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Protein

Metallothionein-1

Gene
N/A
Organism
Tetrahymena pyriformis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions. Binds 12 cadmium ions per molecule.

GO - Molecular functioni

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Cleaved into the following chain:
Metallothionein-2
Short name:
MT-2
OrganismiTetrahymena pyriformis
Taxonomic identifieri5908 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000186701 – 21 Publication2
ChainiPRO_00000186713 – 107Metallothionein-1Add BLAST105
ChainiPRO_00000186724 – 107Metallothionein-2Add BLAST104

Expressioni

Inductioni

By cadmium.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR012484 Metalthion_7
PfamiView protein in Pfam
PF07846 Metallothio_Cad, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKVNNNCCC GENAKPCCTD PNSGCCCVSE TNNCCKSDKK ECCTGTGEGC
60 70 80 90 100
KCTGCKCCEP AKSGCCCGDK AKACCTDPNS GCCCSSKTNK CCDSTNKTEC

KTCECCK
Length:107
Mass (Da):11,097
Last modified:May 1, 1999 - v1
Checksum:i5ABE87BDDA8E465C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005080 Genomic DNA Translation: CAA06337.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005080 Genomic DNA Translation: CAA06337.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012484 Metalthion_7
PfamiView protein in Pfam
PF07846 Metallothio_Cad, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_TETPY
AccessioniPrimary (citable) accession number: O97388
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
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