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Entry version 134 (16 Oct 2019)
Sequence version 3 (16 Aug 2004)
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Protein

Arginyl-tRNA--protein transferase 1

Gene

Ate1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processUbl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginyl-tRNA--protein transferase 1 (EC:2.3.2.8)
Short name:
Arginyltransferase 1
Short name:
R-transferase 1
Alternative name(s):
Arginine-tRNA--protein transferase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ate1
ORF Names:CG9204
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0025720 Ate1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001950901 – 484Arginyl-tRNA--protein transferase 1Add BLAST484

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O96539

PRoteomics IDEntifications database

More...
PRIDEi
O96539

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0025720 Expressed in 31 organ(s), highest expression level in spermathecum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O96539 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O96539 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0085627

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the R-transferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1193 Eukaryota
COG2935 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044926

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O96539

KEGG Orthology (KO)

More...
KOi
K00685

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYTIKCD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O96539

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR017137 Arg-tRNA-P_Trfase_1_euk
IPR030700 N-end_Aminoacyl_Trfase
IPR007472 N-end_Aminoacyl_Trfase_C
IPR007471 N-end_Aminoacyl_Trfase_N

The PANTHER Classification System

More...
PANTHERi
PTHR21367 PTHR21367, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04377 ATE_C, 1 hit
PF04376 ATE_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037207 ATE1_euk, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55729 SSF55729, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: O96539-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSIVSYYG SQQSKCGYCA GANCSLSHGM HAYQLDCRDY QDLIDRGWRR
60 70 80 90 100
CGYYCYKLRN QETCCPCYTI KCNGLEFKLS KSNKRILRRI NRFLRDGKRE
110 120 130 140 150
SKPEAGDGDG EADADYAIVA PEVTASEPQP QLPDKSPPVI NVEQVASLAT
160 170 180 190 200
AQRKPTKQAT AAAVEAPTLG SNKSSLLSSS AAAPISNKPC KKAKQMRLDR
210 220 230 240 250
RLAKLGDSAS YSTKSLTQEK TLRDFLNTDS ETNKHRLKLR LIHVYDDEFR
260 270 280 290 300
RTLPQSFALY KKYQISIHND PPKDQDAYKE HLQATPLQNE KPWDGPEMGY
310 320 330 340 350
GSFHQQYWLD DKLIAVGVID ILPGCVSSVY FFYDPDYSFL SLGTYGSLRE
360 370 380 390 400
IELVQSLAEK VPSLKYYYMG FYIHSCPKMR YKGKLSPSYL LCPETYEWLP
410 420 430 440 450
LTDVIRAKLD EHKYQRLNED PAARDVNEFL MEHLDEVKLL LGGRTRTDYK
460 470 480
HFRQLRGTVS DDDIIIEYSK LVGKECARRM LYVK
Note: No experimental confirmation available.
Length:484
Mass (Da):55,317
Last modified:August 16, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38677BF50672AC6D
GO
Isoform A (identifier: O96539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-181: Missing.

Show »
Length:477
Mass (Da):54,671
Checksum:iB32B8200D1CC4CE8
GO
Isoform C (identifier: O96539-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-181: Missing.
     239-288: LRLIHVYDDE...KEHLQATPLQ → IVLVASSDTE...QRFLVKSPLK

Show »
Length:478
Mass (Da):54,348
Checksum:i0ED47DA90616B696
GO
Isoform D (identifier: O96539-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-288: LRLIHVYDDE...KEHLQATPLQ → IVLVASSDTE...QRFLVKSPLK

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):54,994
Checksum:iD12F3150F3C10876
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KFD5A0A0B4KFD5_DROME
Arginyl-tRNA--protein transferase 1
Ate1 Ate, ATE1, ate1, Dm-Ate1, Dmel\CG9204
485Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO25000 differs from that shown. Deletion of many residues.Curated
The sequence AAO25000 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000339175 – 181Missing in isoform A and isoform C. 3 Publications7
Alternative sequenceiVSP_011157239 – 288LRLIH…ATPLQ → IVLVASSDTERTCADAVIAL YRKYQITVHNDNPARLTLAS MQRFLVKSPLK in isoform C and isoform D. 2 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF079101 mRNA Translation: AAD12369.1
AE013599 Genomic DNA Translation: AAF57496.3
AE013599 Genomic DNA Translation: AAF57497.3
AE013599 Genomic DNA Translation: AAF57498.2
AY051688 mRNA Translation: AAK93112.1
BT001498 mRNA Translation: AAN71253.1
BT003243 mRNA Translation: AAO25000.1 Sequence problems.
AF354710 mRNA Translation: AAL83965.1

NCBI Reference Sequences

More...
RefSeqi
NP_477394.3, NM_058046.5 [O96539-2]
NP_725939.2, NM_166379.3 [O96539-1]
NP_725940.2, NM_166380.3 [O96539-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086317; FBpp0085626; FBgn0025720 [O96539-2]
FBtr0086318; FBpp0085627; FBgn0025720 [O96539-1]
FBtr0086319; FBpp0089149; FBgn0025720 [O96539-4]
FBtr0336634; FBpp0307617; FBgn0025720 [O96539-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37288

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9204

UCSC genome browser

More...
UCSCi
CG9204-RA d. melanogaster [O96539-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079101 mRNA Translation: AAD12369.1
AE013599 Genomic DNA Translation: AAF57496.3
AE013599 Genomic DNA Translation: AAF57497.3
AE013599 Genomic DNA Translation: AAF57498.2
AY051688 mRNA Translation: AAK93112.1
BT001498 mRNA Translation: AAN71253.1
BT003243 mRNA Translation: AAO25000.1 Sequence problems.
AF354710 mRNA Translation: AAL83965.1
RefSeqiNP_477394.3, NM_058046.5 [O96539-2]
NP_725939.2, NM_166379.3 [O96539-1]
NP_725940.2, NM_166380.3 [O96539-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0085627

Proteomic databases

PaxDbiO96539
PRIDEiO96539

Genome annotation databases

EnsemblMetazoaiFBtr0086317; FBpp0085626; FBgn0025720 [O96539-2]
FBtr0086318; FBpp0085627; FBgn0025720 [O96539-1]
FBtr0086319; FBpp0089149; FBgn0025720 [O96539-4]
FBtr0336634; FBpp0307617; FBgn0025720 [O96539-5]
GeneIDi37288
KEGGidme:Dmel_CG9204
UCSCiCG9204-RA d. melanogaster [O96539-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11101
FlyBaseiFBgn0025720 Ate1

Phylogenomic databases

eggNOGiKOG1193 Eukaryota
COG2935 LUCA
GeneTreeiENSGT00500000044926
InParanoidiO96539
KOiK00685
OMAiCYTIKCD
PhylomeDBiO96539

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37288

Protein Ontology

More...
PROi
PR:O96539

Gene expression databases

BgeeiFBgn0025720 Expressed in 31 organ(s), highest expression level in spermathecum
ExpressionAtlasiO96539 differential
GenevisibleiO96539 DM

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR017137 Arg-tRNA-P_Trfase_1_euk
IPR030700 N-end_Aminoacyl_Trfase
IPR007472 N-end_Aminoacyl_Trfase_C
IPR007471 N-end_Aminoacyl_Trfase_N
PANTHERiPTHR21367 PTHR21367, 1 hit
PfamiView protein in Pfam
PF04377 ATE_C, 1 hit
PF04376 ATE_N, 1 hit
PIRSFiPIRSF037207 ATE1_euk, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATE1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96539
Secondary accession number(s): Q7KRL0
, Q86PB1, Q8IH08, Q8N0R9, Q8T7L5, Q9V906, Q9V907
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 16, 2004
Last modified: October 16, 2019
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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