DNAL4

Functionⁱ

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).By similarity

GO - Molecular functionⁱ

dynein intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
microtubule motor activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

microtubule-based movement Source: Reactome
positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Motor protein

Molecular function

Motor protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-177504 Retrograde neurotrophin signalling

Reactomeⁱ

R-HSA-177504 Retrograde neurotrophin signalling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dynein light chain 4, axonemal
Gene namesⁱ	Name:DNAL4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100246.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2955 DNAL4
MIMⁱ	610565 gene
neXtProtⁱ	NX_O96015

Keywords - Cellular componentⁱ

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mirror movements 3 (MRMV3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10126
MalaCards human disease database More...MalaCardsⁱ	DNAL4
MIMⁱ	616059 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000100246
Orphanetⁱ	238722 Familial congenital mirror movements
PharmGKBⁱ	PA27426

Polymorphism and mutation databases

BioMutaⁱ	DNAL4

BioMutaⁱ

DNAL4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000195136	1 – 105	Dynein light chain 4, axonemalAdd BLAST		105

Proteomic databases

EPDⁱ	O96015
PaxDbⁱ	O96015
PeptideAtlas More...PeptideAtlasⁱ	O96015
PRIDEⁱ	O96015
ProteomicsDBⁱ	51197

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100246 Expressed in 154 organ(s), highest expression level in left testis
CleanExⁱ	HS_DNAL4
ExpressionAtlasⁱ	O96015 baseline and differential
Genevisibleⁱ	O96015 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003647

HPAⁱ

HPA003647

Interactionⁱ

Subunit structureⁱ

Consists of at least two heavy chains and a number of intermediate and light chains.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CAMK2D	Q13557	3	EBI-742362,EBI-351018
DYNLL1	P63167	4	EBI-742362,EBI-349105
DYNLL2	Q96FJ2	4	EBI-742362,EBI-742371
FHL5	Q5TD97	4	EBI-742362,EBI-750641
GNA14	O95837	3	EBI-742362,EBI-7951023
NOTCH2NL	Q7Z3S9	3	EBI-742362,EBI-945833
TRIM54	Q9BYV2	3	EBI-742362,EBI-2130429

GO - Molecular functionⁱ

dynein intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115430, 32 interactors
IntActⁱ	O96015, 16 interactors
Molecular INTeraction database More...MINTⁱ	O96015
STRINGⁱ	9606.ENSP00000216068

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O96015
SMRⁱ	O96015
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3430 Eukaryota ENOG4111NK2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000378
HOGENOMⁱ	HOG000211145
HOVERGENⁱ	HBG104642
InParanoidⁱ	O96015
KEGG Orthology (KO) More...KOⁱ	K10412
OMAⁱ	YMFFGGN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WT4
PhylomeDBⁱ	O96015
TreeFamⁱ	TF324136

Family and domain databases

Gene3Dⁱ	3.30.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR037177 DLC_sf IPR001372 Dynein_light_chain_typ-1/2
PANTHERⁱ	PTHR11886 PTHR11886, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01221 Dynein_light, 1 hit
SMARTⁱ	View protein in SMART SM01375 Dynein_light, 1 hit
SUPFAMⁱ	SSF54648 SSF54648, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O96015-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGETEGKKDE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN 
        60         70         80         90        100
ESAAKMIKET MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC 

VWKCS

Length:105

Mass (Da):12,009

Last modified:May 1, 1999 - v1

Checksum:ⁱD0AE8929DEB2AC06

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B0QXZ5	B0QXZ5_HUMAN		Dynein light chain Dynein light chain	DNAL4	68	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	58	K → N in CAG46992 (Ref. 6) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL035366 mRNA Translation: CAA23018.1 BT009847 mRNA Translation: AAP88849.1 AY453399 mRNA Translation: AAS47516.1 CR456487 mRNA Translation: CAG30373.1 AK290566 mRNA Translation: BAF83255.1 CR542177 mRNA Translation: CAG46974.1 CR542195 mRNA Translation: CAG46992.1 AL008583 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60272.1 BC002968 mRNA Translation: AAH02968.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13979.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005731.1, NM_005740.2
UniGeneⁱ	Hs.632766

Genome annotation databases

Ensemblⁱ	ENST00000216068; ENSP00000216068; ENSG00000100246
GeneIDⁱ	10126
KEGGⁱ	hsa:10126
UCSC genome browser More...UCSCⁱ	uc003awj.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O96015	Dynein light chain 4, axonemal		BOVIN		105	UniRef100_O96015
Dynein light chain 4, axonemal		PIG		105
Dynein light chain		PANTR		105
Dynein light chain		MACMU		105
Dynein light chain		FELCA		105
+29

