Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 128 (11 Dec 2019)
Sequence version 1 (01 May 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Inositol-3-phosphate synthase

Gene

Inos

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: myo-inositol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase (Inos)
  2. Inositol-1-monophosphatase (IMP), Putative inositol monophosphatase 3 (CG15743), Inositol-1-monophosphatase (cg17026), Inositol-1-monophosphatase, Inositol-1-monophosphatase (CG17029), Inositol-1-monophosphatase (IMP), Inositol-1-monophosphatase (CG17028-RA), Inositol-1-monophosphatase (IMP), Inositol-1-monophosphatase (CG17028-RA), Inositol-1-monophosphatase, Inositol-1-monophosphatase (Dmel\CG9391)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processInositol biosynthesis, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1855183 Synthesis of IP2, IP, and Ins in the cytosol

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00823;UER00787

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol-3-phosphate synthase (EC:5.5.1.4)
Short name:
MIP synthase
Alternative name(s):
Myo-inositol 1-phosphate synthase
Short name:
IPS
Short name:
MI-1-P synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Inos
ORF Names:CG11143
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0025885 Inos

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001951821 – 565Inositol-3-phosphate synthaseAdd BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei536Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O97477

PRoteomics IDEntifications database

More...
PRIDEi
O97477

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O97477

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Higher expression in adult heads than bodies.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0025885 Expressed in 32 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O97477 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
61549, 69 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088368

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O97477

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0693 Eukaryota
COG1260 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018395

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O97477

KEGG Orthology (KO)

More...
KOi
K01858

Identification of Orthologs from Complete Genome Data

More...
OMAi
EGWDNID

Database of Orthologous Groups

More...
OrthoDBi
451916at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O97477

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002587 Myo-inos-1-P_Synthase
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11510 PTHR11510, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01658 Inos-1-P_synth, 1 hit
PF07994 NAD_binding_5, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015578 Myoinos-ppht_syn, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O97477-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPTNNSTLE VISPKVQVDD EFITTDYDYQ TSHVKRTADG QLQVHPQTTS
60 70 80 90 100
LKIRTGRHVP KLGVMLVGWG GNNGSTLTAA LEANRRQLKW RKRTGVQEAN
110 120 130 140 150
WYGSITQAST VFIGSDEDGG DVYVPMKELL PMVEPDNIIV DGWDISGLHL
160 170 180 190 200
GDAMRRAEVL DVALQDQIYD QLAQLRPRPS IYDPDFIAAN QSDRADNVIR
210 220 230 240 250
GTRLEQYEQI RKDIRDFRER SGVDSVIVLW TANTERFADV QPGLNTTSQE
260 270 280 290 300
LIASLEANHS EVSPSTIFAM ASIAEGCTYI NGSPQNTFVP GLIQLAEEKN
310 320 330 340 350
VFIAGDDFKS GQTKIKSVLV DFLVGAGIKP VSIASYNHLG NNDGKNLSAP
360 370 380 390 400
QQFRSKEISK SNVVDDMVAS NRLLYGPDEH PDHVVVIKYV PYVGDSKRAM
410 420 430 440 450
DEYTSEIMMG GHNTLVIHNT CEDSLLATPL ILDLVILGEL STRIQLRNAE
460 470 480 490 500
KESAPWVPFK PVLSLLSYLC KAPLVPQGSQ VVNSLFRQRA AIENILRGCI
510 520 530 540 550
GLPPISHMTL EQRFDFSTIT NEPPLKRVKI LGQPCSVESV TNGKKLHANG
560
HSNGSAKLAT NGNGH
Length:565
Mass (Da):62,249
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CF53D0D27BE186F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324V → L in AAN71315 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF071103 mRNA Translation: AAD02819.1
AF071104 Genomic DNA Translation: AAD13140.1
AE013599 Genomic DNA Translation: AAF59252.1
AY122137 mRNA Translation: AAM52649.1
BT001560 mRNA Translation: AAN71315.1 Sequence problems.
BT001772 mRNA Translation: AAN71527.1

NCBI Reference Sequences

More...
RefSeqi
NP_477405.1, NM_058057.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089329; FBpp0088368; FBgn0025885

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35671

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11143

UCSC genome browser

More...
UCSCi
CG11143-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071103 mRNA Translation: AAD02819.1
AF071104 Genomic DNA Translation: AAD13140.1
AE013599 Genomic DNA Translation: AAF59252.1
AY122137 mRNA Translation: AAM52649.1
BT001560 mRNA Translation: AAN71315.1 Sequence problems.
BT001772 mRNA Translation: AAN71527.1
RefSeqiNP_477405.1, NM_058057.6

3D structure databases

SMRiO97477
ModBaseiSearch...

Protein-protein interaction databases

BioGridi61549, 69 interactors
STRINGi7227.FBpp0088368

PTM databases

iPTMnetiO97477

Proteomic databases

PaxDbiO97477
PRIDEiO97477

Genome annotation databases

EnsemblMetazoaiFBtr0089329; FBpp0088368; FBgn0025885
GeneIDi35671
KEGGidme:Dmel_CG11143
UCSCiCG11143-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35671
FlyBaseiFBgn0025885 Inos

Phylogenomic databases

eggNOGiKOG0693 Eukaryota
COG1260 LUCA
GeneTreeiENSGT00390000018395
InParanoidiO97477
KOiK01858
OMAiEGWDNID
OrthoDBi451916at2759
PhylomeDBiO97477

Enzyme and pathway databases

UniPathwayiUPA00823;UER00787
ReactomeiR-DME-1855183 Synthesis of IP2, IP, and Ins in the cytosol

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35671

Protein Ontology

More...
PROi
PR:O97477

Gene expression databases

BgeeiFBgn0025885 Expressed in 32 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)
GenevisibleiO97477 DM

Family and domain databases

InterProiView protein in InterPro
IPR002587 Myo-inos-1-P_Synthase
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11510 PTHR11510, 1 hit
PfamiView protein in Pfam
PF01658 Inos-1-P_synth, 1 hit
PF07994 NAD_binding_5, 1 hit
PIRSFiPIRSF015578 Myoinos-ppht_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINO1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O97477
Secondary accession number(s): Q8IGW1, Q8MR42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 1999
Last modified: December 11, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again