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Entry version 175 (13 Feb 2019)
Sequence version 1 (01 May 1999)
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Protein

Histone-lysine N-methyltransferase NSD2

Gene

NSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi453 – 521HMG boxPROSITE-ProRule annotationAdd BLAST69
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri667 – 713PHD-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri714 – 770PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri831 – 875PHD-type 3PROSITE-ProRule annotationAdd BLAST45
Zinc fingeri1239 – 1286PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.1.1.43 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-69473 G2/M DNA damage checkpoint

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O96028

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase NSD2 (EC:2.1.1.43)
Alternative name(s):
Multiple myeloma SET domain-containing protein
Short name:
MMSET
Nuclear SET domain-containing protein 2
Protein trithorax-5
Wolf-Hirschhorn syndrome candidate 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NSD2Imported
Synonyms:KIAA1090, MMSET, TRX5, WHSC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000109685.17

Human Gene Nomenclature Database

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HGNCi
HGNC:12766 NSD2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602952 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O96028

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving NSD2 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.
NSD2 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. NSD2 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
7468

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
NSD2

MalaCards human disease database

More...
MalaCardsi
NSD2

Open Targets

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OpenTargetsi
ENSG00000109685

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
280 Wolf-Hirschhorn syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37369

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3108645

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NSD2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595191 – 1365Histone-lysine N-methyltransferase NSD2Add BLAST1365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei110PhosphothreonineCombined sources1
Modified residuei114PhosphothreonineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei422PhosphothreonineCombined sources1
Modified residuei544PhosphothreonineCombined sources1
Modified residuei614PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O96028

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O96028

MaxQB - The MaxQuant DataBase

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MaxQBi
O96028

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O96028

PeptideAtlas

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PeptideAtlasi
O96028

PRoteomics IDEntifications database

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PRIDEi
O96028

ProteomicsDB human proteome resource

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ProteomicsDBi
51216
51217 [O96028-2]
51218 [O96028-3]
51219 [O96028-4]
51220 [O96028-5]
51221 [O96028-6]
51222 [O96028-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O96028

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O96028

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000109685 Expressed in 223 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O96028 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O96028 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB068246
CAB068247
HPA015801

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113306, 72 interactors

Database of interacting proteins

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DIPi
DIP-57224N

Protein interaction database and analysis system

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IntActi
O96028, 6 interactors

Molecular INTeraction database

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MINTi
O96028

STRING: functional protein association networks

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STRINGi
9606.ENSP00000372347

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O96028

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LSUX-ray2.14A/B973-1203[»]
5VC8X-ray1.80A/B211-350[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O96028

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O96028

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini222 – 286PWWP 1PROSITE-ProRule annotationAdd BLAST65
Domaini880 – 942PWWP 2PROSITE-ProRule annotationAdd BLAST63
Domaini1011 – 1061AWSPROSITE-ProRule annotationAdd BLAST51
Domaini1063 – 1180SETPROSITE-ProRule annotationAdd BLAST118
Domaini1187 – 1203Post-SETPROSITE-ProRule annotationAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri667 – 713PHD-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri714 – 770PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri831 – 875PHD-type 3PROSITE-ProRule annotationAdd BLAST45
Zinc fingeri1239 – 1286PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1081 Eukaryota
COG2940 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157429

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230892

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079978

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O96028

KEGG Orthology (KO)

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KOi
K11424

Identification of Orthologs from Complete Genome Data

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OMAi
EYVMVHR

Database of Orthologous Groups

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OrthoDBi
507784at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O96028

TreeFam database of animal gene trees

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TreeFami
TF329088

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.30.10, 1 hit
3.30.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006560 AWS_dom
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR003616 Post-SET_dom
IPR000313 PWWP_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

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Pfami
View protein in Pfam
PF17907 AWS, 1 hit
PF00505 HMG_box, 1 hit
PF00855 PWWP, 2 hits
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00570 AWS, 1 hit
SM00398 HMG, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00293 PWWP, 2 hits
SM00184 RING, 2 hits
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47095 SSF47095, 1 hit
SSF57903 SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51215 AWS, 1 hit
PS50118 HMG_BOX_2, 1 hit
PS50868 POST_SET, 1 hit
PS50812 PWWP, 2 hits
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O96028-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFSIKQSPL SVQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK
60 70 80 90 100
AQLSSSLQEG VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGAHDAKLRF
110 120 130 140 150
ESQEMKGIGT PPNTTPIKNG SPEIKLKITK TYMNGKPLFE SSICGDSAAD
160 170 180 190 200
VSQSEENGQK PENKARRNRK RSIKYDSLLE QGLVEAALVS KISSPSDKKI
210 220 230 240 250
PAKKESCPNT GRDKDHLLKY NVGDLVWSKV SGYPWWPCMV SADPLLHSYT
260 270 280 290 300
KLKGQKKSAR QYHVQFFGDA PERAWIFEKS LVAFEGEGQF EKLCQESAKQ
310 320 330 340 350
APTKAEKIKL LKPISGKLRA QWEMGIVQAE EAASMSVEER KAKFTFLYVG
360 370 380 390 400
DQLHLNPQVA KEAGIAAESL GEMAESSGVS EEAAENPKSV REECIPMKRR
410 420 430 440 450
RRAKLCSSAE TLESHPDIGK STPQKTAEAD PRRGVGSPPG RKKTTVSMPR
460 470 480 490 500
SRKGDAASQF LVFCQKHRDE VVAEHPDASG EEIEELLRSQ WSLLSEKQRA
510 520 530 540 550
RYNTKFALVA PVQAEEDSGN VNGKKRNHTK RIQDPTEDAE AEDTPRKRLR
560 570 580 590 600
TDKHSLRKRD TITDKTARTS SYKAMEAASS LKSQAATKNL SDACKPLKKR
610 620 630 640 650
NRASTAASSA LGFSKSSSPS ASLTENEVSD SPGDEPSESP YESADETQTE
660 670 680 690 700
VSVSSKKSER GVTAKKEYVC QLCEKPGSLL LCEGPCCGAF HLACLGLSRR
710 720 730 740 750
PEGRFTCSEC ASGIHSCFVC KESKTDVKRC VVTQCGKFYH EACVKKYPLT
760 770 780 790 800
VFESRGFRCP LHSCVSCHAS NPSNPRPSKG KMMRCVRCPV AYHSGDACLA
810 820 830 840 850
AGCSVIASNS IICTAHFTAR KGKRHHAHVN VSWCFVCSKG GSLLCCESCP
860 870 880 890 900
AAFHPDCLNI EMPDGSWFCN DCRAGKKLHF QDIIWVKLGN YRWWPAEVCH
910 920 930 940 950
PKNVPPNIQK MKHEIGEFPV FFFGSKDYYW THQARVFPYM EGDRGSRYQG
960 970 980 990 1000
VRGIGRVFKN ALQEAEARFR EIKLQREARE TQESERKPPP YKHIKVNKPY
1010 1020 1030 1040 1050
GKVQIYTADI SEIPKCNCKP TDENPCGFDS ECLNRMLMFE CHPQVCPAGE
1060 1070 1080 1090 1100
FCQNQCFTKR QYPETKIIKT DGKGWGLVAK RDIRKGEFVN EYVGELIDEE
1110 1120 1130 1140 1150
ECMARIKHAH ENDITHFYML TIDKDRIIDA GPKGNYSRFM NHSCQPNCET
1160 1170 1180 1190 1200
LKWTVNGDTR VGLFAVCDIP AGTELTFNYN LDCLGNEKTV CRCGASNCSG
1210 1220 1230 1240 1250
FLGDRPKTST TLSSEEKGKK TKKKTRRRRA KGEGKRQSED ECFRCGDGGQ
1260 1270 1280 1290 1300
LVLCDRKFCT KAYHLSCLGL GKRPFGKWEC PWHHCDVCGK PSTSFCHLCP
1310 1320 1330 1340 1350
NSFCKEHQDG TAFSCTPDGR SYCCEHDLGA ASVRSTKTEK PPPEPGKPKG
1360
KRRRRRGWRR VTEGK
Length:1,365
Mass (Da):152,258
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B3128E1FA893AAA
GO
Isoform 2 (identifier: O96028-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-652: Missing.
     653-712: VSSKKSERGV...GRFTCSECAS → MAGSFCWRML...SLHPFFNFLL

Show »
Length:713
Mass (Da):80,777
Checksum:iA48D9FB6E1D06EB3
GO
Isoform 3 (identifier: O96028-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     628-647: VSDSPGDEPSESPYESADET → LLWEPTPVKLDLNPAALYCT
     648-1365: Missing.

Show »
Length:647
Mass (Da):71,410
Checksum:i84D0A99908BD7674
GO
Isoform 4 (identifier: O96028-4) [UniParc]FASTAAdd to basket
Also known as: RE-IIBP, IL-5 promoter REII-region-binding protein

The sequence of this isoform differs from the canonical sequence as follows:
     1-781: Missing.

Show »
Length:584
Mass (Da):66,387
Checksum:iDEA3DCB455993E56
GO
Isoform 5 (identifier: O96028-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     629-629: S → K
     630-1365: Missing.

Show »
Length:629
Mass (Da):69,398
Checksum:iEC79BB4E13F1FA93
GO
Isoform 6 (identifier: O96028-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-484: VAEHPDASGEEIE → STKLCFMLASFRI
     485-1365: Missing.

Note: No experimental confirmation available.
Show »
Length:484
Mass (Da):53,484
Checksum:i80778F7E2CFB5C35
GO
Isoform 7 (identifier: O96028-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-273: QKKSARQYHVQFFGDAPER → IFKSKKFEHLKTSQIVLKD
     274-1365: Missing.

Show »
Length:273
Mass (Da):30,199
Checksum:iB8091D5246B40A60
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9L4H0Y9L4_HUMAN
Histone-lysine N-methyltransferase ...
NSD2
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9V2D6R9V2_HUMAN
Histone-lysine N-methyltransferase ...
NSD2
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIS1D6RIS1_HUMAN
Histone-lysine N-methyltransferase ...
NSD2
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9U6H0Y9U6_HUMAN
Histone-lysine N-methyltransferase ...
NSD2
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFE7D6RFE7_HUMAN
Histone-lysine N-methyltransferase ...
NSD2
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83042 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti210T → A in AAU09264 (PubMed:15677557).Curated1
Isoform 2 (identifier: O96028-2)
Sequence conflicti26M → V in BAA83042 (PubMed:10470851).Curated1
Sequence conflicti26M → V in AAI52413 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0214131 – 781Missing in isoform 4. 2 PublicationsAdd BLAST781
Alternative sequenceiVSP_0214141 – 652Missing in isoform 2. 2 PublicationsAdd BLAST652
Alternative sequenceiVSP_021415255 – 273QKKSA…DAPER → IFKSKKFEHLKTSQIVLKD in isoform 7. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_021416274 – 1365Missing in isoform 7. 1 PublicationAdd BLAST1092
Alternative sequenceiVSP_021417472 – 484VAEHP…GEEIE → STKLCFMLASFRI in isoform 6. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_021418485 – 1365Missing in isoform 6. 1 PublicationAdd BLAST881
Alternative sequenceiVSP_021419628 – 647VSDSP…SADET → LLWEPTPVKLDLNPAALYCT in isoform 3. 4 PublicationsAdd BLAST20
Alternative sequenceiVSP_021420629S → K in isoform 5. 1 Publication1
Alternative sequenceiVSP_021421630 – 1365Missing in isoform 5. 1 PublicationAdd BLAST736
Alternative sequenceiVSP_021422648 – 1365Missing in isoform 3. 4 PublicationsAdd BLAST718
Alternative sequenceiVSP_021423653 – 712VSSKK…SECAS → MAGSFCWRMLGLVSKVGNRA RCFSSMAASEEELLDFSGSE LQFNSCSLHLSLHPFFNFLL in isoform 2. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF071593 mRNA Translation: AAC24150.1
AF071594 mRNA Translation: AAC24151.1
AF083386 mRNA Translation: AAD19343.1
AF083387 mRNA Translation: AAD21770.1
AF083388 mRNA Translation: AAD21771.1
AF083389 mRNA Translation: AAD19344.1
AF083390 mRNA Translation: AAD19345.1
AF083391 mRNA Translation: AAD19346.1
AF178206
, AF178199, AF178198, AF178202, AF178204, AF178205, AF178203, AF178201, AF178200 Genomic DNA Translation: AAF23369.1
AF178219
, AF178198, AF178199, AF178200, AF178202, AF178204, AF178207, AF178216, AF178215, AF178214, AF178213, AF178212, AF178211, AF178210, AF178209, AF178208, AF178218, AF178217, AF178205, AF178203, AF178201 Genomic DNA Translation: AAF23370.1
AF330040 mRNA Translation: AAK00344.1
AY694128 mRNA Translation: AAU09264.1
AJ007042 mRNA Translation: CAB45386.1
AB029013 mRNA Translation: BAA83042.2 Different initiation.
AK289697 mRNA Translation: BAF82386.1
AC105448 Genomic DNA No translation available.
AL132868 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82548.1
CH471131 Genomic DNA Translation: EAW82552.1
CH471131 Genomic DNA Translation: EAW82557.1
CH471131 Genomic DNA Translation: EAW82553.1
CH471131 Genomic DNA Translation: EAW82556.1
BC052254 mRNA Translation: AAH52254.1
BC070176 mRNA Translation: AAH70176.1
BC094825 mRNA Translation: AAH94825.2
BC141815 mRNA Translation: AAI41816.1
BC152412 mRNA Translation: AAI52413.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3356.1 [O96028-3]
CCDS33940.1 [O96028-1]
CCDS46999.1 [O96028-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001035889.1, NM_001042424.2 [O96028-1]
NP_015627.1, NM_007331.1 [O96028-5]
NP_579877.1, NM_133330.2 [O96028-1]
NP_579878.1, NM_133331.2 [O96028-1]
NP_579889.1, NM_133334.2 [O96028-3]
NP_579890.1, NM_133335.3 [O96028-1]
XP_005248058.1, XM_005248001.3 [O96028-1]
XP_005248062.1, XM_005248005.2 [O96028-3]
XP_006713977.1, XM_006713914.3 [O96028-3]
XP_011511859.1, XM_011513557.2 [O96028-1]
XP_011511862.1, XM_011513560.2 [O96028-4]
XP_016864076.1, XM_017008587.1 [O96028-4]
XP_016864077.1, XM_017008588.1 [O96028-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.113876

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312087; ENSP00000308780; ENSG00000109685 [O96028-3]
ENST00000353275; ENSP00000329167; ENSG00000109685 [O96028-3]
ENST00000382888; ENSP00000372344; ENSG00000109685 [O96028-2]
ENST00000382891; ENSP00000372347; ENSG00000109685 [O96028-1]
ENST00000382892; ENSP00000372348; ENSG00000109685 [O96028-1]
ENST00000382895; ENSP00000372351; ENSG00000109685 [O96028-1]
ENST00000398261; ENSP00000381311; ENSG00000109685 [O96028-3]
ENST00000420906; ENSP00000399251; ENSG00000109685 [O96028-5]
ENST00000436793; ENSP00000416725; ENSG00000109685 [O96028-7]
ENST00000503128; ENSP00000425761; ENSG00000109685 [O96028-3]
ENST00000508803; ENSP00000423972; ENSG00000109685 [O96028-1]
ENST00000512700; ENSP00000427516; ENSG00000109685 [O96028-7]
ENST00000514045; ENSP00000421681; ENSG00000109685 [O96028-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7468

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7468

UCSC genome browser

More...
UCSCi
uc003gdy.2 human [O96028-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071593 mRNA Translation: AAC24150.1
AF071594 mRNA Translation: AAC24151.1
AF083386 mRNA Translation: AAD19343.1
AF083387 mRNA Translation: AAD21770.1
AF083388 mRNA Translation: AAD21771.1
AF083389 mRNA Translation: AAD19344.1
AF083390 mRNA Translation: AAD19345.1
AF083391 mRNA Translation: AAD19346.1
AF178206
, AF178199, AF178198, AF178202, AF178204, AF178205, AF178203, AF178201, AF178200 Genomic DNA Translation: AAF23369.1
AF178219
, AF178198, AF178199, AF178200, AF178202, AF178204, AF178207, AF178216, AF178215, AF178214, AF178213, AF178212, AF178211, AF178210, AF178209, AF178208, AF178218, AF178217, AF178205, AF178203, AF178201 Genomic DNA Translation: AAF23370.1
AF330040 mRNA Translation: AAK00344.1
AY694128 mRNA Translation: AAU09264.1
AJ007042 mRNA Translation: CAB45386.1
AB029013 mRNA Translation: BAA83042.2 Different initiation.
AK289697 mRNA Translation: BAF82386.1
AC105448 Genomic DNA No translation available.
AL132868 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82548.1
CH471131 Genomic DNA Translation: EAW82552.1
CH471131 Genomic DNA Translation: EAW82557.1
CH471131 Genomic DNA Translation: EAW82553.1
CH471131 Genomic DNA Translation: EAW82556.1
BC052254 mRNA Translation: AAH52254.1
BC070176 mRNA Translation: AAH70176.1
BC094825 mRNA Translation: AAH94825.2
BC141815 mRNA Translation: AAI41816.1
BC152412 mRNA Translation: AAI52413.1
CCDSiCCDS3356.1 [O96028-3]
CCDS33940.1 [O96028-1]
CCDS46999.1 [O96028-5]
RefSeqiNP_001035889.1, NM_001042424.2 [O96028-1]
NP_015627.1, NM_007331.1 [O96028-5]
NP_579877.1, NM_133330.2 [O96028-1]
NP_579878.1, NM_133331.2 [O96028-1]
NP_579889.1, NM_133334.2 [O96028-3]
NP_579890.1, NM_133335.3 [O96028-1]
XP_005248058.1, XM_005248001.3 [O96028-1]
XP_005248062.1, XM_005248005.2 [O96028-3]
XP_006713977.1, XM_006713914.3 [O96028-3]
XP_011511859.1, XM_011513557.2 [O96028-1]
XP_011511862.1, XM_011513560.2 [O96028-4]
XP_016864076.1, XM_017008587.1 [O96028-4]
XP_016864077.1, XM_017008588.1 [O96028-4]
UniGeneiHs.113876