Protein	Similar proteins		Species	Score	Length	Source
O96015	Dynein light chain 4, axonemal		BOVIN		105	UniRef90_O96015
Dynein light chain 4, axonemal		PIG		105
Dynein light chain 4, axonemal		MOUSE		105
Dynein light chain		PANTR		105
Dynein light chain		MACMU		105
+74

Protein	Similar proteins		Species	Score	Length	Source
O96015	Dynein light chain 4, axonemal		BOVIN		105	UniRef50_O96015
Dynein light chain 4, axonemal		PIG		105
Dynein light chain 4, axonemal		MOUSE		105
Dynein light chain		PANTR		105
Dynein light chain		MACMU		105
+195

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL035366 mRNA Translation: CAA23018.1 BT009847 mRNA Translation: AAP88849.1 AY453399 mRNA Translation: AAS47516.1 CR456487 mRNA Translation: CAG30373.1 AK290566 mRNA Translation: BAF83255.1 CR542177 mRNA Translation: CAG46974.1 CR542195 mRNA Translation: CAG46992.1 AL008583 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60272.1 BC002968 mRNA Translation: AAH02968.1
CCDSⁱ	CCDS13979.1
RefSeqⁱ	NP_005731.1, NM_005740.2
UniGeneⁱ	Hs.632766

3D structure databases

ProteinModelPortalⁱ	O96015
SMRⁱ	O96015
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115430, 32 interactors
IntActⁱ	O96015, 16 interactors
MINTⁱ	O96015
STRINGⁱ	9606.ENSP00000216068

Polymorphism and mutation databases

BioMutaⁱ	DNAL4

BioMutaⁱ

DNAL4

Proteomic databases

EPDⁱ	O96015
PaxDbⁱ	O96015
PeptideAtlasⁱ	O96015
PRIDEⁱ	O96015
ProteomicsDBⁱ	51197

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10126
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216068; ENSP00000216068; ENSG00000100246
GeneIDⁱ	10126
KEGGⁱ	hsa:10126
UCSCⁱ	uc003awj.4 human

Organism-specific databases

CTDⁱ	10126
DisGeNETⁱ	10126
EuPathDBⁱ	HostDB:ENSG00000100246.12
GeneCardsⁱ	DNAL4
HGNCⁱ	HGNC:2955 DNAL4
HPAⁱ	HPA003647
MalaCardsⁱ	DNAL4
MIMⁱ	610565 gene 616059 phenotype
neXtProtⁱ	NX_O96015
OpenTargetsⁱ	ENSG00000100246
Orphanetⁱ	238722 Familial congenital mirror movements
PharmGKBⁱ	PA27426
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3430 Eukaryota ENOG4111NK2 LUCA
GeneTreeⁱ	ENSGT00390000000378
HOGENOMⁱ	HOG000211145
HOVERGENⁱ	HBG104642
InParanoidⁱ	O96015
KOⁱ	K10412
OMAⁱ	YMFFGGN
OrthoDBⁱ	EOG091G0WT4
PhylomeDBⁱ	O96015
TreeFamⁱ	TF324136

Enzyme and pathway databases

Reactomeⁱ	R-HSA-177504 Retrograde neurotrophin signalling

Reactomeⁱ

R-HSA-177504 Retrograde neurotrophin signalling

Miscellaneous databases

ChiTaRSⁱ	DNAL4 human
GeneWikiⁱ	DNAL4
GenomeRNAiⁱ	10126
Protein Ontology More...PROⁱ	PR:O96015
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100246 Expressed in 154 organ(s), highest expression level in left testis
CleanExⁱ	HS_DNAL4
ExpressionAtlasⁱ	O96015 baseline and differential
Genevisibleⁱ	O96015 HS

Family and domain databases

Gene3Dⁱ	3.30.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR037177 DLC_sf IPR001372 Dynein_light_chain_typ-1/2
PANTHERⁱ	PTHR11886 PTHR11886, 1 hit
Pfamⁱ	View protein in Pfam PF01221 Dynein_light, 1 hit
SMARTⁱ	View protein in SMART SM01375 Dynein_light, 1 hit
SUPFAMⁱ	SSF54648 SSF54648, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DNAL4_HUMAN
Accessionⁱ	O96015Primary (citable) accession number: O96015 Secondary accession number(s): Q6FGB2, Q6FGD0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM

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UniProtKB - O96015 (DNAL4_HUMAN)

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Dynein light chain 4, axonemal

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