UniProtKB - O96020 (CCNE2_HUMAN)
G1/S-specific cyclin-E2
CCNE2
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- protein kinase binding Source: Ensembl
GO - Biological processi
- cell division Source: UniProtKB-KW
- DNA replication initiation Source: Ensembl
- G1/S transition of mitotic cell cycle Source: GO_Central
- homologous chromosome pairing at meiosis Source: Ensembl
- mitotic cell cycle phase transition Source: GO_Central
- regulation of cellular protein localization Source: Ensembl
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- telomere maintenance Source: Ensembl
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
PathwayCommonsi | O96020 |
Reactomei | R-HSA-1538133, G0 and Early G1 R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69231, Cyclin D associated events in G1 R-HSA-69563, p53-Dependent G1 DNA Damage Response R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
SignaLinki | O96020 |
SIGNORi | O96020 |
Names & Taxonomyi
Protein namesi | Recommended name: G1/S-specific cyclin-E2 |
Gene namesi | Name:CCNE2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1590, CCNE2 |
MIMi | 603775, gene |
neXtProti | NX_O96020 |
VEuPathDBi | HostDB:ENSG00000175305.16 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- centrosome Source: GO_Central
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cyclin E1-CDK2 complex Source: GO_Central
- cyclin E2-CDK2 complex Source: UniProtKB
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 392 | T → A: Increase of steady state level. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9134 |
OpenTargetsi | ENSG00000175305 |
PharmGKBi | PA26155 |
Miscellaneous databases
Pharosi | O96020, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2094126 |
Genetic variation databases
BioMutai | CCNE2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080461 | 1 – 404 | G1/S-specific cyclin-E2Add BLAST | 404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 383 | PhosphoserineCombined sources | 1 | |
Modified residuei | 392 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O96020 |
MassIVEi | O96020 |
MaxQBi | O96020 |
PaxDbi | O96020 |
PeptideAtlasi | O96020 |
PRIDEi | O96020 |
ProteomicsDBi | 51213 [O96020-1] 51214 [O96020-2] |
PTM databases
iPTMneti | O96020 |
PhosphoSitePlusi | O96020 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000175305, Expressed in C1 segment of cervical spinal cord and 186 other tissues |
ExpressionAtlasi | O96020, baseline and differential |
Genevisiblei | O96020, HS |
Organism-specific databases
HPAi | ENSG00000175305, Tissue enhanced (bone marrow, brain, testis) |
Interactioni
Subunit structurei
Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
Binary interactionsi
Hide detailsO96020
With | #Exp. | IntAct |
---|---|---|
CDK2 [P24941] | 11 | EBI-375033,EBI-375096 |
CDKN1A [P38936] | 6 | EBI-375033,EBI-375077 |
CDKN1B [P46527] | 3 | EBI-375033,EBI-519280 |
HTT [P42858] | 6 | EBI-375033,EBI-466029 |
WFS1 [O76024] | 3 | EBI-375033,EBI-720609 |
GO - Molecular functioni
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114582, 19 interactors |
ComplexPortali | CPX-2016, Cyclin E2-CDK2 complex |
DIPi | DIP-31733N |
IntActi | O96020, 19 interactors |
MINTi | O96020 |
STRINGi | 9606.ENSP00000429089 |
Chemistry databases
BindingDBi | O96020 |
Miscellaneous databases
RNActi | O96020, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0655, Eukaryota |
GeneTreei | ENSGT00940000156934 |
InParanoidi | O96020 |
OMAi | SWGCSKD |
PhylomeDBi | O96020 |
TreeFami | TF101005 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR028858, Cyclin_E IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF70, PTHR10177:SF70, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRRSSRLQA KQQPQPSQTE SPQEAQIIQA KKRKTTQDVK KRREEVTKKH
60 70 80 90 100
QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS
110 120 130 140 150
PLPDLSWGCS KEVWLNMLKK ESRYVHDKHF EVLHSDLEPQ MRSILLDWLL
160 170 180 190 200
EVCEVYTLHR ETFYLAQDFF DRFMLTQKDI NKNMLQLIGI TSLFIASKLE
210 220 230 240 250
EIYAPKLQEF AYVTDGACSE EDILRMELII LKALKWELCP VTIISWLNLF
260 270 280 290 300
LQVDALKDAP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILTAAA
310 320 330 340 350
LCHFTSIEVV KKASGLEWDS ISECVDWMVP FVNVVKSTSP VKLKTFKKIP
360 370 380 390 400
MEDRHNIQTH TNYLAMLEEV NYINTFRKGG QLSPVCNGGI MTPPKSTEKP
PGKH
The sequence of this isoform differs from the canonical sequence as follows:
167-211: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8WUE3 | Q8WUE3_HUMAN | CCNE2 protein | CCNE2 hCG_15054 | 374 | Annotation score: | ||
H0YBQ2 | H0YBQ2_HUMAN | G1/S-specific cyclin-E2 | CCNE2 | 152 | Annotation score: | ||
E5RHN2 | E5RHN2_HUMAN | G1/S-specific cyclin-E2 | CCNE2 | 61 | Annotation score: | ||
E5RK20 | E5RK20_HUMAN | G1/S-specific cyclin-E2 | CCNE2 | 75 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021347 | 387 | N → S1 PublicationCorresponds to variant dbSNP:rs28399585Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001256 | 167 – 211 | Missing in isoform Short. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF106690 mRNA Translation: AAD08816.1 AF112857 mRNA Translation: AAD08819.1 AF091433 mRNA Translation: AAC80528.1 AF102778 mRNA Translation: AAC78145.1 AY850195 Genomic DNA Translation: AAV97813.1 |
CCDSi | CCDS6264.1 [O96020-1] |
RefSeqi | NP_477097.1, NM_057749.2 [O96020-1] XP_016869446.1, XM_017013957.1 XP_016869447.1, XM_017013958.1 [O96020-1] XP_016869448.1, XM_017013959.1 [O96020-1] |
Genome annotation databases
Ensembli | ENST00000308108; ENSP00000309181; ENSG00000175305 [O96020-1] ENST00000520509; ENSP00000429089; ENSG00000175305 [O96020-1] |
GeneIDi | 9134 |
KEGGi | hsa:9134 |
UCSCi | uc003yhc.4, human [O96020-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF106690 mRNA Translation: AAD08816.1 AF112857 mRNA Translation: AAD08819.1 AF091433 mRNA Translation: AAC80528.1 AF102778 mRNA Translation: AAC78145.1 AY850195 Genomic DNA Translation: AAV97813.1 |
CCDSi | CCDS6264.1 [O96020-1] |
RefSeqi | NP_477097.1, NM_057749.2 [O96020-1] XP_016869446.1, XM_017013957.1 XP_016869447.1, XM_017013958.1 [O96020-1] XP_016869448.1, XM_017013959.1 [O96020-1] |
3D structure databases
SMRi | O96020 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114582, 19 interactors |
ComplexPortali | CPX-2016, Cyclin E2-CDK2 complex |
DIPi | DIP-31733N |
IntActi | O96020, 19 interactors |
MINTi | O96020 |
STRINGi | 9606.ENSP00000429089 |
Chemistry databases
BindingDBi | O96020 |
ChEMBLi | CHEMBL2094126 |
PTM databases
iPTMneti | O96020 |
PhosphoSitePlusi | O96020 |
Genetic variation databases
BioMutai | CCNE2 |
Proteomic databases
jPOSTi | O96020 |
MassIVEi | O96020 |
MaxQBi | O96020 |
PaxDbi | O96020 |
PeptideAtlasi | O96020 |
PRIDEi | O96020 |
ProteomicsDBi | 51213 [O96020-1] 51214 [O96020-2] |
Protocols and materials databases
Antibodypediai | 3593, 357 antibodies |
DNASUi | 9134 |
Genome annotation databases
Ensembli | ENST00000308108; ENSP00000309181; ENSG00000175305 [O96020-1] ENST00000520509; ENSP00000429089; ENSG00000175305 [O96020-1] |
GeneIDi | 9134 |
KEGGi | hsa:9134 |
UCSCi | uc003yhc.4, human [O96020-1] |
Organism-specific databases
CTDi | 9134 |
DisGeNETi | 9134 |
GeneCardsi | CCNE2 |
HGNCi | HGNC:1590, CCNE2 |
HPAi | ENSG00000175305, Tissue enhanced (bone marrow, brain, testis) |
MIMi | 603775, gene |
neXtProti | NX_O96020 |
OpenTargetsi | ENSG00000175305 |
PharmGKBi | PA26155 |
VEuPathDBi | HostDB:ENSG00000175305.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0655, Eukaryota |
GeneTreei | ENSGT00940000156934 |
InParanoidi | O96020 |
OMAi | SWGCSKD |
PhylomeDBi | O96020 |
TreeFami | TF101005 |
Enzyme and pathway databases
PathwayCommonsi | O96020 |
Reactomei | R-HSA-1538133, G0 and Early G1 R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69231, Cyclin D associated events in G1 R-HSA-69563, p53-Dependent G1 DNA Damage Response R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
SignaLinki | O96020 |
SIGNORi | O96020 |
Miscellaneous databases
BioGRID-ORCSi | 9134, 20 hits in 999 CRISPR screens |
ChiTaRSi | CCNE2, human |
GenomeRNAii | 9134 |
Pharosi | O96020, Tbio |
PROi | PR:O96020 |
RNActi | O96020, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175305, Expressed in C1 segment of cervical spinal cord and 186 other tissues |
ExpressionAtlasi | O96020, baseline and differential |
Genevisiblei | O96020, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR028858, Cyclin_E IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF70, PTHR10177:SF70, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNE2_HUMAN | |
Accessioni | O96020Primary (citable) accession number: O96020 Secondary accession number(s): O95439 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families