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Entry version 95 (02 Jun 2021)
Sequence version 1 (01 May 1999)
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Protein

Uncharacterized protein PFB0145c

Gene

PFB0145c

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein PFB0145c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PFB0145c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_0203000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Possible candidate for an effective malaria vaccine as determined by epitope response in sera.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003568321 – 1979Uncharacterized protein PFB0145cAdd BLAST1979

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O96133

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Developmental stagei

Merozoite

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
1207947, 1 interactor

Protein interaction database and analysis system

More...
IntActi
O96133, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O96133

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 42DisorderedSequence analysisAdd BLAST42
Regioni54 – 116DisorderedSequence analysisAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili126 – 908Sequence analysisAdd BLAST783
Coiled coili935 – 1095Sequence analysisAdd BLAST161
Coiled coili1126 – 1307Sequence analysisAdd BLAST182
Coiled coili1398 – 1471Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi65 – 116Polar residuesSequence analysisAdd BLAST52

Keywords - Domaini

Coiled coil

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_243476_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O96133

Identification of Orthologs from Complete Genome Data

More...
OMAi
YEASKTD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O96133

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O96133-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFTFKNKKK KKEASSDKVS KESFNEEDNE NNEKREKSDS WYKKIIETKG
60 70 80 90 100
KSKTKYKNDN SLDDNINEDI INNNNNNNND NNNDNNNDNN NDNNNDNNND
110 120 130 140 150
NNNENNNDNN NFNNYSDEIS KNIIHKDNEL ENQLKDTLKS ISSLSNKIVN
160 170 180 190 200
YESKIEELEK ELKEVKDKNI DNNDYENKLK EKEDFVKQKI DMLNEKENLL
210 220 230 240 250
QEKELDINKR EKKINEKEKN IIKKEETFHN IEKEYLEKNK ERETISIEII
260 270 280 290 300
DIKKHLEKLK IEIKEKKEDL ENLNKKLLSK ENVLKELKGC VKEKNETINS
310 320 330 340 350
LNDNIIEKEK KYKLLEYELE EKNKQIDLLN KQEKEKEKEK EREKEKEREK
360 370 380 390 400
EKEKEYDTLI KELKDEKISI LEKVHSIKVR EMDIEKREHN FLHMEDQLKD
410 420 430 440 450
LKNSFVKNNN QLKVYKCEIK NLKTELEKKE KELKDIENVS KEEINKLINQ
460 470 480 490 500
LNEKEKQILA FNKNHKEEIH GLKEELKESV KITKIETQEL QEMVDIKQKE
510 520 530 540 550
LDQLQEKYNA QIESISIELS KKEKEYNQYK NTYIEEINNL NEKLEETNKE
560 570 580 590 600
YTNLQNNYTN EINMLNNDIH MLNGNIKTMN TQISTLKNDV HLLNEQIDKL
610 620 630 640 650
NNEKGTLNSK ISELNVQIMD LKEEKDFLNN QIVDLSNQID LLTRKMEEKE
660 670 680 690 700
NKMLEQENKY KQEMELLRGN IKSSENILNN DEEVCDLKRK LSLKESEMKM
710 720 730 740 750
MKEEHDKKLA ELKDDCDVRI REMNEKNEDK INMLKEEYED KINTLKEQNE
760 770 780 790 800
DKINTLKEQN EDKINTLKEE YEHKINTMKE EYEHKINTLN EQNEHKINTL
810 820 830 840 850
NEQNEHKINT MKEEYEDKMN TLNEQNEDKM NSLKEEYENK INQINSNNEI
860 870 880 890 900
KIKDVVNEYI EEVDKLKVTL DEKKKQFDKE INYAHIKAHE KEQILLTEME
910 920 930 940 950
ELKCQRDNKY SDLYEKYIKL IKSICMIINI ECCDDIENED IIRRIEEYIN
960 970 980 990 1000
NNKGLKKEVE EKEHKRHSSF NILKSKEKFF KNSIEDKSHE LKKKHEKDLL
1010 1020 1030 1040 1050
SKDKEIEEKN KKIKELNNDI KKLQDEILVY KKQSNAQQVD HKKKSWILLK
1060 1070 1080 1090 1100
DKSKEKIKDK ENQINVEKNE EKDLKKKDDE IRILNEELVK YKTILYNLKK
1110 1120 1130 1140 1150
DPLLQNQDLL SKIDINSLTI NEGMCVDKIE EHILDYDEEI NKSRSNLFQL
1160 1170 1180 1190 1200
KNEICSLTTE VMELNNKKNE LIEENNKLNL VDQGKKKLKK DVEKQKKEIE
1210 1220 1230 1240 1250
KLNKQLTKCN KQIDELNEEV EKLNNENIEL ITYSNDLNNK FDMKENNLMM
1260 1270 1280 1290 1300
KLDENEDNIK KMKSKIDDME KEIKYREDEK KRNLNEINNL KKKNEDMCIK
1310 1320 1330 1340 1350
YNEMNIKYGD ICVKYEEMSL TYKETSLKYE QIKVKYDEKC SQYDEIRFQY
1360 1370 1380 1390 1400
DEKCFQYDEI NKKYGALLNI NITNKMVDSK VDRNNNEIIS VDNKVEGIAN
1410 1420 1430 1440 1450
YLKQIFELNE EIIRLKGEIN KISLLYSNEL NEKNSYDINM KHIQEQLLFL
1460 1470 1480 1490 1500
EKTNKENEEK IINLTSQYSD AYKKKSDESK LCGAQFVDDV NIYGNISNNN
1510 1520 1530 1540 1550
IRTNEYKYEE MFDTNIEEKN GMHLSKYIHL LEENKFRCMK IIYENENIKS
1560 1570 1580 1590 1600
SNKIIGLYNY SRYYGLREDL CKEEIVPSKI GNISNKNENN NKKNNTCDGY
1610 1620 1630 1640 1650
DEKVTIVLCI ILNEIIKFLF LNDEYVLLFE KIHKNVWKRM YIPEEIKFFI
1660 1670 1680 1690 1700
LKYITLLNNL RDYIISVHNN MKNEKYDECW FLFQHYFERS SDVRKEMVHF
1710 1720 1730 1740 1750
LLERKSQENL ISFKSKLKSK KEKILTMDIL NFSKEHMQLK TIAHLRKEIN
1760 1770 1780 1790 1800
YEKLSKDTLN RDYNLLLYKY QECVSKLKRV KNLMKEINQN VFIEKYDDIS
1810 1820 1830 1840 1850
KELDNFSDGY NEQNEQHVMD PILLNNNKNK NNKLITEHNN PIINRLTNFT
1860 1870 1880 1890 1900
QNRDSKYKNK IMDDVKQRKI NSTMNNTNKN GINIIYNHYE NLNKPNYNDN
1910 1920 1930 1940 1950
INRLNSYHQN IHIANSIHPN RNQNKSFLTN QANSTYSVMK NYINSDKPNL
1960 1970
NGKKSVRNIF NEIVDENVNK TFVHKSVFF
Length:1,979
Mass (Da):237,747
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C6CD6307AFF7D37
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE001362 Genomic DNA Translation: AAC71819.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C71622

NCBI Reference Sequences

More...
RefSeqi
XP_001349543.1, XM_001349507.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT98043; CZT98043; PF3D7_0203000

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0203000.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
812625

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0203000

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001362 Genomic DNA Translation: AAC71819.1
PIRiC71622
RefSeqiXP_001349543.1, XM_001349507.1

3D structure databases

SMRiO96133
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi1207947, 1 interactor
IntActiO96133, 1 interactor

Proteomic databases

PRIDEiO96133

Genome annotation databases

EnsemblProtistsiCZT98043; CZT98043; PF3D7_0203000
GeneDBiPF3D7_0203000.1:pep
GeneIDi812625
KEGGipfa:PF3D7_0203000

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0203000

Phylogenomic databases

HOGENOMiCLU_243476_0_0_1
InParanoidiO96133
OMAiYEASKTD
PhylomeDBiO96133

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYB145_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96133
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 1, 1999
Last modified: June 2, 2021
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
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