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LSUX-ray2.14A/B973-1203[»]
5VC8X-ray1.80A/B211-350[»]
ProteinModelPortaliO96028
SMRiO96028
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113306, 72 interactors
DIPiDIP-57224N
IntActiO96028, 6 interactors
MINTiO96028
STRINGi9606.ENSP00000372347

Chemistry databases

BindingDBiO96028
ChEMBLiCHEMBL3108645

PTM databases

iPTMnetiO96028
PhosphoSitePlusiO96028

Polymorphism and mutation databases

BioMutaiNSD2

Proteomic databases

EPDiO96028
jPOSTiO96028
MaxQBiO96028
PaxDbiO96028
PeptideAtlasiO96028
PRIDEiO96028
ProteomicsDBi51216
51217 [O96028-2]
51218 [O96028-3]
51219 [O96028-4]
51220 [O96028-5]
51221 [O96028-6]
51222 [O96028-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7468
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312087; ENSP00000308780; ENSG00000109685 [O96028-3]
ENST00000353275; ENSP00000329167; ENSG00000109685 [O96028-3]
ENST00000382888; ENSP00000372344; ENSG00000109685 [O96028-2]
ENST00000382891; ENSP00000372347; ENSG00000109685 [O96028-1]
ENST00000382892; ENSP00000372348; ENSG00000109685 [O96028-1]
ENST00000382895; ENSP00000372351; ENSG00000109685 [O96028-1]
ENST00000398261; ENSP00000381311; ENSG00000109685 [O96028-3]
ENST00000420906; ENSP00000399251; ENSG00000109685 [O96028-5]
ENST00000436793; ENSP00000416725; ENSG00000109685 [O96028-7]
ENST00000503128; ENSP00000425761; ENSG00000109685 [O96028-3]
ENST00000508803; ENSP00000423972; ENSG00000109685 [O96028-1]
ENST00000512700; ENSP00000427516; ENSG00000109685 [O96028-7]
ENST00000514045; ENSP00000421681; ENSG00000109685 [O96028-5]
GeneIDi7468
KEGGihsa:7468
UCSCiuc003gdy.2 human [O96028-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7468
DisGeNETi7468
EuPathDBiHostDB:ENSG00000109685.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NSD2
GeneReviewsiNSD2
HGNCiHGNC:12766 NSD2
HPAiCAB068246
CAB068247
HPA015801
MalaCardsiNSD2
MIMi602952 gene
neXtProtiNX_O96028
OpenTargetsiENSG00000109685
Orphaneti280 Wolf-Hirschhorn syndrome
PharmGKBiPA37369

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1081 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000157429
HOGENOMiHOG000230892
HOVERGENiHBG079978
InParanoidiO96028
KOiK11424
OMAiEYVMVHR
OrthoDBi507784at2759
PhylomeDBiO96028
TreeFamiTF329088

Enzyme and pathway databases

BRENDAi2.1.1.43 2681
ReactomeiR-HSA-3214841 PKMTs methylate histone lysines
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-69473 G2/M DNA damage checkpoint
SIGNORiO96028

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WHSC1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WHSC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7468

Protein Ontology

More...
PROi
PR:O96028

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109685 Expressed in 223 organ(s), highest expression level in testis
ExpressionAtlasiO96028 baseline and differential
GenevisibleiO96028 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
3.30.40.10, 4 hits
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR003616 Post-SET_dom
IPR000313 PWWP_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF17907 AWS, 1 hit
PF00505 HMG_box, 1 hit
PF00855 PWWP, 2 hits
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00398 HMG, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00293 PWWP, 2 hits
SM00184 RING, 2 hits
SM00317 SET, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
SSF57903 SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50118 HMG_BOX_2, 1 hit
PS50868 POST_SET, 1 hit
PS50812 PWWP, 2 hits
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96028
Secondary accession number(s): A2A2T2
, A2A2T3, A2A2T4, A7MCZ1, D3DVQ2, O96031, Q4VBY8, Q672J1, Q6IS00, Q86V01, Q9BZB4, Q9UI92, Q9UPR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 1999
Last modified: February 13, 2019
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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