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Entry version 89 (07 Apr 2021)
Sequence version 1 (01 May 1999)
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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

STPCACHL

Organism
Stylophora pistillata (Smooth cauliflower coral)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STPCACHLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStylophora pistillata (Smooth cauliflower coral)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri50429 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaScleractiniaAstrocoeniinaPocilloporidaeStylophora

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 101HelicalSequence analysisAdd BLAST19
Transmembranei121 – 142HelicalSequence analysisAdd BLAST22
Transmembranei154 – 173HelicalSequence analysisAdd BLAST20
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei328 – 350HelicalSequence analysisAdd BLAST23
Transmembranei470 – 488HelicalSequence analysisAdd BLAST19
Transmembranei508 – 529HelicalSequence analysisAdd BLAST22
Transmembranei596 – 618HelicalSequence analysisAdd BLAST23
Transmembranei675 – 699HelicalSequence analysisAdd BLAST25
Transmembranei850 – 869HelicalSequence analysisAdd BLAST20
Transmembranei889 – 909HelicalSequence analysisAdd BLAST21
Transmembranei921 – 938HelicalSequence analysisAdd BLAST18
Transmembranei982 – 1001HelicalSequence analysisAdd BLAST20
Transmembranei1091 – 1119HelicalSequence analysisAdd BLAST29
Transmembranei1170 – 1191HelicalSequence analysisAdd BLAST22
Transmembranei1203 – 1221HelicalSequence analysisAdd BLAST19
Transmembranei1295 – 1313HelicalSequence analysisAdd BLAST19
Transmembranei1388 – 1411HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1549 – 1583Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni395 – 434DisorderedSequence analysisAdd BLAST40
Regioni712 – 821DisorderedSequence analysisAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi400 – 434PolyampholyteSequence analysisAdd BLAST35
Compositional biasi712 – 732PolyampholyteSequence analysisAdd BLAST21
Compositional biasi747 – 779PolarSequence analysisAdd BLAST33
Compositional biasi793 – 817PolarSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01630, LVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O97017-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQNGYPRAN FTQGSKIFWP NGTDLMQTRA RLNGHGGKYA KSVAAKRQKK
60 70 80 90 100
SGNTVRPKRA LLCLSLGNPI RSAAINLVEW KPFDVMILIT IFANCAALAA
110 120 130 140 150
FEPLPEKDSS EINDNLEVAE YVFLAVFTME AVLKIIAYGF LFHPGAYLRN
160 170 180 190 200
GWNILDFVIV VVGLATILVK ATLSSGSFDV KALRAFRVLR PLRLVSGVPS
210 220 230 240 250
LQVVLNSIIK ALIPLFHIAL LVVFVVIIYA IIGVELFMGR LHKTCYDNVT
260 270 280 290 300
GAESFEEPHP CSSGSSGFQC DKAAGQVCEG GWKGPNHGIT NFDNIGLACM
310 320 330 340 350
TVFQCITLEG WTDVLYWIND AVGNSWPWVY FVTLIIWGSF FVLNLVLGVL
360 370 380 390 400
SGEFAKEKAR RQKSGEFQKF REKQQVEDAY NGYLDWITQA EDIEGDSESE
410 420 430 440 450
SGDESKASKK TSSRQSRTED IEMIDRNERQ DSISQHDTHH YGWCHNEKKV
460 470 480 490 500
LKKWHHRRQT ELRKAVKTQA FYWIVIVVVF LNSLTLALEH YDQPDWLTKF
510 520 530 540 550
LDIANKLFLG IFTIEMIVKM YCLGFHGYFA SLFNRFDCLV VISSLLELAI
560 570 580 590 600
TEALKQPPIG ISVLRCIRLL RIFKVTRYWS SLSNLVASLL NSMRSIAGLL
610 620 630 640 650
LLLSLFMLIC SLLGMQIFGG KFNTDDDEIP RSNFDSFWRA LITVFQILTG
660 670 680 690 700
EDWNAVMYDG IRAWGGIGEG GSAIAILYFI FLVVVGNYIL LNVFLAIAVD
710 720 730 740 750
NLADAENLTE MEEEKKKKKE KAREKEALKM KGSVDSQGRI DQDGAIVPNH
760 770 780 790 800
SSASRSNVTL DKSTQELHST GTLNGNGVAR TASHDDVEAQ STDISEIVGS
810 820 830 840 850
KSAVSNNNES ASASSSDDID RAPMPPESAL FIFSPTNIFR VVCYKIATNT
860 870 880 890 900
YFVNFILCLI IVSSILLAAE DPLNASAKRN QVLNYFDYFF TSVFTFEILV
910 920 930 940 950
KFISYGLILH KGSFCRSAFN LLDLLVVSVS VISISLRTSQ FSVVRILRVL
960 970 980 990 1000
RVLRPLRAIN RAKGLKHVVQ SVFVAVKTIG NIKLVTMLFQ FLFAVIGVQL
1010 1020 1030 1040 1050
FKGTFFSCND EKILTAEECQ GNYIDFKGPG LSNPVVKERE WRRHDFNFDN
1060 1070 1080 1090 1100
VGNAMLTLFT VMTFEGWPGI LENSIDSTEV DKGPNQNNRP WVAIYYIIYI
1110 1120 1130 1140 1150
IIIAFFMVNI FVGFVIVTFQ SEGREEFKGC ELDKNQRQCI EFALKAKPLK
1160 1170 1180 1190 1200
RYIPENRLQF HIWPVVTSQA FEYLIFAFIV CNTVVLMMQY YQEPKLYTRV
1210 1220 1230 1240 1250
LDGFNIGFTA VFLLECILKL IAFKPKNYFT DRWNLFDFII VVGSIIDITM
1260 1270 1280 1290 1300
NEVSSEQMFA FGFFRLFRAL RLVKLLNQGS GIKTLLWTFI KSFQALPYVA
1310 1320 1330 1340 1350
LLIVMMFFIY AVIGMQMFGR IAINSDTAIN RNNNFQTFPQ SLMVLFRSAT
1360 1370 1380 1390 1400
GENWQQIMLA CTHRDDVKCD QNADPQEPSG LCGSDFAYFY FVSFYSICSF
1410 1420 1430 1440 1450
LIINLFVAVI MDNFDYLTRD WSILGPHHLD EYVRVWSEYD PDAHGCVKHV
1460 1470 1480 1490 1500
DIVTVLKRIA PPLGFGKFCP HREACKRLVT MNMGLTKDGM VDFNATLFGL
1510 1520 1530 1540 1550
IRSSLNIKRP EGKGSIDKAN EEVRNIILRI WPKTSMELLD KVVQPSGVRD
1560 1570 1580 1590 1600
DVTVGKFYAT YLIQEYFRRF KARQKAQNQA NEPHGNSTMA LQAGLRTLHG
1610 1620 1630 1640 1650
LGPQLRRAIS GQLGSDDDEL FLKEDDSQKA HDKGFWESLK SAVSVSPRHS
1660 1670 1680 1690 1700
FRRSASFRLS AFLGKNGSGL ETKKKSSSMS NLSEKMATTM FSDQKYLMPT
1710 1720 1730 1740 1750
TSTSADDNAN VKEAEQPRIE LPLLHPDDTG SFTAIKDHAG LKAASSLPLS
1760 1770 1780 1790 1800
PVEGESRDPI PYVRQRSKSE VIPPWLATRE VAHLGRELQR SRSASIKNLL
1810 1820 1830 1840 1850
ESAFVDEGVS ITLDDPLLRV AEQEIREAFE VSEDDLNQAL TACCRRAAIL
1860 1870 1880 1890
SPIRKKEEIG EDKTMDTTKE PPRISHRWSN EPDVPIIITD L
Length:1,891
Mass (Da):213,241
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAB705AEBF9B4134
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U64465 mRNA Translation: AAD11470.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T43262

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64465 mRNA Translation: AAD11470.1
PIRiT43262

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 2 hits
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01630, LVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO97017_STYPI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O97017
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: April 7, 2021
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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