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Entry version 170 (29 Sep 2021)
Sequence version 1 (01 May 1999)
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Protein

G-protein coupled receptor Mth

Gene

mth

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up-regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro.

4 Publications

Miscellaneous

Agonists of mth share minimal sequence homology, suggesting a remarkable promiscuity of mth for activation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processExocytosis, Neurotransmitter transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.14.2, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor Mth
Alternative name(s):
Protein methuselah
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mth
ORF Names:CG6936
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0023000, mth

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0023000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 218ExtracellularSequence analysisAdd BLAST194
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei219 – 239Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini240 – 248CytoplasmicSequence analysis9
Transmembranei249 – 269Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini270 – 278ExtracellularSequence analysis9
Transmembranei279 – 299Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini300 – 320CytoplasmicSequence analysisAdd BLAST21
Transmembranei321 – 341Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini342 – 370ExtracellularSequence analysisAdd BLAST29
Transmembranei371 – 391Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini392 – 424CytoplasmicSequence analysisAdd BLAST33
Transmembranei425 – 445Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini446 – 454ExtracellularSequence analysis9
Transmembranei455 – 475Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini476 – 514CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature and dietary paraquat, a free-radical generator.1 Publication

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3309000

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Add BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001302025 – 514G-protein coupled receptor MthAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 83Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi85 ↔ 90Combined sources2 Publications
Disulfide bondi94 ↔ 188Combined sources2 Publications
Disulfide bondi95 ↔ 106Combined sources2 Publications
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi150 ↔ 209Combined sources2 Publications
Glycosylationi170N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O97148

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O97148

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0023000, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O97148, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O97148, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
63614, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072470

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O97148

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O97148

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O97148

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168274

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002753_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O97148

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFCITAG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O97148

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00251, Mth_Ecto, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.180.11, 1 hit
2.30.160.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR044860, Methusela_ecto_dom_1
IPR023311, Methusela_ecto_dom_2
IPR010596, Methuselah_N_dom
IPR036272, Methuselah_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF06652, Methuselah_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63877, SSF63877, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: O97148-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTLLVLRIS TVILVVLVIQ KSYADILECD YFDTVDISAA QKLQNGSYLF
60 70 80 90 100
EGLLVPAILT GEYDFRILPD DSKQKVARHI RGCVCKLKPC VRFCCPHDHI
110 120 130 140 150
MDNGVCYDNM SDEELAELDP FLNVTLDDGS VSRRHFKNEL IVQWDLPMPC
160 170 180 190 200
DGMFYLDNRE EQDKYTLFEN GTFFRHFDRV TLRKREYCLQ HLTFADGNAT
210 220 230 240 250
SIRIAPHNCL IVPSITGQTV VMISSLICMV LTIAVYLFVK KLQNLHGKCF
260 270 280 290 300
ICYMVCLFMG YLFLLLDLWQ ISISFCKPAG FLGYFFVMAA FFWLSVISLH
310 320 330 340 350
LWNTFRGSSH KANRFLFEHR FLAYNTYAWG MAVVLTGITV LADNIVENQD
360 370 380 390 400
WNPRVGHEGH CWIYTQAWSA MLYFYGPMVF LIAFNITMFI LTAKRILGVK
410 420 430 440 450
KDIQNFAHRQ ERKQKLNSDK QTYTFFLRLF IIMGLSWSLE IGSYFSQSNQ
460 470 480 490 500
TWANVFLVAD YLNWSQGIII FILFVLKRST WRLLQESIRG EGEEVNNSEE
510
EISLENTTTR NVLL
Length:514
Mass (Da):59,644
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2A5370CECCD1D5C
GO
Isoform B (identifier: O97148-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     487-514: SIRGEGEEVNNSEEEISLENTTTRNVLL → RNHPKSTRSVISNRSMASRITVGTTPKNKARNSPLA

Show »
Length:522
Mass (Da):60,446
Checksum:i81C85F368E891600
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JHX3E1JHX3_DROME
Methuselah, isoform E
mth Dmel\CG6936, MTH, Mth, CG6936, Dmel_CG6936
514Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG22708 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22709 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22710 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22711 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22712 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22713 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22714 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22715 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22716 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22717 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22718 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22719 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22720 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22721 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22722 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22723 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22724 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22725 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22726 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22727 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22728 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22729 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22730 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22731 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22732 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22733 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22734 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22735 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22736 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22737 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG22738 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti54L → I in strain: MA97_6. 1 Publication1
Natural varianti132S → A in strain: ZIM(S)49 and ZIM(H)44. 1 Publication1
Natural varianti151D → N in strain: CT97_3, MFL97_1 and ZIM(S)37. 1 Publication1
Natural varianti281F → V in strain: ZIM(S)49 and ZIM(H)44. 1 Publication1
Natural varianti357H → N in strain: DPF96_3.0, HFL97_15, JFL97_1, JFL97_9 and ZIM(S)37. 1 Publication1
Natural varianti387T → N in strain: ZIM(S)35. 1 Publication1
Natural varianti407A → V in strain: ZIM(H)23. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002023487 – 514SIRGE…RNVLL → RNHPKSTRSVISNRSMASRI TVGTTPKNKARNSPLA in isoform B. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF109308 mRNA Translation: AAD16981.1
AF280552 Genomic DNA Translation: AAG22708.1 Sequence problems.
AF280553 Genomic DNA Translation: AAG22709.1 Sequence problems.
AF280554 Genomic DNA Translation: AAG22710.1 Sequence problems.
AF280555 Genomic DNA Translation: AAG22711.1 Sequence problems.
AF280556 Genomic DNA Translation: AAG22712.1 Sequence problems.
AF280557 Genomic DNA Translation: AAG22713.1 Sequence problems.
AF280558 Genomic DNA Translation: AAG22714.1 Sequence problems.
AF280559 Genomic DNA Translation: AAG22715.1 Sequence problems.
AF280560 Genomic DNA Translation: AAG22716.1 Sequence problems.
AF280561 Genomic DNA Translation: AAG22717.1 Sequence problems.
AF280562 Genomic DNA Translation: AAG22718.1 Sequence problems.
AF280563 Genomic DNA Translation: AAG22719.1 Sequence problems.
AF280564 Genomic DNA Translation: AAG22720.1 Sequence problems.
AF280565 Genomic DNA Translation: AAG22721.1 Sequence problems.
AF280566 Genomic DNA Translation: AAG22722.1 Sequence problems.
AF280567 Genomic DNA Translation: AAG22723.1 Sequence problems.
AF280568 Genomic DNA Translation: AAG22724.1 Sequence problems.
AF280569 Genomic DNA Translation: AAG22725.1 Sequence problems.
AF280570 Genomic DNA Translation: AAG22726.1 Sequence problems.
AF280571 Genomic DNA Translation: AAG22727.1 Sequence problems.
AF280572 Genomic DNA Translation: AAG22728.1 Sequence problems.
AF280573 Genomic DNA Translation: AAG22729.1 Sequence problems.
AF280574 Genomic DNA Translation: AAG22730.1 Sequence problems.
AF280575 Genomic DNA Translation: AAG22731.1 Sequence problems.
AF280576 Genomic DNA Translation: AAG22732.1 Sequence problems.
AF280577 Genomic DNA Translation: AAG22733.1 Sequence problems.
AF280578 Genomic DNA Translation: AAG22734.1 Sequence problems.
AF280579 Genomic DNA Translation: AAG22735.1 Sequence problems.
AF280580 Genomic DNA Translation: AAG22736.1 Sequence problems.
AF280581 Genomic DNA Translation: AAG22737.1 Sequence problems.
AF280582 Genomic DNA Translation: AAG22738.1 Sequence problems.
AE014296 Genomic DNA Translation: AAF47379.2
AE014296 Genomic DNA Translation: AAN11440.1
AY052111 mRNA Translation: AAK93535.1
BT044433 mRNA Translation: ACH92498.1

NCBI Reference Sequences

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RefSeqi
NP_001246535.1, NM_001259606.2 [O97148-1]
NP_523871.1, NM_079147.4 [O97148-1]
NP_728521.1, NM_167829.3 [O97148-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0072570; FBpp0072469; FBgn0023000 [O97148-1]
FBtr0072571; FBpp0072470; FBgn0023000 [O97148-2]
FBtr0306850; FBpp0297746; FBgn0023000 [O97148-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
38058

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG6936

UCSC genome browser

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UCSCi
CG6936-RA, d. melanogaster [O97148-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109308 mRNA Translation: AAD16981.1
AF280552 Genomic DNA Translation: AAG22708.1 Sequence problems.
AF280553 Genomic DNA Translation: AAG22709.1 Sequence problems.
AF280554 Genomic DNA Translation: AAG22710.1 Sequence problems.
AF280555 Genomic DNA Translation: AAG22711.1 Sequence problems.
AF280556 Genomic DNA Translation: AAG22712.1 Sequence problems.
AF280557 Genomic DNA Translation: AAG22713.1 Sequence problems.
AF280558 Genomic DNA Translation: AAG22714.1 Sequence problems.
AF280559 Genomic DNA Translation: AAG22715.1 Sequence problems.
AF280560 Genomic DNA Translation: AAG22716.1 Sequence problems.
AF280561 Genomic DNA Translation: AAG22717.1 Sequence problems.
AF280562 Genomic DNA Translation: AAG22718.1 Sequence problems.
AF280563 Genomic DNA Translation: AAG22719.1 Sequence problems.
AF280564 Genomic DNA Translation: AAG22720.1 Sequence problems.
AF280565 Genomic DNA Translation: AAG22721.1 Sequence problems.
AF280566 Genomic DNA Translation: AAG22722.1 Sequence problems.
AF280567 Genomic DNA Translation: AAG22723.1 Sequence problems.
AF280568 Genomic DNA Translation: AAG22724.1 Sequence problems.
AF280569 Genomic DNA Translation: AAG22725.1 Sequence problems.
AF280570 Genomic DNA Translation: AAG22726.1 Sequence problems.
AF280571 Genomic DNA Translation: AAG22727.1 Sequence problems.
AF280572 Genomic DNA Translation: AAG22728.1 Sequence problems.
AF280573 Genomic DNA Translation: AAG22729.1 Sequence problems.
AF280574 Genomic DNA Translation: AAG22730.1 Sequence problems.
AF280575 Genomic DNA Translation: AAG22731.1 Sequence problems.
AF280576 Genomic DNA Translation: AAG22732.1 Sequence problems.
AF280577 Genomic DNA Translation: AAG22733.1 Sequence problems.
AF280578 Genomic DNA Translation: AAG22734.1 Sequence problems.
AF280579 Genomic DNA Translation: AAG22735.1 Sequence problems.
AF280580 Genomic DNA Translation: AAG22736.1 Sequence problems.
AF280581 Genomic DNA Translation: AAG22737.1 Sequence problems.
AF280582 Genomic DNA Translation: AAG22738.1 Sequence problems.
AE014296 Genomic DNA Translation: AAF47379.2
AE014296 Genomic DNA Translation: AAN11440.1
AY052111 mRNA Translation: AAK93535.1
BT044433 mRNA Translation: ACH92498.1
RefSeqiNP_001246535.1, NM_001259606.2 [O97148-1]
NP_523871.1, NM_079147.4 [O97148-1]
NP_728521.1, NM_167829.3 [O97148-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FJRX-ray2.30A/B25-219[»]
2PZXX-ray3.50A/B/C/D25-212[»]
SMRiO97148
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi63614, 1 interactor
STRINGi7227.FBpp0072470

Chemistry databases

BindingDBiO97148
ChEMBLiCHEMBL3309000

Protein family/group databases

TCDBi9.A.14.14.2, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiO97148

Proteomic databases

PaxDbiO97148

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
38058

Genome annotation databases

EnsemblMetazoaiFBtr0072570; FBpp0072469; FBgn0023000 [O97148-1]
FBtr0072571; FBpp0072470; FBgn0023000 [O97148-2]
FBtr0306850; FBpp0297746; FBgn0023000 [O97148-1]
GeneIDi38058
KEGGidme:Dmel_CG6936
UCSCiCG6936-RA, d. melanogaster [O97148-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38058
FlyBaseiFBgn0023000, mth
VEuPathDBiVectorBase:FBgn0023000

Phylogenomic databases

eggNOGiKOG4193, Eukaryota
GeneTreeiENSGT00940000168274
HOGENOMiCLU_002753_3_0_1
InParanoidiO97148
OMAiDFCITAG
PhylomeDBiO97148

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
38058, 1 hit in 1 CRISPR screen
EvolutionaryTraceiO97148

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
38058

Protein Ontology

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PROi
PR:O97148

Gene expression databases

BgeeiFBgn0023000, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues
ExpressionAtlasiO97148, baseline and differential
GenevisibleiO97148, DM

Family and domain databases

CDDicd00251, Mth_Ecto, 1 hit
Gene3Di2.170.180.11, 1 hit
2.30.160.11, 1 hit
InterProiView protein in InterPro
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR044860, Methusela_ecto_dom_1
IPR023311, Methusela_ecto_dom_2
IPR010596, Methuselah_N_dom
IPR036272, Methuselah_N_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF06652, Methuselah_N, 1 hit
SUPFAMiSSF63877, SSF63877, 1 hit
PROSITEiView protein in PROSITE
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTH_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O97148
Secondary accession number(s): B5RJF9
, Q9GN21, Q9GN78, Q9GND6, Q9GNE8, Q9GT57, Q9GT58, Q9GT59, Q9GT60, Q9W0R4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 1999
Last modified: September 29, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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