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Protein

Beta-1,3-galactosyltransferase 4

Gene

B3GALT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in GM1/GD1B/GA1 ganglioside biosynthesis.1 Publication

Catalytic activityi

UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS00059-MONOMER
BRENDAi2.4.1.62 2681
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Chemistry databases

SwissLipidsiSLP:000000772

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 4 (EC:2.4.1.621 Publication)
Short name:
Beta-1,3-GalTase 4
Short name:
Beta3Gal-T4
Short name:
Beta3GalT4
Short name:
GalT4
Short name:
b3Gal-T4
Alternative name(s):
Gal-T2
Ganglioside galactosyltransferase
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
Gene namesi
Name:B3GALT4
Synonyms:GALT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000235863.3
HGNCiHGNC:919 B3GALT4
MIMi603095 gene
neXtProtiNX_O96024

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 19Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST11
Topological domaini20 – 378LumenalSequence analysisAdd BLAST359

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8705
OpenTargetsiENSG00000235863
PharmGKBiPA25212

Polymorphism and mutation databases

BioMutaiB3GALT4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191601 – 378Beta-1,3-galactosyltransferase 4Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO96024
PaxDbiO96024
PeptideAtlasiO96024
PRIDEiO96024
ProteomicsDBi51215

PTM databases

iPTMnetiO96024
PhosphoSitePlusiO96024

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and pancreas and, to a lesser extent, in brain, placenta, kidney, liver and lung.2 Publications

Gene expression databases

BgeeiENSG00000235863 Expressed in 216 organ(s), highest expression level in blood
CleanExiHS_B3GALT4
ExpressionAtlasiO96024 baseline and differential
GenevisibleiO96024 HS

Organism-specific databases

HPAiHPA043001

Interactioni

Protein-protein interaction databases

BioGridi114248, 4 interactors
IntActiO96024, 4 interactors
MINTiO96024
STRINGi9606.ENSP00000390784

Structurei

3D structure databases

ProteinModelPortaliO96024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOGENOMiHOG000064523
HOVERGENiHBG050651
InParanoidiO96024
KOiK00715
OMAiPFCSWLQ
OrthoDBiEOG091G0AXM
PhylomeDBiO96024
TreeFamiTF318639

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit

Sequencei

Sequence statusi: Complete.

O96024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLRLFRRLL LAALLLVIVW TLFGPSGLGE ELLSLSLASL LPAPASPGPP
60 70 80 90 100
LALPRLLIPN QEACSGPGAP PFLLILVCTA PENLNQRNAI RASWGGLREA
110 120 130 140 150
RGLRVQTLFL LGEPNAQHPV WGSQGSDLAS ESAAQGDILQ AAFQDSYRNL
160 170 180 190 200
TLKTLSGLNW AEKHCPMARY VLKTDDDVYV NVPELVSELV LRGGRWGQWE
210 220 230 240 250
RSTEPQREAE QEGGQVLHSE EVPLLYLGRV HWRVNPSRTP GGRHRVSEEQ
260 270 280 290 300
WPHTWGPFPP YASGTGYVLS ASAVQLILKV ASRAPLLPLE DVFVGVSARR
310 320 330 340 350
GGLAPTQCVK LAGATHYPLD RCCYGKFLLT SHRLDPWKMQ EAWKLVGGSD
360 370
GERTAPFCSW FQGVLGILRC RAIAWLQS
Length:378
Mass (Da):41,537
Last modified:May 1, 1999 - v1
Checksum:i4E55DFC72AE96213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15061 mRNA Translation: CAA75345.1
AL031228 Genomic DNA Translation: CAA20230.1
AB026730 mRNA Translation: BAA88988.1
BC032574 mRNA Translation: AAH32574.1
CCDSiCCDS34425.1
RefSeqiNP_003773.1, NM_003782.3
UniGeneiHs.534375

Genome annotation databases

EnsembliENST00000383209; ENSP00000372696; ENSG00000206285
ENST00000415322; ENSP00000394876; ENSG00000226936
ENST00000419471; ENSP00000398660; ENSG00000235155
ENST00000430971; ENSP00000414880; ENSG00000236802
ENST00000451237; ENSP00000390784; ENSG00000235863
GeneIDi8705
KEGGihsa:8705

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Beta-1,3-galactosyltransferase 4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15061 mRNA Translation: CAA75345.1
AL031228 Genomic DNA Translation: CAA20230.1
AB026730 mRNA Translation: BAA88988.1
BC032574 mRNA Translation: AAH32574.1
CCDSiCCDS34425.1
RefSeqiNP_003773.1, NM_003782.3
UniGeneiHs.534375

3D structure databases

ProteinModelPortaliO96024
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114248, 4 interactors
IntActiO96024, 4 interactors
MINTiO96024
STRINGi9606.ENSP00000390784

Chemistry databases

SwissLipidsiSLP:000000772

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

PTM databases

iPTMnetiO96024
PhosphoSitePlusiO96024

Polymorphism and mutation databases

BioMutaiB3GALT4

Proteomic databases

EPDiO96024
PaxDbiO96024
PeptideAtlasiO96024
PRIDEiO96024
ProteomicsDBi51215

Protocols and materials databases

DNASUi8705
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383209; ENSP00000372696; ENSG00000206285
ENST00000415322; ENSP00000394876; ENSG00000226936
ENST00000419471; ENSP00000398660; ENSG00000235155
ENST00000430971; ENSP00000414880; ENSG00000236802
ENST00000451237; ENSP00000390784; ENSG00000235863
GeneIDi8705
KEGGihsa:8705

Organism-specific databases

CTDi8705
DisGeNETi8705
EuPathDBiHostDB:ENSG00000235863.3
GeneCardsiB3GALT4
HGNCiHGNC:919 B3GALT4
HPAiHPA043001
MIMi603095 gene
neXtProtiNX_O96024
OpenTargetsiENSG00000235863
PharmGKBiPA25212
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOGENOMiHOG000064523
HOVERGENiHBG050651
InParanoidiO96024
KOiK00715
OMAiPFCSWLQ
OrthoDBiEOG091G0AXM
PhylomeDBiO96024
TreeFamiTF318639

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:HS00059-MONOMER
BRENDAi2.4.1.62 2681

Miscellaneous databases

GeneWikiiB3GALT4
GenomeRNAii8705
PROiPR:O96024
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000235863 Expressed in 216 organ(s), highest expression level in blood
CleanExiHS_B3GALT4
ExpressionAtlasiO96024 baseline and differential
GenevisibleiO96024 HS

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB3GT4_HUMAN
AccessioniPrimary (citable) accession number: O96024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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