Protein Wnt-11

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• frizzled binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• GTPase activator activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20103596
• protein kinase activator activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
  • 20219091
• transcription regulatory region DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 19847889

GO - Biological processⁱ

• adrenal gland development Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 9757009
• artery morphogenesis Source: Ensembl
• bicellular tight junction assembly Source: Ensembl
• bone mineralization Source: Ensembl
• canonical Wnt signaling pathway Source: Ensembl
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to mechanical stimulus Source: Ensembl
• cellular response to retinoic acid Source: UniProtKB
• cloacal septation Source: UniProtKBInferred from expression patternⁱ
  • 9757009
• convergent extension involved in axis elongation Source: Ensembl
• embryonic skeletal system development Source: UniProtKBInferred from expression patternⁱ
  • 9757009
• epithelial to mesenchymal transition Source: Ensembl
• lung-associated mesenchyme development Source: UniProtKBInferred from expression patternⁱ
  • 9757009
• maintenance of epithelial cell apical/basal polarity Source: Ensembl
• mesonephric duct development Source: UniProtKBInferred from expression patternⁱ
  • 9757009
• negative regulation of apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20219091
• negative regulation of canonical Wnt signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
• negative regulation of cartilage development Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 9757009
• negative regulation of cell death Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20219091
• negative regulation of cell growth Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
• negative regulation of cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
• negative regulation of fibroblast growth factor production Source: Ensembl
• negative regulation of mesenchymal cell proliferation Source: Ensembl
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
  • 20219091
• neuroendocrine cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20219091
• neuron differentiation Source: UniProtKB
• notochord morphogenesis Source: Ensembl
• osteoblast differentiation Source: Ensembl
• outflow tract morphogenesis Source: Ensembl
• paraxial mesoderm formation Source: Ensembl
• planar cell polarity pathway involved in axis elongation Source: Ensembl
• planar cell polarity pathway involved in gastrula mediolateral intercalation Source: Ensembl
• positive regulation of apoptotic process Source: Ensembl
• positive regulation of cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20219091
• positive regulation of gene expression Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20219091
• positive regulation of GTPase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
• positive regulation of protein kinase C signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
• positive regulation of stress fiber assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19847889
• positive regulation of transforming growth factor beta2 production Source: Ensembl
• protein localization to cell surface Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
• protein phosphorylation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20103596
• response to nutrient levels Source: Ensembl
• secondary palate development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 18413325
• somite development Source: Ensembl
• ureteric bud morphogenesis Source: UniProtKBInferred from expression patternⁱ
  • 9757009
• ventricular septum morphogenesis Source: Ensembl
• Wnt signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• Wnt signaling pathway, calcium modulating pathway Source: ParkinsonsUK-UCLNon-traceable author statementⁱ
  • 24431302
• Wnt signaling pathway, planar cell polarity pathway Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG 
        60         70         80         90        100
LVSAQVQLCR SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY 
       110        120        130        140        150
LLDLERGTRE SAFVYALSAA AISHAIARAC TSGDLPGCSC GPVPGEPPGP 
       160        170        180        190        200
GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA 
       210        220        230        240        250
LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR 
       260        270        280        290        300
PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 
       310        320        330        340        350
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER 

YVCK                                                   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. Human chromosome 11
   Human chromosome 11: entries, gene names and cross-references to MIM