UniProtKB - O96013 (PAK4_HUMAN)
Serine/threonine-protein kinase PAK 4
PAK4
Functioni
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
8 PublicationsCatalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 350 | ATPPROSITE-ProRule annotationCombined sources1 Publication | 1 | |
Active sitei | 440 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 327 – 335 | ATPPROSITE-ProRule annotationCombined sources1 Publication | 9 | |
Nucleotide bindingi | 396 – 398 | ATPCombined sources1 Publication | 3 | |
Nucleotide bindingi | 458 – 460 | ATPCombined sources1 Publication | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cadherin binding involved in cell-cell adhesion Source: BHF-UCL
- protein kinase activity Source: ProtInc
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- apoptotic process Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- cell migration Source: UniProtKB
- cellular response to organic cyclic compound Source: Ensembl
- cytoskeleton organization Source: UniProtKB
- dendritic spine development Source: Ensembl
- intracellular signal transduction Source: GO_Central
- negative regulation of endothelial cell apoptotic process Source: BHF-UCL
- positive regulation of angiogenesis Source: BHF-UCL
- protein phosphorylation Source: GO_Central
- regulation of cell growth Source: UniProtKB
- regulation of MAPK cascade Source: GO_Central
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Cell cycle |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | O96013 |
Reactomei | R-HSA-428540, Activation of RAC1 R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013407, RHOH GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013409, RHOJ GTPase cycle R-HSA-9013420, RHOU GTPase cycle R-HSA-9013423, RAC3 GTPase cycle R-HSA-9013424, RHOV GTPase cycle |
SignaLinki | O96013 |
SIGNORi | O96013 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase PAK 4 (EC:2.7.11.1)Alternative name(s): p21-activated kinase 4 Short name: PAK-4 |
Gene namesi | Name:PAK4 Synonyms:KIAA1142 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16059, PAK4 |
MIMi | 605451, gene |
neXtProti | NX_O96013 |
VEuPathDBi | HostDB:ENSG00000130669 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways.1 Publication
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: ProtInc
Other locations
- adherens junction Source: BHF-UCL
- cytoplasm Source: GO_Central
- focal adhesion Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 445 | S → N: Approximately 30-fold increased autophosphorylation (constitutively active mutant). 1 Publication | 1 | |
Mutagenesisi | 474 | S → E: Approximately 3-fold increased autophosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 10298 |
OpenTargetsi | ENSG00000130669 |
PharmGKBi | PA32920 |
Miscellaneous databases
Pharosi | O96013, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4482 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O96013 |
GuidetoPHARMACOLOGYi | 2136 |
Genetic variation databases
BioMutai | PAK4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086474 | 1 – 591 | Serine/threonine-protein kinase PAK 4Add BLAST | 591 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineCombined sources | 1 | |
Modified residuei | 78 | N6-methyllysineCombined sources | 1 | |
Modified residuei | 104 | PhosphoserineCombined sources | 1 | |
Modified residuei | 148 | PhosphoserineCombined sources | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 181 | PhosphoserineCombined sources | 1 | |
Modified residuei | 187 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 195 | PhosphoserineCombined sources | 1 | |
Modified residuei | 207 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 258 | PhosphoserineCombined sources | 1 | |
Modified residuei | 267 | PhosphoserineCombined sources | 1 | |
