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Entry version 127 (31 Jul 2019)
Sequence version 3 (22 Sep 2009)
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Protein
Submitted name:

26S proteasome regulatory subunit RPN1,putative

Gene

PF3D7_0205900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-5689603 UCH proteinases
R-PFA-5689880 Ub-specific processing proteases
R-PFA-6798695 Neutrophil degranulation
R-PFA-68949 Orc1 removal from chromatin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
26S proteasome regulatory subunit RPN1,putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0205900Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0205900

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

ProteasomeImported

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O96153

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O96153

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O96153, 2 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 366RPN1_RPN2_NInterPro annotationAdd BLAST321
Domaini907 – 960RPN1_CInterPro annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni631 – 695DisorderedSequence analysisAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi639 – 687PolarSequence analysisAdd BLAST49

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K03028

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVDICAY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016643 26S_Psome_Rpn1
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002015 Proteasome/cyclosome_rpt
IPR041433 RPN1_C
IPR040892 RPN1_RPN2_N

The PANTHER Classification System

More...
PANTHERi
PTHR10943:SF1 PTHR10943:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01851 PC_rep, 1 hit
PF18051 RPN1_C, 1 hit
PF17781 RPN1_RPN2_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015965 26S_Psome_Rpn1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O96153-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAEDKKAVS IQVPVKDVDD KRRKLNNSKI KKEELNEEEK KKKEELELLI
60 70 80 90 100
TRLRDEDVNV VNLSISLLNK EIIDTSGILT SSLLALKVLK THYNTLIEIF
110 120 130 140 150
NEMIFEECKK KLSNMISALS TTIGDENNIV KFVITGNKHD LINYGHEYIK
160 170 180 190 200
NLITKLLVEY KILKEEENNQ NGLTTTSTTS NKLVTINHIY DIVNIVVPYC
210 220 230 240 250
FAHNTEYEAI DLLIEVDKIN DIYLYVDEKS CDRSILYLLN LTHYSSSTDE
260 270 280 290 300
YYKLMDVILN ILKKHNKHVE CLKILLRLNK IDKIKDLIFE CNDILICKQI
310 320 330 340 350
ALICSRHCVH IQFTEEEIKK YTHLNLNEIS TLTSGEHLSP IFLKLAKDLD
360 370 380 390 400
VEEPKLPEDV YKSHLEEKRN TTVWDSAKQN LSSTFVNAFV NAAFCKDKLM
410 420 430 440 450
TVNSSLWIFK NKDYGLMSAT ASMGLLLMWN LDEGLSQIDK FQYSSDQYVK
460 470 480 490 500
AGALMAFGLA CTNIKNECDP AYALLSEHID AENALEKMGA ILGFGYAYAG
510 520 530 540 550
TNRENLLDIL IPPLVDNGCI IECSVYAALS LGLVFVGSQN REIAEYIIDT
560 570 580 590 600
VLEKEKINNS LDTPIAKLYA VALGLLFLCS REKCEATLSA LEIIKHPISK
610 620 630 640 650
YMIATVEGMA FAGSNDVLKV QKMLQVLVEK RGDKKNNSDN KTTTANNTDN
660 670 680 690 700
NKSSNADINK TTTTDTSKKT DNNNNNSSSN NKNTKSNEEK SSSSKNYVED
710 720 730 740 750
NLDQCVAILN IALIALTDDI SSDMTTRIID HFLQYSNVNQ KKAVPLALAL
760 770 780 790 800
LFTSFPKPNI VDILSKLTHD QDPDVALHAI ISLGFVGAGT NNSRIAILLR
810 820 830 840 850
QLSAFYCKDT NAIFVVRLAQ GLLYMGKGLL TINPLHSNRS IINYVSLGSL
860 870 880 890 900
LITIHACLQL KSTILGKYHY LLYHLVPCIY PRMLVTVNEK LESLPVSVRV
910 920 930 940 950
GQAVDIVGQA GKPKTITGFQ THVTPVLLSH TDRAEMATEE YISVNDTLEG
960
IVILKKDPNY IPPSIN
Length:966
Mass (Da):108,358
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EBB1D10AC2E43F3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999943 Genomic DNA Translation: CZT98072.1

NCBI Reference Sequences

More...
RefSeqi
XP_001349569.2, XM_001349533.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT98072; CZT98072; PF3D7_0205900

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0205900.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
812651

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0205900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999943 Genomic DNA Translation: CZT98072.1
RefSeqiXP_001349569.2, XM_001349533.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiO96153, 2 interactors

PTM databases

SwissPalmiO96153

Proteomic databases

PRIDEiO96153

Genome annotation databases

EnsemblProtistsiCZT98072; CZT98072; PF3D7_0205900
GeneDBiPF3D7_0205900.1:pep
GeneIDi812651
KEGGipfa:PF3D7_0205900

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0205900

Phylogenomic databases

KOiK03028
OMAiMVDICAY

Enzyme and pathway databases

ReactomeiR-PFA-5689603 UCH proteinases
R-PFA-5689880 Ub-specific processing proteases
R-PFA-6798695 Neutrophil degranulation
R-PFA-68949 Orc1 removal from chromatin

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR016643 26S_Psome_Rpn1
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002015 Proteasome/cyclosome_rpt
IPR041433 RPN1_C
IPR040892 RPN1_RPN2_N
PANTHERiPTHR10943:SF1 PTHR10943:SF1, 1 hit
PfamiView protein in Pfam
PF01851 PC_rep, 1 hit
PF18051 RPN1_C, 1 hit
PF17781 RPN1_RPN2_N, 1 hit
PIRSFiPIRSF015965 26S_Psome_Rpn1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO96153_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96153
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: September 22, 2009
Last modified: July 31, 2019
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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