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UniProtKB - O97157 (ADAS_TRYBB)
Protein
Alkyldihydroxyacetonephosphate synthase
Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Functioni
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
By similarityCatalytic activityi
- a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H+EC:2.5.1.26
Cofactori
FADBy similarity
: ether lipid biosynthesis Pathwayi
This protein is involved in the pathway ether lipid biosynthesis, which is part of Glycerolipid metabolism.View all proteins of this organism that are known to be involved in the pathway ether lipid biosynthesis and in Glycerolipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 342 | Important for enzyme activityBy similarity | 1 | |
Binding sitei | 437 | SubstrateBy similarity | 1 | |
Active sitei | 498 | Proton donor/acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 158 – 164 | FADBy similarity | 7 | |
Nucleotide bindingi | 228 – 234 | FADBy similarity | 7 | |
Nucleotide bindingi | 241 – 244 | FADBy similarity | 4 | |
Nucleotide bindingi | 291 – 297 | FADBy similarity | 7 |
GO - Molecular functioni
- alkylglycerone-phosphate synthase activity Source: UniProtKB
- FAD binding Source: UniProtKB
- oxidoreductase activity Source: InterPro
GO - Biological processi
- ether lipid biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
BRENDAi | 2.5.1.26, 6519 |
UniPathwayi | UPA00781 |
Names & Taxonomyi
Protein namesi | Recommended name: Alkyldihydroxyacetonephosphate synthase (EC:2.5.1.26)Short name: Alkyl-DHAP synthase Alternative name(s): Alkylglycerone-phosphate synthase |
Organismi | Trypanosoma brucei brucei |
Taxonomic identifieri | 5702 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Trypanosoma › |
Subcellular locationi
Peroxisome
- Peroxisome By similarity
Peroxisome
- peroxisome Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000128180 | 1 – 613 | Alkyldihydroxyacetonephosphate synthaseAdd BLAST | 613 |
Interactioni
Subunit structurei
Homodimer.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 307 | FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 534 – 536 | Important for enzyme activityBy similarity | 3 | |
Regioni | 572 – 593 | DisorderedSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 611 – 613 | Microbody targeting signalSequence analysis | 3 |
Sequence similaritiesi
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.Curated
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.43.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
i Sequence
Sequence statusi: Complete.
O97157-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKRMITDAF EEIKWNGWGD TGVCIKYDEA RQLPIHTNGK PMKHLLKFMK
60 70 80 90 100
DDVLKVKGEF KIKPTPGLTK EEAIKRLPPP VVKQPFVDEL RQVLSKDQIR
110 120 130 140 150
LDAYARLTHI FGKNYRDLWR VRRGMIDRPP DAVILPNNHD DCVKIMELAQ
160 170 180 190 200
KHNVVVVPFG GGTNVTGGVE PNPFETRRMV ISIDMRRMGR MLHIDTESGT
210 220 230 240 250
AVFEVGVLGP DIDEQLSRYG FMMGHDPDSY AYSTLGGWIA ARGSGAMSNK
260 270 280 290 300
YGDIENMILA MRVVTPVGVV ETPLTSRPCG VDLNAMFVGS EGAFGLVTEA
310 320 330 340 350
VVKIERLPEV KRYEGWLFPS FEVAFTAFHT CTRKGIHPCT MRLYDEDDTR
360 370 380 390 400
LSFAASTDSG LVSTFFSKCF KKYIATVKGW NLSKISLVVV GFEGTKAQTN
410 420 430 440 450
CQRSELVGVF QAFGATCLGT KPGNTWQEKK YDLPYLRDFA LAHNFWADVF
460 470 480 490 500
ETSVLYTDAI HCWRAVKKSF AEVMAENGKN AWIGCHTAHQ YRFGCCLYFT
510 520 530 540 550
FIGGQADEND LKIFLQVKKR AMEVMLQHRG NLTHHHGIGY EHVPWMKRYN
560 570 580 590 600
GEGGLDAIMK FKKALDPKNI CNPGKLLPSP PSEKETPKAT QARQNREMMF
610
DKMGIPGALQ AHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF119091 Genomic DNA Translation: AAD19697.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF119091 Genomic DNA Translation: AAD19697.1 |
3D structure databases
SMRi | O97157 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00781 |
BRENDAi | 2.5.1.26, 6519 |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.43.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAS_TRYBB | |
Accessioni | O97157Primary (citable) accession number: O97157 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | September 29, 2021 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families