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UniProtKB - O96689 (O96689_DROME)
Protein
Submitted name:
FI11703p
Gene
vtd
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: FlyBase
GO - Biological processi
- mitotic cell cycle Source: FlyBase
- mitotic sister chromatid cohesion Source: FlyBase
- neuron remodeling Source: FlyBase
- positive regulation of gene expression Source: FlyBase
- replication-born double-strand break repair via sister chromatid exchange Source: GO_Central
- synaptonemal complex assembly Source: GO_Central
- synaptonemal complex organization Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-2468052, Establishment of Sister Chromatid Cohesion R-DME-2470946, Cohesin Loading onto Chromatin R-DME-2500257, Resolution of Sister Chromatid Cohesion |
Names & Taxonomyi
Protein namesi | Submitted name: FI11703pImportedSubmitted name: Rad21 mitotic cohesinImportedSubmitted name: Verthandi, isoform AImported |
Gene namesi | Name:vtdImported Synonyms:80FhImported, CG40222Imported, cohesinImported, Dmel\CG17436Imported, DmRAD21Imported, DRAD21Imported, DRad21Imported, Drad21Imported, dRad21Imported, drad21Imported, l(3)80FhImported, l(3)Lh3Imported, l3Imported, lethal 3Imported, RAD21Imported, Rad21Imported, rad21Imported, Rad21-RAImported, Scc1Imported, scc1Imported, VTDImported, VtdImported ORF Names:CG17436Imported, Dmel_CG17436Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0260987, vtd |
VEuPathDBi | VectorBase:FBgn0260987 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nuclear meiotic cohesin complex Source: GO_Central
- nuclear mitotic cohesin complex Source: GO_Central
- nucleus Source: FlyBase
- synaptonemal complex Source: FlyBase
Other locations
- cohesin complex Source: FlyBase
- pericentric heterochromatin Source: FlyBase
- polytene chromosome interband Source: FlyBase
Keywords - Cellular componenti
NucleusARBA annotationInteractioni
Protein-protein interaction databases
DIPi | DIP-18950N |
IntActi | O96689, 1 interactor |
STRINGi | 7227.FBpp0112469 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 102 | Rad21_Rec8_NInterPro annotationAdd BLAST | 102 | |
Domaini | 658 – 710 | Rad21_Rec8InterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 545 – 571 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the rad21 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG1213, Eukaryota |
GeneTreei | ENSGT00940000170664 |
HOGENOMi | CLU_015775_1_0_1 |
Family and domain databases
Gene3Di | 1.10.10.580, 1 hit |
InterProi | View protein in InterPro IPR039781, Rad21/Rec8-like IPR006909, Rad21/Rec8_C_eu IPR006910, Rad21_Rec8_N IPR023093, ScpA-like_C IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12585, PTHR12585, 2 hits |
Pfami | View protein in Pfam PF04824, Rad21_Rec8, 1 hit PF04825, Rad21_Rec8_N, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O96689-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFYEHIILAK KGPLARIWLA AHWDKKITKA HVFETNIEKS VEGILQPKVK
60 70 80 90 100
LALRTSGHLL LGVVRIYSRK AKYLLADCNE AFVKIKMAFR PGMVDLPEGH
110 120 130 140 150
REANVNAITL PEVFHDFDTA LPELNDIDIE AQFSINQSRA DEITMREDYG
160 170 180 190 200
SLSLSLQDDG FGDIGFEAET PEIIRCSIPS NINDKIFDND VLENIESLDP