Modified residuei | 291 | PhosphoserineCombined sources | 1 | |
Modified residuei | 474 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O96013 |
jPOSTi | O96013 |
MassIVEi | O96013 |
MaxQBi | O96013 |
PaxDbi | O96013 |
PeptideAtlasi | O96013 |
PRIDEi | O96013 |
ProteomicsDBi | 51192 [O96013-1] 51193 [O96013-2] 51194 [O96013-3] 51195 [O96013-4] |
PTM databases
GlyGeni | O96013, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O96013 |
MetOSitei | O96013 |
PhosphoSitePlusi | O96013 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000130669, Expressed in type B pancreatic cell and 245 other tissues |
ExpressionAtlasi | O96013, baseline and differential |
Genevisiblei | O96013, HS |
Organism-specific databases
HPAi | ENSG00000130669, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
O96013
With | #Exp. | IntAct |
---|---|---|
CDC42 [P60953] | 3 | EBI-713738,EBI-81752 |
INKA1 [Q96EL1] | 3 | EBI-713738,EBI-10285157 |
TERF1 [P54274] | 2 | EBI-713738,EBI-710997 |
WASL [O00401] | 8 | EBI-713738,EBI-957615 |
YWHAZ [P63104] | 4 | EBI-713738,EBI-347088 |
Isoform 2 [O96013-2]
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-21659863,EBI-77613 |
SNCA [P37840] | 3 | EBI-21659863,EBI-985879 |
GO - Molecular functioni
- cadherin binding involved in cell-cell adhesion Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 115586, 118 interactors |
DIPi | DIP-39742N |
IntActi | O96013, 323 interactors |
MINTi | O96013 |
STRINGi | 9606.ENSP00000469413 |
Chemistry databases
BindingDBi | O96013 |
Miscellaneous databases
RNActi | O96013, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O96013 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O96013 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 24 | CRIBPROSITE-ProRule annotationAdd BLAST | 14 | |
Domaini | 321 – 572 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 320 | LinkerAdd BLAST | 296 | |
Regioni | 95 – 301 | DisorderedSequence analysisAdd BLAST | 207 | |
Regioni | 298 – 323 | GEF-interaction domain (GID)Add BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 146 – 165 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 236 – 252 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 274 – 293 | Pro residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0578, Eukaryota |
GeneTreei | ENSGT01040000240717 |
HOGENOMi | CLU_000288_26_6_1 |
InParanoidi | O96013 |
OMAi | VCIATMK |
PhylomeDBi | O96013 |
TreeFami | TF105352 |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit |
DisProti | DP01184 |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP
60 70 80 90 100
KPLVDPACIT SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL
110 120 130 140 150
RRDSPPPPAR ARQENGMPEE PATTARGGPG KAGSRGRFAG HSEAGGGSGD
160 170 180 190 200
RRRAGPEKRP KSSREGSGGP QESSRDKRPL SGPDVGTPQP AGLASGAKLA
210 220 230 240 250
AGRPFNTYPR ADTDHPSRGA QGEPHDVAPN GPSAGGLAIP QSSSSSSRPP
260 270 280 290 300
TRARGAPSPG VLGPHASEPQ LAPPACTPAA PAVPGPPGPR SPQREPQRVS
310 320 330 340 350
HEQFRAALQL VVDPGDPRSY LDNFIKIGEG STGIVCIATV RSSGKLVAVK
360 370 380 390 400
KMDLRKQQRR ELLFNEVVIM RDYQHENVVE MYNSYLVGDE LWVVMEFLEG
410 420 430 440 450
GALTDIVTHT RMNEEQIAAV CLAVLQALSV LHAQGVIHRD IKSDSILLTH
460 470 480 490 500
DGRVKLSDFG FCAQVSKEVP RRKSLVGTPY WMAPELISRL PYGPEVDIWS
510 520 530 540 550
LGIMVIEMVD GEPPYFNEPP LKAMKMIRDN LPPRLKNLHK VSPSLKGFLD
560 570 580 590
RLLVRDPAQR ATAAELLKHP FLAKAGPPAS IVPLMRQNRT R
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R0L9 | M0R0L9_HUMAN | Non-specific serine/threonine prote... | PAK4 | 182 | Annotation score: | ||
M0R2X4 | M0R2X4_HUMAN | Non-specific serine/threonine prote... | PAK4 | 131 | Annotation score: | ||
M0R3G6 | M0R3G6_HUMAN | Non-specific serine/threonine prote... | PAK4 | 93 | Annotation score: | ||
