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Entry version 79 (08 May 2019)
Sequence version 1 (01 May 1999)
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Protein

Uncharacterized protein PFB0460c

Gene

PFB0460c

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PFB0460C-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein PFB0460c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PFB0460c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
PlasmoDB:PF3D7_0210200

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Possible candidate for an effective malaria vaccine as determined by epitope response in sera.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003887611 – 2573Uncharacterized protein PFB0460cAdd BLAST2573

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O96185

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O96185

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Developmental stagei

Merozoite

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O96185

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili413 – 452Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 59Asn-richSequence analysisAdd BLAST19
Compositional biasi472 – 592Asn-richSequence analysisAdd BLAST121
Compositional biasi786 – 1159Asn-richSequence analysisAdd BLAST374
Compositional biasi1299 – 1344Asn-richSequence analysisAdd BLAST46
Compositional biasi1303 – 1339Asp-richSequence analysisAdd BLAST37
Compositional biasi1600 – 1646Ser-richSequence analysisAdd BLAST47
Compositional biasi1683 – 1726Asn-richSequence analysisAdd BLAST44
Compositional biasi2337 – 2478Asn-richSequence analysisAdd BLAST142
Compositional biasi2338 – 2386Asp-richSequence analysisAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000284282

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O96185

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O96185-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFKNNEKYM DEENDQESDD EFFKVKRKPQ INVDAEEDED NNNNNNNNNN
60 70 80 90 100
NSNISNHMNE FDLEEEDEDD YEDENYIVGE TIEIDESKLK NEKIEEDIFN
110 120 130 140 150
ENNLLHGIKT RELLEQEILI LFSNMLKKET ILCKDIKSGS NDPMDEISLF
160 170 180 190 200
KDDMVDDKEL KDFEKSSLKI KNKEVYNFIY NKMNLHIKEN KKKDEKEKKN
210 220 230 240 250
KIHNNDENNN MIYYKNIDKT HYILDNNVVH ILNDINTYLK RERDYMNRKF
260 270 280 290 300
GTYIDSTYKN PMYVTLYIFN NDILKDIILQ VIDIIRNDFD HAIYKDIDEN
310 320 330 340 350
QLIKNLIILI NHLTTRPSKE WFDYWKRHMP TFNDKKSEYN VYKYLQLQKS
360 370 380 390 400
DRRILYDTLK NDIYIKELQK RSDILDQYQK GLQSLKCLLA NKNFLTMLNE
410 420 430 440 450
FRYNTQLFID ADYREIEENE KVMEMQRREN ELLEEKKRLK QELESYHDDS
460 470 480 490 500
STDDDSSADE QQDERREVLT HNDPINKKDD PINKNDDPIN KNDDPINKND
510 520 530 540 550
DNINKNDDNI NKNDDNICNS NDHTHNSNDH THNSNDHTHN SNDHTHNSND
560 570 580 590 600
HTHFSNDHTH FSNDHTHFSN DHTHFSNDHT HNSNDHTHNS KNHAHFSNEV
610 620 630 640 650
DKTNDYKYHS EKKKKNNVIR SKMYNIKKRI SKINDELHEL SNFFLIDKTK
660 670 680 690 700
REKLMFEYNE NVFLVRNILT QVLGIRNKTD NRDINLNNVH YAILQNILDK
710 720 730 740 750
HGCLHLIIDE MRDLFEKEIK KYEEESNIYI PYIKQNTMKQ IWEYIRLFYN
760 770 780 790 800
IICYIDPIDL VKSLTYQKST HIIKKEKKKT KTDMDNNNNN NNNNNNDNNN
810 820 830 840 850
IMMNQKFLNN YHNKKHLNTS DNVNNMKTNN LRNYNKDINL KNVGKDMNKR
860 870 880 890 900
KSMAQQQNKR KSNYINIKQK NLMITHLSRI NPLLAKSKVR KPNEEKHLKK
910 920 930 940 950
RKRKFIERKN LIDHYEIFSF EDFSFNMFSE DRLFNKYNIL DIFDYSNLYK
960 970 980 990 1000
IQDFLNNIIG INEEFESIYE NDDNFHYSLK VFLNICIKDL RRCINEFYNF
1010 1020 1030 1040 1050
QWDIKIILNM HAWIVTYYTN LYIYENRKRF YNSRNKNKNN KEHQMNRDDE
1060 1070 1080 1090 1100
RKCTKEYTNQ NEGEMKYDHN RKREDEQKNH KYCNINCNIN CNINCNKNCN
