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UniProtKB - O97555 (GDIA_CANLF)
Protein
Rab GDP dissociation inhibitor alpha
Gene
GDI1
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
1 PublicationGO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- Rab GDP-dissociation inhibitor activity Source: UniProtKB
GO - Biological processi
- negative regulation of axonogenesis Source: UniProtKB
- negative regulation of protein targeting to membrane Source: UniProtKB
- protein transport Source: InterPro
- Rab protein signal transduction Source: UniProtKB
- vesicle-mediated transport Source: GO_Central
Keywordsi
Molecular function | GTPase activation |
Names & Taxonomyi
Protein namesi | Recommended name: Rab GDP dissociation inhibitor alphaShort name: Rab GDI alpha Alternative name(s): Guanosine diphosphate dissociation inhibitor 1 Short name: GDI-1 |
Gene namesi | Name:GDI1 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Golgi apparatus
- trans-Golgi network By similarity
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Golgi apparatusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056670 | 1 – 447 | Rab GDP dissociation inhibitor alphaAdd BLAST | 447 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 427 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
Interacts with RHOH (By similarity).
Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9615.ENSCAFP00000028963 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Rab GDI family.Curated
Phylogenomic databases
InParanoidi | O97555 |
OrthoDBi | 763627at2759 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR018203, GDP_dissociation_inhibitor IPR000806, RabGDI |
PANTHERi | PTHR11787, PTHR11787, 1 hit |
Pfami | View protein in Pfam PF00996, GDI, 1 hit |
PRINTSi | PR00892, RABGDI PR00891, RABGDIREP |
SUPFAMi | SSF51905, SSF51905, 2 hits |
i Sequence
Sequence statusi: Complete.
O97555-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE
60 70 80 90 100
ELYKRFQLLE GPPEAMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVVEGSFI YKGGKIYKVP STETEALASN LMGMFEKRRF RKFLVFVANF
160 170 180 190 200
DENDPKTFEG VDPQSTSMRD VYRKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCLETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI
360 370 380 390 400
AIASTTVETA EPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGSESQVFC
410 420 430 440
SCSYDATTHF ETTCNDIKDI YKRMAGSAFD FENMKRKQND VFGEADQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF027360 mRNA Translation: AAD04246.1 |
RefSeqi | NP_001003185.1, NM_001003185.1 |
Genome annotation databases
GeneIDi | 403819 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF027360 mRNA Translation: AAD04246.1 |
RefSeqi | NP_001003185.1, NM_001003185.1 |
3D structure databases
SMRi | O97555 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9615.ENSCAFP00000028963 |
Genome annotation databases
GeneIDi | 403819 |
Organism-specific databases
CTDi | 2664 |
Phylogenomic databases
InParanoidi | O97555 |
OrthoDBi | 763627at2759 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR018203, GDP_dissociation_inhibitor IPR000806, RabGDI |
PANTHERi | PTHR11787, PTHR11787, 1 hit |
Pfami | View protein in Pfam PF00996, GDI, 1 hit |
PRINTSi | PR00892, RABGDI PR00891, RABGDIREP |
SUPFAMi | SSF51905, SSF51905, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GDIA_CANLF | |
Accessioni | O97555Primary (citable) accession number: O97555 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families