CCNE2

Functionⁱ

Essential for the control of the cell cycle at the late G1 and early S phase.

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase activity Source: Reactome
cyclin-dependent protein serine/threonine kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
DNA replication initiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: Reactome
mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cellular protein localization Source: Ensembl
regulation of cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mitotic nuclear division
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synapsis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
telomere maintenance Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Cell cycle, Cell division

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1538133 G0 and Early G1 R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69563 p53-Dependent G1 DNA Damage Response
SignaLinkⁱ	O96020
SIGNORⁱ	O96020

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G1/S-specific cyclin-E2
Gene namesⁱ	Name:CCNE2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175305.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1590 CCNE2
MIMⁱ	603775 gene
neXtProtⁱ	NX_O96020

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	392	T → A: Increase of steady state level. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9134
Open Targets More...OpenTargetsⁱ	ENSG00000175305
PharmGKBⁱ	PA26155

Chemistry databases

ChEMBLⁱ	CHEMBL2094126

ChEMBLⁱ

CHEMBL2094126

Polymorphism and mutation databases

BioMutaⁱ	CCNE2

BioMutaⁱ

CCNE2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080461	1 – 404	G1/S-specific cyclin-E2Add BLAST		404

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	21	PhosphoserineCombined sources	1
Modified residueⁱ	383	PhosphoserineCombined sources	1
Modified residueⁱ	392	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O96020
PaxDbⁱ	O96020
PeptideAtlas More...PeptideAtlasⁱ	O96020
PRIDEⁱ	O96020
ProteomicsDBⁱ	51213 51214 [O96020-2]

PTM databases

iPTMnetⁱ	O96020
PhosphoSitePlusⁱ	O96020

Expressionⁱ

Tissue specificityⁱ

According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.

Inductionⁱ

Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.

Gene expression databases

Bgeeⁱ	ENSG00000175305 Expressed in 171 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_CCNE2
ExpressionAtlasⁱ	O96020 baseline and differential
Genevisibleⁱ	O96020 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB007825 CAB019374

HPAⁱ

CAB007825
CAB019374

Interactionⁱ

Subunit structureⁱ

Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDK2	P24941	10	EBI-375033,EBI-375096
CDKN1A	P38936	4	EBI-375033,EBI-375077
CDKN1B	P46527	3	EBI-375033,EBI-519280

GO - Molecular functionⁱ

protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114582, 14 interactors
ComplexPortalⁱ	CPX-2016 Cyclin E2-CDK2 complex
Database of interacting proteins More...DIPⁱ	DIP-31733N
IntActⁱ	O96020, 11 interactors
Molecular INTeraction database More...MINTⁱ	O96020
STRINGⁱ	9606.ENSP00000309181

Chemistry databases

BindingDBⁱ

O96020

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O96020
SMRⁱ	O96020
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0655 Eukaryota ENOG410XS2J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118939
HOGENOMⁱ	HOG000231743
HOVERGENⁱ	HBG050834
InParanoidⁱ	O96020
KEGG Orthology (KO) More...KOⁱ	K06626
OMAⁱ	KFIQIAQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DAW
PhylomeDBⁱ	O96020
TreeFamⁱ	TF101005

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR028858 Cyclin_E IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF70 PTHR10177:SF70, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform Long (identifier: O96020-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRSSRLQA KQQPQPSQTE SPQEAQIIQA KKRKTTQDVK KRREEVTKKH 
        60         70         80         90        100
QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS 
       110        120        130        140        150
PLPDLSWGCS KEVWLNMLKK ESRYVHDKHF EVLHSDLEPQ MRSILLDWLL 
       160        170        180        190        200
EVCEVYTLHR ETFYLAQDFF DRFMLTQKDI NKNMLQLIGI TSLFIASKLE 
       210        220        230        240        250
EIYAPKLQEF AYVTDGACSE EDILRMELII LKALKWELCP VTIISWLNLF 
       260        270        280        290        300
LQVDALKDAP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILTAAA 
       310        320        330        340        350
LCHFTSIEVV KKASGLEWDS ISECVDWMVP FVNVVKSTSP VKLKTFKKIP 
       360        370        380        390        400
MEDRHNIQTH TNYLAMLEEV NYINTFRKGG QLSPVCNGGI MTPPKSTEKP 

PGKH

Length:404

Mass (Da):46,757

Last modified:May 1, 1999 - v1

Checksum:ⁱD7DC9BEEF3FD62EC

GO

Isoform Short (identifier: O96020-2) [UniParc]FASTA Add to basket

Also known as: SV

The sequence of this isoform differs from the canonical sequence as follows:
167-211: Missing.

« Hide

        10         20         30         40         50
MSRRSSRLQA KQQPQPSQTE SPQEAQIIQA KKRKTTQDVK KRREEVTKKH 
        60         70         80         90        100
QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS 
       110        120        130        140        150
PLPDLSWGCS KEVWLNMLKK ESRYVHDKHF EVLHSDLEPQ MRSILLDWLL 
       160        170        180        190        200
EVCEVYTLHR ETFYLAYVTD GACSEEDILR MELIILKALK WELCPVTIIS 
       210        220        230        240        250
WLNLFLQVDA LKDAPKVLLP QYSQETFIQI AQLLDLCILA IDSLEFQYRI 
       260        270        280        290        300
LTAAALCHFT SIEVVKKASG LEWDSISECV DWMVPFVNVV KSTSPVKLKT 
       310        320        330        340        350
FKKIPMEDRH NIQTHTNYLA MLEEVNYINT FRKGGQLSPV CNGGIMTPPK 

STEKPPGKH

Show »

Length:359

Mass (Da):41,465

Checksum:ⁱ2A774B409828EC47

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8WUE3	Q8WUE3_HUMAN	CCNE2 protein CCNE2 protein (Cyclin E2, isoform CRA_a) (G1/S-specific cyclin-E2)	CCNE2 hCG_15054	374	Annotation score:
H0YBQ2	H0YBQ2_HUMAN	G1/S-specific cyclin-E2 G1/S-specific cyclin-E2	CCNE2	152	Annotation score:
E5RHN2	E5RHN2_HUMAN	G1/S-specific cyclin-E2 G1/S-specific cyclin-E2	CCNE2	61	Annotation score:
E5RK20	E5RK20_HUMAN	G1/S-specific cyclin-E2 G1/S-specific cyclin-E2	CCNE2	75	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_021347	387	N → S1 PublicationCorresponds to variant dbSNP:rs28399585Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001256	167 – 211	Missing in isoform Short. 1 PublicationAdd BLAST		45

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF106690 mRNA Translation: AAD08816.1 AF112857 mRNA Translation: AAD08819.1 AF091433 mRNA Translation: AAC80528.1 AF102778 mRNA Translation: AAC78145.1 AY850195 Genomic DNA Translation: AAV97813.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6264.1 [O96020-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_477097.1, NM_057749.2 [O96020-1] XP_016869446.1, XM_017013957.1 XP_016869447.1, XM_017013958.1 [O96020-1] XP_016869448.1, XM_017013959.1 [O96020-1]
UniGeneⁱ	Hs.521693

Genome annotation databases

Ensemblⁱ	ENST00000308108; ENSP00000309181; ENSG00000175305 [O96020-1] ENST00000520509; ENSP00000429089; ENSG00000175305 [O96020-1]
GeneIDⁱ	9134
KEGGⁱ	hsa:9134
UCSC genome browser More...UCSCⁱ	uc003yhc.4 human [O96020-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O96020	Cyclin E2, isoform CRA_e		HUMAN		404	UniRef100_O96020

Protein	Similar proteins		Species	Score	Length	Source
O96020	G1/S-specific cyclin-E2		BOVIN		404	UniRef90_O96020
G1/S-specific cyclin-E2		MOUSE		404
Cyclin E2, isoform CRA_e		HUMAN		404
Uncharacterized protein		FELCA		406
G1/S-specific cyclin-E2		BALAS		405
+152
O96020-2	G1/S-specific cyclin-E2 isoform X2		PHYCD		356	UniRef90_O96020-2
Uncharacterized protein		PIG		356
UPI0007881C63		ROUAE		356
UPI000C87C746		PTEVA		356
UPI000CCBE46F		MYOLU		356
+2

Protein	Similar proteins		Species	Score	Length	Source
O96020	G1/S-specific cyclin-E2		BOVIN		404	UniRef50_O96020
G1/S-specific cyclin-E2		MOUSE		404
Cyclin E2, isoform CRA_e		HUMAN		404
Uncharacterized protein		FELCA		406
Uncharacterized protein		PIG		405
+349
O96020-2	G1/S-specific cyclin-E2 isoform X2		PHYCD		356	UniRef50_O96020-2
Uncharacterized protein		PIG		356
Uncharacterized protein		PAPAN		385
Uncharacterized protein		MACMU		370
Cyclin E2		DANRE		392
+122

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF106690 mRNA Translation: AAD08816.1 AF112857 mRNA Translation: AAD08819.1 AF091433 mRNA Translation: AAC80528.1 AF102778 mRNA Translation: AAC78145.1 AY850195 Genomic DNA Translation: AAV97813.1
CCDSⁱ	CCDS6264.1 [O96020-1]
RefSeqⁱ	NP_477097.1, NM_057749.2 [O96020-1] XP_016869446.1, XM_017013957.1 XP_016869447.1, XM_017013958.1 [O96020-1] XP_016869448.1, XM_017013959.1 [O96020-1]
UniGeneⁱ	Hs.521693

3D structure databases

ProteinModelPortalⁱ	O96020
SMRⁱ	O96020
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114582, 14 interactors
ComplexPortalⁱ	CPX-2016 Cyclin E2-CDK2 complex
DIPⁱ	DIP-31733N
IntActⁱ	O96020, 11 interactors
MINTⁱ	O96020
STRINGⁱ	9606.ENSP00000309181

Chemistry databases

BindingDBⁱ	O96020
ChEMBLⁱ	CHEMBL2094126

PTM databases

iPTMnetⁱ	O96020
PhosphoSitePlusⁱ	O96020

Polymorphism and mutation databases

BioMutaⁱ	CCNE2

BioMutaⁱ

CCNE2

Proteomic databases

MaxQBⁱ	O96020
PaxDbⁱ	O96020
PeptideAtlasⁱ	O96020
PRIDEⁱ	O96020
ProteomicsDBⁱ	51213 51214 [O96020-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9134
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308108; ENSP00000309181; ENSG00000175305 [O96020-1] ENST00000520509; ENSP00000429089; ENSG00000175305 [O96020-1]
GeneIDⁱ	9134
KEGGⁱ	hsa:9134
UCSCⁱ	uc003yhc.4 human [O96020-1]

Organism-specific databases

CTDⁱ	9134
DisGeNETⁱ	9134
EuPathDBⁱ	HostDB:ENSG00000175305.16
GeneCardsⁱ	CCNE2
HGNCⁱ	HGNC:1590 CCNE2
HPAⁱ	CAB007825 CAB019374
MIMⁱ	603775 gene
neXtProtⁱ	NX_O96020
OpenTargetsⁱ	ENSG00000175305
PharmGKBⁱ	PA26155
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0655 Eukaryota ENOG410XS2J LUCA
GeneTreeⁱ	ENSGT00760000118939
HOGENOMⁱ	HOG000231743
HOVERGENⁱ	HBG050834
InParanoidⁱ	O96020
KOⁱ	K06626
OMAⁱ	KFIQIAQ
OrthoDBⁱ	EOG091G0DAW
PhylomeDBⁱ	O96020
TreeFamⁱ	TF101005

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1538133 G0 and Early G1 R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69563 p53-Dependent G1 DNA Damage Response
SignaLinkⁱ	O96020
SIGNORⁱ	O96020

Miscellaneous databases

ChiTaRSⁱ	CCNE2 human
GenomeRNAiⁱ	9134
Protein Ontology More...PROⁱ	PR:O96020
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175305 Expressed in 171 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_CCNE2
ExpressionAtlasⁱ	O96020 baseline and differential
Genevisibleⁱ	O96020 HS

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR028858 Cyclin_E IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF70 PTHR10177:SF70, 1 hit
Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNE2_HUMAN
Accessionⁱ	O96020Primary (citable) accession number: O96020 Secondary accession number(s): O95439
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - O96020 (CCNE2_HUMAN)

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G1/S-specific cyclin-E2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