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Entry version 84 (08 May 2019)
Sequence version 2 (01 Oct 2000)
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Protein

GRIP and coiled-coil domain-containing protein PFC0235w

Gene

PFC0235w

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PFC0235W-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein PFC0235w
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PFC0235w
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0305200

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Possible candidate for an effective malaria vaccine as determined by epitope response in sera.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003640211 – 1139GRIP and coiled-coil domain-containing protein PFC0235wAdd BLAST1139

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O97237

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Developmental stagei

Merozoite

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
1209621, 5 interactors

Protein interaction database and analysis system

More...
IntActi
O97237, 6 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O97237

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1084 – 1135GRIPPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili467 – 649Sequence analysisAdd BLAST183
Coiled coili753 – 913Sequence analysisAdd BLAST161

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 462Asn-richSequence analysisAdd BLAST461
Compositional biasi927 – 1033Asn-richSequence analysisAdd BLAST107

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O97237

Identification of Orthologs from Complete Genome Data

More...
OMAi
DYDNIKS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O97237

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000237 GRIP_dom

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50913 GRIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O97237-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFCDNNEMN ETKNFMMSNK NDDIVVDCDE YIDGNVFEKN TNMGNIYDEN
60 70 80 90 100
YNVDMKNDNL LSKLNDNISF TYTTNGQVEG QENEIKEKQN ILHYQIYIDN
110 120 130 140 150
DEDKYKYCSN SNLHKNEEEH EKGSPNNIYE ELDNNLEKKY FYYNSDSKHC
160 170 180 190 200
IDEKNETNDL ENENVVTSMD VSYENVLNDN FIKSRSTSIN YTDNSFVLNK
210 220 230 240 250
ENLKSSHHIN GYYINDHDNI KSDIINDHDN IKSDIINDYD NIKGDKINEY
260 270 280 290 300
DNIKSDKIND YDNIKSDIIN DYDNIKSDKI NDYDNIKSDK INDYDNIKSD
310 320 330 340 350
KINDYDNIKS DKINDYDNIK SDKINHYDNI KSDKINDYDN IKSDKINDYD
360 370 380 390 400
NIKSDKINDY DNIKYNDDSQ INNNVSNKVN SPDDDPNTYE KDKKDIINCN
410 420 430 440 450
IYEENKNNMN NIIHNDKENI HMVDTGKNEE NNNIDNKNND DINKVNVLTR
460 470 480 490 500
VDTENYILNE ENILPLHTND DVTKLLDEIN DLKNTIENMK KEKINLLSKF
510 520 530 540 550
KAYTLNNKKE LEELKIKCKN KEEQIKMYEN KLQNKEDEIM NYVNEIQNKD
560 570 580 590 600
KKIESYHIKL HNKEEEIMNY VNEIQNKEEE IIKYVNELQN SDVQKEKKEL
610 620 630 640 650
KTINEVLKNT NEKLEKEITS LLGEMKKIEE ENKVLKIFKE EKNKINNEKV
660 670 680 690 700
TQIKGDDIND DNDMKFKQIL LDNKTFNKLL VNELNIVEEN ILFCFSIDKD
710 720 730 740 750
KNRLLVCIKQ NDDNFFVIPN CIFDEKFPGL QKKTESMIIQ DIHEKEILEL
760 770 780 790 800
KNKQMNELYI LKKEKEDIYK EYEEYKKKVT SLINETNYNY KNIEEKENEI
810 820 830 840 850
KELNNTLNKY KEEMNNYKEE IIVINEKYKL LEIELCKEKN IRDQQNVGIS
860 870 880 890 900
DLKKKMLKEK IELEKKYKEQ YEKETQQKIN DMKIIFDNKE KILQDQIDDL
910 920 930 940 950
LHKIEKLTFS NDEKTKTIEN LQIYMDNDDN IMNQEGIQKN EKKQIIDNPI
960 970 980 990 1000
NTDEKDLLNY IPDNHINSDL NHINSNVEND YVEKRNKNNV HLSKKETNYQ
1010 1020 1030 1040 1050
HNINEQENDN NNNNNNNNNN NNVEKLKSIN STNTSIPIYP YEYKKIRKKL
1060 1070 1080 1090 1100
ETYEILLNEQ QEGKKKMTEE INSLKNQVKN YESINGNYQH IIYQKNILSN
1110 1120 1130
FIAQIPSRIQ VDDYVSVIFN SFNFSNQEIE AINIKRSKK
Length:1,139
Mass (Da):135,723
Last modified:October 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i761530047DA11FF9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844502 Genomic DNA Translation: CAB39003.2

NCBI Reference Sequences

More...
RefSeqi
XP_001351128.1, XM_001351092.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAB39003; CAB39003; PF3D7_0305200

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0305200.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
814370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0305200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844502 Genomic DNA Translation: CAB39003.2
RefSeqiXP_001351128.1, XM_001351092.1

3D structure databases

SMRiO97237
ModBaseiSearch...

Protein-protein interaction databases

BioGridi1209621, 5 interactors
IntActiO97237, 6 interactors

Proteomic databases

PRIDEiO97237

Genome annotation databases

EnsemblProtistsiCAB39003; CAB39003; PF3D7_0305200
GeneDBiPF3D7_0305200.1:pep
GeneIDi814370
KEGGipfa:PF3D7_0305200

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0305200

Phylogenomic databases

InParanoidiO97237
OMAiDYDNIKS
PhylomeDBiO97237

Enzyme and pathway databases

BioCyciPLASMO:PFC0235W-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYGCC1_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O97237
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 84 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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