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Entry version 90 (07 Apr 2021)
Sequence version 2 (01 May 2000)
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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

TuCa1

Organism
Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TuCa1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHalocynthia roretzi (Sea squirt) (Cynthia roretzi)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7729 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaPyuridaeHalocynthia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 68HelicalSequence analysisAdd BLAST18
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei120 – 138HelicalSequence analysisAdd BLAST19
Transmembranei181 – 203HelicalSequence analysisAdd BLAST23
Transmembranei261 – 282HelicalSequence analysisAdd BLAST22
Transmembranei294 – 316HelicalSequence analysisAdd BLAST23
Transmembranei430 – 447HelicalSequence analysisAdd BLAST18
Transmembranei467 – 484HelicalSequence analysisAdd BLAST18
Transmembranei553 – 573HelicalSequence analysisAdd BLAST21
Transmembranei631 – 659HelicalSequence analysisAdd BLAST29
Transmembranei801 – 822HelicalSequence analysisAdd BLAST22
Transmembranei842 – 863HelicalSequence analysisAdd BLAST22
Transmembranei872 – 889HelicalSequence analysisAdd BLAST18
Transmembranei923 – 956HelicalSequence analysisAdd BLAST34
Transmembranei1048 – 1074HelicalSequence analysisAdd BLAST27
Transmembranei1125 – 1143HelicalSequence analysisAdd BLAST19
Transmembranei1155 – 1178HelicalSequence analysisAdd BLAST24
Transmembranei1253 – 1275HelicalSequence analysisAdd BLAST23
Transmembranei1349 – 1373HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1507 – 1541Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni362 – 384DisorderedSequence analysisAdd BLAST23
Regioni735 – 764DisorderedSequence analysisAdd BLAST30
Regioni1607 – 1736DisorderedSequence analysisAdd BLAST130
Regioni1925 – 1946DisorderedSequence analysisAdd BLAST22
Regioni2071 – 2125DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili668 – 710Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1607 – 1624PolarSequence analysisAdd BLAST18
Compositional biasi1641 – 1672PolarSequence analysisAdd BLAST32
Compositional biasi1681 – 1700PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1708 – 1732PolarSequence analysisAdd BLAST25
Compositional biasi2083 – 2097PolarSequence analysisAdd BLAST15
Compositional biasi2102 – 2116PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01630, LVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O96057-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGTTNPTTR KRKIKPDPNA GRAPQALLCL SLKNPIRKAC MKIVDWRPFD
60 70 80 90 100
VLILLTILAN CVALAVYVPF PGDDSNRTNE ILEKVEYIFL GIFTIEAILK
110 120 130 140 150
IIAYGLFFHP NAYLRNGWNV IDFVIVVIGL VSIVLETANV GSTDKVRSLR
160 170 180 190 200
AFRVLRPLRL VSGVPSLEVV LNAIIRAMVP LLHIALLVIF VIIIYAVVGL
210 220 230 240 250
ELFKGKLHKT CYHNEVAVLI MEDEAKPCAD SDSWGRHCSG GMICESDWAG
260 270 280 290 300
PSKGIINFDT FYFAVITVFQ CITMEGWTDV LYYMNDAVGN LWPWIYFVSL
310 320 330 340 350
IIIGSFFVMN LILGVLSGEF SKEREKANAR GEFQKLREKQ QTDEDMKGYM
360 370 380 390 400
DWITQAEDLD PMNDEDREDR RSASNEQLND ADSEVSGLQI DETWWQMQRR
410 420 430 440 450
ALFKVCYSRR WRRWNRKTRR RCRTMVKSKS FYWLVIVLVF CNTLSLATEH
460 470 480 490 500
