UniProtKB - O96014 (WNT11_HUMAN)
Protein
Protein Wnt-11
Gene
WNT11
Organism
Homo sapiens (Human)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
- GTPase activator activity Source: UniProtKB
- protein kinase activator activity Source: UniProtKB
GO - Biological processi
- adrenal gland development Source: UniProtKB
- artery morphogenesis Source: Ensembl
- atrial septum development Source: Ensembl
- bicellular tight junction assembly Source: Ensembl
- bone mineralization Source: Ensembl
- canonical Wnt signaling pathway Source: GO_Central
- cell fate commitment Source: GO_Central
- cellular response to mechanical stimulus Source: Ensembl
- cellular response to retinoic acid Source: UniProtKB
- cloacal septation Source: UniProtKB
- convergent extension involved in axis elongation Source: Ensembl
- embryonic skeletal system development Source: UniProtKB
- epithelial to mesenchymal transition Source: Ensembl
- lung-associated mesenchyme development Source: UniProtKB
- maintenance of epithelial cell apical/basal polarity Source: Ensembl
- mesonephric duct development Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of cartilage development Source: UniProtKB
- negative regulation of cell death Source: UniProtKB
- negative regulation of cell growth Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of fibroblast growth factor production Source: Ensembl
- negative regulation of mesenchymal cell proliferation Source: Ensembl
- negative regulation of transcription, DNA-templated Source: UniProtKB
- neuroendocrine cell differentiation Source: UniProtKB
- neuron differentiation Source: UniProtKB
- notochord morphogenesis Source: Ensembl
- osteoblast differentiation Source: Ensembl
- outflow tract morphogenesis Source: Ensembl
- paraxial mesoderm formation Source: Ensembl
- planar cell polarity pathway involved in axis elongation Source: Ensembl
- planar cell polarity pathway involved in gastrula mediolateral intercalation Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of cell migration Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source: Ensembl
- positive regulation of protein kinase C signaling Source: UniProtKB
- positive regulation of stress fiber assembly Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transforming growth factor beta2 production Source: Ensembl
- primary heart field specification Source: Ensembl
- protein localization to cell surface Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- response to nutrient levels Source: Ensembl
- secondary heart field specification Source: Ensembl
- secondary palate development Source: BHF-UCL
- somite development Source: Ensembl
- ureteric bud morphogenesis Source: UniProtKB
- ventricular septum morphogenesis Source: Ensembl
- Wnt signaling pathway Source: Reactome
- Wnt signaling pathway, calcium modulating pathway Source: ParkinsonsUK-UCL
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | O96014 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-4086398, Ca2+ pathway R-HSA-4086400, PCP/CE pathway |
SIGNORi | O96014 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-11 |
Gene namesi | Name:WNT11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000085741.12 |
HGNCi | HGNC:12776, WNT11 |
MIMi | 603699, gene |
neXtProti | NX_O96014 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular matrix Source: Ensembl
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 7481 |
OpenTargetsi | ENSG00000085741 |
PharmGKBi | PA37378 |
Miscellaneous databases
Pharosi | O96014, Tbio |
Polymorphism and mutation databases
BioMutai | WNT11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000041465 | 25 – 354 | Protein Wnt-11Add BLAST | 330 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 40 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 80 ↔ 91 | By similarity | ||
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 130 ↔ 138 | By similarity | ||
Disulfide bondi | 140 ↔ 157 | By similarity | ||
Glycosylationi | 160 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 209 ↔ 223 | By similarity | ||
Disulfide bondi | 211 ↔ 218 | By similarity | ||
Lipidationi | 215 | O-palmitoleoyl serine; by PORCNBy similarity | 1 | |
Disulfide bondi | 283 ↔ 314 | By similarity | ||
Disulfide bondi | 299 ↔ 309 | By similarity | ||
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 304 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 313 ↔ 353 | By similarity | ||
Disulfide bondi | 329 ↔ 344 | By similarity | ||
Disulfide bondi | 331 ↔ 341 | By similarity | ||
Disulfide bondi | 336 ↔ 337 | By similarity |
Post-translational modificationi
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
jPOSTi | O96014 |
MassIVEi | O96014 |
PaxDbi | O96014 |
PeptideAtlasi | O96014 |
PRIDEi | O96014 |
ProteomicsDBi | 51196 |
PTM databases
GlyGeni | O96014, 5 sites |
iPTMneti | O96014 |
PhosphoSitePlusi | O96014 |
Expressioni
Tissue specificityi
Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000085741, Expressed in left adrenal gland and 145 other tissues |
ExpressionAtlasi | O96014, baseline and differential |
Genevisiblei | O96014, HS |
Organism-specific databases
HPAi | ENSG00000085741, Tissue enhanced (adipose tissue, breast) |
Interactioni
Binary interactionsi
Hide detailsO96014
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 113318, 23 interactors |
IntActi | O96014, 20 interactors |
MINTi | O96014 |
STRINGi | 9606.ENSP00000325526 |
Miscellaneous databases
RNActi | O96014, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Wnt family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000158413 |
HOGENOMi | CLU_033039_1_0_1 |
InParanoidi | O96014 |
OMAi | WLALSHT |
OrthoDBi | 797177at2759 |
PhylomeDBi | O96014 |
TreeFami | TF105310 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR026536, Wnt-11 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit PTHR12027:SF7, PTHR12027:SF7, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O96014-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG
60 70 80 90 100
LVSAQVQLCR SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY
110 120 130 140 150
LLDLERGTRE SAFVYALSAA AISHAIARAC TSGDLPGCSC GPVPGEPPGP
160 170 180 190 200
GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA
210 220 230 240 250
LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR
260 270 280 290 300
PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN
310 320 330 340 350
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER
YVCK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH8YS97 | H8YS97_HUMAN | Protein Wnt | WNT11 | 262 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 121 | A → T in CAA74159 (PubMed:9757009).Curated | 1 | |
Sequence conflicti | 121 | A → T in CAA73223 (PubMed:9757009).Curated | 1 | |
Sequence conflicti | 156 | G → R in CAA74159 (PubMed:9757009).Curated | 1 | |
Sequence conflicti | 156 | G → R in CAA73223 (PubMed:9757009).Curated | 1 | |
Sequence conflicti | 271 | S → W in CAA74159 (PubMed:9757009).Curated | 1 | |
Sequence conflicti | 271 | S → W in CAA73223 (PubMed:9757009).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13843 , Y13844, Y13845, Y13846, Y13847 Genomic DNA Translation: CAA74159.1 Y12692 mRNA Translation: CAA73223.1 AB070218 mRNA Translation: BAB72099.1 AK313570 mRNA Translation: BAG36343.1 BC074790 mRNA Translation: AAH74790.1 BC074791 mRNA Translation: AAH74791.1 BC113386 mRNA Translation: AAI13387.1 BC113388 mRNA Translation: AAI13389.1 |
CCDSi | CCDS8242.1 |
RefSeqi | NP_004617.2, NM_004626.2 XP_005274288.1, XM_005274231.1 |
Genome annotation databases
Ensembli | ENST00000322563; ENSP00000325526; ENSG00000085741 |
GeneIDi | 7481 |
KEGGi | hsa:7481 |
UCSCi | uc001oxe.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13843 , Y13844, Y13845, Y13846, Y13847 Genomic DNA Translation: CAA74159.1 Y12692 mRNA Translation: CAA73223.1 AB070218 mRNA Translation: BAB72099.1 AK313570 mRNA Translation: BAG36343.1 BC074790 mRNA Translation: AAH74790.1 BC074791 mRNA Translation: AAH74791.1 BC113386 mRNA Translation: AAI13387.1 BC113388 mRNA Translation: AAI13389.1 |
CCDSi | CCDS8242.1 |
RefSeqi | NP_004617.2, NM_004626.2 XP_005274288.1, XM_005274231.1 |
3D structure databases
SMRi | O96014 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113318, 23 interactors |
IntActi | O96014, 20 interactors |
MINTi | O96014 |
STRINGi | 9606.ENSP00000325526 |
PTM databases
GlyGeni | O96014, 5 sites |
iPTMneti | O96014 |
PhosphoSitePlusi | O96014 |
Polymorphism and mutation databases
BioMutai | WNT11 |
Proteomic databases
jPOSTi | O96014 |
MassIVEi | O96014 |
PaxDbi | O96014 |
PeptideAtlasi | O96014 |
PRIDEi | O96014 |
ProteomicsDBi | 51196 |
Protocols and materials databases
Antibodypediai | 31189, 134 antibodies |
DNASUi | 7481 |
Genome annotation databases
Ensembli | ENST00000322563; ENSP00000325526; ENSG00000085741 |
GeneIDi | 7481 |
KEGGi | hsa:7481 |
UCSCi | uc001oxe.4, human |
Organism-specific databases
CTDi | 7481 |
DisGeNETi | 7481 |
EuPathDBi | HostDB:ENSG00000085741.12 |
GeneCardsi | WNT11 |
HGNCi | HGNC:12776, WNT11 |
HPAi | ENSG00000085741, Tissue enhanced (adipose tissue, breast) |
MIMi | 603699, gene |
neXtProti | NX_O96014 |
OpenTargetsi | ENSG00000085741 |
PharmGKBi | PA37378 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000158413 |
HOGENOMi | CLU_033039_1_0_1 |
InParanoidi | O96014 |
OMAi | WLALSHT |
OrthoDBi | 797177at2759 |
PhylomeDBi | O96014 |
TreeFami | TF105310 |
Enzyme and pathway databases
PathwayCommonsi | O96014 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-4086398, Ca2+ pathway R-HSA-4086400, PCP/CE pathway |
SIGNORi | O96014 |
Miscellaneous databases
BioGRID-ORCSi | 7481, 3 hits in 843 CRISPR screens |
GeneWikii | WNT11 |
GenomeRNAii | 7481 |
Pharosi | O96014, Tbio |
PROi | PR:O96014 |
RNActi | O96014, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000085741, Expressed in left adrenal gland and 145 other tissues |
ExpressionAtlasi | O96014, baseline and differential |
Genevisiblei | O96014, HS |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR026536, Wnt-11 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit PTHR12027:SF7, PTHR12027:SF7, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT11_HUMAN | |
Accessioni | O96014Primary (citable) accession number: O96014 Secondary accession number(s): B2R8Z6, Q14DE8, Q8WZ98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 10, 2002 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM