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Protein

Protein Wnt-11

Gene

WNT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • GTPase activator activity Source: UniProtKB
  • protein kinase activator activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-4086398 Ca2+ pathway
R-HSA-4086400 PCP/CE pathway
SIGNORiO96014

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Gene namesi
Name:WNT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000085741.12
HGNCiHGNC:12776 WNT11
MIMi603699 gene
neXtProtiNX_O96014

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7481
OpenTargetsiENSG00000085741
PharmGKBiPA37378

Polymorphism and mutation databases

BioMutaiWNT11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004146525 – 354Protein Wnt-11Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 91By similarity
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 138By similarity
Disulfide bondi140 ↔ 157By similarity
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi209 ↔ 223By similarity
Disulfide bondi211 ↔ 218By similarity
Lipidationi215O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi299 ↔ 314By similarity
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 344By similarity
Disulfide bondi331 ↔ 341By similarity
Disulfide bondi336 ↔ 337By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiO96014
PeptideAtlasiO96014
PRIDEiO96014
ProteomicsDBi51196

PTM databases

iPTMnetiO96014
PhosphoSitePlusiO96014

Expressioni

Tissue specificityi

Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000085741 Expressed in 122 organ(s), highest expression level in left adrenal gland
CleanExiHS_WNT11
ExpressionAtlasiO96014 baseline and differential
GenevisibleiO96014 HS

Organism-specific databases

HPAiHPA050101
HPA063569

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113318, 8 interactors
IntActiO96014, 17 interactors
MINTiO96014
STRINGi9606.ENSP00000325526

Structurei

3D structure databases

ProteinModelPortaliO96014
SMRiO96014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiO96014
KOiK01384
OMAiQCNKTSH
OrthoDBiEOG091G0OFF
PhylomeDBiO96014
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026536 Wnt-11
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF7 PTHR12027:SF7, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O96014-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG
60 70 80 90 100
LVSAQVQLCR SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY
110 120 130 140 150
LLDLERGTRE SAFVYALSAA AISHAIARAC TSGDLPGCSC GPVPGEPPGP
160 170 180 190 200
GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA
210 220 230 240 250
LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR
260 270 280 290 300
PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN
310 320 330 340 350
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER

YVCK
Length:354
Mass (Da):39,179
Last modified:May 10, 2002 - v2
Checksum:i0E29717C98541DBB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H8YS97H8YS97_HUMAN
Protein Wnt
WNT11
262Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121A → T in CAA74159 (PubMed:9757009).Curated1
Sequence conflicti121A → T in CAA73223 (PubMed:9757009).Curated1
Sequence conflicti156G → R in CAA74159 (PubMed:9757009).Curated1
Sequence conflicti156G → R in CAA73223 (PubMed:9757009).Curated1
Sequence conflicti271S → W in CAA74159 (PubMed:9757009).Curated1
Sequence conflicti271S → W in CAA73223 (PubMed:9757009).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13843
, Y13844, Y13845, Y13846, Y13847 Genomic DNA Translation: CAA74159.1
Y12692 mRNA Translation: CAA73223.1
AB070218 mRNA Translation: BAB72099.1
AK313570 mRNA Translation: BAG36343.1
BC074790 mRNA Translation: AAH74790.1
BC074791 mRNA Translation: AAH74791.1
BC113386 mRNA Translation: AAI13387.1
BC113388 mRNA Translation: AAI13389.1
CCDSiCCDS8242.1
RefSeqiNP_004617.2, NM_004626.2
XP_005274288.1, XM_005274231.1
UniGeneiHs.108219

Genome annotation databases

EnsembliENST00000322563; ENSP00000325526; ENSG00000085741
GeneIDi7481
KEGGihsa:7481
UCSCiuc001oxe.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13843
, Y13844, Y13845, Y13846, Y13847 Genomic DNA Translation: CAA74159.1
Y12692 mRNA Translation: CAA73223.1
AB070218 mRNA Translation: BAB72099.1
AK313570 mRNA Translation: BAG36343.1
BC074790 mRNA Translation: AAH74790.1
BC074791 mRNA Translation: AAH74791.1
BC113386 mRNA Translation: AAI13387.1
BC113388 mRNA Translation: AAI13389.1
CCDSiCCDS8242.1
RefSeqiNP_004617.2, NM_004626.2
XP_005274288.1, XM_005274231.1
UniGeneiHs.108219

3D structure databases

ProteinModelPortaliO96014
SMRiO96014
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113318, 8 interactors
IntActiO96014, 17 interactors
MINTiO96014
STRINGi9606.ENSP00000325526

PTM databases

iPTMnetiO96014
PhosphoSitePlusiO96014

Polymorphism and mutation databases

BioMutaiWNT11

Proteomic databases

PaxDbiO96014
PeptideAtlasiO96014
PRIDEiO96014
ProteomicsDBi51196

Protocols and materials databases

DNASUi7481
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322563; ENSP00000325526; ENSG00000085741
GeneIDi7481
KEGGihsa:7481
UCSCiuc001oxe.4 human

Organism-specific databases

CTDi7481
DisGeNETi7481
EuPathDBiHostDB:ENSG00000085741.12
GeneCardsiWNT11
HGNCiHGNC:12776 WNT11
HPAiHPA050101
HPA063569
MIMi603699 gene
neXtProtiNX_O96014
OpenTargetsiENSG00000085741
PharmGKBiPA37378
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiO96014
KOiK01384
OMAiQCNKTSH
OrthoDBiEOG091G0OFF
PhylomeDBiO96014
TreeFamiTF105310

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-4086398 Ca2+ pathway
R-HSA-4086400 PCP/CE pathway
SIGNORiO96014

Miscellaneous databases

GeneWikiiWNT11
GenomeRNAii7481
PROiPR:O96014
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085741 Expressed in 122 organ(s), highest expression level in left adrenal gland
CleanExiHS_WNT11
ExpressionAtlasiO96014 baseline and differential
GenevisibleiO96014 HS

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026536 Wnt-11
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF7 PTHR12027:SF7, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWNT11_HUMAN
AccessioniPrimary (citable) accession number: O96014
Secondary accession number(s): B2R8Z6, Q14DE8, Q8WZ98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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