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UniProtKB - O96689 (O96689_DROME)

Entry version 168 (19 Jan 2022)
Sequence version 1 (01 May 1999)
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Protein
Submitted name:

FI11703p

Gene

vtd

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-2468052, Establishment of Sister Chromatid Cohesion
R-DME-2470946, Cohesin Loading onto Chromatin
R-DME-2500257, Resolution of Sister Chromatid Cohesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI11703pImported
Submitted name:
Rad21 mitotic cohesinImported
Submitted name:
Verthandi, isoform AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vtdImported
Synonyms:80FhImported, CG40222Imported, cohesinImported, Dmel\CG17436Imported, DmRAD21Imported, DRAD21Imported, DRad21Imported, Drad21Imported, dRad21Imported, drad21Imported, l(3)80FhImported, l(3)Lh3Imported, l3Imported, lethal 3Imported, RAD21Imported, Rad21Imported, rad21Imported, Rad21-RAImported, Scc1Imported, scc1Imported, VTDImported, VtdImported
ORF Names:CG17436Imported, Dmel_CG17436Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0260987, vtd

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0260987

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0260987, Expressed in embryo and 44 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-18950N

Protein interaction database and analysis system

More...IntActi		O96689, 1 interactor

STRING: functional protein association networks

More...STRINGi		7227.FBpp0112469

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 102Rad21_Rec8_NInterPro annotationAdd BLAST102
Domaini658 – 710Rad21_Rec8InterPro annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni545 – 571DisorderedSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rad21 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1213, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000170664

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015775_1_0_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.580, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039781, Rad21/Rec8-like
IPR006909, Rad21/Rec8_C_eu
IPR006910, Rad21_Rec8_N
IPR023093, ScpA-like_C
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR12585, PTHR12585, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04824, Rad21_Rec8, 1 hit
PF04825, Rad21_Rec8_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O96689-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFYEHIILAK KGPLARIWLA AHWDKKITKA HVFETNIEKS VEGILQPKVK 
        60         70         80         90        100
LALRTSGHLL LGVVRIYSRK AKYLLADCNE AFVKIKMAFR PGMVDLPEGH 
       110        120        130        140        150
REANVNAITL PEVFHDFDTA LPELNDIDIE AQFSINQSRA DEITMREDYG 
       160        170        180        190        200
SLSLSLQDDG FGDIGFEAET PEIIRCSIPS NINDKIFDND VLENIESLDP 
       210        220        230        240        250
HSLDAHADMP GSRLDGDGFG DSFGQPALFE DDLFGDPSQP VEQITKESTT 
       260        270        280        290        300
VLNADDSDED AIDNIHNVPS PATSLVNSIE DEKEENNLNG HASVSENVPM 
       310        320        330        340        350
NEITLVQNED EGFALAPLDV SMYKGVTKAK RKRKLIIDEI KNISGEEMKA 
       360        370        380        390        400
QLADTSDILT TLDLAPPTKR LMYWKETGGV EKLFSLPSRS IPARALFGNY 
       410        420        430        440        450
NRQLFSHSTF FEDFSSVVPM EILALEFYTK ENENALIIFN KKGRKRKNDN 
       460        470        480        490        500
MSNLFLDHVP DSVVQSLEAP EVLRANHKSL GVSTVSVEIV SKEQESISCQ 
       510        520        530        540        550
NELTFFDNMR SPDLLSLNEM EQFSSINELP LTPRNMNHEM GDDFNQGDST 
       560        570        580        590        600
PAGLDHGHAT PQHGNIGEMD HDSVIPTKKT AVILNESVGT SVLSDNGVSK 
       610        620        630        640        650
RTNNILKGWD NYEIPSFVGQ NHGDEQMENE TDEQFEERVL NKRAAHLFID 
       660        670        680        690        700
VRAHFIAKDS LELSQLTSGN SRKQAAQKFY SLLVLKKFKV LHIDQSAPYA 
       710 
DITITRGPTF ENPKI
Length:715
Mass (Da):79,945
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E457E71B410DEE5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A021WW32A0A021WW32_DROME
Verthandi, isoform B
vtd 80Fh, CG40222, cohesin, Dmel\CG17436, DmRAD21
633Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF109926 mRNA Translation: AAD04175.1
AH009610 Genomic DNA Translation: AAF82099.1
BT100037 mRNA Translation: ACX61578.1
AE014296 Genomic DNA Translation: EAA46289.1

NCBI Reference Sequences

More...RefSeqi		NP_001015132.1, NM_001015132.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0113746; FBpp0112469; FBgn0260987

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3354896

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG17436

UCSC genome browser

More...UCSCi		CG17436-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109926 mRNA Translation: AAD04175.1
AH009610 Genomic DNA Translation: AAF82099.1
BT100037 mRNA Translation: ACX61578.1
AE014296 Genomic DNA Translation: EAA46289.1
RefSeqiNP_001015132.1, NM_001015132.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-18950N
IntActiO96689, 1 interactor
STRINGi7227.FBpp0112469

Genome annotation databases

EnsemblMetazoaiFBtr0113746; FBpp0112469; FBgn0260987
GeneIDi3354896
KEGGidme:Dmel_CG17436
UCSCiCG17436-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3354896
FlyBaseiFBgn0260987, vtd
VEuPathDBiVectorBase:FBgn0260987

Phylogenomic databases

eggNOGiKOG1213, Eukaryota
GeneTreeiENSGT00940000170664
HOGENOMiCLU_015775_1_0_1

Enzyme and pathway databases

ReactomeiR-DME-2468052, Establishment of Sister Chromatid Cohesion
R-DME-2470946, Cohesin Loading onto Chromatin
R-DME-2500257, Resolution of Sister Chromatid Cohesion

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3354896, 1 hit in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		vtd, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3354896

Gene expression databases

BgeeiFBgn0260987, Expressed in embryo and 44 other tissues

Family and domain databases

Gene3Di1.10.10.580, 1 hit
InterProiView protein in InterPro
IPR039781, Rad21/Rec8-like
IPR006909, Rad21/Rec8_C_eu
IPR006910, Rad21_Rec8_N
IPR023093, ScpA-like_C
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR12585, PTHR12585, 2 hits
PfamiView protein in Pfam
PF04824, Rad21_Rec8, 1 hit
PF04825, Rad21_Rec8_N, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO96689_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96689
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: January 19, 2022
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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