M0R1R1 | M0R1R1_HUMAN | Serine/threonine-protein kinase PAK... | PAK4 | 149 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040970 | 135 | R → Q1 PublicationCorresponds to variant dbSNP:rs56099436Ensembl. | 1 | |
Natural variantiVAR_040971 | 139 | A → T1 PublicationCorresponds to variant dbSNP:rs35655056Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017572 | 69 – 221 | Missing in isoform 3. 3 PublicationsAdd BLAST | 153 | |
Alternative sequenceiVSP_004892 | 120 | E → K in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_004893 | 121 – 285 | Missing in isoform 2. 1 PublicationAdd BLAST | 165 | |
Alternative sequenceiVSP_017573 | 132 – 221 | Missing in isoform 4. 1 PublicationAdd BLAST | 90 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ011855 mRNA Translation: CAA09820.1 AF005046 mRNA Translation: AAD01210.1 AB032968 mRNA Translation: BAA86456.1 Different initiation. AK074728 mRNA Translation: BAC11166.1 Different initiation. AK294586 mRNA Translation: BAG57777.1 AL834236 mRNA Translation: CAD38914.2 CH471126 Genomic DNA Translation: EAW56861.1 BC002921 mRNA Translation: AAH02921.1 BC011368 mRNA Translation: AAH11368.1 BC025282 mRNA Translation: AAH25282.1 BC034511 mRNA Translation: AAH34511.1 |
CCDSi | CCDS12528.1 [O96013-1] CCDS33019.1 [O96013-3] |
RefSeqi | NP_001014831.1, NM_001014831.2 [O96013-1] NP_001014832.1, NM_001014832.1 [O96013-1] NP_001014834.1, NM_001014834.2 [O96013-3] NP_001014835.1, NM_001014835.1 [O96013-3] NP_005875.1, NM_005884.3 [O96013-1] XP_011524618.1, XM_011526316.1 [O96013-1] XP_011524619.1, XM_011526317.2 [O96013-1] XP_011524620.1, XM_011526318.2 [O96013-1] XP_011524621.1, XM_011526319.2 [O96013-1] XP_011524622.1, XM_011526320.1 [O96013-3] |
Genome annotation databases
Ensembli | ENST00000321944; ENSP00000326864; ENSG00000130669 [O96013-4] ENST00000358301; ENSP00000351049; ENSG00000130669 ENST00000360442; ENSP00000353625; ENSG00000130669 ENST00000593690; ENSP00000469413; ENSG00000130669 ENST00000599386; ENSP00000471157; ENSG00000130669 [O96013-3] ENST00000599470; ENSP00000470284; ENSG00000130669 [O96013-3] |
GeneIDi | 10298 |
KEGGi | hsa:10298 |
UCSCi | uc002okj.2, human [O96013-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ011855 mRNA Translation: CAA09820.1 AF005046 mRNA Translation: AAD01210.1 AB032968 mRNA Translation: BAA86456.1 Different initiation. AK074728 mRNA Translation: BAC11166.1 Different initiation. AK294586 mRNA Translation: BAG57777.1 AL834236 mRNA Translation: CAD38914.2 CH471126 Genomic DNA Translation: EAW56861.1 BC002921 mRNA Translation: AAH02921.1 BC011368 mRNA Translation: AAH11368.1 BC025282 mRNA Translation: AAH25282.1 BC034511 mRNA Translation: AAH34511.1 |
CCDSi | CCDS12528.1 [O96013-1] CCDS33019.1 [O96013-3] |
RefSeqi | NP_001014831.1, NM_001014831.2 [O96013-1] NP_001014832.1, NM_001014832.1 [O96013-1] NP_001014834.1, NM_001014834.2 [O96013-3] NP_001014835.1, NM_001014835.1 [O96013-3] NP_005875.1, NM_005884.3 [O96013-1] XP_011524618.1, XM_011526316.1 [O96013-1] XP_011524619.1, XM_011526317.2 [O96013-1] XP_011524620.1, XM_011526318.2 [O96013-1] XP_011524621.1, XM_011526319.2 [O96013-1] XP_011524622.1, XM_011526320.1 [O96013-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BVA | X-ray | 2.30 | A/B | 300-591 | [»] | |
2CDZ | X-ray | 2.30 | A | 291-591 | [»] | |
2J0I | X-ray | 1.60 | A | 291-591 | [»] | |
2OV2 | X-ray | 2.10 | I/J/K/L/M/N/O/P | 10-44 | [»] | |
2Q0N | X-ray | 1.75 | A | 291-591 | [»] | |
2X4Z | X-ray | 2.10 | A | 297-591 | [»] | |
4APP | X-ray | 2.20 | A | 300-591 | [»] | |
4FIE | X-ray | 3.11 | A/B | 5-591 | [»] | |
4FIF | X-ray | 2.60 | A/B | 286-591 | [»] | |
C/D | 49-56 | [»] | ||||
4FIG | X-ray | 3.01 | A/B | 286-591 | [»] | |
4FIH | X-ray | 1.97 | A | 286-591 | [»] | |
4FII | X-ray | 2.00 | A | 286-591 | [»] | |
B | 49-56 | [»] | ||||
4FIJ | X-ray | 2.30 | A | 286-591 | [»] | |
4JDH | X-ray | 2.00 | A | 286-591 | [»] | |
4JDI | X-ray | 1.85 | A | 286-591 | [»] | |
