

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3302 – 3349ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dystrophin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760741 – 3680DystrophinAdd BLAST3680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3478PhosphoserineBy similarity1
Modified residuei3485PhosphoserineBy similarity1
Modified residuei3495PhosphoserineBy similarity1
Modified residuei3607PhosphoserineBy similarity1
Modified residuei3608PhosphoserineBy similarity1
Modified residuei3612PhosphoserineBy similarity1
Modified residuei3618PhosphoserineBy similarity1
Modified residuei3619PhosphoserineBy similarity1
Modified residuei3661PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O97592

PRoteomics IDEntifications database

More...
PRIDEi
O97592

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYNM (By similarity). Interacts with the syntrophins SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 (By similarity). Interacts with SYNM; SNTA1 and SNTB1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells. Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9615.ENSCAFP00000031637

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O97592

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O97592

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 119Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini134 – 240Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST107
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati340 – 448Spectrin 1Add BLAST109
Repeati449 – 557Spectrin 2Add BLAST109
Repeati560 – 668Spectrin 3Add BLAST109
Repeati720 – 829Spectrin 4Add BLAST110
Repeati831 – 935Spectrin 5Add BLAST105
Repeati944 – 1047Spectrin 6Add BLAST104
Repeati1050 – 1156Spectrin 7Add BLAST107
Repeati1159 – 1265Spectrin 8Add BLAST107
Repeati1268 – 1369Spectrin 9Add BLAST102
Repeati1370 – 1465Spectrin 10Add BLAST96
Repeati1470 – 1570Spectrin 11Add BLAST101
Repeati1573 – 1678Spectrin 12Add BLAST106
Repeati1681 – 1780Spectrin 13Add BLAST100
Repeati1781 – 1876Spectrin 14Add BLAST96
Repeati1879 – 1981Spectrin 15Add BLAST103
Repeati1994 – 2103Spectrin 16Add BLAST110
Repeati2106 – 2210Spectrin 17Add BLAST105
Repeati2213 – 2320Spectrin 18Add BLAST108
Repeati2321 – 2418Spectrin 19Add BLAST98
Repeati2470 – 2572Spectrin 20Add BLAST103
Repeati2575 – 2681Spectrin 21Add BLAST107
Repeati2684 – 2797Spectrin 22Add BLAST114
Repeati2803 – 2925Spectrin 23Add BLAST123
Repeati2930 – 3035Spectrin 24Add BLAST106
Domaini3050 – 3083WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 237Actin-bindingAdd BLAST237
Regioni63 – 72ANK2- and ANK-3 bindingBy similarity10
Regioni1418 – 1915Interaction with SYNMBy similarityAdd BLAST498
Regioni3053 – 3403Interaction with SYNMBy similarityAdd BLAST351
Regioni3461 – 3513Binds to SNTB1By similarityAdd BLAST53

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3302 – 3349ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4286 Eukaryota
COG5069 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005495

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O97592

KEGG Orthology (KO)

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KOi
K10366

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR016344 Dystrophin
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ

The PANTHER Classification System

More...
PANTHERi
PTHR44318:SF1 PTHR44318:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 16 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002341 Dystrophin/utrophin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 22 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O97592-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLWWEEVEDC YEREDVQKKT FTKWVNAQFS KFGKQHIENL FSDLQDGRRL
60 70 80 90 100
LDLLEGLTGQ KLPKEKGSTR VHALNNVNKA LRVLQKNNVD LVNIGSTDIV
110 120 130 140 150
DGNHKLTLGL IWNIILHWQV KNVMKNIMAG LQQTNSEKIL LSWVRQSTRN
160 170 180 190 200
YPQVNVINFT TSWSDGLALN ALIHSHRPDL FDWNSVVCQQ SATQRLEHAF
210 220 230 240 250
NIAKYQLGIE KLLDPEDVAT TYPDKKSILM YITSLFQVLP QQVSIEAIQE
260 270 280 290 300
VEMLPRPSQV TREEHFQIHH QMHYSQQITV SLAQGYERAP SFPKPRFKSY
310 320 330 340 350
AYTQAAYVTT SDPTRSPLPS QHLETPEDKS FGRSLTETEA NLDSYQTALE
360 370 380 390 400
EVLSWLLSAE DALQAQGEIS NDVEEVKEQF HTHEGYMMDL TSHQGRVGNV
410 420 430 440 450
LQLGSQLIGT GKLSEDEETE VQEQMNLLNS RWECLRVASM EKQSNLHKVL
460 470 480 490 500
MDLQNQQLKE LNDWLTKTEE RTRKMEKEPL GPDIEDLKRQ VQQHKVLQED
510 520 530 540 550
LEQEQVRVNS LTHMVVVVDE SSGDHATAAL EEQLKVLGDR WANICRWTED
560 570 580 590 600
RWVLLQDILL KWQRFTEEQC LFSAWLSEKE DAVNKIHTTG FKDQSEVLSN
610 620 630 640 650
LQKLAVLKTD LEKKKQTMDK LCSLNQDLLS ALKNTVVAHK MEAWLDNFAQ
660 670 680 690 700
RWDNLVQKLE KSSAQISQAV TTTQPSLTQT TVMETVTMVT TREHILVKHA
710 720 730 740 750
QEELPPPPPQ KKRQIIVDSE IRKRLDVDIT ELHSWITRSE AVLQSPEFAI
760 770 780 790 800
YRKEGNFSDL KEKVNAIERE KAEKFRKLQD ASRSAQALVE QMVNEGVNAD
810 820 830 840 850
SIKQASEQLN SRWIEFCQLL SERLNWLEYQ NNIITFYNQL QQLEQMTTTA
860 870 880 890 900
ENWLKTQPTT TSEPTAIKSQ LKICKDEINR LSALQPQIER LKIQSIALKE
910 920 930 940 950
KGQGPMFLDA DFVAFTNHFN QVFADVQARE KELQTIFDSL PPMRYQETMS
960 970 980 990 1000
TILTWIQQSE TKLSIPQVTV TEYDIMEQRL GELQALQSSL QEQQNGLNYL
1010 1020 1030 1040 1050
STTVKEMSKK APLSDISRKY QSEFEEIEGR WKKLSSQLVE HCQKLEEQMA
1060 1070 1080 1090 1100
KLRKIQNHIK TLKKWITEVD VFLKEEWPAL GDSEILKRQL KQCRLLVNDI
1110 1120 1130 1140 1150
QTIQPSLNSV NEGAQKMKNE AEPEFAGRLE TELRELNTQW DYMCRQVYAR
1160 1170 1180 1190 1200
KEALKGGLDK TVSLQKDLSE MHEWMTQAEE EYLERDFEYK TPDELQTAVE
1210 1220 1230 1240 1250
EMKRAKEEAQ QKEAKVKLLT ESVNSVIAQA PPAAQEALKK ELDTLTTNYQ
1260 1270 1280 1290 1300
WLCTRLNGKC KTLEEVWACW HELLSYLEKA NKWLSEVEVK LKTTENISGG
1310 1320 1330 1340 1350
AEEIAEVLDS LENLMQHSED NPNQIRILAQ TLTDGGVMDE LINEELETFN
1360 1370 1380 1390 1400
SRWRELHEEA VRRQKLLEQS IQSAQEIEKS LHLIQESLSS IDKQLAAYIA
1410 1420 1430 1440 1450
DKVDAAQMPQ EAQKIQSDLT SHEISLEEMK KHNQGKETAQ RVLSQIDVAQ
1460 1470 1480 1490 1500
KKLQDVSMKF RLFQKPANFE QRLQESKMIL DEVKMHLPAL ETKSVEQEVV
1510 1520 1530 1540 1550
QSQLNHCVNL YKSLSEVKSE VEMVIKTGRQ IVQKKQTENP KELDERVTAL
1560 1570 1580 1590 1600
KLHYNELGAK VTERKQQLEK CLKLSRKMRK EMNALTEWLA ATDMELTKRS
1610 1620 1630 1640 1650
AVEGMPSNLD SEVAWGKATQ KEIEKQKVHL KSVTEVGEAL KTVLGKKEML
1660 1670 1680 1690 1700
VEDKLSLLNS NWIAVTSRAE EWLNLLLEYQ KHMETFDQNV DYITNWIIQA
1710 1720 1730 1740 1750
DALLDESEKK KPQQKEDILK RLKAEMNDIR PKVDSTRDQA ANLMANRGDH
1760 1770 1780 1790 1800
CRKVVEPKIS ELNHRFAAIS HRIKTGKASI PLKELEQFNS DIQKLLEPLE
1810 1820 1830 1840 1850
AEIQQGVNLK EEDFNKDMSE DNEGTVKELL QRGDNLQQRI TDERKREEIK
1860 1870 1880 1890 1900
IKQQLLQTKH NALKDLRSQR RKKALEISHQ WYQYKRQADD LLKCLDDIEK
1910 1920 1930 1940 1950
KLASLPEPRD ERKIKEIDRE LQKKKEELNA VRRQAEGLSE DGAAMAVEPT
1960 1970 1980 1990 2000
QIQLSKRWRE IESKFAQFRR LNFAQIHTVH EESVVAMTED MPLEISYVPS
2010 2020 2030 2040 2050
TYLTEITHVS QALSEVEELL NAPDLCAQDF EDLFKQEESL KNIKDSLQQI
2060 2070 2080 2090 2100
SGRIDIIHNK KTAALHSATP AERAKLQEAL SRLDFQWERV NNMYKDRQGR
2110 2120 2130 2140 2150
FDRSVEKWRR FHYDMKILNQ WLTEAEQFLK KTQIPENWEH AKYKWYLKEL
2160 2170 2180 2190 2200
QDGIGQRQSV VRVLNATGEE IIQQSSKTDA SILQEKLGSL NLRWQEVCKQ
2210 2220 2230 2240 2250
LAERKKRLEE QKNILSEFQR DVNEFVLWLE EADNVANIPL EPGNEQQLKE
2260 2270 2280 2290 2300
KLEQVKLLAE ELPLRQGILK QLNETGGTVL VSAPLSPEEQ DKLENKLKQT
2310 2320 2330 2340 2350
NLQWIKVSRN LPEKQEEIEA HVKDLGQLEE QLNHLLLWLS PIRNQLEIYN
2360 2370 2380 2390 2400
QPNQTGPFDI KEIEVAVQAK QPDVEGILSK GQHLYKEKPA TQPAKRKLED
2410 2420 2430 2440 2450
LSSDWKVVTQ LLQELRAKQP GPAPGLTTVR APPSQTVTLV TQPAVTKETA
2460 2470 2480 2490 2500
ISKLEMPSSL LLEVPALADF NRAWTELTDW LSLLDRVIKS QRVMVGDLED
2510 2520 2530 2540 2550
INEMIIKQKA TLQDLEQRRP QLEELITAAQ NLKNKTSNQE ARTIITDRIE
2560 2570 2580 2590 2600
RIQSQWDEVQ EHLQNRRLQL TEMLKDSTQW LEAKEEAEQV LGQARAKLES
2610 2620 2630 2640 2650
WKEAPYTVDA IQKKITETKQ LAKDLRQWQI NVDVANDLAL KLLRDYSADD
2660 2670 2680 2690 2700
TRKVHMITEN INASWASIHK RLSEREAALE ETHRLLQQFP LDLEKFLAWL
2710 2720 2730 2740 2750
TEAETTANVL QDATHKERLL EDSKGVRELM KQWQDLQGEI EAHTDIYHNL
2760 2770 2780 2790 2800
DENGQKVLRS LEGSDDAALL QRRLDNMNFK WSELRKKSLN IRSHLEASSD
2810 2820 2830 2840 2850
QWKRLHLSLQ ELLVWLQLKD DELSRQAPIG GDFPAVQKQN DVHRAFKREL
2860 2870 2880 2890 2900
KTKEPVIMST LETVRIFLTE QPLEGLEKLY QEPRELPPEE RAQNVTRLLR
2910 2920 2930 2940 2950
KQAEEVNTQW EKLNVHSADW QRKIDEALER LQELQEATDE LDLKLRQAEV
2960 2970 2980 2990 3000
IKGSWQPVGD LLIDSLQDHL EKVKALRGEI TPLKENVSYV NDLARQLTTL
3010 3020 3030 3040 3050
GIQLSPYNLN TLEDLNTRWK LLQVAIEDRI RQLHEAHRDF GPASQHFLST
3060 3070 3080 3090 3100
SVQGPWERAI SPNKVPYYIN HETQTTCWDH PKMTELYQSL ADLNNVRFSA
3110 3120 3130 3140 3150
YRTAMKLRRL QKALCLDLLS LSAACDALDQ HNLKQNDQPM DILQVINCLT
3160 3170 3180 3190 3200
TIYDRLEQEH NNLVNVPLCV DMCLNWLLNV YDTGRTGRIR VLSFKTGIIS
3210 3220 3230 3240 3250
LCKAHLEDKY RYLFKQVASS TGFCDQRRLG LLLHDSIQIP RQLGEVASFG
3260 3270 3280 3290 3300
GSNIEPSVRS CFQFANNKPE IEAALFLDWM RLEPQSMVWL PVLHRVAAAE
3310 3320 3330 3340 3350
TAKHQAKCNI CKECPIIGFR YRSLKHFNYD ICQSCFFSGR VAKGHKMHYP
3360 3370 3380 3390 3400
MVEYCTPTTS GEDVRDFAKV LKNKFRTKRY FAKHPRMGYL PVQTVLEGDN
3410 3420 3430 3440 3450
METPVTLINF WPVDSAPASS PQLSHDDTHS RIEHYASRLK KMENSNGSYL
3460 3470 3480 3490 3500
NDSISPNESI DDEHLLIQHY WRSLNQESPL SQPRSPAQIL ISLESEERGE
3510 3520 3530 3540 3550
LERILADLEG RNRNLQAEYD RLKQQHEHKG LSPLPSPPEM MPTSPQSPRD
3560 3570 3580 3590 3600
AELIAEAKLL RQHKGRLEAR MQILEDHNKQ LESQLHRLRQ LLEQPQAEAK
3610 3620 3630 3640 3650
VNGTTVSSPS TSLQRSDSSQ PMLLRVVGSQ TSESMGEEDL LSPPQDTSTG
3660 3670 3680
LEEVMEQLNH SFPSSRGRNT PGKPMREDTM
Length:3,680
Mass (Da):425,653
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i539F1C9D72377872
GO

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF070485 mRNA Translation: AAC83646.1

NCBI Reference Sequences

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RefSeqi
NP_001003343.1, NM_001003343.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cfa.3738

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
606758

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cfa:606758

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070485 mRNA Translation: AAC83646.1
RefSeqiNP_001003343.1, NM_001003343.1
UniGeneiCfa.3738

3D structure databases

ProteinModelPortaliO97592
SMRiO97592
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000031637

Proteomic databases

PaxDbiO97592
PRIDEiO97592

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi606758
KEGGicfa:606758

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1756

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
HOVERGENiHBG005495
InParanoidiO97592
KOiK10366

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR016344 Dystrophin
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PANTHERiPTHR44318:SF1 PTHR44318:SF1, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 16 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 22 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMD_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O97592
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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