Actin-related protein 2/3 complex subunit

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin filament binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• structural constituent of cytoskeleton Source: FlyBase <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex."
    Hudson A.M., Cooley L.
    J Cell Biol 156:677-687(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• actin filament-based process Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Arp2/3-dependent pseudocleavage furrow assembly in syncytial Drosophila embryos."
    Stevenson V., Hudson A., Cooley L., Theurkauf W.E.
    Curr Biol 12:705-711(2002) [PubMed] [Europe PMC] [Abstract]
• actin filament reorganization involved in cell cycle Source: FlyBaseInferred from mutant phenotypeⁱ
  • "SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila."
    Zallen J.A., Cohen Y., Hudson A.M., Cooley L., Wieschaus E., Schejter E.D.
    J Cell Biol 156:689-701(2002) [PubMed] [Europe PMC] [Abstract]
• Arp2/3 complex-mediated actin nucleation Source: FlyBaseInferred from sequence or structural similarityⁱ
  • "A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex."
    Hudson A.M., Cooley L.
    J Cell Biol 156:677-687(2002) [PubMed] [Europe PMC] [Abstract]
• axonal fasciculation Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila."
    Zallen J.A., Cohen Y., Hudson A.M., Cooley L., Wieschaus E., Schejter E.D.
    J Cell Biol 156:689-701(2002) [PubMed] [Europe PMC] [Abstract]
• axonogenesis Source: FlyBaseInferred from genetic interactionⁱ
  • "SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila."
    Zallen J.A., Cohen Y., Hudson A.M., Cooley L., Wieschaus E., Schejter E.D.
    J Cell Biol 156:689-701(2002) [PubMed] [Europe PMC] [Abstract]
• cell adhesion mediated by integrin Source: FlyBaseInferred from mutant phenotypeⁱ
  • "WAVE forms hetero- and homo-oligomeric complexes at integrin junctions in Drosophila visualized by bimolecular fluorescence complementation."
    Gohl C., Banovic D., Grevelhorster A., Bogdan S.
    J Biol Chem 285:40171-40179(2010) [PubMed] [Europe PMC] [Abstract]
• cell morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis."
    D'Ambrosio M.V., Vale R.D.
    J Cell Biol 191:471-478(2010) [PubMed] [Europe PMC] [Abstract]
• chaeta morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila."
    Zallen J.A., Cohen Y., Hudson A.M., Cooley L., Wieschaus E., Schejter E.D.
    J Cell Biol 156:689-701(2002) [PubMed] [Europe PMC] [Abstract]
• compound eye morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila."
    Zallen J.A., Cohen Y., Hudson A.M., Cooley L., Wieschaus E., Schejter E.D.
    J Cell Biol 156:689-701(2002) [PubMed] [Europe PMC] [Abstract]
• intracellular protein transport Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors."
    Rajan A., Tien A.C., Haueter C.M., Schulze K.L., Bellen H.J.
    Nat Cell Biol 11:815-824(2009) [PubMed] [Europe PMC] [Abstract]
• nuclear envelope budding Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila Wash and the Wash regulatory complex function in nuclear envelope budding."
    Verboon J.M., Nakamura M., Davidson K.A., Decker J.R., Nandakumar V., Parkhurst S.M.
    J Cell Sci 133:jcs243576-jcs243576(2020) [PubMed] [Europe PMC] [Abstract]
• positive regulation of filopodium assembly Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model."
    Goncalves-Pimentel C., Gombos R., Mihaly J., Sanchez-Soriano N., Prokop A.
    PLoS One 6:e18340-e18340(2011) [PubMed] [Europe PMC] [Abstract]
• pseudocleavage involved in syncytial blastoderm formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Arp2/3-dependent pseudocleavage furrow assembly in syncytial Drosophila embryos."
    Stevenson V., Hudson A., Cooley L., Theurkauf W.E.
    Curr Biol 12:705-711(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of actin filament polymerization Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• actin filament binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAETYTFGTS LASITCHAWN KDRTQIALSP NNHEIHIYSR EGSDWKLADV 
        60         70         80         90        100
LNQHDLRVMG IDWAKNTNRI VSCAADRNAY VWTQGDDGKW KPALVLLRIN 
       110        120        130        140        150
RAATCVKWSP AENKFAVGSG ARLISVCYFE SENDWWVSKH IKKPIRSTVT 
       160        170        180        190        200
SLDWHPNNVL LLAGSTDYKV RVFSAFIKDI EEPPTPTPWG NRKPLGQLMA 
       210        220        230        240        250
EFRNSQTSGG GWINSVSFSS DGNKVCWVGH DSCVSIADAT NGNTVIRCRT 
       260        270        280        290        300
GYLPFLSCEW VSPTSVVVAG YSCVPLLYSL TADGKLVLSG KLDKSQKKES 
       310        320        330        340        350
SGITAMRIFQ SMDRNMRTEN TDTVVDSIHQ NAITSVRLYA GDKASATKVS 
       360        370 
TSGVDGQLVI WNVEQGGING GMRNLQI                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