YRQPPWLTLA QDLANKILLT LFTIEMLVKM YSLGMQQYFV SLFNRFDCFV
510 520 530 540 550
VCGGIVELVL TSSKIMEPLG ISVLRCVRLL RIFKMTSSWN SLSNLVASLL
560 570 580 590 600
NSIRSIASLL VLLFLFIIIF ALLGMQMFGG RFSEIEQEDK IRSNFDTFLQ
610 620 630 640 650
ALLTVFQILT GEDWNVVMYN GIEAYGGAST IGLLTSVYFI VLFIGGNYIL
660 670 680 690 700
LNVFLAIAVD NLADAESLGA AQKEKEEEKK MKKTLRLKKL RKLFKKKDQT
710 720 730 740 750
SVENQEVNQE DTLNRVEEMP NYYTPDHDIR IEVTEASDTN SDKHLPEVSD
760 770 780 790 800
GEMEPEVPVG PRPRRMSEMH LSEKKVPLPE GSSFFILSNT NRLRVFCYDI
810 820 830 840 850
VNYNWFNNAI LACIILSSIA LACEDPVSAH SARNKVLEYF DYVFTGVFAV
860 870 880 890 900
EIVLKMTAFG VFLHKGSFCR SYFNLLDLLV VAVSLVSMLS NSDKFSVVKI
910 920 930 940 950
LRVLPSVLRP LRAINRAKGL KHVVQCVFVA ISTIGNIMVI TGLLQFMFAC
960 970 980 990 1000
IGVQLFKGRL YYCTDQSKET KEECHGKFFV YSKDGNGEPR VEERLWENSE
1010 1020 1030 1040 1050
FNYDNVMNAM LTLFVVATFE GWPGLLYKSI DSWSENHGPR YDARQAVALF
1060 1070 1080 1090 1100
YFVFIIVIAF FMMNIFVGFV IVTFQEQGEQ EYKNCELDKN QRQCLEYALK
1110 1120 1130 1140 1150
AKPVKRYIPK NPWQYKVWFI VNSTYFEYFM LVLILLNTVC LAVQHHQQSK
1160 1170 1180 1190 1200
ELTVILNHMN YVFTALFALE MIVKLVAYKP RGYLSDPWNV FDSLIVIGSI
1210 1220 1230 1240 1250
VDIVFSELDH GNEKSFSINF FRLFRVLRLV KLLSRGEGIR TLLWTFIKSF
1260 1270 1280 1290 1300
PALPYVALLI IMLFFIYAVI GMQIFGKIKP NDGSQINRNN NFQTFLQAVL
1310 1320 1330 1340 1350
LLFRCATGES WQEVMLACAS GNECDDESDW NYYGDKDISA KFTCGNDFAY
1360 1370 1380 1390 1400
TYFLTFYMLC AFLIINLFVA VIMDNFDYLT RDWSILGLHH LDEFVRVWSE
1410 1420 1430 1440 1450
YDHEASGRIK HLHVVKLLRH IQPPLGFGKL CPQRMACRKL VSMNMPLNSD
1460 1470 1480 1490 1500
GTVMFNATLF ALVRTSLKIK SEGNIDQANE ELRAVIKKIW KRTSMKLLDQ
1510 1520 1530 1540 1550
VVPPAGNDDV TVGKFYATYL IQDYFRKFKE SKERRLRERD GRHHPNNANT
1560 1570 1580 1590 1600
LTLQAGIREV QDVSPELKRS ISGNLVPNEY EESELVSMDD EPEHRRRHSI
1610 1620 1630 1640 1650
FGQLRSLASP GTPVMTSRRP LTVSDNTPAV GHRKHEQNSD QNPLVNRLTP
1660 1670 1680 1690 1700
QQPFPNATPS HAQATEKSVN RSLDGIHTMP RDANIGRHHG SIDDFSRYHK
1710 1720 1730 1740 1750
SPTQPDGFVV EPTFTSPSHN TNRNNSANPT ECMVHRPNGK CQKMQRAYSE
1760 1770 1780 1790 1800
EDKGERGDRN FIVPYLSMDG GMNTVQHWGR DAREQRPCYC GKPRRLLRPC
1810 1820 1830 1840 1850
SKRSLNLDYT PLQRNETPVK SPTTENLSKR TLQSCDRSFS FPGKNRIDSF
1860 1870 1880 1890 1900
TSIEDECLLS RDSRDADSIF FNEIGGSGIS SSDSDMFESD SGSCDDECGS
1910 1920 1930 1940 1950
VRTYRTANTI SPQCAFKTFS EVNSQPGSKS DVGVTRKLPP TPEAPSRIFR
1960 1970 1980 1990 2000
LPMMSKNWRK SRENMPLCDI KTSETAPLIN SRNETSFHRN SIPRHKLTRQ
2010 2020 2030 2040 2050
FSTNYDNRHH ADDMDYRRDN EVIIYNKGDD GRGCSKTRSF VQIFQSLTNG
2060 2070 2080 2090 2100
DSDNDSTNVC QPKSYCRSDS VWDEEEETPI KRSQVEISPS GSRTRSPVPR
2110 2120
NGHEGCIERD EEADLASEMI VPNVK
Length:2,125
Mass (Da):242,983
Last modified:May 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C8B25B37A10F0C0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB013604 mRNA Translation: BAA34927.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T30890

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013604 mRNA Translation: BAA34927.2
PIRiT30890

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01630, LVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO96057_HALRO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96057
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 90 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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