UniProtKB - O97067 (PTH2_DROME)
Protein
Probable peptidyl-tRNA hydrolase 2
Gene
CG1307
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.By similarity
Catalytic activityi
- EC:3.1.1.29
GO - Molecular functioni
- aminoacyl-tRNA hydrolase activity Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:CG1307 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0026566, CG1307 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrion Source: FlyBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120282 | 1 – 186 | Probable peptidyl-tRNA hydrolase 2Add BLAST | 186 |
Proteomic databases
PaxDbi | O97067 |
PRIDEi | O97067 |
Expressioni
Gene expression databases
Bgeei | FBgn0026566, Expressed in embryo and 38 other tissues |
ExpressionAtlasi | O97067, baseline and differential |
Genevisiblei | O97067, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 66012, 19 interactors |
DIPi | DIP-17218N |
IntActi | O97067, 7 interactors |
STRINGi | 7227.FBpp0290838 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PTH2 family.Curated
Phylogenomic databases
eggNOGi | KOG3282, Eukaryota |
GeneTreei | ENSGT00390000015991 |
HOGENOMi | CLU_073661_0_3_1 |
InParanoidi | O97067 |
OMAi | LRQWEYC |
OrthoDBi | 1564104at2759 |
PhylomeDBi | O97067 |
Family and domain databases
CDDi | cd02430, PTH2, 1 hit |
Gene3Di | 3.40.1490.10, 1 hit |
InterProi | View protein in InterPro IPR023476, Pep_tRNA_hydro_II_dom_sf IPR002833, PTH2 |
PANTHERi | PTHR12649, PTHR12649, 1 hit |
Pfami | View protein in Pfam PF01981, PTH2, 1 hit |
SUPFAMi | SSF102462, SSF102462, 1 hit |
TIGRFAMsi | TIGR00283, arch_pth2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O97067-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDKLLDPTQ IINGLAVMLS FFVGYRYALK RGDAKDSVTE GAATPFSQES
60 70 80 90 100
SVSSGSEASV SDKGYGGLND NFKMVLVVRN DLKMGKGKIA AQCGHGAVGA
110 120 130 140 150
YQRAVVRTPR LLRSWENCGC AKIAVRVESE AELMAIKKEA ERQQLNTCLI
160 170 180
RDAGRTQIEA NSKTVLAVGP AAAADIDRVT GHLKLL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE1JJ73 | E1JJ73_DROME | Aminoacyl-tRNA hydrolase | Dmel\CG1307 BG:DS00004.12, CG1307, Dmel_CG1307 | 186 | Annotation score: |
Sequence cautioni
The sequence AAD19814 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAM52710 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE001572 Genomic DNA Translation: AAD19814.1 Sequence problems. AE014297 Genomic DNA Translation: AAN13366.1 AY122198 mRNA Translation: AAM52710.1 Different initiation. |
RefSeqi | NP_001287202.1, NM_001300273.1 NP_649675.2, NM_141418.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0301623; FBpp0290838; FBgn0026566 FBtr0346140; FBpp0311968; FBgn0026566 |
GeneIDi | 40814 |
KEGGi | dme:Dmel_CG1307 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE001572 Genomic DNA Translation: AAD19814.1 Sequence problems. AE014297 Genomic DNA Translation: AAN13366.1 AY122198 mRNA Translation: AAM52710.1 Different initiation. |
RefSeqi | NP_001287202.1, NM_001300273.1 NP_649675.2, NM_141418.4 |
3D structure databases
SMRi | O97067 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 66012, 19 interactors |
DIPi | DIP-17218N |
IntActi | O97067, 7 interactors |
STRINGi | 7227.FBpp0290838 |
Proteomic databases
PaxDbi | O97067 |
PRIDEi | O97067 |
Genome annotation databases
EnsemblMetazoai | FBtr0301623; FBpp0290838; FBgn0026566 FBtr0346140; FBpp0311968; FBgn0026566 |
GeneIDi | 40814 |
KEGGi | dme:Dmel_CG1307 |
Organism-specific databases
FlyBasei | FBgn0026566, CG1307 |
Phylogenomic databases
eggNOGi | KOG3282, Eukaryota |
GeneTreei | ENSGT00390000015991 |
HOGENOMi | CLU_073661_0_3_1 |
InParanoidi | O97067 |
OMAi | LRQWEYC |
OrthoDBi | 1564104at2759 |
PhylomeDBi | O97067 |
Miscellaneous databases
BioGRID-ORCSi | 40814, 0 hits in 1 CRISPR screen |
GenomeRNAii | 40814 |
PROi | PR:O97067 |
Gene expression databases
Bgeei | FBgn0026566, Expressed in embryo and 38 other tissues |
ExpressionAtlasi | O97067, baseline and differential |
Genevisiblei | O97067, DM |
Family and domain databases
CDDi | cd02430, PTH2, 1 hit |
Gene3Di | 3.40.1490.10, 1 hit |
InterProi | View protein in InterPro IPR023476, Pep_tRNA_hydro_II_dom_sf IPR002833, PTH2 |
PANTHERi | PTHR12649, PTHR12649, 1 hit |
Pfami | View protein in Pfam PF01981, PTH2, 1 hit |
SUPFAMi | SSF102462, SSF102462, 1 hit |
TIGRFAMsi | TIGR00283, arch_pth2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTH2_DROME | |
Accessioni | O97067Primary (citable) accession number: O97067 Secondary accession number(s): Q8MR09, Q9VI42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 28, 2003 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families