4JDJ | X-ray | 2.30 | A | 286-591 | [»] | |
4JDK | X-ray | 2.40 | A | 286-591 | [»] | |
4L67 | X-ray | 2.80 | A | 300-591 | [»] | |
B | 36-60 | [»] | ||||
4NJD | X-ray | 2.50 | A | 300-591 | [»] | |
4O0V | X-ray | 2.80 | A | 300-591 | [»] | |
4O0X | X-ray | 2.48 | A | 300-591 | [»] | |
4O0Y | X-ray | 2.20 | A | 300-591 | [»] | |
4XBR | X-ray | 2.94 | A | 278-591 | [»] | |
4XBU | X-ray | 2.06 | A | 286-591 | [»] | |
5BMS | X-ray | 2.90 | A | 300-591 | [»] | |
5I0B | X-ray | 3.09 | A | 300-591 | [»] | |
5UPK | X-ray | 2.40 | A | 1-45 | [»] | |
B | 286-591 | [»] | ||||
5UPL | X-ray | 3.00 | A | 2-591 | [»] | |
5VED | X-ray | 2.30 | A | 286-591 | [»] | |
5VEE | X-ray | 2.50 | A | 286-591 | [»] | |
5VEF | X-ray | 1.75 | A | 286-591 | [»] | |
5XVA | X-ray | 1.85 | A | 300-591 | [»] | |
5XVF | X-ray | 2.65 | A | 300-588 | [»] | |
5XVG | X-ray | 2.10 | A | 300-591 | [»] | |
5ZJW | X-ray | 1.80 | A | 300-591 | [»] | |
6WLX | X-ray | 2.20 | A | 286-591 | [»] | |
6WLY | X-ray | 1.90 | A | 286-591 | [»] | |
7CMB | X-ray | 2.59 | A | 300-591 | [»] | |
7CP3 | X-ray | 2.90 | A | 300-591 | [»] | |
7CP4 | X-ray | 2.50 | A | 300-591 | [»] | |
SMRi | O96013 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115586, 118 interactors |
DIPi | DIP-39742N |
IntActi | O96013, 323 interactors |
MINTi | O96013 |
STRINGi | 9606.ENSP00000469413 |
Chemistry databases
BindingDBi | O96013 |
ChEMBLi | CHEMBL4482 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O96013 |
GuidetoPHARMACOLOGYi | 2136 |
PTM databases
GlyGeni | O96013, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O96013 |
MetOSitei | O96013 |
PhosphoSitePlusi | O96013 |
Genetic variation databases
BioMutai | PAK4 |
Proteomic databases
EPDi | O96013 |
jPOSTi | O96013 |
MassIVEi | O96013 |
MaxQBi | O96013 |
PaxDbi | O96013 |
PeptideAtlasi | O96013 |
PRIDEi | O96013 |
ProteomicsDBi | 51192 [O96013-1] 51193 [O96013-2] 51194 [O96013-3] 51195 [O96013-4] |
Protocols and materials databases
Antibodypediai | 16732, 628 antibodies from 43 providers |
CPTCi | O96013, 1 antibody |
DNASUi | 10298 |
Genome annotation databases
Organism-specific databases
CTDi | 10298 |
DisGeNETi | 10298 |
GeneCardsi | PAK4 |
HGNCi | HGNC:16059, PAK4 |
HPAi | ENSG00000130669, Low tissue specificity |
MIMi | 605451, gene |
neXtProti | NX_O96013 |
OpenTargetsi | ENSG00000130669 |
PharmGKBi | PA32920 |
VEuPathDBi | HostDB:ENSG00000130669 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0578, Eukaryota |
GeneTreei | ENSGT01040000240717 |
HOGENOMi | CLU_000288_26_6_1 |
InParanoidi | O96013 |
OMAi | VCIATMK |
PhylomeDBi | O96013 |
TreeFami | TF105352 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | O96013 |
Reactomei | R-HSA-428540, Activation of RAC1 R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013407, RHOH GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013409, RHOJ GTPase cycle R-HSA-9013420, RHOU GTPase cycle R-HSA-9013423, RAC3 GTPase cycle R-HSA-9013424, RHOV GTPase cycle |
SignaLinki | O96013 |
SIGNORi | O96013 |
Miscellaneous databases
BioGRID-ORCSi | 10298, 15 hits in 1082 CRISPR screens |
ChiTaRSi | PAK4, human |
EvolutionaryTracei | O96013 |
GeneWikii | PAK4 |
GenomeRNAii | 10298 |
Pharosi | O96013, Tchem |
PROi | PR:O96013 |
RNActi | O96013, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130669, Expressed in type B pancreatic cell and 245 other tissues |
ExpressionAtlasi | O96013, baseline and differential |
Genevisiblei | O96013, HS |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit |
DisProti | DP01184 |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PAK4_HUMAN | |
Accessioni | O96013Primary (citable) accession number: O96013 Secondary accession number(s): B4DGG6 Q9ULS8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 220 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families