1110 1120 1130 1140 1150
KNCNINYNNG DNNVYDNNVY DNNDDYNDDY NDDYNDDYND DYNDVNQNTY
1160 1170 1180 1190 1200
VKHNNQNENS SLFISRIQMV LGLQMYIGDN SIHSEFLCDT FQRVIREEKM
1210 1220 1230 1240 1250
MKNSSQVILC CLRCLYSDLN LLDIHSLSTD ENVKSICKTS LDNLLKRNIL
1260 1270 1280 1290 1300
TTLSWILQNF KILSHEKHIF IYSLKCSLLI INLLAKLGGT TYIIKEKKNI
1310 1320 1330 1340 1350
HNDSHDDNND DSVNDSNDDT NNVNVNVNVN DYYDDDDDDN NNNNRIDKKK
1360 1370 1380 1390 1400
KHKKKKYNNE PMEKIDVSDL VEEIFNGKIV NICMHILENF KRNSLYINDL
1410 1420 1430 1440 1450
IITYFEHLIK HKNNEYNFLI FFDIKYFLIF KDIINDPEAY NNPHYYWIPC
1460 1470 1480 1490 1500
FFENIIACFF KIWKSNYFIV NELLFTKDIN KNNSNLLNEK YLLSIFSNYN
1510 1520 1530 1540 1550
EGNDPFIFQQ LNEGIYINDI FINLNNKKRL ESLEWSNEDI ENLKFYFKQF
1560 1570 1580 1590 1600
KHMHNFLPFI SEMLNKSSNV VKNQLIYLNY LDKRGKVIYD DQYESDNMIS
1610 1620 1630 1640 1650
SSSSSSSSSS SSSSLSSSSS LSCVSYLSEA QNSNNKSNDS LKMSYSKKKK
1660 1670 1680 1690 1700
QHTNEHMNHH QNYPMRKTKQ PLLYIIYKLK KLNYNNNNNN NNNNNNNDDN
1710 1720 1730 1740 1750
TKDQPKLTVN EINCNVDTVL EEINVNLKSL YELKKLSKNK IFNNKALAFD
1760 1770 1780 1790 1800
IPLSISPDLL EHHYFKKLLK HIGFLYNQNV DEWILNENLD IDIFKKTIDK
1810 1820 1830 1840 1850
FEQLYIMDIQ KLKKKLSSHK LNVQTNDQGE RQDERNIDHE DEPVSSNTED
1860 1870 1880 1890 1900
DHEENDYFTY DHIDERDHKK CDDKKYSDNT NETYDDQKCD DNTNETYDNE
1910 1920 1930 1940 1950
KCDEAINNKH MDEQELHLRS PSIKTKGTLK LLKLMYEFFI SNDDECRLFF
1960 1970 1980 1990 2000
NNLINTIKEK CIIIFEKLKK CKLDHDILYK DTTNNYYDHT SHPVQICFED
2010 2020 2030 2040 2050
YKIYLNNNEK SILKGRCKHK NILEELLEIL GLYISNVPCL IISKHIKEEE
2060 2070 2080 2090 2100
FYERITTIND HKTLSLNDLN MIITTKEKEI KEKKKKKKEE RKPSAHQKFA
2110 2120 2130 2140 2150
FIKSICEYLN YNYIIRNTYK SEQNTNNHND NNIIYNNTYS KLKDTYFGDD
2160 2170 2180 2190 2200
KLLTALYDKL NIWNNRRKKK NDDMVLEIPI PQFVGSMCNV GTSEGEHEQK
2210 2220 2230 2240 2250
LDESKNIYTK EYNNDEKFLK SHINCQDDTQ KISSLVIHIG ICLKGEYHDE
2260 2270 2280 2290 2300
SILKWTCEQI HREWMKIMLK LFYNILYDTT YNVIGKLFKE YKNIKEILND
2310 2320 2330 2340 2350
QSSDFLDMYK SDKKKKKKKK ELDDVEKEGQ PKMGVGNDDN INGDKNIYDD
2360 2370 2380 2390 2400
NINGDDNING DKNIYDDDKN IYDDDDNING DKNIYDGNYK ISYSKEYEHI
2410 2420 2430 2440 2450
HMDEKKEVEK EYHIYDNNNN NDNNNDNNND NNNNSHTLAF QNRTQGETTF
2460 2470 2480 2490 2500
TNINNITNDI CEKGNKYTSN VNNINNINEM TCKESVEVNE IIQKTNKRKF
2510 2520 2530 2540 2550
HNIELKEHYC YDLFKKRKLE NTYRNTYKKN RKIIINCLLT NKNIFQYKEH
2560 2570
DIVNKVKQIF IKAKHMATNG VRK
Length:2,573
Mass (Da):308,145
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49E0D7E8967066CF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE001362 Genomic DNA Translation: AAC71881.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D71614

NCBI Reference Sequences

More...
RefSeqi
XP_001349610.1, XM_001349574.1

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0210200.1:pep

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001362 Genomic DNA Translation: AAC71881.1
PIRiD71614
RefSeqiXP_001349610.1, XM_001349574.1

3D structure databases

SMRiO96185
ModBaseiSearch...

PTM databases

SwissPalmiO96185

Proteomic databases

PRIDEiO96185

Genome annotation databases

GeneDBiPF3D7_0210200.1:pep

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0210200

Phylogenomic databases

HOGENOMiHOG000284282
InParanoidiO96185

Enzyme and pathway databases

BioCyciPLASMO:PFB0460C-MONOMER

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYPF08_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96185
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 1, 1999
Last modified: May 8, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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