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Protein

Defective in tip formation protein A

Gene

dtfA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for correct organization of the actin cytoskeleton and cytokinesis. Also required for apical sorting of prestalk cells, a prerequisite for formation of the tip at the mound stage and subsequent formation of the fruiting body. May be required for cell adhesion.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell-cell adhesion Source: dictyBase
  • mitotic cytokinesis Source: dictyBase
  • multicellular organism development Source: UniProtKB-KW
  • sorocarp development Source: dictyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion, Cell cycle, Cell division

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Defective in tip formation protein A
Alternative name(s):
Cell surface protein dtfA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dtfA
ORF Names:DDB_G0289389
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0289389 dtfA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • cell surface Source: dictyBase

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003279651 – 1402Defective in tip formation protein AAdd BLAST1402

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O96668

PRoteomics IDEntifications database

More...
PRIDEi
O96668

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from the tight mound stage. Also expressed in prespore and prestalk cells.1 Publication

Keywords - Developmental stagei

Fruiting body

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191273

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati12 – 1811 Publication7
Repeati40 – 4621 Publication7
Repeati60 – 6631 Publication7
Repeati86 – 9241 Publication7

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 924 X 7 AA repeat of T-T-T-[IV]-[AQ]-P-PAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili350 – 383Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi39 – 42Poly-Thr4
Compositional biasi71 – 87Poly-ThrAdd BLAST17
Compositional biasi122 – 131Poly-Asn10
Compositional biasi239 – 245Poly-Gln7
Compositional biasi246 – 252Poly-Pro7
Compositional biasi265 – 279Poly-GlnAdd BLAST15
Compositional biasi430 – 439Poly-Gln10
Compositional biasi446 – 450Poly-Ser5
Compositional biasi707 – 742Poly-AsnAdd BLAST36
Compositional biasi798 – 802Poly-Glu5

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O96668

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O96668-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDIEASKKP HTTTVAPPQI NFIKNNENIF QPKPISNVTT TTVQPPQIVS
60 70 80 90 100
PPSPPSPPQT TTIAPPTILP TTKTTTTTTT TTTTTTTVQP PQIVSPPIIN
110 120 130 140 150
NLIIQNNLNT PSLSSTPSPL PNNNNSNEND NDINNLKISK EEYQTQIEIQ
160 170 180 190 200
QQIQRQQILE RQQLLQRRNQ EQLDLLERHN DYQELINTHQ NFVPPNNRFS
210 220 230 240 250
QQIHVSQLKK QSSQSQLQQQ LSSQSLQQIQ QKSKQPPPQQ QQQQQPPPPP
260 270 280 290 300
IPLLPQIHQQ LKPKQQQEQQ QQQEQQQQQT ENERINELRR LKRKKEYHND
310 320 330 340 350
EYKDDEIYLD NILKGIDIRK LEKLTAVELR KIGKTLGVPM GNNTKGETFQ
360 370 380 390 400
RIKSFIENHK KKKQKYREYQ SEKNQQQKSN SKKLVNNSTI YDLPIKDIEH
410 420 430 440 450
LEQLFWRIFR NIVLFRKIIG NLSRGGFFDQ QQQQQQQQQS TMTTTSSSSS
460 470 480 490 500
PMTSSDDKFF YCYNYIFSKT FKYDQIIHVS WIVDSNYFGL LKYKVSRGDL
510 520 530 540 550
LVFCNHNTIN DGDVNDDEDQ NTKYEFCKMF KKIFNSIRSI QDKSFYRDLF
560 570 580 590 600
TNYSEFIFDR INKRYPIDIY LVGSLAIECN CLVATKLLIS EFQFRPVMNH
610 620 630 640 650
SLQLAIKSGS YKMVKLIVTT IHRQMSLNPN NKPFDIEMFS KINNPSIKII
660 670 680 690 700
NLLIQLRLFT YSNIINLVIA DAKLINDNNE NDILQFNKNL KNQIFNYSNL
710 720 730 740 750
LNSFTFNNNI NNNNNNNINN NNNNNNNNNN NNNNNNNNNN SNLSNNTIEY
760 770 780 790 800
SKIKTKTVFN QFTIKQLINS CKLIVTFDLK NQYQQQYYKR HYEDSDNEEE
810 820 830 840 850
EEITQASFTI NTMAEIEFIE TQITKEEKHC FVKKVIQKQL LKDGEKEDYD
860 870 880 890 900
GIKRLAELYV SLNPHLKVYC NFMYKIIYGN ENCYDQDLDD EDLFDYRVTR
910 920 930 940 950
VFDSNCFKQS LKYGSPGYWI EYKEVEMKYA FLSNKYRNEI TPNLLFKYVS
960 970 980 990 1000
PNNLNKQLKF IKKIYNSSIE NGNSNGNGNG NGGTVIGGIL DRLLLFYLII
1010 1020 1030 1040 1050
ENNNLELLSI VIKEFPLISN FCYIAKSNSE IYNLKIPRFI RSIEMLEFCF
1060 1070 1080 1090 1100
SNFRDHFYLP QSNSLTADFY GFQNVELLRK YDQLMVLDDM DKGIIVSNKK
1110 1120 1130 1140 1150
VRASFDDFHF IFEWGSSLKN YNNYLKMLAY IVEDPYGLYT IVTNEILLLS
1160 1170 1180 1190 1200
AILSPTTSSG EPLLNLNIER QLIFQEIISS FSTILEGTEL KYYPEQMFQE
1210 1220 1230 1240 1250
STHLKRFFDW IFENRSEDLL IGGRCVITQS VQSHMLYRAG RLDIVLRKGY
1260 1270 1280 1290 1300
YYDDTNEGSK KIMPVGLALV LDDIGKYGDV VALEKYIRSC IPLMKQQSEL
1310 1320 1330 1340 1350
LTLLDKDERE SRACFSQCQR HFSSLLSKAS IYGRINIFQH IFYNHQFIFD
1360 1370 1380 1390 1400
KKSLLFARKG FLSKISFKKL ILECHYHKQH HILDFIQNVI GLDITPKQIK

SN
Length:1,402
Mass (Da):164,017
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05A17C292E8F2306
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191N → I in AAC98306 (PubMed:9693138).Curated1
Sequence conflicti471F → Y in AAC98306 (PubMed:9693138).Curated1
Sequence conflicti825K → E in AAC98306 (PubMed:9693138).Curated1
Sequence conflicti828K → E in AAC98306 (PubMed:9693138).Curated1
Sequence conflicti838K → Q in AAC98306 (PubMed:9693138).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF102575 Genomic DNA Translation: AAC98306.1
AAFI02000140 Genomic DNA Translation: EAL62722.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17456

NCBI Reference Sequences

More...
RefSeqi
XP_636226.1, XM_631134.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL62722; EAL62722; DDB_G0289389

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8627114

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0289389

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102575 Genomic DNA Translation: AAC98306.1
AAFI02000140 Genomic DNA Translation: EAL62722.1
PIRiT17456
RefSeqiXP_636226.1, XM_631134.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi44689.DDB0191273

Proteomic databases

PaxDbiO96668
PRIDEiO96668

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL62722; EAL62722; DDB_G0289389
GeneIDi8627114
KEGGiddi:DDB_G0289389

Organism-specific databases

dictyBaseiDDB_G0289389 dtfA

Phylogenomic databases

PhylomeDBiO96668

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O96668

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTFA_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96668
Secondary accession number(s): Q54HK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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