Intermediate neuroblasts defective protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS."
    Zhao G., Boekhoff-Falk G., Wilson B.A., Skeath J.B.
    Proc Natl Acad Sci U S A 104:3847-3852(2007) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS."
    Zhao G., Boekhoff-Falk G., Wilson B.A., Skeath J.B.
    Proc Natl Acad Sci U S A 104:3847-3852(2007) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS."
    Zhao G., Boekhoff-Falk G., Wilson B.A., Skeath J.B.
    Proc Natl Acad Sci U S A 104:3847-3852(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• brain development Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Neuroblast formation and patterning during early brain development in Drosophila."
    Urbach R., Technau G.M.
    Bioessays 26:739-751(2004) [PubMed] [Europe PMC] [Abstract]
• central nervous system development Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity."
    Weiss J.B., Von Ohlen T., Mellerick D.M., Dressler G., Doe C.Q., Scott M.P.
    Genes Dev. 12:3591-3602(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• dorsal/ventral pattern formation Source: FlyBaseTraceable author statementⁱ
  • "Genetic control of Drosophila nerve cord development."
    Skeath J.B., Thor S., Skeath J.B.
    Curr Opin Neurobiol 13:8-15(2003) [PubMed] [Europe PMC] [Abstract]
  • "Neuroblast formation and patterning during early brain development in Drosophila."
    Urbach R., Technau G.M.
    Bioessays 26:739-751(2004) [PubMed] [Europe PMC] [Abstract]
• ectoderm development Source: FlyBaseTraceable author statementⁱ
  • "Neuroblast formation and patterning during early brain development in Drosophila."
    Urbach R., Technau G.M.
    Bioessays 26:739-751(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Role of en and novel interactions between msh, ind, and vnd in dorsoventral patterning of the Drosophila brain and ventral nerve cord."
    Seibert J., Urbach R.
    Dev Biol 346:332-345(2010) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity."
    Weiss J.B., Von Ohlen T., Mellerick D.M., Dressler G., Doe C.Q., Scott M.P.
    Genes Dev. 12:3591-3602(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• negative regulation of transcription by RNA polymerase II Source: FlyBaseInferred from direct assayⁱ
  • "Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS."
    Zhao G., Boekhoff-Falk G., Wilson B.A., Skeath J.B.
    Proc Natl Acad Sci U S A 104:3847-3852(2007) [PubMed] [Europe PMC] [Abstract]
• neuroblast fate determination Source: FlyBaseTraceable author statementⁱ
  • "Genetic control of Drosophila nerve cord development."
    Skeath J.B., Thor S., Skeath J.B.
    Curr Opin Neurobiol 13:8-15(2003) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• pattern specification process Source: FlyBase <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "A simple plan--cnidarians and the origins of developmental mechanisms."
    Ball E.E., Hayward D.C., Saint R., Miller D.J.
    Nat Rev Genet 5:567-577(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS."
    Zhao G., Boekhoff-Falk G., Wilson B.A., Skeath J.B.
    Proc Natl Acad Sci U S A 104:3847-3852(2007) [PubMed] [Europe PMC] [Abstract]
• ventral cord development Source: FlyBaseInferred from high throughput mutant phenotypeⁱ
  • "Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells."
    Bivik C., Bahrampour S., Ulvklo C., Nilsson P., Angel A., Fransson F., Lundin E., Renhorn J., Thor S.
    Genetics 200:1229-1244(2015) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• transcription factor binding Source: FlyBaseInferred from physical interactionⁱ
  • "Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS."
    Zhao G., Boekhoff-Falk G., Wilson B.A., Skeath J.B.
    Proc Natl Acad Sci U S A 104:3847-3852(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSRSFLMDSL LSDRPNLSQK KEKLGSPVGS PTAAAAVAAA AMLPSIPMLP 
        60         70         80         90        100
YPASYVGSYL FSLGIQQQQQ QQQQQQQQAA AAAAAAAAAA ALQQHPHVSS 
       110        120        130        140        150
SPGSLYHPYA QLFASKRKSS GFSNYEGCYP SPPLSANPNS QQLPPIHNLY 
       160        170        180        190        200
GSPVVGGLPL PEPGSFCTSP SASSSASLDY TNNFDEPQGK RFKHESSCSP 
       210        220        230        240        250
NSSPLKNHSS GGPVEITPLI NDYADSSKRI RTAFTSTQLL ELEREFSHNA 
       260        270        280        290        300
YLSRLRRIEI ANRLRLSEKQ VKIWFQNRRV KQKKGGSESP TFNLSTNSNG 
       310        320
SPQASPVSPQ VKVHELKVEA                                  

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