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UniProtKB - O97182 (O97182_DROME)
Protein
Actin-related protein 2/3 complex subunit
Gene
Arpc1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
UniRule annotationGO - Molecular functioni
- actin filament binding Source: GO_Central
- structural constituent of cytoskeleton Source: FlyBase
GO - Biological processi
- actin filament-based process Source: FlyBase
- actin filament reorganization involved in cell cycle Source: FlyBase
- Arp2/3 complex-mediated actin nucleation Source: FlyBase
- axonal fasciculation Source: FlyBase
- axonogenesis Source: FlyBase
- cell adhesion mediated by integrin Source: FlyBase
- cell morphogenesis Source: FlyBase
- chaeta morphogenesis Source: FlyBase
- compound eye morphogenesis Source: FlyBase
- intracellular protein transport Source: FlyBase
- nuclear envelope budding Source: FlyBase
- positive regulation of filopodium assembly Source: FlyBase
- pseudocleavage involved in syncytial blastoderm formation Source: FlyBase
- regulation of actin filament polymerization Source: InterPro
Keywordsi
Molecular function | Actin-bindingUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-DME-2029482, Regulation of actin dynamics for phagocytic cup formation R-DME-5663213, RHO GTPases Activate WASPs and WAVEs R-DME-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-related protein 2/3 complex subunitUniRule annotation |
Gene namesi | Name:Arpc1Imported Synonyms:34DdImported, ARC-P41Imported, Arc41Imported, arc41Imported, ArcP41Imported, ARPC1Imported, ArpC1Imported, arpc1Imported, BG:DS00941.7Imported, br32Imported, D-sop2Imported, Dmel\CG8978Imported, DSop2Imported, Dsop2Imported, l(2)34DdImported, l(2)br32Imported, l(2)Sop2Imported, p41Imported, p42Imported, sopImported, Sop2Imported, sop2Imported, Spo2Imported ORF Names:CG8978Imported, Dmel_CG8978Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0001961, Arpc1 |
VEuPathDBi | VectorBase:FBgn0001961 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- Arp2/3 protein complex Source: FlyBase
Cytosol
- cytosol Source: FlyBase
Nucleus
- nuclear lamina Source: FlyBase
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0001961, Expressed in embryonic/larval hemocyte (Drosophila) and 52 other tissues |
Interactioni
GO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7227.FBpp0080146 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 51 – 82 | WDPROSITE-ProRule annotationAdd BLAST | 32 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1523, Eukaryota |
GeneTreei | ENSGT00950000183183 |
HOGENOMi | CLU_034396_1_0_1 |
OMAi | YVWEPSP |
OrthoDBi | 848569at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR030140, ARC1A IPR017383, ARPC1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10709, PTHR10709, 1 hit PTHR10709:SF11, PTHR10709:SF11, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 1 hit |
PIRSFi | PIRSF038093, ARP2/3_su1, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O97182-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAETYTFGTS LASITCHAWN KDRTQIALSP NNHEIHIYSR EGSDWKLADV
60 70 80 90 100
LNQHDLRVMG IDWAKNTNRI VSCAADRNAY VWTQGDDGKW KPALVLLRIN
110 120 130 140 150
RAATCVKWSP AENKFAVGSG ARLISVCYFE SENDWWVSKH IKKPIRSTVT
160 170 180 190 200
SLDWHPNNVL LLAGSTDYKV RVFSAFIKDI EEPPTPTPWG NRKPLGQLMA
210 220 230 240 250
EFRNSQTSGG GWINSVSFSS DGNKVCWVGH DSCVSIADAT NGNTVIRCRT
260 270 280 290 300
GYLPFLSCEW VSPTSVVVAG YSCVPLLYSL TADGKLVLSG KLDKSQKKES
310 320 330 340 350
SGITAMRIFQ SMDRNMRTEN TDTVVDSIHQ NAITSVRLYA GDKASATKVS
360 370
TSGVDGQLVI WNVEQGGING GMRNLQI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53339.1 AY058778 mRNA Translation: AAL14007.1 AE014134 Genomic DNA Translation: AAN10852.1 AJ133649 mRNA Translation: CAB38634.1 |
RefSeqi | NP_476596.1, NM_057248.5 NP_723845.1, NM_165063.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0080569; FBpp0080146; FBgn0001961 FBtr0080570; FBpp0080147; FBgn0001961 |
GeneIDi | 34793 |
KEGGi | dme:Dmel_CG8978 |
UCSCi | CG8978-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53339.1 AY058778 mRNA Translation: AAL14007.1 AE014134 Genomic DNA Translation: AAN10852.1 AJ133649 mRNA Translation: CAB38634.1 |
RefSeqi | NP_476596.1, NM_057248.5 NP_723845.1, NM_165063.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0080146 |
Protocols and materials databases
DNASUi | 34793 |
Genome annotation databases
EnsemblMetazoai | FBtr0080569; FBpp0080146; FBgn0001961 FBtr0080570; FBpp0080147; FBgn0001961 |
GeneIDi | 34793 |
KEGGi | dme:Dmel_CG8978 |
UCSCi | CG8978-RA, d. melanogaster |
Organism-specific databases
CTDi | 34793 |
FlyBasei | FBgn0001961, Arpc1 |
VEuPathDBi | VectorBase:FBgn0001961 |
Phylogenomic databases
eggNOGi | KOG1523, Eukaryota |
GeneTreei | ENSGT00950000183183 |
HOGENOMi | CLU_034396_1_0_1 |
OMAi | YVWEPSP |
OrthoDBi | 848569at2759 |
Enzyme and pathway databases
Reactomei | R-DME-2029482, Regulation of actin dynamics for phagocytic cup formation R-DME-5663213, RHO GTPases Activate WASPs and WAVEs R-DME-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
BioGRID-ORCSi | 34793, 0 hits in 3 CRISPR screens |
GenomeRNAii | 34793 |
Gene expression databases
Bgeei | FBgn0001961, Expressed in embryonic/larval hemocyte (Drosophila) and 52 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR030140, ARC1A IPR017383, ARPC1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10709, PTHR10709, 1 hit PTHR10709:SF11, PTHR10709:SF11, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 1 hit |
PIRSFi | PIRSF038093, ARP2/3_su1, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | O97182_DROME | |
Accessioni | O97182Primary (citable) accession number: O97182 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | January 19, 2022 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |