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Protein

Protein PDF

Gene

Pdf

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neuropeptide PDF is the main transmitter regulating circadian locomotor rhythms. Required to maintain behavioral rhythms under constant conditions by coordinating pacemaker interactions in the circadian system. Ectopic expression induces long periods, while its absence leads to short periods.3 Publications

GO - Molecular functioni

  • neuropeptide hormone activity Source: FlyBase
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processBiological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PDF
Cleaved into the following 2 chains:
Alternative name(s):
Pigment-dispersing factor homolog
Gene namesi
Name:Pdf
ORF Names:CG6496
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0023178 Pdf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PeptideiPRO_000004316225 – 79PDF precursor-related peptideBy similarityAdd BLAST55
PeptideiPRO_000004316383 – 100Neuropeptide PDF1 PublicationAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100Alanine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiO96690

Expressioni

Tissue specificityi

Predominantly expressed in adult head. Expressed at higher level in males than in females. In adult brain, it is specifically expressed in the ventral lateral neurons (LNvs) as well as in 2-4 tritocerebral cells and 4-6 abdominal cells.3 Publications

Developmental stagei

Expressed at constant level, without strong circadian variations. Its amount nevertheless oscillates along day and night cycles in the termini of dorsally projected axons of LNvs.2 Publications

Gene expression databases

BgeeiFBgn0023178 Expressed in 12 organ(s), highest expression level in brain
ExpressionAtlasiO96690 baseline and differential
GenevisibleiO96690 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi68089, 4 interactors
STRINGi7227.FBpp0084396

Family & Domainsi

Sequence similaritiesi

Belongs to the arthropod PDH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KC1M Eukaryota
ENOG4110MPR LUCA
InParanoidiO96690
OMAiWFNNVGV
OrthoDBiEOG091G1AC3
PhylomeDBiO96690

Family and domain databases

InterProiView protein in InterPro
IPR009396 Pigment_DH
PfamiView protein in Pfam
PF06324 Pigment_DH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96690-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARYTYLVAL VLLAICCQWG YCGAMAMPDE ERYVRKEYNR DLLDWFNNVG
60 70 80 90 100
VGQFSPGQVA TLCRYPLILE NSLGPSVPIR KRNSELINSL LSLPKNMNDA

GK
Length:102
Mass (Da):11,545
Last modified:December 6, 2005 - v2
Checksum:i7F7E0CAA40AE39C2
GO

Sequence cautioni

The sequence AAL49303 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4Y → F in AAC98309 (PubMed:9615286).Curated1

Mass spectrometryi

Molecular mass is 1972.02 Da from positions 83 - 100. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110059 Genomic DNA Translation: AAC98309.1
AE014297 Genomic DNA Translation: AAF56593.1
AY071681 mRNA Translation: AAL49303.2 Different initiation.
RefSeqiNP_524517.1, NM_079793.3
UniGeneiDm.21687

Genome annotation databases

EnsemblMetazoaiFBtr0085024; FBpp0084396; FBgn0023178
GeneIDi43193
KEGGidme:Dmel_CG6496

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110059 Genomic DNA Translation: AAC98309.1
AE014297 Genomic DNA Translation: AAF56593.1
AY071681 mRNA Translation: AAL49303.2 Different initiation.
RefSeqiNP_524517.1, NM_079793.3
UniGeneiDm.21687

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68089, 4 interactors
STRINGi7227.FBpp0084396

Proteomic databases

PaxDbiO96690

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085024; FBpp0084396; FBgn0023178
GeneIDi43193
KEGGidme:Dmel_CG6496

Organism-specific databases

CTDi64146
FlyBaseiFBgn0023178 Pdf

Phylogenomic databases

eggNOGiENOG410KC1M Eukaryota
ENOG4110MPR LUCA
InParanoidiO96690
OMAiWFNNVGV
OrthoDBiEOG091G1AC3
PhylomeDBiO96690

Miscellaneous databases

GenomeRNAii43193
PROiPR:O96690

Gene expression databases

BgeeiFBgn0023178 Expressed in 12 organ(s), highest expression level in brain
ExpressionAtlasiO96690 baseline and differential
GenevisibleiO96690 DM

Family and domain databases

InterProiView protein in InterPro
IPR009396 Pigment_DH
PfamiView protein in Pfam
PF06324 Pigment_DH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDF_DROME
AccessioniPrimary (citable) accession number: O96690
Secondary accession number(s): Q7JYY1, Q9VBE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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