210 220 230 240 250
HSLDAHADMP GSRLDGDGFG DSFGQPALFE DDLFGDPSQP VEQITKESTT
260 270 280 290 300
VLNADDSDED AIDNIHNVPS PATSLVNSIE DEKEENNLNG HASVSENVPM
310 320 330 340 350
NEITLVQNED EGFALAPLDV SMYKGVTKAK RKRKLIIDEI KNISGEEMKA
360 370 380 390 400
QLADTSDILT TLDLAPPTKR LMYWKETGGV EKLFSLPSRS IPARALFGNY
410 420 430 440 450
NRQLFSHSTF FEDFSSVVPM EILALEFYTK ENENALIIFN KKGRKRKNDN
460 470 480 490 500
MSNLFLDHVP DSVVQSLEAP EVLRANHKSL GVSTVSVEIV SKEQESISCQ
510 520 530 540 550
NELTFFDNMR SPDLLSLNEM EQFSSINELP LTPRNMNHEM GDDFNQGDST
560 570 580 590 600
PAGLDHGHAT PQHGNIGEMD HDSVIPTKKT AVILNESVGT SVLSDNGVSK
610 620 630 640 650
RTNNILKGWD NYEIPSFVGQ NHGDEQMENE TDEQFEERVL NKRAAHLFID
660 670 680 690 700
VRAHFIAKDS LELSQLTSGN SRKQAAQKFY SLLVLKKFKV LHIDQSAPYA
710
DITITRGPTF ENPKI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A021WW32 | A0A021WW32_DROME | Verthandi, isoform B | vtd 80Fh, CG40222, cohesin, Dmel\CG17436, DmRAD21 | 633 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109926 mRNA Translation: AAD04175.1 AH009610 Genomic DNA Translation: AAF82099.1 BT100037 mRNA Translation: ACX61578.1 AE014296 Genomic DNA Translation: EAA46289.1 |
RefSeqi | NP_001015132.1, NM_001015132.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0113746; FBpp0112469; FBgn0260987 |
GeneIDi | 3354896 |
KEGGi | dme:Dmel_CG17436 |
UCSCi | CG17436-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109926 mRNA Translation: AAD04175.1 AH009610 Genomic DNA Translation: AAF82099.1 BT100037 mRNA Translation: ACX61578.1 AE014296 Genomic DNA Translation: EAA46289.1 |
RefSeqi | NP_001015132.1, NM_001015132.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-18950N |
IntActi | O96689, 1 interactor |
STRINGi | 7227.FBpp0112469 |
Genome annotation databases
EnsemblMetazoai | FBtr0113746; FBpp0112469; FBgn0260987 |
GeneIDi | 3354896 |
KEGGi | dme:Dmel_CG17436 |
UCSCi | CG17436-RA, d. melanogaster |
Organism-specific databases
CTDi | 3354896 |
FlyBasei | FBgn0260987, vtd |
VEuPathDBi | VectorBase:FBgn0260987 |
Phylogenomic databases
eggNOGi | KOG1213, Eukaryota |
GeneTreei | ENSGT00940000170664 |
HOGENOMi | CLU_015775_1_0_1 |
Enzyme and pathway databases
Reactomei | R-DME-2468052, Establishment of Sister Chromatid Cohesion R-DME-2470946, Cohesin Loading onto Chromatin R-DME-2500257, Resolution of Sister Chromatid Cohesion |
Miscellaneous databases
BioGRID-ORCSi | 3354896, 1 hit in 3 CRISPR screens |
ChiTaRSi | vtd, fly |
GenomeRNAii | 3354896 |
Gene expression databases
Bgeei | FBgn0260987, Expressed in embryo and 44 other tissues |
Family and domain databases
Gene3Di | 1.10.10.580, 1 hit |
InterProi | View protein in InterPro IPR039781, Rad21/Rec8-like IPR006909, Rad21/Rec8_C_eu IPR006910, Rad21_Rec8_N IPR023093, ScpA-like_C IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12585, PTHR12585, 2 hits |
Pfami | View protein in Pfam PF04824, Rad21_Rec8, 1 hit PF04825, Rad21_Rec8_N, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | O96689_DROME | |
Accessioni | O96689Primary (citable) accession number: O96689 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | January 19, 2022 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |