UniProtKB - O96299 (O96299_DROME)
Protein
Submitted name:
LD47736p
Gene
Sodh-2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Cofactori
Zn2+UniRule annotation
GO - Molecular functioni
- L-iditol 2-dehydrogenase activity Source: FlyBase
- zinc ion binding Source: InterPro
GO - Biological processi
- sorbitol catabolic process Source: FlyBase
Keywordsi
Molecular function | OxidoreductaseImportedARBA annotation |
Ligand | Metal-bindingUniRule annotation, ZincUniRule annotation |
Enzyme and pathway databases
Reactomei | R-DME-5652227, Fructose biosynthesis R-DME-5661270, Formation of xylulose-5-phosphate |
Names & Taxonomyi
Protein namesi | Submitted name: LD47736pImportedSubmitted name: Sorbitol dehydrogenaseImportedSubmitted name: Sorbitol dehydrogenase-2Imported (EC:1.1.1.14Imported) |
Gene namesi | Name:Sodh-2Imported Synonyms:DM_7299382Imported, Dmel\CG4649Imported, SdhImported, Sdh-2Imported, SODH-2Imported ORF Names:CG4649Imported, Dmel_CG4649Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0022359, Sodh-2 |
Expressioni
Gene expression databases
Bgeei | FBgn0022359, Expressed in arthropod fat body and 21 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | O96299, 2 interactors |
STRINGi | 7227.FBpp0081800 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 347 | PKS_ERInterPro annotationAdd BLAST | 336 |
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
GeneTreei | ENSGT00550000074781 |
HOGENOMi | CLU_026673_11_5_1 |
OMAi | ETWYAMS |
OrthoDBi | 1019156at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
O96299-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATDNLTAVL HGIEDLRLEQ RPIPEIADDE VLLAMDSVGI CGSDVHYLAH
60 70 80 90 100
GRIGDFVLTK PMIIGHEAAG VVAKLGKKVT TLKVGDRVAI EPGVPCRYCD
110 120 130 140 150
HCKQGRYNLC ADMVFCATPP YDGNLTRYYK HAADFCFKLP DHVSMEEGAL
160 170 180 190 200
LEPLSVGVHA CRRAGVGLGS KVLILGAGPI GLVTLLAAQA MGASEILITD
210 220 230 240 250
LVQQRLDVAK ELGATHTLLL QRDQSAEETV KVVHQTMSEV PDKSIDCCGA
260 270 280 290 300
ESSARLAIFA TRSGGVVVVV GMGAPEVKLP LINALAREID IRGVFRYCND
310 320 330 340 350
YSAALALVAS GKVNVKRLVT HHYDITETAE AFETSRRGTG GAIKVMIHVQ
360
PRDANNKVKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF002213 Genomic DNA Translation: AAD00903.1 AE014297 Genomic DNA Translation: AAF54573.1 AY058731 mRNA Translation: AAL13960.1 |
RefSeqi | NP_524311.1, NM_079587.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0082324; FBpp0081800; FBgn0022359 |
GeneIDi | 41313 |
KEGGi | dme:Dmel_CG4649 |
UCSCi | CG4649-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF002213 Genomic DNA Translation: AAD00903.1 AE014297 Genomic DNA Translation: AAF54573.1 AY058731 mRNA Translation: AAL13960.1 |
RefSeqi | NP_524311.1, NM_079587.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | O96299, 2 interactors |
STRINGi | 7227.FBpp0081800 |
Genome annotation databases
EnsemblMetazoai | FBtr0082324; FBpp0081800; FBgn0022359 |
GeneIDi | 41313 |
KEGGi | dme:Dmel_CG4649 |
UCSCi | CG4649-RA, d. melanogaster |
Organism-specific databases
CTDi | 41313 |
FlyBasei | FBgn0022359, Sodh-2 |
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
GeneTreei | ENSGT00550000074781 |
HOGENOMi | CLU_026673_11_5_1 |
OMAi | ETWYAMS |
OrthoDBi | 1019156at2759 |
Enzyme and pathway databases
Reactomei | R-DME-5652227, Fructose biosynthesis R-DME-5661270, Formation of xylulose-5-phosphate |
Miscellaneous databases
BioGRID-ORCSi | 41313, 0 hits in 1 CRISPR screen |
ChiTaRSi | Sodh-2, fly |
GenomeRNAii | 41313 |
Gene expression databases
Bgeei | FBgn0022359, Expressed in arthropod fat body and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O96299_DROME | |
Accessioni | O96299Primary (citable) accession number: O96299 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |